Manipulations of Natural System Functions Within the Mississippi Delta: a Simulation-Modeling Study.

This dissertation uses two estuarine spatial models and energy analysis of two river diversions within the Mississippi Delta to test the hypothesis that natural river inputs maximize marsh coverage and have net societal benefits. Substantial advancements including a higher resolution, variable time-step hydrodynamic module, a mass-balance sediment component, and a marsh colonization routine, distinguished the Mississippi Deltas Model (MDM) from the Barataria-Terrebonne Landscape Simulation Model (BTELSS). These advancements made the MDM capable of simulating the progradation of river deltas with varying river regimes. No Action Plans (NAP), simulated by both models, were used as a baseline of comparison for simulations and predicted continued land loss in the Barataria and Terrebonne basins, and land gain in and around the Atchafalaya and Wax Lake Deltas. The river diversion simulation with the BTELSS resulted in the preservation of 113 km2 of marsh and identified river diversions as alternatives that can slow the rate of land loss in abandoned delta lobes. In the LDM simulations with magnified river flow and sediment discharge increased the growth of the deltas above the NAP rate of 2.5 km2/yr, and reversed the trend in surrounding marshes from land loss to land gain. Areas with diminished river inputs due to jetty construction experienced declines in marsh coverage. The results from the model simulations supported the hypothesis that natural river inputs maximize marsh coverage. The river diversion study demonstrated the ability of energy analysis to compare natural energies and economic resources on a common basis and identified a unique concentration of natural energies that characterize delta settings. By relying primarily upon renewable energies inherent in delta environments to produce both economic and ecological benefits, the diversions represent an important component of sustainable management plans for deltaic systems. The amount of additional energy exported due to the diversions outweighed the economic costs and supported the hypothesis that restoring riverine inputs to deltaic marshes has net societal benefits. By maximizing marsh coverage and producing societal benefits, the optimization of natural riverine inputs is a sustainable approach to protect and restore deltaic ecosystems

Flight Research at Ames: Fifty-Seven Years of Development and Validation of Aeronautical Technology

This NASA special publication presents a general overview of the flight research that has been conducted at Ames Research Center over the last 57 years. Icing research, transonic model testing, aerodynamics, variable stability aircraft, boundary layer control, short takeoff and landing (STOL), vertical/ short takeoff and landing (V/STOL) and rotorcraft research are among the major topics of interest discussed. Flying qualities, stability and control, performance evaluations, gunsight tracking and guidance and control displays research are also presented. An epilogue is included which presents the significant contributions that came about as a result of research and development conducted at Ames

William (Bill) Peterson's contributions to ocean science, management, and policy

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Schwing, F. B., Sissenwine, M. J., Batchelder, H., Dam, H. G., Gomez-Gutierrez, J., Keister, J. E., Liu, H., & Peterson, J. O. William (Bill) Peterson's contributions to ocean science, management, and policy. Progress in Oceanography, 182, (2020): 102241, doi:10.1016/j.pocean.2019.102241.In addition to being an esteemed marine ecologist and oceanographer, William T. (Bill) Peterson was a dedicated public servant, a leader in the ocean science community, and a mentor to a generation of scientists. Bill recognized the importance of applied science and the need for integrated “big science” programs to advance our understanding of ecosystems and to guide their management. As the first US GLOBEC program manager, he was pivotal in transitioning the concept of understanding how climate change impacts marine ecosystems to an operational national research program. The scientific insight and knowledge generated by US GLOBEC informed and advanced the ecosystem-based management approaches now being implemented for fishery management in the US. Bill held significant leadership roles in numerous international efforts to understand global and regional ecological processes, and organized and chaired a number of influential scientific conferences and their proceedings. He was passionate about working with and training young researchers. Bill’s academic affiliations, notably at Stony Brook and Oregon State Universities, enabled him to advise, train, and mentor a host of students, post-doctoral researchers, and laboratory technicians. Under his collegial guidance they became critical independent thinkers and diligent investigators. His former students and colleagues carry on Bill Peterson’s legacy of research that helps us understand marine ecosystems and informs more effective resource stewardship and conservation

The changing role of the local news media in enabling citizens to engage in local democracies

Using Leeds City Council in the United Kingdom as a case study, we analyse comparatively the changing role of local journalism in the public communications and engagement strategies of local government. Drawing on over 20 semi-structured interviews with elected politicians, Council strategists, mainstream journalists, and citizen journalists, the article explores perceptions of the mainstream news media's role versus new modes of communication in engaging and communicating with citizens. We evaluate the Council's perceptions of its online and offline practices of engagement with different publics, and focus in particular on their interactions with journalists, the news media, and citizen journalists. The article considers how moves towards digital modes of engagement are changing perceptions of the professional role orientations of journalists in mediating between the Council and the general public

Mimesis stories: composing new nature music for the shakuhachi

Nature is a widespread theme in much new music for the shakuhachi (Japanese bamboo flute). This article explores the significance of such music within the contemporary shakuhachi scene, as the instrument travels internationally and so becomes rooted in landscapes outside Japan, taking on the voices of new creatures and natural phenomena. The article tells the stories of five compositions and one arrangement by non-Japanese composers, first to credit composers’ varied and personal responses to this common concern and, second, to discern broad, culturally syncretic traditions of nature mimesis and other, more abstract, ideas about the naturalness of sounds and creative processes (which I call musical naturalism). Setting these personal stories and longer histories side by side reveals that composition creates composers (as much as the other way around). Thus it hints at much broader terrain: the refashioning of human nature at the confluence between cosmopolitan cultural circulations and contemporary encounters with the more-than-human world

Oral Migalastat HCl Leads to Greater Systemic Exposure and Tissue Levels of Active α-Galactosidase A in Fabry Patients when Co-Administered with Infused Agalsidase.

UnlabelledMigalastat HCl (AT1001, 1-Deoxygalactonojirimycin) is an investigational pharmacological chaperone for the treatment of α-galactosidase A (α-Gal A) deficiency, which leads to Fabry disease, an X-linked, lysosomal storage disorder. The currently approved, biologics-based therapy for Fabry disease is enzyme replacement therapy (ERT) with either agalsidase alfa (Replagal) or agalsidase beta (Fabrazyme). Based on preclinical data, migalastat HCl in combination with agalsidase is expected to result in the pharmacokinetic (PK) enhancement of agalsidase in plasma by increasing the systemic exposure of active agalsidase, thereby leading to increased cellular levels in disease-relevant tissues. This Phase 2a study design consisted of an open-label, fixed-treatment sequence that evaluated the effects of single oral doses of 150 mg or 450 mg migalastat HCl on the PK and tissue levels of intravenously infused agalsidase (0.2, 0.5, or 1.0 mg/kg) in male Fabry patients. As expected, intravenous administration of agalsidase alone resulted in increased α-Gal A activity in plasma, skin, and peripheral blood mononuclear cells (PBMCs) compared to baseline. Following co-administration of migalastat HCl and agalsidase, α-Gal A activity in plasma was further significantly increased 1.2- to 5.1-fold compared to agalsidase administration alone, in 22 of 23 patients (95.6%). Importantly, similar increases in skin and PBMC α-Gal A activity were seen following co-administration of migalastat HCl and agalsidase. The effects were not related to the administered migalastat HCl dose, as the 150 mg dose of migalastat HCl increased α-Gal A activity to the same extent as the 450 mg dose. Conversely, agalsidase had no effect on the plasma PK of migalastat. No migalastat HCl-related adverse events or drug-related tolerability issues were identified.Trial registrationClinicalTrials.gov NCT01196871

The Grizzly, February 18, 2016

Norovirus Sickens 200+ • Ursinus Remembers Dr. Richard King • Rainbow Resource Center Comes Back • Mid-term Recharge Created to Help Students Through Slump • Renowned Author Visits Campus • Quaker Group Formalizing • Activities, Meals and Deals for Students Without Wheels • From Bike Lanes to BWC • Opinions: Wismer Wasted by Health Code Violations; Admin Response to Illness Strikes Controversy • For Hot-Shooting Knowles, Injury Ends Season Early But Future Still Shines Bright • Norovirus Keeps Wrestling Team Away from CC Championshipshttps://digitalcommons.ursinus.edu/grizzlynews/1683/thumbnail.jp

Uptake Coefficients of Some Volatile Organic Compounds by Soot and Their Application in Understanding Particulate Matter Evolution in Aircraft Engine Exhaust Plumes

To assist microphysical modeling on particulate matter (PM) evolution emitted from aircraft engines, uptake coefficients of some volatile organic compounds on soot were experimentally determined in this study. The determined values vary from (1.0±0.1)×10⁻⁶ for water-miscible propylene glycol to (2.5±0.1)×10⁻⁵ for 2,6-dimethylnaphthalene, a polycyclic aromatic hydrocarbon. An inverse power-law correlation between uptake coefficient on soot and solubility in water was observed. Using the correlation, microphysical simulations were performed for the exhaust plume evolution from an idling aircraft, and we found that the model-predicted volatile PM composition on soot is comparable with those results from past field measurements.United States. Department of Defense (Contract W912HQ-08-C-0052

A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy

Background: Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease. Methods: Patients had well-documented Lyme disease, with at least 3 weeks of prior IV antibiotics, current positive IgG Western blot, and objective memory impairment. Healthy individuals served as controls for practice effects. Patients were randomly assigned to 10 weeks of double-masked treatment with IV ceftriaxone or IV placebo and then no antibiotic therapy. The primary outcome was neurocognitive performance at week 12—specifically, memory. Durability of benefit was evaluated at week 24. Group differences were estimated according to longitudinal mixed-effects models. Results: After screening 3368 patients and 305 volunteers, 37 patients and 20 healthy individuals enrolled. Enrolled patients had mild to moderate cognitive impairment and marked levels of fatigue, pain, and impaired physical functioning. Across six cognitive domains, a significant treatment-by-time interaction favored the antibiotic-treated group at week 12. The improvement was generalized (not specific to domain) and moderate in magnitude, but it was not sustained to week 24. On secondary outcome, patients with more severe fatigue, pain, and impaired physical functioning who received antibiotics were improved at week 12, and this was sustained to week 24 for pain and physical functioning. Adverse events from either the study medication or the PICC line were noted among 6 of 23 (26.1%) patients given IV ceftriaxone and among 1 of 14 (7.1%) patients given IV placebo; these resolved without permanent injury. Conclusion: IV ceftriaxone therapy results in short-term cognitive improvement for patients with posttreatment Lyme encephalopathy, but relapse in cognition occurs after the antibiotic is discontinued. Treatment strategies that result in sustained cognitive improvement are needed