227 research outputs found

    Science and Theology: A Working Synthesis

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    Theologians and scientists, working independently, have provided worldviews that lead to questions about the meaning of existence and human life. When these disciplines interact, opportunity exists for more profound insight. Two individuals, Johannes Kepler in the sixteenth century and Pierre Teilhard de Chardin in the twentieth, attempted theological reconstructions based on revolutionary theories of their eras. Informed by a fierce faith in God and a rigorous pursuit of truth derived from the scientific method, their attempts at synthesizing these fields led to results that were unexpected, even unwanted. Yet they provide lessons in the present age for interpretations of the new discoveries and the responsibility of humankind to play an active role in the modern creation story

    Social studies references in six Rhode Island high schools

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    Thesis (Ed.M.)--Boston Universit

    Cockroach Allergy and Asthma in a 30-Year-Old Man

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    A growing body of evidence has implicated allergens derived from cockroaches as an important environmental factor that may aggravate asthma in sensitized persons. We present the case of a 30-year-old man with asthma and a cockroach allergy. Allergy skin testing confirmed hypersensitivity to cockroach extract, and a home visit revealed visual evidence of infestation and the presence of Bla g 1 German cockroach allergen in vacuumed dust. As is typical of patients with a cockroach allergy and asthma, multiple factors in addition to cockroach allergen appeared to aggravate the patient's asthma. A multimodality therapeutic regimen, which included medications as well as cleaning of the home, integrated pest management, and professional application of chemical controls, resulted in substantial clinical improvement. The pathophysiology, epidemiology, and clinical features of cockroach-allergic asthma are reviewed, and an approach to diagnosis and management is suggested.National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences (AI39769, AI35786); National Heart, Lung, and Blood Institute (HL03062

    Disinforming the Public

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    Saint-Sernin Bertrand, Frank Marie-Thérèse, Mignaval Pierre. N° 54 — SAINT-SERNIN Bertrand. In: Témoins et acteurs des politiques de l'éducation depuis la Libération. Tome 4 - Inventaire de soixante-quatre entretiens. Paris : Institut national de recherche pédagogique, 2005. pp. 152-154. (Témoins et acteurs des politiques de l'éducation, 1

    The biological determinism of John Steinbeck as seen in Sea of Cortez and as exemplified in his novels

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    Thesis (M.A.)--Boston UniversityBy thus searching for evidences of Steinbeck's philosophy as he bas outlined it in Sea of Cortez, and illustrated it in his fiction, it can be seen that a coherent philosophy dominates all of Steinbeck's writings. By analyzing this philosophy in terms of the accepted philosophical schools ot thought it can be seen that the theory of biological determinism is consistent with those concepts which are Steinbeck's and its application thereby justified

    Unprecedented incorporation of α-emitter radioisotope 213Bi into porphyrin chelates with reference to a daughter isotope mediated assistance mechanism.

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    International audienceFor the first time, α-emitter radioisotope (213)Bi has been incorporated into porphyrin chelates, with rates matching with the short period of the radionuclide. An in situ transmetalation mechanism involving the daughter isotope (209)Pb is expected to boost the (213)Bi radiolabeling process

    Convergent genetic and expression data implicate immunity in Alzheimer's disease

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    Background Late–onset Alzheimer's disease (AD) is heritable with 20 genes showing genome wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease we extended these genetic data in a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated gene expression networks in human brain. Results ALIGATOR identified an excess of curated biological pathways showing enrichment of association. Enriched areas of biology included the immune response (p = 3.27×10-12 after multiple testing correction for pathways), regulation of endocytosis (p = 1.31×10-11), cholesterol transport (p = 2.96 × 10-9) and proteasome-ubiquitin activity (p = 1.34×10-6). Correlated gene expression analysis identified four significant network modules, all related to the immune response (corrected p 0.002 – 0.05). Conclusions The immune response, regulation of endocytosis, cholesterol transport and protein ubiquitination represent prime targets for AD therapeutics

    Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

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    Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction
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