Plan de negocio para la creaci?n de una comunidad virtual para el intercambio de informaci?n de mascotas y centralizaci?n de los servicios asociados

En los ?ltimos a?os ha habido un crecimiento en lo que respecta a la preocupaci?n por los animales, tanto en el Per? como en el mundo. La presente tesis desea establecer los indicios para la creaci?n de un plan de negocio acerca de una comunidad virtual para amantes de animales en la cual se permita la interrelaci?n entre las personas para el intercambio de informaci?n y el acceso a todos los servicios que tengan relaci?n con las mascotas, as? como permitir adquirir productos de diferentes tiendas virtuales. Este proyecto no solo permitir? acercar a las personas amante de animales, sino que ser? una oportunidad para que establecimientos que no tengan presencia en redes, puedan digitalizar sus tiendas y llegar a mas clientes, as? como tambi?n permitir? a cualquier persona o proveedores independientes a exponer la posibilidad de brindar distintos servicios para las mascotas, entres cuidado de mascotas, paseo o entrenamiento de perros, etc. Luego de un an?lisis financiero y en base a todos los costos, y estimaci?n de ingresos obtuvimos una VAN de S/. 93, 118 y una TIR de 28.29% haciendo al proyecto rentable

Impact of cardiovascular risk factors on the clinical presentation and survival of pulmonary embolism without identifiable risk factor

Background: The nature of pulmonary embolism (PE) without identifiable risk factor (IRF) remains unclear. The objective of this study is to investigate the potential relationship between cardiovascular risk factors (CVRFs) and PE without IRF (unprovoked) and assess their role as markers of disease severity and prognosis. Methods: A case-control study was performed of patients with PE admitted to our hospital [2010-2019]. Subjects with PE without IRF were included in the cohort of cases, whereas patients with PE with IRF were allocated to the control group. Variables of interest included age, active smoking, obesity, and diagnosis of arterial hypertension, dyslipidemia or diabetes mellitus. Results: A total of 1,166 patients were included in the study, of whom 64.2% had PE without IRF. The risk for PE without IRF increased with age [odds ratio (OR): 2.68; 95% confidence interval (CI): 1.95-3.68], arterial hypertension (OR: 1.63; 95% CI: 1.27-2.07), and dyslipidemia (OR: 1.63; 95% CI: 1.24-2.15). The risk for PE without IRF was higher as the number of CVRF increased, being 3.99 (95% CI: 2.02-7.90) for subjects with >/=3 CVRF. The percentage of high-risk unprovoked PE increased significantly as the number of CVRF rose [0.6% for no CVRF; 23.8% for a CRF, P/=3, P<0.001 (OR: 14.1; 95% CI: 4.06-49.4)]. No significant differences were observed in 1-month survival between cases and controls, whereas differences in 24-month survival reached significance. Conclusions: A relationship was observed between CVRF and PE without IRF, as the risk for unprovoked PE increased with the number of CVRF. In addition, the number of CVRF was associated with PE without IRF severity, but not with prognosis

Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials.

Funder: laura and john arnold foundationBACKGROUND: Convalescent plasma has been widely used to treat COVID-19 and is under investigation in numerous randomized clinical trials, but results are publicly available only for a small number of trials. The objective of this study was to assess the benefits of convalescent plasma treatment compared to placebo or no treatment and all-cause mortality in patients with COVID-19, using data from all available randomized clinical trials, including unpublished and ongoing trials (Open Science Framework, https://doi.org/10.17605/OSF.IO/GEHFX ). METHODS: In this collaborative systematic review and meta-analysis, clinical trial registries (ClinicalTrials.gov, WHO International Clinical Trials Registry Platform), the Cochrane COVID-19 register, the LOVE database, and PubMed were searched until April 8, 2021. Investigators of trials registered by March 1, 2021, without published results were contacted via email. Eligible were ongoing, discontinued and completed randomized clinical trials that compared convalescent plasma with placebo or no treatment in COVID-19 patients, regardless of setting or treatment schedule. Aggregated mortality data were extracted from publications or provided by investigators of unpublished trials and combined using the Hartung-Knapp-Sidik-Jonkman random effects model. We investigated the contribution of unpublished trials to the overall evidence. RESULTS: A total of 16,477 patients were included in 33 trials (20 unpublished with 3190 patients, 13 published with 13,287 patients). 32 trials enrolled only hospitalized patients (including 3 with only intensive care unit patients). Risk of bias was low for 29/33 trials. Of 8495 patients who received convalescent plasma, 1997 died (23%), and of 7982 control patients, 1952 died (24%). The combined risk ratio for all-cause mortality was 0.97 (95% confidence interval: 0.92; 1.02) with between-study heterogeneity not beyond chance (I2 = 0%). The RECOVERY trial had 69.8% and the unpublished evidence 25.3% of the weight in the meta-analysis. CONCLUSIONS: Convalescent plasma treatment of patients with COVID-19 did not reduce all-cause mortality. These results provide strong evidence that convalescent plasma treatment for patients with COVID-19 should not be used outside of randomized trials. Evidence synthesis from collaborations among trial investigators can inform both evidence generation and evidence application in patient care

El impacto econ?mico-demogr?fico de la descentralizaci?n industrial en la meseta central, 1970-1990

P?ginas 157-185 (29 p.)Las transformaciones econ?mico-espaciales de las tres ?ltimas d?cadas, han modificado la funcionalidad de las regiones socio naturales del pa?s. En ese lapso, se han instrumentado diferentes estrategias de desarrollo econ?mico en atenci?n a los ritmos desiguales de crecimiento hasta ahora observados. Durante el periodo 1940-1970, la industrializaci?n se circunscribe dentro de un modelo de relaciones campo-ciudad orientado al desarrollo y fortalecimiento de la econom?a urbana. Pese a los esfuerzos realizados, todav?a en 1970, y para efectos demogr?ficos, M?xico era un pa?s rural. Una d?cada m?s tarde, a la par de la crisis agraria, se observ? un proceso de urbanizaci?n amplio hacia las ciudades con m?s de un mill?n de habitantes

Perfil de estabilidad dimensional de las maderas primavera y Rosa Morada

El perfil de estabilidad dimensional de las maderas Roseodendron donnell-smithii (Primavera) y Tabebuia rosea (Rosa morada) se determin� mediante la investigaci�n experimental de sus principales �ndices de movimiento dimensional y anisotrop�as, de acuerdo a la norma DIN 52 184. Se recolectaron seis �rboles de cada especie del estado de Chiapas; a partir de la zona de di�metro normal de cada �rbol se elaboraron 24 espec�menes de prueba de 25 x 25 x 10 mm saturados de humedad y se acondicionaron secuencialmente en clima con humedad relativa del aire de 65, 85, 35 y 0 % e inmersi�n en agua hasta saturaci�n, para calcular diversos �ndices. Los resultados indican: hinchamiento m�ximo radial = 3.3 y 3.0 % y tangencial = 6.2 y 6.9 %; hinchamiento diferencial radial = 0.14 y 0.15 % / % y tangencial = 0.24 y 0.29 %/ %; contracci�n radial normal por secado = 1.3 y 0.88 % y tangencial = 2.5 y 1.8 %, anisotrop�a del hinchamiento diferencial = 1.7 y 2.0, y anisotrop�a de la contracci�n por secado = 2.0 y 2.2. Con base en esta �ltima, se infiere que puede tener comportamiento estable ante cambios de su contenido de humedad desde el estado verde al seco (CH?12 %). Las manufacturas elaboradas con madera seca de estas especies manifestar�n muy buena estabilidad dimensional en uso con ambientes de humedades relativas del aire de 65 a 85 % � 65 a 35 %. A excepci�n de la contracci�n normal por secado (mayor en madera Primavera), el movimiento dimensional de ambas result� similar no obstante su diferencia en densidad