Algebras of operations in K-theory

We describe explicitly the algebras of degree zero operations in connective and periodic p-local complex K-theory. Operations are written uniquely in terms of certain infinite linear combinations of Adams operations, and we give formulas for the product and coproduct structure maps. It is shown that these rings of operations are not Noetherian. Versions of the results are provided for the Adams summand and for real K-theory.Comment: 25 page

Alien Registration- Francis, Sarah (Old Town, Penobscot County)

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CHARACTERIZING pRB’S ROLE IN CELL CYCLE CONTROL, MAMMARY GLAND DEVELOPMENT, AND TUMORIGENESIS: A UNIQUE CONNECTION TO TGF-p SIGNALLING

The ability to respond to anti-growth signals is critical to maintain tissue homeostasis and loss of this proliferative control mechanism is considered a hallmark of cancer. Negative growth regulation generally occurs during the G0/G1 phase of the cell cycle, yet the redundancy and complexity among components of this regulatory network have made it difficult to discern how negative growth cues protect cells from aberrant proliferation. . Transforming growth factor (3(TGF-P) is a crucial mediator of mammary epithelial morphogenesis and can negatively regulate cell cycle progression. TGF-P has been shown to inhibit cyclin dependent kinase activity, which leads to activation of the retinoblastoma protein (pRB) and growth arrest. However, unlike other components of TGF-P cytostatic signalling, pRB is thought to be dispensable for mammary development. Using gene-targeted mice where the LXCXE binding cleft on pRB has been disrupted (R b l^ and RblNF), we have discovered that pRB plays a crucial role in mammary gland development. In particular, Rbl and RblNFmutant female mice have hyperplastic mammary epithelium due to insensitivity to TGF-P growth inhibition. In contrast with previous studies that highlight the inhibition of cyclin/CDK activity by TGF-P signalling, these experiments reveal that active transcriptional repression of E2F target genes by pRB is also a key component of TGF-p cytostatic signalling. However, loss of pRB-LXCXE interactions does not cause overt defects in other TGF-P signalling pathways such as apoptosis and differentiation. Taken together, this work demonstrates a unique functional connection between pRB and TGF-p in growth control and mammary development. iii These findings were extended to explore the importance of the pRB anti­ proliferative response during tumour formation and progression. Cytostatic control is considered a key tumour suppressive mechanism in the mammary gland. Here I show that LXCXE-dependent growth control by pRB blocks formation of mammary tumours in Wap-p53R172Htransgenic mice. In contrast, the same growth control mechanism is unnecessary to protect against Neu or 7,72-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Taken together, this work demonstrates that anti-proliferative control by pRB can act as a barrier against oncogenic transformation. Strikingly, these data also reveals that this tumour suppressive effect is context-dependent

The algebra of cell-zeta values

In this paper, we introduce cell-forms on $\mathcal{M}_{0,n}$, which are top-dimensional differential forms diverging along the boundary of exactly one cell (connected component) of the real moduli space $\mathcal{M}_{0,n}(\mathbb{R})$. We show that the cell-forms generate the top-dimensional cohomology group of $\mathcal{M}_{0,n}$, so that there is a natural duality between cells and cell-forms. In the heart of the paper, we determine an explicit basis for the subspace of differential forms which converge along a given cell $X$. The elements of this basis are called insertion forms, their integrals over $X$ are real numbers, called cell-zeta values, which generate a $\mathbb{Q}$-algebra called the cell-zeta algebra. By a result of F. Brown, the cell-zeta algebra is equal to the algebra of multizeta values. The cell-zeta values satisfy a family of simple quadratic relations coming from the geometry of moduli spaces, which leads to a natural definition of a formal version of the cell-zeta algebra, conjecturally isomorphic to the formal multizeta algebra defined by the much-studied double shuffle relations

Hybrid Food Preservation Program Improves Food Preservation and Food Safety Knowledge

The growing trend in home food preservation raises concerns about whether the resulting food products will be safe to eat. The increase public demand for food preservation information led to the development of the comprehensive food preservation program, Preserve the Taste of Summer (PTTS). PTTS is a comprehensive hybrid food preservation program comprised of online lessons and corresponding in-person workshops. PTTS participants reported increases in knowledge about food preservation food safety and recommended food preservation techniques after participating

Reproductive performance of resident and migrant males, females and pairs in a partially migratory bird

We thank everyone from the Centre for Ecology & Hydrology (CEH) who contributed to data collection, and Scottish Natural Heritage for access to the Isle of May National Nature Reserve. We thank the Scottish Ornithologists’ Club (SOC) for their support, and all volunteer observers, particularly Raymond Duncan, Moray Souter and Bob Swann. HG was funded by a Natural Environment Research Council (NERC) CASE studentship supported by CEH and SOC, FD, SW, MPH, MN and SB were funded by NERC and the Joint Nature Conservation Committee, and JMR was part-funded by the Royal Society. Finally, we thank the Associate Editor and two reviewers for constructive comments on the manuscript. The data are available from the Dryad Digital Repository https://doi.org/10.5061/dryad.532j0 (Grist et al., 2017)Peer reviewedPublisher PD

LIFE Lessons Newsletters

LIFE Lessons is a set of eight newsletters (4 Fitness and Nutrition; 4 Social Wellness) that are part of the Living (well through) Intergenerational Fitness and Exercise (LIFE) physical activity program for older adults. They are intended for use with the LIFE Program only.https://lib.dr.iastate.edu/fshn_hs_extensionpubs/1001/thumbnail.jp