Can we predict the success of prostatic surgery for male lower urinary tract symptoms : ICI-RS 2018?

Aims: Male lower urinary tract symptoms (LUTS) are common and bothersome symptoms in the aging population, of which the etiology is multifactorial. Prostatic surgery may be considered to alleviate some of these LUTS, especially in patients in which benign prostatic obstruction is believed to be the underlying cause. The aim of this paper is to discuss underlying pathophysiology, signs, and conditions that may lead to success or failure after prostatic surgery in male patients with LUTS. Methods: The paper is a report of presentations and subsequent discussions at the annual International Consultation on Incontinence Research Society, in June 2018 in Bristol. Results and conclusions: Unfavorable outcomes after prostatic surgery are reported in 25% to 30% of the patients. This may be due to persistent or de novo symptoms, related to the multifactorial origin of symptoms. Specific underlying conditions such as with detrusor overactivity, detrusor underactivity, and nocturnal polyuria are discussed in their relationship with prostatic surgery. Knowledge gaps are addressed and specific research questions proposed

Les territoires du futur

En vingt ans, le territoire français a connu de profondes modifications. Son image, sa réalité changent : concentration des populations et des activités, grande mobilité des hommes, différenciation des espaces ruraux, détérioration de l'environnement, mobilisation des acteurs locaux, ouverture européenne... L'avenir s'annonce incertain. Fruit d'une recherche initiée par la Délégation à l'aménagement du territoire et à l'action régionale, cet ouvrage propose six images du futur. Il discute leurs probabilités, leurs conséquences pour notre vie quotidienne. Il suggère des choix stratégiques aux pouvoirs publics. Instrument de dialogue, il stimulera la réflexion de tous. Par ses vues d'ensemble, il veut réduire les incertitudes du futu

Electron-Sponge Behavior and Electronic Structures in Cobalt-Centered Pentagonal Prismatic Co11Te7(CO)10 and Co11Te5(CO)15 Cluster Anions (lien).

International audienc

Development of a flowchart reflecting the current attitude and approach towards idiopathic overactive bladder treatment in Belgium : a Delphi study

Aims Idiopathic overactive bladder syndrome (iOAB) is a prevalent condition in urological practice. The variability in management between specialists and between centers remains high. Even existing guidelines contain inconsistencies. We aimed to develop a treatment algorithm for iOAB for use in daily clinical practice. Methods From October 2018 till November 2019, a Delphi study was conducted to obtain expert consensus on the management of iOAB. Members from the Belgian Working Group of Functional Urology were asked to rate online statements, based on gaps and variabilities between the American Urology Association (AUA), European Association of Urology (EAU) and International Consultation on Incontinence (ICI) guidelines on iOAB. The consensus was reached if >= 75% of the panel agreed on the level of appropriateness. Two Delphi rounds and an open discussion session were held. Results Twenty out of 49 members completed the first round and 18 completed the second round. The consensus was reached on 44/143 statements and 15/56 statements in the first and second round, respectively. The consensus was reached on criteria by which to phenotype OAB patients, the terminology relating to the first-, second- and third-line treatment, the duration of therapies, the chronological order, and the choice between therapies. No consensus was reached on the role of percutaneous tibial nerve stimulation (PTNS) in the treatment algorithm. Conclusions A flowchart reflecting the current attitude and approach of a Delphi expert panel towards the treatment of iOAB was developed. We propose its use in daily clinical practice to increase the standardization of OAB treatment

L'aménagement en 50 tendances

217 p.Nos modes de vie changent. Nous nous déplaçons de plus en plus, nous n'habitons plus a proximité de notre travail, l'économie est à la fois de plus en plus locale et de plus en plus globale, la décentralisation transforme peu à peu la France...Dès lors, les règles du jeu de l'aménagement du territoire en sont bouleversées. On parle d'un nouveau territoire en sont bouleversées. On parle d'un nouveau territoire en gestation, bientôt constitué autour d'agglomérations et de pays, on entend améliorer les approches et les procédures de la planification territoiriale, on donne aux politiques territoriales le nouvel horizon du développement durable... Les auteurs de cet ouvrage, en analysant l'ampleur de ces mutations, nous donnent à voir les enjeux que cela soulève pour les politiques d'aménagement. En cinquante aperçus formulés selon des angles d'approche différents, ils témoignent des lignes d'évolution des systèmes urbains et des logiques territoriales en soulignant les freins, les blocages ou les chances de changement. En tête des questionnements, on trouve les mutations de l'Etat et des grandes institutions, les effets de la mondialisation sur les dynamiques spatiales et urbaines, les transformations des politiques urbaines, lse contradictions et les enjeux du développement durable, les nouveaux outils et les nouvelles approches des questions d'aménagement. Avec cet examen des principales tendances à l'œuvre, le lecteur, comme le décideur, s'ouvrira à une vision approfondie des enjeux en cours et aux nécessités d'une pensée beaucoup plus prospective. Une synthèse qui vient à point nommé au moment où va s'engager une nouvelle phase de décentralisation

Discriminations systémiques : Justice

Complete small ribosomal subunit RNA sequences were used to infer the relationship between several basidiomycetous yeasts, and to resolve the evolutionary position of the basidiomycetes among the fungi. The sequences were determined for Rhodosporidium toruloides (anamorph Rhodotorula glutinis), Filobasidiella neoformans (anamorph Cryptococcus neoformans), Trichosporon cutaneum, Bullera alba and Sporobolomyces roseus. The sequence of Leucosporidium scottii (anamorph formerly named Candida scottii) srRNA has already been published previously (Hendriks et al., J. Mol. Evol. 32, 167-177 (1991)). Using a tree construction program based on a distance matrix, a phylogenetic tree was constructed for all hitherto known fungal srRNA sequences, oomycetes and slime moulds not included. It showed the ascomycetes and the basidiomycetes to be sister groups, probably evolved from a zygomycete-like ancestor and diverged from each other about 840 Myr ago. Among the basidiomycetes, two clearly distinct groups can be recognized, one formed by the teliospore forming species (Rhodosporidium toruloides and Leucosporidium scottii), and the asexual yeast Sporobolomyces roseus, and the other formed by the non-teliospore forming species Filobasidiella neoformans and the asexual yeasts Bullera alba and Trichosporon cutaneum

Retrieval of MetOp-A/IASI CO profiles and validation with MOZAIC data

The IASI (Infrared Atmospheric Sounding Interferometer) nadir-looking thermal infrared sounder onboard MetOp-A enables the monitoring of atmospheric constituents on a global scale. This paper presents a quality assessment of IASI CO profiles retrieved by the two different retrieval algorithms SOFRID and FORLI, by an intercomparison with airborne in-situ CO profiles from the MOZAIC program for the 2008-2009 period. Lower (surface-480 hPa) and upper tropospheric partial column (480-225 hPa) comparisons as well as profile comparisons are made. The retrieval errors of the IASI products are less than 21% in the lower troposphere and less than 10% in the upper troposphere. A statistical analysis shows similar correlation coefficients for the two retrieval algorithms and smoothed MOZAIC of r ∼ 0.8 and r ∼ 0.7 in the lower and upper troposphere respectively. Comparison with smoothed MOZAIC data of the temporal variation of the CO profiles at the airports of Frankfurt and Windhoek demonstrates that the IASI products are able to capture the seasonal variability at these sites. At Frankfurt SOFRID (respectively FORLI) is positively biased by 10.5% (13.0%) compared to smoothed MOZAIC in the upper (lower) troposphere, and the limited sensitivity of the IASI instrument to the boundary layer when thermal contrast is low is identified. At Windhoek, the impact of the vegetation fires in Southern Africa from July to November is captured by both SOFRID and FORLI, with an overestimation of the CO background values (fire maxima) by SOFRID (FORLI) by 12.8% (10%). Profile comparisons at Frankfurt and Windhoek show that the largest discrepancies are found between the two IASI products and MOZAIC for the nighttime retrievals. © 2012 Author(s).SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Electron-Sponge Behavior, Reactivity and Electronic Structures of Cobalt-Centered Cubic Co9Te6(CO)8 Clusters

International audienceExtended investigations of the reaction sequence [Cp′2Nb(Te2)H]/CH3Li/[Co2(CO)8] (Cp′ = tBuC5H4) led to the identification of Lin[3] {3 = [Co9Te6(CO)8]; n = 1, 2} salts through their transformation with [PPN]Cl into [PPN]n[3] (PPN = Ph3PNPPh3). These compounds form in the solid state columnar ([PPN][3]) or undulated 2D ([PPN]2[3]) supramolecular networks. Electrochemical studies of [Cp*2Nb(CO)2][3] (Cp* = C5Me5) or [Na(THF)6][3] revealed the presence of the redox couples [3]-/[3]2-/[3]3-/[3]4-/[3]5- regardless of the nature of the cation, whereas in the anodic part oxidative degradation of the cluster takes place. This behavior is in agreement with the observation that [3]- containing salts form with PPh3AuCl or dppe decomposition products like [(PPh3)2Au][CoCl3PPh3] or [Co(CO)2dppe]2(μ-Te). A neutral cluster comprising the Co@Co8(μ4-Te)6 core formed in the reaction of [Cp*2Nb(CO)2][Co11Te7(CO)10] with PPh3AuCl, which gave [Co9Te6(CO)4(PPh3)4] (4) after oxidative cluster degradation and CO substitution. 4 was characterized by X-ray crystallography. DFT calculations carried out on all members of the [3]n (n = +1 to -5) family and on related species indicate that there is no significant Jahn-Teller distortion (and therefore no connectivity change) for any of the considered electron counts. Magnetic investigations on [PPN][3] show that the ground state of [3]- is a spin triplet with spins interacting antiferromagnetically in a 1D space

Ethics of Connected and Automated Vehicles: Recommendations on road safety, privacy, fairness, explainability and responsibility

Connected and Automated Vehicles (CAVs) are emerging as a new technology and new form of mobility in Europe. Expectations are high: these vehicles can bring down the number of road fatalities near zero; increase accessibility of mobility services; and help to reduce harmful emissions from transport by making traffic more efficient. However, technological progress alone will not be able to bring about the full potential of CAVs. The timely and systematic integration of ethical and societal considerations, from inception to use, will be essential to ensure their ethical and positive impact. With its strategy on Connected and Automated Mobility, the European Commission aims to make Europe a world leader in the development and deployment of CAVs. To tackle ethical issues, the Commission formed in 2019 an independent Expert Group to provide practical support to researchers, policymakers, manufacturers and developers in the safe and responsible transition towards connected and automated mobility. The 20 recommendations presented in this report consider ethical principles and shared moral values as stimuli in shaping CAV innovation, rather than be perceived as an obstruction to their progress

Innate myeloid cell TNFR1 mediates first line defence against primary Mycobacterium tuberculosis infection

TNF is crucial for controlling Mycobacterium tuberculosis infection and understanding how will help immunomodulating the host response. Here we assessed the contribution of TNFR1 pathway from innate myeloid versus T cells. We first established the prominent role of TNFR1 in haematopoietic cells for controlling M. tuberculosis in TNFR1 KO chimera mice. Further, absence of TNFR1 specifically on myeloid cells (M-TNFR1 KO) recapitulated the uncontrolled M. tuberculosis infection seen in fully TNFR1 deficient mice, with increased bacterial burden, exacerbated lung inflammation, and rapid death. Pulmonary IL-12p40 over-expression was attributed to a prominent CD11b(+) Gr1(high) cell population in infected M-TNFR1 KO mice. By contrast, absence of TNFR1 on T-cells did not compromise the control of M. tuberculosis infection over 6-months. Thus, the protective TNF/TNFR1 pathway essential for controlling primary M. tuberculosis infection depends on innate macrophage and neutrophil myeloid cells, while TNFR1 pathway in T cells is dispensable