Suivi clinique des patients implantés d un défibrilateur automatique implantable aux CHU d Angers et de Rennes entre 2005 et 2008

ANGERS-BU Médecine-Pharmacie (490072105) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Matériaux nanocomposites pour l'optique

Les effets intrinsèques de confinement et les fortes interactions aux interfaces, caractéristiques des nano-objets sont à la base de nouvelles propriétés optiques telles que l émission de lumière, l absorption ou l exaltation de la réponse optique non linéaire qui dépendent fortement de l environnement des nano-objerts et de leur couplage avec celui-ci. Notre but est d élaborer ces nano-systèmes basés sur la mise en interaction de deux matériaux différents à l échelle nanométrique afin d étudier et d analyser l origine physique de leurs propriétés optiques linéaires et non linéaires. Nous nous sommes intéressés aux propriétés des systèmes mixtes ou composites suivants : métal / luminophore Agn / Agmx+, semi-conducteur / métal (CdS / Agn)Nanotools show confinement effects and high interactions from their surface. They are th support of new optical properties like photoemission, absorption or non linear optical emission The modification of intrinsic effects depends of the environment and the coupling wit nonmaterials. The aim of this work is to synthesize nanocomposite materials (mixing two differen types of materials) for optics in order to analyse linear and non linear optical properties : Metal Phosphorus Ag / Ag x+ , semi-conductor / métal (CdS / Ag )BORDEAUX1-BU Sciences-Talence (335222101) / SudocSudocFranceF

Pratiques participatives dans les bibliothèques du territoire (Les)

Table ronde animée par Olivier Caudron, inspecteur général des bibliothèques. Avec la participation de : - Frédéric Duton, directrice du SCD de Poitiers. - Patrick Treguer, responsable de Lieu Multiple Espace Mendès-France, Poitiers - Évelyne Guiraud, directrice de la médiathèque de Saint-Médard-en-Jalles. - Agnès Brangier, responsable de la médiathèque du comité d\u27entreprise Maïf, Niort

Insight into the PrPC -> PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants

Prion diseases are associated with the conversion of the_-helix rich prion protein (PrPC) into a _-structure-rich insoluble conformer (PrPSc) that is thought to be infectious. The mechanism for the PrPC 3 PrPSc conversion and its relationship with the pathological effects of prion diseases are poorly understood, partly because of our limited knowledge of the structure of PrPSc. In particular, the way in which mutations in the PRNP gene yield variants that confer different susceptibilities to disease needs to be clarified. We report here the 2.5-Å-resolution crystal structures of three scrapie-susceptibility ovine PrP variants complexed with an antibody that binds to PrPC and to PrPSc; they identify two important features of the PrPC 3 PrPSc conversion. First, the epitope of the antibody mainly consists of the last two turns of ovine PrP second _-helix. We show that this is a structural invariant in the PrPC 3 PrPSc conversion; taken together with biochemical data, this leads to a model of the conformational change in which the two PrPC Cterminal _-helices are conserved in PrPSc, whereas secondary structure changes are located in the N-terminal _-helix. Second, comparison of the structures of scrapie-sensitivity variants defines local changes in distant parts of the protein that account for the observed differences of PrPC stability, resistant variants being destabilized compared with sensitive ones. Additive contributions of these sensitivity-modulating mutations to resistance suggest a possible causal relationship between scrapie resistance and lowered stability of the PrP protein

Amyloidogenic unfolding intermediates differentiate sheep prion protein variants

International audienc

Construire des pratiques participatives dans les bibliothèques

Dans l’air du temps, la participation se décline dans toute la société : des budgets participatifs dans les communes et les quartiers jusqu’aux nouvelles formes revendicatives comme les Nuits debout. Mais qu’en est-il pour les bibliothèques ? Qui participe ? Les professionnels ? Les usagers actuels ou futurs ? Cette journée organisée par le Centre du livre et de la lecture en Poitou-Charentes et l’Enssib propose de découvrir des pratiques participatives mises en place dans les bibliothèques (département des Yvelines, Lezoux, Saint-Médard-en-Jalles, comité d\u27entreprise de la Maïf,…) mais aussi en portant un regard vers d’autres lieux culturels : musée de la Grande Guerre du Pays de Meaux et Lieu Multiple de l’Espace Mendés-France à Poitiers. Articulé autour de l’ouvrage écrit sous la direction de Raphaëlle Bats (Construire des pratiques participatives dans les bibliothèques, éd. Presses de l’enssib) cette journée débutera par une introduction volontairement provocatrice de l’écrivain Lionel Bourg et sera conclue par l’humoriste Fred Abrachkoff. Entre les deux : des débats, des rencontres et votre participation

On the proportion of ballast versus non-ballast associated carbon export in the surface ocean

The role of biominerals in driving carbon export from the surface ocean is unclear. We compiled surface particulate organic carbon (POC), and mineral ballast export fluxes from 55 different locations in the Atlantic and Southern Oceans. Substantial surface POC export accompanied by negligible mineral export was recorded implying that association with mineral phases is not a precondition for organic export to occur. The proportion of non-mineral associated sinking POC ranged from 0 to 80% and was highest in areas previously shown to be dominated by diatoms. This is consistent with previous estimates showing that transfer efficiency in such regions is low. However we propose that, rather than the low transfer efficiency arising from diatom blooms being inherently characterized by poorly packaged aggregates which are efficiently exported but which disintegrate readily in mid water, it is due to such environments having very high levels of unballasted organic C export

Role of congenital long-QT syndrome in unexplained sudden infant death: proposal for an electrocardiographic screening in relatives.

International audienceINTRODUCTION: Congenital long-QT syndrome (LQTS) is a sporadic or familial inherited arrhythmia. It can lead to sudden death by ventricular fibrillation which occurs at any age but particularly during infancy. Recent studies of postmortem molecular analysis in infants who died of unexplained sudden infant death syndrome (SIDS) showed abnormal mutations to LQTS in 10% to 12%. Current methods of etiologic investigation of sudden infant death syndrome do not allow the diagnosis of LQTS. A targeted anamnesis together with systematic electrocardiograms of first- and second-degree relatives could be an efficient LQTS diagnostic tool. Therefore, we propose to include them in screening procedures for SIDS etiologies. CONCLUSION: LQTS accounts for a significant number of unexplained SIDS. We suggest adding a systematic familial electrocardiographic screening to the current etiologic investigations in order to track congenital LQTS in relatives