969 research outputs found
Frequent Cross-Species Transmission of Parvoviruses among Diverse Carnivore Hosts
Although parvoviruses are commonly described in domestic carnivores, little is known about their biodiversity in nondomestic species. A phylogenetic analysis of VP2 gene sequences from puma, coyote, gray wolf, bobcat, raccoon, and striped skunk revealed two major groups related to either feline panleukopenia virus (“FPV-like”) or canine parvovirus (“CPV-like”). Crossspecies transmission was commonplace, with multiple introductions into each host species but, with the exception of raccoons, relatively little evidence for onward transmission in nondomestic species
Constraints on the Ultra-High Energy Neutrino Flux from Gamma-Ray Bursts from a Prototype Station of the Askaryan Radio Array
We report on a search for ultra-high-energy (UHE) neutrinos from gamma-ray
bursts (GRBs) in the data set collected by the Testbed station of the Askaryan
Radio Array (ARA) in 2011 and 2012. From 57 selected GRBs, we observed no
events that survive our cuts, which is consistent with 0.12 expected background
events. Using NeuCosmA as a numerical GRB reference emission model, we estimate
upper limits on the prompt UHE GRB neutrino fluence and quasi-diffuse flux from
to GeV. This is the first limit on the prompt UHE GRB
neutrino quasi-diffuse flux above GeV.Comment: 14 pages, 8 figures, Published in Astroparticle Physics Journa
Predicting the public health benefit of vaccinating cattle against Escherichia coli O157
Identifying the major sources of risk in disease transmission is key to designing effective controls. However, understanding of transmission dynamics across species boundaries is typically poor, making the design and evaluation of controls particularly challenging for zoonotic pathogens. One such global pathogen is Escherichia coli O157, which causes a serious and sometimes fatal gastrointestinal illness. Cattle are the main reservoir for E. coli O157, and vaccines for cattle now exist. However, adoption of vaccines is being delayed by conflicting responsibilities of veterinary and public health agencies, economic drivers, and because clinical trials cannot easily test interventions across species boundaries, lack of information on the public health benefits. Here, we examine transmission risk across the cattle–human species boundary and show three key results. First, supershedding of the pathogen by cattle is associated with the genetic marker stx2. Second, by quantifying the link between shedding density in cattle and human risk, we show that only the relatively rare supershedding events contribute significantly to human risk. Third, we show that this finding has profound consequences for the public health benefits of the cattle vaccine. A naïve evaluation based on efficacy in cattle would suggest a 50% reduction in risk; however, because the vaccine targets the major source of human risk, we predict a reduction in human cases of nearly 85%. By accounting for nonlinearities in transmission across the human–animal interface, we show that adoption of these vaccines by the livestock industry could prevent substantial numbers of human E. coli O157 cases
Performance of two Askaryan Radio Array stations and first results in the search for ultra-high energy neutrinos
Ultra-high energy neutrinos are interesting messenger particles since, if
detected, they can transmit exclusive information about ultra-high energy
processes in the Universe. These particles, with energies above
, interact very rarely. Therefore, detectors that
instrument several gigatons of matter are needed to discover them. The ARA
detector is currently being constructed at South Pole. It is designed to use
the Askaryan effect, the emission of radio waves from neutrino-induced cascades
in the South Pole ice, to detect neutrino interactions at very high energies.
With antennas distributed among 37 widely-separated stations in the ice, such
interactions can be observed in a volume of several hundred cubic kilometers.
Currently 3 deep ARA stations are deployed in the ice of which two have been
taking data since the beginning of the year 2013. In this publication, the ARA
detector "as-built" and calibrations are described. Furthermore, the data
reduction methods used to distinguish the rare radio signals from overwhelming
backgrounds of thermal and anthropogenic origin are presented. Using data from
only two stations over a short exposure time of 10 months, a neutrino flux
limit of is
calculated for a particle energy of 10^{18}eV, which offers promise for the
full ARA detector.Comment: 21 pages, 34 figures, 1 table, includes supplementary materia
Eye contact modulates facial mimicry in 4-month-old infants: an EMG and fNIRS study
Mimicry, the tendency to spontaneously and unconsciously copy others' behaviour, plays an important role in social interactions. It facilitates rapport between strangers, and is flexibly modulated by social signals, such as eye contact. However, little is known about the development of this phenomenon in infancy, and it is unknown whether mimicry is modulated by social signals from early in life. Here we addressed this question by presenting 4-month-old infants with videos of models performing facial actions (e.g., mouth opening, eyebrow raising) and hand actions (e.g., hand opening and closing, finger actions) accompanied by direct or averted gaze, while we measured their facial and hand muscle responses using electromyography to obtain an index of mimicry (Experiment 1). In Experiment 2 the infants observed the same stimuli while we used functional near-infrared spectroscopy to investigate the brain regions involved in modulating mimicry by eye contact. We found that 4-month-olds only showed evidence of mimicry when they observed facial actions accompanied by direct gaze. Experiment 2 suggests that this selective facial mimicry may have been associated with activation over posterior superior temporal sulcus. These findings provide the first demonstration of modulation of mimicry by social signals in young human infants, and suggest that mimicry plays an important role in social interactions from early in life. [Abstract copyright: Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.
- …