Psychopathic traits and social reward

Psychopathy is a personality disorder defined by atypical affective and interpersonal functioning, and impulsive and antisocial behaviour. This thesis explored associations between psychopathic traits and social reward processing in adults, and callous-unemotional (CU) traits and social reward processing in adolescents. The goal was to investigate what could potentially explain the atypical social behaviour seen in these individuals. In this thesis, five research questions were proposed. Firstly, in Chapter 2: What types of social interactions and relationships are valued by individuals with high levels of psychopathic traits? Secondly, in Chapter 3: What is the structure of social reward? Thirdly, in Chapter 4: In what way are psychopathic traits in adults associated with self-report and experimental measures of social reward? Finally, in Chapter 5: What is socially rewarding for adolescents, and in what way is this associated with callous-unemotional traits? The principal findings were as follows. In Chapter 2, I found that individuals with high levels of psychopathic traits were not motivated to have affiliative, long-term relationships. In Chapter 3, I developed and validated the Social Reward Questionnaire, a measure of individual differences in social reward value. In Chapter 4, I found that adults with high levels of psychopathic traits showed a pattern of ‘inverted’ social reward, in which being cruel was enjoyable and being kind was not. Additionally, social approval may have reward value for individuals with high levels of interpersonal psychopathic traits. In Chapter 5, I validated the Social Reward Questionnaire – Adolescent Version for use with 11-16 year olds. Like adults with high levels of psychopathic traits, adolescents with high levels of CU traits displayed a pattern of ‘inverted’ social reward. Together, these studies are an important initial exploration of the role that atypical social reward processing may play in explaining the problematic social behaviour seen in psychopathy

How good is damped molecular dynamics as a method to simulate radiation damage in metals?

Published versio

Amplified Concern for Social Risk in Adolescence: Development and Validation of a New Measure

In adolescence, there is a heightened propensity to take health risks such as smoking, drinking or driving too fast. Another facet of risk taking, social risk, has largely been neglected. A social risk can be defined as any decision or action that could lead to an individual being excluded by their peers, such as appearing different to one’s friends. In the current study, we developed and validated a measure of concern for health and social risk for use in individuals of 11 years and over (N = 1399). Concerns for both health and social risk declined with age, challenging the commonly held stereotype that adolescents are less worried about engaging in risk behaviours, compared with adults. The rate of decline was steeper for social versus health risk behaviours, suggesting that adolescence is a period of heightened concern for social risk. We validated our measure against measures of rejection sensitivity, depression and risk-taking behaviour. Greater concern for social risk was associated with increased sensitivity to rejection and greater depressed mood, and this association was stronger for adolescents compared with adults. We conclude that social risks should be incorporated into future models of risk-taking behaviour, especially when they are pitted against health risks

A Novel Aerobic Mechanism for Reductive Palladium Biomineralization and Recovery by Escherichia coli

Aerobically grown E. coli cells reduced Pd(II) via a novel mechanism using formate as the electron donor. This reduction was monitored in real-time using extended X-ray absorption fine structure. Transmission electron microscopy analysis showed that Pd(0) nanoparticles, confirmed by X-ray diffraction, were precipitated outside the cells. The rate of Pd(II) reduction by E. coli mutants deficient in a range of oxidoreductases was measured, suggesting a molybdoprotein-mediated mechanism, distinct from the hydrogenase-mediated Pd(II) reduction previously described for anaerobically grown E. coli cultures. The potential implications for Pd(II) recovery and bioPd catalyst fabrication are discussed

Aiding the design of radiation resistant materials with multiphysics simulations of damage processes

The design of metals and alloys resistant to radiation damage involves the physics of electronic excitations and the creation of defects and microstructure. During irradiation damage of metals by high energy particles, energy is exchanged between ions and electrons. Such non-adiabatic processes violate the Born-Oppenheimer approximation, on which all conservative classical interatomic potentials rest. By treating the electrons of a metal explicitly and quantum mechanically we are able to explore the influence of electronic excitations on the ionic motion during irradiation damage. Simple theories suggest that moving ions should feel a damping force proportional to their velocity and directly opposed to it. In contrast, our simulations of a forced oscillating ion have revealed the full complexity of this force: in reality it is anisotropic and dependent on the ion velocity and local atomic environment. A large set of collision cascade simulations has allowed us to explore the form of the damping force further. We have a means of testing various schemes in the literature for incorporating such a force within molecular dynamics (MD) against our semi-classical evolution with explicitly modelled electrons. We find that a model in which the damping force is dependent upon the local electron density is superior to a simple fixed damping model. We also find that applying a lower kinetic energy cut-off for the damping force results in a worse model. A detailed examination of the nature of the forces reveals that there is much scope for further improving the electronic force models within MD. © 2010 Materials Research Society.Accepted versio

Overshooting Americanisation. Accent stylisation in pop singing – acoustic properties of the bath and trap vowels in focus

The paper addresses the problem of overshoot involved in singing accent stylisation. Selected phonetic features indexed as “American” and “Cockney” are analysed in the singing and speaking styles of a British vocalist, Adele. Overshoot, understood as a greater frequency or an exaggerated quality of a given feature, is characteristic of staged performance (Bell and Gibson 2011; Coupland 2007). PRAAT is used to establish the acoustic properties (F1 and F2) of the BATH and TRAP vowels, as well as the presence or absence of the BATH-TRAP split. The results show that Americanisation regarding the BATH-TRAP split in singing is present and the Americanised vowel tokens are “overshot”, having higher F2 frequency compared with the regular British TRAP vowel

Leaf photosynthesis and associations with grain yield, biomass and nitrogen-use efficiency in landraces, synthetic-derived lines and cultivars in wheat

Future genetic progress in wheat grain yield will depend on increasing above-ground biomass and this must be achieved without commensurate increases in N fertilizer inputs to minimise environmental impacts. Our objective was to quantify variation in grain yield, above-ground biomass and N-use efficiency (NUE) and associated traits in a panel of diverse hexaploid wheat germplasm comprising: (i) landraces from the AE Watkins collection, (ii) synthetic-derived hexaploid lines in a cv. Paragon spring wheat background and (iii) UK modern cultivars including cv. Paragon under low N and high N conditions. A field experiment was carried out in two seasons examining 15 genotypes (five landraces, five synthetic-derived (SD) hexaploid lines and five UK modern cultivars) under low N and high N conditions at Nottingham University farm, UK. Machine-harvested grain yield, above-ground biomass and NUE were measured. Physiological traits were assessed including flag-leaf light-saturated photosynthetic rate (Amax) and relative chlorophyll content (SPAD) under HN conditions; and flag-leaf senescence duration and rate and Normalized Difference Vegetative Index (NDVI) under LN and HN conditions. Under HN conditions, the modern cultivars overall produced higher grain yield than the SD lines (+9.7%) and the landraces (+60.4%); and the modern cultivars and SD lines also produced higher biomass than the landraces (30.3% and 28.4%, respectively). Under LN conditions, reduction in grain yield and biomass compared to HN conditions was least for the landraces (−1% and −8.6%, respectively), intermediate for the SD lines (−7.4 and −10.2%, respectively) and highest for the modern cultivars (−9.3 and −24.6%, respectively). As a result, the SD lines had higher biomass (+17%) than the modern cultivars under LN conditions. Under HN conditions the synthetic derivatives (23.8 μmol m−2 s−1) and modern cultivars (241.1 μmol m−2 s−1) had higher pre-anthesis Amax than the landraces (19.7 μmol m−2 s−1) (P < 0.001). Pre-anthesis Amax was strongly positively linearly associated with above-ground biomass (R2 = 0.63, P < 0.001) and grain yield (R2 = 0.75, P < 0.001) amongst the 15 genotypes. Flag-leaf Amax was also positively linearly associated with flag-leaf relative chlorophyll content at anthesis (R2 = 0.74; P < 0.001). Comparing the SD lines to the recurrent parent Paragon, under HN conditions one line (SD 22) had higher pre-anthesis flag-leaf Amax than Paragon (P < 0.05). Under LN conditions one line (SD 24, +27%) had higher yield than Paragon (P < 0.05) and two lines (SD 24 and SD 38, +32% and +31%, respectively) had more biomass than Paragon (P < 0.05). Our results indicated that introgressing traits from synthetic-derived wheat and landraces into UK modern wheat germplasm offers scope to raise above-ground biomass and grain yield in moderate-to-low N availability environments