The next steps in improving the outcomes of advanced ovarian cancer

Worldwide ovarian cancer affects over 200,000 women per year. Overall survival rates are poor due to two predominate reasons. First, the majority of patients present with advanced disease creating significant difficulty with effecting disease eradication. Second, acquisition of chemotherapy resistance results in untreatable progressive disease. Advances in treatment of advanced ovarian cancer involve a spectrum of interventions including improvements in frontline debulking surgery and combination chemotherapy. Anti-angiogenic factors have been shown to have activity in frontline and recurrent disease while novel chemotherapeutic agents and targeted treatments are in development particularly for disease that is resistant to platinum-based chemotherapy. These developments aim to improve the progression-free and overall survival of women with advanced ovarian cancer

Estimating Photometric Redshifts for X-ray sources in the X-ATLAS field, using machine-learning techniques

We present photometric redshifts for 1,031 X-ray sources in the X-ATLAS field, using the machine learning technique TPZ (Carrasco Kind & Brunner 2013). X-ATLAS covers 7.1 deg2 observed with the XMM-Newton within the Science Demonstration Phase (SDP) of the H-ATLAS field, making it one of the largest contiguous areas of the sky with both XMMNewton and Herschel coverage. All of the sources have available SDSS photometry while 810 have additionally mid-IR and/or near-IR photometry. A spectroscopic sample of 5,157 sources primarily in the XMM/XXL field, but also from several X-ray surveys and the SDSS DR13 redshift catalogue, is used for the training of the algorithm. Our analysis reveals that the algorithm performs best when the sources are split, based on their optical morphology, into point-like and extended sources. Optical photometry alone is not enough for the estimation of accurate photometric redshifts, but the results greatly improve when, at least, mid-IR photometry is added in the training process. In particular, our measurements show that the estimated photometric redshifts for the X-ray sources of the training sample, have a normalized absolute median deviation, n_mad=0.06, and the percentage of outliers, eta=10-14 percent, depending on whether the sources are extended or point-like. Our final catalogue contains photometric redshifts for 933 out of the 1,031 X-ray sources with a median redshift of 0.9.Comment: 10 pages, 13 figures, A&A accepte

Finding counterparts for All-sky X-ray surveys with Nway: a Bayesian algorithm for cross-matching multiple catalogues

We release the AllWISE counterparts and Gaia matches to 106,573 and 17,665 X-ray sources detected in the ROSAT 2RXS and XMMSL2 surveys with |b|>15. These are the brightest X-ray sources in the sky, but their position uncertainties and the sparse multi-wavelength coverage until now rendered the identification of their counterparts a demanding task with uncertain results. New all-sky multi-wavelength surveys of sufficient depth, like AllWISE and Gaia, and a new Bayesian statistics based algorithm, NWAY, allow us, for the first time, to provide reliable counterpart associations. NWAY extends previous distance and sky density based association methods and, using one or more priors (e.g., colors, magnitudes), weights the probability that sources from two or more catalogues are simultaneously associated on the basis of their observable characteristics. Here, counterparts have been determined using a WISE color-magnitude prior. A reference sample of 4524 XMM/Chandra and Swift X-ray sources demonstrates a reliability of ~ 94.7% (2RXS) and 97.4% (XMMSL2). Combining our results with Chandra-COSMOS data, we propose a new separation between stars and AGN in the X-ray/WISE flux-magnitude plane, valid over six orders of magnitude. We also release the NWAY code and its user manual. NWAY was extensively tested with XMM-COSMOS data. Using two different sets of priors, we find an agreement of 96% and 99% with published Likelihood Ratio methods. Our results were achieved faster and without any follow-up visual inspection. With the advent of deep and wide area surveys in X-rays (e.g. SRG/eROSITA, Athena/WFI) and radio (ASKAP/EMU, LOFAR, APERTIF, etc.) NWAY will provide a powerful and reliable counterpart identification tool.Comment: MNRAS, Paper accepted for publication. Updated catalogs are available at www.mpe.mpg.de/XraySurveys/2RXS_XMMSL2 . NWAY available at https://github.com/JohannesBuchner/nwa

The XXL Survey X: K-band luminosity - weak-lensing mass relation for groups and clusters of galaxies

We present the K-band luminosity-halo mass relation, $L_{K,500}-M_{500,WL}$, for a subsample of 20 of the 100 brightest clusters in the XXL Survey observed with WIRCam at the Canada-France-Hawaii Telescope (CFHT). For the first time, we have measured this relation via weak-lensing analysis down to $M_{500,WL} =3.5 \times 10^{13}\,M_\odot$. This allows us to investigate whether the slope of the $L_K-M$ relation is different for groups and clusters, as seen in other works. The clusters in our sample span a wide range in mass, $M_{500,WL} =0.35-12.10 \times 10^{14}\,M_\odot$, at $0<z<0.6$. The K-band luminosity scales as $\log_{10}(L_{K,500}/10^{12}L_\odot) \propto \beta log_{10}(M_{500,WL}/10^{14}M_\odot)$ with $\beta = 0.85^{+0.35}_{-0.27}$ and an intrinsic scatter of $\sigma_{lnL_K|M} =0.37^{+0.19}_{-0.17}$. Combining our sample with some clusters in the Local Cluster Substructure Survey (LoCuSS) present in the literature, we obtain a slope of $1.05^{+0.16}_{-0.14}$ and an intrinsic scatter of $0.14^{+0.09}_{-0.07}$. The flattening in the $L_K-M$ seen in previous works is not seen here and might be a result of a bias in the mass measurement due to assumptions on the dynamical state of the systems. We also study the richness-mass relation and find that group-sized halos have more galaxies per unit halo mass than massive clusters. However, the brightest cluster galaxy (BCG) in low-mass systems contributes a greater fraction to the total cluster light than BCGs do in massive clusters; the luminosity gap between the two brightest galaxies is more prominent for group-sized halos. This result is a natural outcome of the hierarchical growth of structures, where massive galaxies form and gain mass within low-mass groups and are ultimately accreted into more massive clusters to become either part of the BCG or one of the brighter galaxies. [Abridged]Comment: A&A, in pres

The XXL Survey: XII. Optical spectroscopy of X-ray-selected clusters and the frequency of AGN in superclusters

This article belongs to the first series of XXL publications. It presents multifibre spectroscopic observations of three 0.55 sq.deg. fields in the XXL Survey, which were selected on the basis of their high density of X-ray-detected clusters. The observations were obtained with the AutoFib2+WYFFOS (AF2) wide-field fibre spectrograph mounted on the 4.2m William Herschel Telescope. The paper first describes the scientific rationale, the preparation, the data reduction, and the results of the observations, and then presents a study of active galactic nuclei (AGN) within three superclusters. We obtained redshifts for 455 galaxies in total, 56 of which are counterparts of X-ray point-like sources. We were able to determine the redshift of the merging supercluster XLSSC-e, which consists of six individual clusters at z~0.43, and we confirmed the redshift of supercluster XLSSC-d at z~0.3. More importantly, we discovered a new supercluster, XLSSC-f, that comprises three galaxy clusters also at z~0.3. We find a significant 2D overdensity of X-ray point-like sources only around the supercluster XLSSC-f. This result is also supported by the spatial (3D) analysis of XLSSC-f, where we find four AGN with compatible spectroscopic redshifts and possibly one more with compatible photometric redshift. In addition, we find two AGN (3D analysis) at the redshift of XLSSC-e, but no AGN in XLSSC-d. Comparing these findings with the optical galaxy overdensity we conclude that the total number of AGN in the area of the three superclusters significantly exceeds the field expectations. The difference in the AGN frequency between the three superclusters cannot be explained by the present study because of small number statistics. Further analysis of a larger number of superclusters within the 50 sq. deg. of the XXL is needed before any conclusions on the effect of the supercluster environment on AGN can be reached.Comment: 11 pages, published by A&

Detailed Shape and Evolutionary Behavior of the X-ray Luminosity Function of Active Galactic Nuclei

We construct the rest-frame 2--10 keV intrinsic X-ray luminosity function of Active Galactic Nuclei (AGNs) from a combination of X-ray surveys from the all-sky Swift BAT survey to the Chandra Deep Field-South. We use ~3200 AGNs in our analysis, which covers six orders of magnitude in flux. The inclusion of the XMM and Chandra COSMOS data has allowed us to investigate the detailed behavior of the XLF and evolution. In deriving our XLF, we take into account realistic AGN spectrum templates, absorption corrections, and probability density distributions in photometric redshift. We present an analytical expression for the overall behavior of the XLF in terms of the luminosity-dependent density evolution, smoothed two power-law expressions in 11 redshift shells, three-segment power-law expression of the number density evolution in four luminosity classes, and binned XLF. We observe a sudden flattening of the low luminosity end slope of the XLF slope at z>~0.6. Detailed structures of the AGN downsizing have been also revealed, where the number density curves have two clear breaks at all luminosity classes above log LX>43. The two break structure is suggestive of two-phase AGN evolution, consisting of major merger triggering and secular processes.Comment: 39 Pages, 9 figures. ApJ in pres

Discovering extremely compact and metal-poor, star-forming dwarf galaxies out to z ~ 0.9 in the VIMOS Ultra-Deep Survey

We report the discovery of 31 low-luminosity (-14.5 > M_{AB}(B) > -18.8), extreme emission line galaxies (EELGs) at 0.2 < z < 0.9 identified by their unusually high rest-frame equivalent widths (100 < EW[OIII] < 1700 A) as part of the VIMOS Ultra Deep Survey (VUDS). VIMOS optical spectra of unprecedented sensitivity ($I_{AB}$ ~ 25 mag) along with multiwavelength photometry and HST imaging are used to investigate spectrophotometric properties of this unique sample and explore, for the first time, the very low stellar mass end (M* < 10^8 M$_{\odot}$) of the luminosity-metallicity (LZR) and mass-metallicity (MZR) relations at z < 1. Characterized by their extreme compactness (R50 < 1 kpc), low stellar mass and enhanced specific star formation rates (SFR/M* ~ 10^{-9} - 10^{-7} yr^{-1}), the VUDS EELGs are blue dwarf galaxies likely experiencing the first stages of a vigorous galaxy-wide starburst. Using T_e-sensitive direct and strong-line methods, we find that VUDS EELGs are low-metallicity (7.5 < 12+log(O/H) < 8.3) galaxies with high ionization conditions, including at least three EELGs showing HeII 4686A emission and four EELGs of extremely metal-poor (<10% solar) galaxies. The LZR and MZR followed by EELGs show relatively large scatter, being broadly consistent with the extrapolation toward low luminosity and mass from previous studies at similar redshift. However, we find evidences that galaxies with younger and more vigorous star formation -- as characterized by their larger EWs, ionization and sSFR -- tend to be more metal-poor at a given stellar mass.Comment: Letter in A&A 568, L8 (2014). This replacement matches the published versio

The 2-10 keV unabsorbed luminosity function of AGN from the XMM-Newton LSS, CDFS and COSMOS surveys

The XMM-LSS, XMM-COSMOS, and XMM-CDFS surveys are complementary in terms of sky coverage and depth. Together, they form a clean sample with the least possible variance in instrument effective areas and PSF. Therefore this is one of the best samples available to determine the 2-10 keV luminosity function of AGN and its evolution. The samples and the relevant corrections for incompleteness are described. A total of 2887 AGN is used to build the LF in the luminosity interval 10^42-10^46 erg/s, and in the redshift interval 0.001-4. A new method to correct for absorption by considering the probability distribution for the column density conditioned on the hardness ratio is presented. The binned luminosity function and its evolution is determined with a variant of the Page-Carrera method, improved to include corrections for absorption and to account for the full probability distribution of photometric redshifts. Parametric models, namely a double power-law with LADE or LDDE evolution, are explored using Bayesian inference. We introduce the Watanabe-Akaike information criterion (WAIC) to compare the models and estimate their predictive power. Our data are best described by the LADE model, as hinted by the WAIC indicator. We also explore the 15-parameter extended LDDE model recently proposed by Ueda et al., and find that this extension is not supported by our data. The strength of our method is that it provides: un-absorbed non-parametric estimates; credible intervals for luminosity function parameters; model choice according to which one has more predictive power for future data.Comment: In press on A&A. The revised version corrects typos and the LF normalisations in tables 1,2,5 and figs.9-12, which were on an incorrect scale. Online material available at http://www.astro.lu.se/~piero/xlf/xlf-paper-tables2.tgz . The software is available on the author's website http://www.astro.lu.se/~piero/LFTools/index.html and on github: https://github.com/piero-ranalli/LFTool

Discovery of a rich proto-cluster at z=2.9 and associated diffuse cold gas in the VIMOS Ultra-Deep Survey (VUDS)

[Abridged] We characterise a massive proto-cluster at z=2.895 that we found in the COSMOS field using the spectroscopic sample of the VIMOS Ultra-Deep Survey (VUDS). This is one of the rare structures at z~3 not identified around AGNs or radio galaxies, so it is an ideal laboratory to study galaxy formation in dense environments. The structure comprises 12 galaxies with secure spectroscopic redshift in an area of 7'x8', in a z bin of Dz=0.016. The measured galaxy number overdensity is delta_g=12+/-2. This overdensity has total mass of M~8.1x10^(14)M_sun in a volume of 13x15x17 Mpc^3. Simulations indicate that such an overdensity at z~2.9 is a proto-cluster that will collapse in a cluster of total mass M~2.5x10^(15)M_sun at z=0. We compare the properties of the galaxies within the overdensity with a control sample at the same z but outside the overdensity. We did not find any statistically significant difference between the properties (stellar mass, SFR, sSFR, NUV-r, r-K) of the galaxies inside and outside the overdensity. The stacked spectrum of galaxies in the overdensity background shows a significant absorption feature at the wavelength of Lya redshifted at z=2.895 (lambda=4736 A), with a rest frame EW = 4+/- 1.4 A. Stacking only background galaxies without intervening sources at z~2.9 along their line of sight, we find that this absorption feature has a rest frame EW of 10.8+/-3.7 A, with a detection S/N of ~4. These EW values imply a high column density (N(HI)~3-20x10^(19)cm^(-2)), consistent with a scenario where such absorption is due to intervening cold gas streams, falling into the halo potential wells of the proto-cluster galaxies. However, we cannot exclude the hypothesis that this absorption is due to the diffuse gas within the overdensity.Comment: 15 pages, 9 figures, accepted for publication in A&A (revised version after referee's comments and language editing