A Rapid Electrochemical Impedance Spectroscopy and Sensor-Based Method for Monitoring Freeze-Damage in Tangerines

[EN] This study focuses on the analysis and early detection of freeze-damage in tangerines using a specific double-needle sensor and Electrochemical Impedance Spectroscopy (EIS). Freeze damage may appear in citrus fruits both in the field and in postharvest processes resulting in quality loss and a difficult commercialization of the fruit. EIS has been used to test a set of homogeneous tangerine samples both fresh and later frozen to analyze electrochemical and biological differences. A double-needle electrode associated to a specifically designed electronic device and software has been designed and used to send an AC electric sinusoidal signal 1 V in amplitude and frequency range [100Hz to 1MHz] to the analyzed samples and then receive the electrochemical impedance response. EIS measurements lead to distinct values of both impedance module and phase of fresh and frozen samples over a wide frequency range. Statistical treatment of the received data set by Principal Components Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) shows a clear classification of the samples depending on the experienced freeze phenomenon, with high sensitivity (1.00), specificity (>= 0.95) and confidence level (95%). Later Artificial Neural Networks (ANN) analysis based on 20-3-1 architecture has allowed to create a mathematical prediction model able to correctly classify 100% of the analyzed samples (CCR =100% for training, validation and test phases, and overall classification), being fast, easy, robust and reliable, and an interesting alternative method to the traditional laboratory analyses.This work was supported by the Spanish Government/FEDER funds [Ministerio de Economia y Empresa (MINECO)/Fondo Europeo de Desarrollo Regional (FEDER)] under Grant RTI2018-100910-B-C43 and in part by the Conselleria d'Educacio, Investigacio, Cultura i Esport de la Generalitat Valenciana under Grant GV/2018/090.Albelda Aparisi, P.; Fortes Sánchez, E.; Contat-Rodrigo, L.; Masot Peris, R.; Laguarda-Miro, N. (2021). A Rapid Electrochemical Impedance Spectroscopy and Sensor-Based Method for Monitoring Freeze-Damage in Tangerines. IEEE Sensors Journal. 21(10):12009-12018. https://doi.org/10.1109/JSEN.2021.3065846S1200912018211

Géneros en escena y cuerpos brincantes en la devoción en el Reisado: subversiones en la cultura popular brasileña

Este trabajo tiene como objetivo reflexionar sobre la participación de las personas LGBTQ+ en una tradición religiosa de la cultura popular del Nordeste de Brasil. Por lo tanto, utilizamos la cartografía sentimental como metodología para seguir los procesos subjetivos y las políticas de subjetivación, tanto en el exterior, en las instancias de creación de los escenarios, como en el interior, en la performance. La Teoría Corpomedia aparece como un concepto importante para repensar los movimientos del cuerpo de lo que puede moverse de los rígidos códigos de tradición y oralidad. El estudio señala que cuando el brincante disidente del sistema de género y sexo ocupa un personaje en la trama de Reisado, un espacio legítimo para la presentación y el reconocimiento del género abre el devenir para el cuerpo. Si la identidad del noreste se asocia con la construcción del género masculino en el corte regional, sostenemos que la performance de las diferencias sexuales y de género puede deshacer los límites de la representación corporal

Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial

Background: Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor. Methods: The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population). Findings: Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI. Interpretation: In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk