Exploring social influences on the joint Simon task: empathy and friendship

Tasks for which people must act together to achieve a goal are a feature of daily life. The present study explored social influences on joint action using a Simon procedure for which participants (n=44) were confronted with a series of images of hands and asked to respond via button press whenever the index finger wore a ring of a certain color (red or green) regardless of pointing direction (left or right). In an initial joint condition they performed the task while sitting next to another person (friend or stranger) who responded to the other color. In a subsequent individual condition they repeated the task on their own; additionally, they completed self-report tests of empathy. Consistent with past research, participants reacted more quickly when the finger pointed toward them rather than their co-actor(the Simon Effect or SE). The effect remained robust when the co-actor was no longer present and was unaffected by degree of acquaintance; however,its magnitude was correlated positively with empathy only among friends. For friends, the SE was predicted by cognitive perspective taking when the co-actor was present and by propensity for fantasizing when the co-actor was absent. We discuss these findings in relation to social accounts (e.g., task co-representation) and non-social accounts (e.g.,referential coding) of joint action

Selection by pairwise comparisons with limited resources

We analyze different methods of sorting and selecting a set of objects by their intrinsic value, via pairwise comparisons whose outcome is uncertain. After discussing the limits of repeated Round Robins, two new methods are presented: The {\it ran-fil} requires no previous knowledge on the set under consideration, yet displaying good performances even in the least favorable case. The {\it min-ent} method sets a benchmark for optimal dynamic tournaments design.Comment: 10 pages, 3 fig

Optimization of routine identification of clinically relevant gram-negative bacteria by use of matrix-assisted laser desorption ionization-time of flight mass spectrometry and the bruker biotyper

Matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) might complement and one day replace phenotypic identification of bacteria in the clinical microbiology laboratory, but there is no consensus standard regarding the requirements for its validation prior to clinical use in the United States. The objective of this study was to assess the preanalytical variables influencing Gram-negative identification by use of the Bruker Biotyper MALDI-TOF MS system, including density of organism spotting on a stainless steel target plate and the direct overlay of organisms with formic acid. A heavy smear with formic acid overlay was either superior or equivalent to alternative smear conditions. Microbiological preanalytical variables were also assayed, such as culture medium, growth temperature, and use of serial subculture. Postanalytical analysis included the application of modified species-level identification acceptance criteria. Biotyper identifications were compared with those using traditional phenotypic methods, and discrepancies were resolved with 16S rRNA gene sequencing. Compared to the recommended score cutoffs of the manufacturer, the application of optimized Biotyper score cutoffs for species-level identification increased the rate of identification by 6.75% for the enteric Gram-negative bacteria and 4.25% for the nonfermenting Gram-negative bacteria. Various incubation temperatures, growth medium types, and repeat subcultures did not result in misidentification. We conclude that the Bruker MALDI Biotyper is a robust system for the identification of Gram-negative organisms in the clinical laboratory and that meaningful performance improvements can be made by implementing simple pre- and postanalytical techniques

Evaluating the impact of a longitudinal patient case on the development of professionalism and professional identity

This article explores the student outcomes of a progressive case on the development of professional identity and professionalism within first-year student pharmacists

Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections

Urinary catheterization elicits major histological and immunological changes that render the bladder susceptible to microbial invasion, colonization, and dissemination. However, it is not understood how catheters induce these changes, how these changes act to promote infection, or whether they may have any protective benefit. In the present study, we examined how catheter-associated inflammation impacts infection by Enterococcus faecalis, a leading cause of catheter-associated urinary tract infection (CAUTI), a source of significant societal and clinical challenges. Using a recently optimized murine model of foreign body-associated UTI, we found that the implanted catheter itself was the primary inducer of inflammation. In the absence of the silicone tubing implant, E. faecalis induced only minimal inflammation and was rapidly cleared from the bladder. The catheter-induced inflammation was only minimally altered by subsequent enterococcal infection and was not suppressed by inhibitors of the neurogenic pathway and only partially by dexamethasone. Despite the robust inflammatory response induced by urinary implantation, E. faecalis produced biofilm and high bladder titers in these animals. Induction of inflammation in the absence of an implanted catheter failed to promote infection, suggesting that the presence of the catheter itself is essential for E. faecalis persistence in the bladder. Immunosuppression prior to urinary catheterization enhanced E. faecalis colonization, suggesting that implant-mediated inflammation contributes to the control of enterococcal infection. Thus, this study underscores the need for novel strategies against CAUTIs that seek to reduce the deleterious effects of implant-mediated inflammation on bladder homeostasis while maintaining an active immune response that effectively limits bacterial invaders

Survey of CAMHS clinicians about their experience of remote consultation: brief report.

The Covid-19 crisis necessitated rapid adoption of remote consultations across National Health Service (NHS) child and adolescent mental health services (CAMHS). This study aimed to understand practitioners' experiences of rapid implementation of remote consultations across CAMHS in one NHS trust in the east of England. Data were collected through a brief questionnaire documenting clinicians' experiences following remote delivery of services. The questionnaire began before 'lockdown' and focused on assessment consultations (n = 102) as part of a planned move to virtual assessment. As the roll-out of remote consultations was extended at lockdown, we extended the questionnaire to include all remote clinical contacts (n = 202). Despite high levels of initial concern, clinicians' reports were positive overall; importantly, however, their experiences varied by team. When restrictions on face-to-face working are lifted, a blended approach of remote and face-to-face service delivery is recommended to optimise access and capacity while retaining effective and safe care.Non

Exploration of a cognitive model to predict post-traumatic stress symptoms following childbirth

Women can suffer from post-traumatic stress disorder (PTSD) following childbirth. This study investigated the application of a cognitive model to PTS symptoms following childbirth and explored the addition of social support to the model. Methods: Women (N=138) completed questionnaires in pregnancy, three-weeks and three-months after birth, measuring prior trauma, beliefs, and coping in pregnancy; and birth interventions, social support, post-traumatic cognitions, and PTS symptoms post-birth. Results: Using structural equation modeling, a cognitive model explained 23% of the variance in PTS symptoms three-weeks postpartum. Three-months postpartum, the model explained only 9% of the variance in PTS symptoms. The addition of social support, partially mediated by post-traumatic cognitions, increased the variance to 16%. Discussion: Results suggest that a cognitive model accounts for early PTS symptoms after birth. Social support after birth increases the explanatory power of the model at three months. A test of the model on a larger sample is warranted

General practitioners’ perceptions of irritable bowel syndrome: a Q-methodological study

Background; Irritable bowel syndrome (IBS) is a common disorder that imposes a significant burden upon societies, health care and quality of life, worldwide. While a diverse range of patient viewpoints on IBS have been explored, the opinions of the GPs they ideally need to develop therapeutic partnerships with are less well defined. Objective; To explore how GPs perceive IBS, using Q-methodology, which allows quantitative interpretation of qualitative data. Design and Setting; A Q-methodological study of GPs in Leeds, UK. Method; Thirty-three GPs completed an online Q-sort in which they ranked their level of agreement with 66 statements. Factor analysis of the Q-sorts was performed to determine the accounts that predominated in understandings of IBS. Ten of the GPs were interviewed in person and responses to the statements recorded to help explain the accounts. Results; Analysis yielded one predominant account shared by all GPs—that IBS was a largely psychological disorder. This account overshadowed a debate represented by a minority, polarized between those who viewed IBS as almost exclusively psychological, versus those who believed IBS had an organic basis, with a psychological component. The overwhelming similarity in responses indicates that all GPs shared a common perspective on IBS. Interviews suggested degrees of uncertainty and discomfort around the aetiology of IBS. Conclusion; There was overwhelming agreement in the way GPs perceived IBS. This contrasts with the range of patient accounts of IBS and may explain why both GPs and their patients face difficult negotiations in achieving therapeutic relationships