5,885 research outputs found
Interim report on the analysis of the microwave power module
The results of a traveling wave tube multistage depressed collector (TWT-MDC) design study in support of the DARPA/DoD Microwave Power Module (MPM) Program are described. The study stressed the MDC as a key element in obtaining the required high overall efficiencies in the MPM application. The results showed that an efficient MDC, utilizing conventional design and fabrication techniques can be designed for the first generation MPM TWT, which permits a package one wavelength thick (.66 in. at 18 GHz). The overall TWT efficiency goal of 40 percent for electronic countermeasure (ECM) applications appears to be readily achievable. However, the 50 percent goal for radar applications presents a considerable challenge
New Insights Into Sunflower (Helianthus annuus L.) FatA and FatB Thioesterases, Their Regulation, Structure and Distribution
Sunflower seeds (Helianthus annuus L.) accumulate large quantities of triacylglycerols (TAG) between 12 and 28 days after flowering (DAF). This is the period of maximal acyl-acyl carrier protein (acyl-ACP) thioesterase activity in vitro, the enzymes that terminate the process of de novo fatty acid synthesis by catalyzing the hydrolysis of the acyl-ACPs synthesized by fatty acid synthase. Fatty acid thioesterases can be classified into two families with distinct substrate specificities, namely FatA and FatB. Here, some new aspects of these enzymes have been studied, assessing how both enzymes contribute to the acyl composition of sunflower oil, not least through the changes in their expression during the process of seed filling. Moreover, the binding pockets of these enzymes were modeled based on new data from plant thioesterases, revealing important differences in their volume and geometry. Finally, the subcellular location of the two enzymes was evaluated and while both possess an N-terminal plastid transit peptide, only in FatB contains a hydrophobic sequence that could potentially serve as a transmembrane domain. Indeed, using in vivo imaging and organelle fractionation, H. annuus thioesterases, HaFatA and HaFatB, appear to be differentially localized in the plastid stroma and membrane envelope, respectively. The divergent roles fulfilled by HaFatA and HaFatB in oil biosynthesis are discussed in the light of our data.España MINECO y FEDER Projects AGL2014- 53537-R y AGL2017-83449-
K-Band Traveling-Wave Tube Amplifier
A new space-qualified, high-power, high-efficiency, K-band traveling-wave tube amplifier (TWTA) will provide high-rate, high-capacity, direct-to-Earth communications for science data and video gathered by the Lunar Reconnaissance Orbiter (LRO) during its mission. Several technological advances were responsible for the successful demonstration of the K-band TWTA
Technology Development for the Caltech Submillimeter Observatory Balanced Receivers
The Caltech Submillimeter Observatory (CSO) is located on top of Mauna Kea,
Hawaii, at an altitude of 4.2 km. The existing suite of facility heterodyne
receivers covering the submillimeter band is rapidly aging and in need of
replacement. To facilitate deep integrations and automated spectral line
surveys, a family of remote programmable, synthesized, dual-frequency balanced
receivers covering the astronomical important 180 - 720 GHz atmospheric windows
is in an advanced stage of development. Installation of the first set of
receivers is expected in the spring of 2012.
Dual-frequency observation will be an important mode of operation offered by
the new facility instrumentation. Two band observations are accomplished by
separating the H and V polarizations of the incoming signal and routing them
via folded optics to the appropriate polarization sensitive balanced mixer.
Scientifically this observation mode facilitates pointing for the higher
receiver band under mediocre weather conditions and a doubling of scientific
throughput (2 x 4 GHz) under good weather conditions.Comment: 12 pages, 17 figures; IEEE Terahertz Science & Technology, January
2012, Volume 2, Issue
Quantifying the relative importance of riverine and open-ocean nitrogen sources for hypoxia formation in the northern Gulf of Mexico
The Mississippi and Atchafalaya River System discharges large amounts of freshwater and nutrients into the northern Gulf of Mexico (NGoM). These lead to increased stratification and elevate primary production in the outflow region. Consequently, hypoxia (oxygen <62.5 mmol/m3), extending over an area of roughly 15,000 km2, forms every summer in bottom waters. High‐resolution models have significantly improved our understanding of the processes controlling hypoxia formation in the NGoM and have strongly implicated riverine nutrients as the dominant nutrient source. However, the relative importance of different nutrient sources (i.e., the Mississippi and Atchafalaya Rivers and offshore) has not been assessed before now. Here, we combine a high‐resolution model with an element tracing method to directly quantify the relative contributions of nitrogen from the two rivers and the open ocean to primary production and sediment oxygen consumption, which is the main oxygen sink contributing to hypoxia in the NGoM. Our results indicate that, averaged over 2001–2011, Mississippi and Atchafalaya nitrogen support 51 ± 9% and 33 ± 9% of summer sediment oxygen consumption, respectively, while open‐ocean nitrogen supports 16 ± 2%. The higher relative impact of Mississippi inputs results from longer transit times compared to those of Atchafalaya inputs. We also analyze the effect of riverine nitrogen load reductions and a larger diversion of discharge to the Atchafalaya River. These scenario simulations show that nutrient load reductions are most effective in mitigating hypoxia
Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue
Introduction Left ventricular dysfunction is a frequent and potentially severe side effect of many tyrosine kinase inhibitors (TKI). The mode of toxicity is not identified, but may include impairment of mitochondrial or sarcomeric function, autophagy or angiogenesis, either as an on-target or off-target mechanism. Methods and Results We studied concentration-response curves and time courses for nine TKIs in three-dimensional, force generating engineered heart tissue (EHT) from neonatal rat heart cells. We detected a concentration- and time-dependent decline in contractile force for gefitinib, lapatinib, sunitinib, imatinib, sorafenib, vandetanib and lestaurtinib and no decline in contractile force for erlotinib and dasatinib after 96 hours of incubation. The decline in contractile force was associated with an impairment of autophagy (LC3 Western blot) and appearance of autophagolysosomes (transmission electron microscopy). Conclusion This study demonstrates the feasibility to study TKI-mediated force effects in EHTs and identifies an association between a decline in contractility and inhibition of autophagic flux
Structure of unbound neutron-rich He studied using single-neutron transfer
The 8He(d,p) reaction was studied in inverse kinematics at 15.4A MeV using
the MUST2 Si-CsI array in order to shed light on the level structure of 9He.
The well known 16O(d,p)17O reaction, performed here in reverse kinematics, was
used as a test to validate the experimental methods. The 9He missing mass
spectrum was deduced from the kinetic energies and emission angles of the
recoiling protons. Several structures were observed above the neutron-emission
threshold and the angular distributions were used to deduce the multipolarity
of the transitions. This work confirms that the ground state of 9He is located
very close to the neutron threshold of 8He and supports the occurrence of
parity inversion in 9He.Comment: Exp\'erience GANIL/SPIRAL1/MUST
Randomized Controlled Trial on Effectiveness of Ultrasonography Screening for Breast Cancer in Women Aged 40–49 (J-START): Research Design
In cancer screening, it is essential to undertake effective screening with appropriate methodology, which should be supported by evidence of a reduced mortality rate. At present, mammography is the only method for breast cancer screening with such evidence. However, mammography does not achieve sufficient accuracy in breasts with high density at ages below 50. Although ultrasonography achieves better accuracy in Breast Cancer detection even in dense breasts, the effectiveness has not been verified. We have planned a randomized controlled trial to assess the effectiveness of ultrasonography in women aged 40–49, with a design to study 50 000 women with mammography and ultrasonography (intervention group), and 50 000 controls with mammography only (control group). The participants are scheduled to take second round screening with the same modality 2 years on. The primary endpoints are sensitivity and specificity, and the secondary endpoint is the rate of advanced breast cancers
Resistance and resilience of social–ecological systems to recurrent typhoon disturbance on a subtropical island: Taiwan
Tropical cyclones (TCs) have major effects on ecological and social systems. However, studies integrating the effects of TCs on both social and ecological systems are rare, especially in the northwest Pacific, where the frequency of TCs (locally named typhoons) is the highest in the world. We synthesized studies of effects of recurrent typhoons on social and ecological systems in Taiwan over the last several decades. Many responses to TCs are comparable between social and ecological systems. High forest ecosystem resistance, evident from tree mortality below 2% even following multiple strong typhoons, is comparable with resistance of social systems, including the only 4% destruction of river embankments following a typhoon that brought nearly 3000 mm rainfall in three days. High resilience as reflected by quick returns of leaf area index, mostly in one year, and streamwater chemistry, one to several weeks to pre‐typhoon levels of ecosystems, are comparable to quick repair of the power grid within one to several days and returns of vegetable price within several weeks to pre‐typhoon levels of the social systems. Landslides associated with intense typhoons have buried mountain villages and transported large quantities of woody debris to the coast, affecting the coastal plains and reefs, illustrating a ridge‐to‐reef link between ecological and societal systems. Metrics of both social and ecological function showed large fluctuations in response to typhoons but quickly returned to pre‐disturbance levels, except when multiple intense typhoons occurred within a single season. Our synthesis illustrates that the social–ecological systems in Taiwan are highly dynamic and responsive to frequent typhoon disturbance, with extraordinarily high resistance and resilience. For ecosystems, the efficient responsiveness results from the selective force of TCs on ecosystem structure and processes. For social systems, it is the result of the effects of TCs on planning and decision making by individuals (e.g., farmers), management sectors, and ultimately the government. In regions with frequent TCs, the social–ecological systems are inevitably highly dynamic and rapid responses are fundamental to system resistance and resilience which in turn is key to maintaining structure and function of the social–ecological systems
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