Estudi sobre la quantificació del grau de consciència del malalt durant la sedació pal·liativa

En el camp de la medicina, aquests darrers anys s’ha pogut observar una clara tendència a l’alça, en reduir el patiment i augmentar la tranquil·litat al final de la vida. Tothom en algun moment ha de morir, i que aquest procés sigui indolor s’ha convertit en una prioritat, com s’ha pogut veure amb les cures pal·liatives o l’eutanàsia. En aquest punt entra en joc l’índex bispectral. En l’actualitat, aquest valor es fa servir en àmbits relacionats amb l’anestèsia, com a complement de les escales observacionals. Però cal destacar que aquest índex proporciona dades objectives, en contraposició a les escales observacionals que són purament subjectives. En aquest treball es busca analitzar la situació actual del BIS, així com intentar simular i predir aquest índex amb un ordinador, per tal de poder implementar aquesta recerca al mercat. Aquest estudi va lligat a un altre anomenat: «A new based-model BIS Index study for awareness monitoring during palliative sedation». Aquest ha sigut realitzat per Carlota Lacasa Vela de la Universitat Internacional de Catalunya (UIC) i en aquests dos estudis s'han establert diferents enfocaments, un des d'una perspectiva més mèdica i en l’altre estudi un enfoc en el camp de l'enginyeria. Per a dur a terme aquest treball, s’ha fet una àmplia recerca bibliogràfica d’articles científics i treballs anteriors. Un cop realitzada aquesta part, es van haver d’aconseguir les dades necessàries per poder treballar amb identificació de sistemes. Aquestes dades de treball, van ser proporcionades per l’hospital de la Vall d’Hebron. Es va utilitzar el programari Matlab i l’eina d’identificació de sistemes per estimar els paràmetres per tal d’aconseguir el model òptim amb el mínim nombre de canals necessaris. Els resultats de l’estudi conclouen que podem simular a 2min 35seg vista, l’estat del pacient una vegada s’ha administrat la dosi de fàrmacs pertinent. Per tant, amb aquest codi, es podria veure si la dosi subministrada és l’adequada o, per al contrari, és inferior o superior a la desitjada. Cal més estudi en aquest camp i portar a la realitat aquests avenços, però és un bon pas per a enfrontar en la problemàtica que existeix en cures pal·liatives, relacionades amb la sobre sedació o sub-sedació. Per tant, en cap cas cal eliminar al 100% les escales observacionals, però sí que hauria de ser una realitat la seva convivència a l’hora de tractar els pacient

Apuntes sobre la transparencia

Trece contribuciones de expertos españoles y extranjeros sobre transparencia

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level

Ultralight vector dark matter search using data from the KAGRA O3GK run

Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM

Ecotoxicological analysis during the removal of carbofuran in fungal bioaugmented matrices

Biomixtures are used for the removal of pesticides from agricultural wastewater. As biomixtures employ high content of lignocellulosic substrates, their bioaugmentation with ligninolytic fungi represents a novel approach for their enhancement. Nonetheless, the decrease in the concentration of the pesticide may result in sublethal concentrations that still affect ecosystems. Two matrices, a microcosm of rice husk (lignocellulosic substrate) bioaugmented with the fungus Trametes versicolor and a biomixture that contained fungally colonized rice husk were used in the degradation of the insecticide/nematicide carbofuran (CFN). Elutriates simulating lixiviates from these matrices were used to assay the ecotoxicological effects at sublethal level over Daphnia magna (Straus) and the fish Oreochromis aureus (Steindachner) and Oncorhynchus mykiss (Walbaum). Elutriates obtained after 30 d of treatment in the rice husk microcosms at dilutions over 2.5% increased the offspring of D. magna as a trade-off stress response, and produced mortality of neonates at dilutions over 5%. Elutriates (dilution 1:200) obtained during a 30 d period did not produce alterations on the oxygen consumption and ammonium excretion of O. mykiss, however these physiological parameters were affected in O. aureus at every time point of treatment, irrespective of the decrease in CFN concentration. When the fungally colonized rice husk was used to prepare a biomixture, where more accelerated degradation is expected, similar alterations on the responses by O. aureus were achieved. Results suggest that despite the good removal of the pesticide, it is necessary to optimize biomixtures to minimize their residual toxicity and potential chronic effects on aquatic life.Universidad de Costa Rica/[802-B4-609]/UCR/Costa RicaUniversidad de Costa Rica/[802-B2-046]/UCR/Costa RicaMinisterio de Ciencia, Tecnología y Telecomunicaciones/[FI-093-13]/MICITT/Costa RicaMinisterio de Ciencia, Tecnología y Telecomunicaciones/[802-B4-503]/MICITT/Costa RicaDivision of Nuclear Techniques in Food and Agriculture/[TC COS5/029]/FAO/IAEA/AustriaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro en Investigación en Contaminación Ambiental (CICA

Fungal bioaugmentation of two rice husk-based biomixtures for the removal of carbofuran in on-farm biopurification systems

The ligninolytic fungus Trametes versicolor was employed in the bioaugmentation of compost- (GCS) and peat-based (GTS) biomixtures for the removal of the insecticide-nematicide carbofuran (CFN). Among several lignocellulosic substrates, fungal colonization was best supported in rice husk, and this pre-colonized substrate was used to prepare the biomixtures. Estimated half-lives for CFN were 3.4 and 8.1 days in the GTS and GCS biomixtures, respectively. The CFN transformation products 3-hydroxycarbofuran and 3-ketocarbofuran were detected at the moment of CFN application, but their concentration continuously decreased to complete removal in both biomixtures. Mineralization of 14Cradiolabeled CFN was faster in GTS (k=0.00248 day−1) than in GCS (k=0.00188 day−1). Complete elimination of the toxicity in the matrices was demonstrated after 48 days. Overall data suggest that the bioaugmentation improved the performance of the GTS rather than the GCS biomixture.Universidad de Costa Rica/[802-B2-046]/UCR/Costa RicaUniversidad de Costa Rica/[802-B4-503]/UCR/Costa RicaUniversidad de Costa Rica/[802-B4-609]/UCR/Costa RicaMinisterio de Ciencia, Tecnología y Telecomunicaciones/[FI-093-13]/MICITT/Costa RicaFood and Agriculture Organization/[TC COS5/029]/FAO/Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro en Investigación en Contaminación Ambiental (CICA

Optimization of a Fungally Bioaugmented Biomixture for Carbofuran Removal in On-Farm Biopurification Systems

Biomixtures comprise the active part of biopurification systems (BPS) for the removal of pesticide-containing wastewater from agricultural origin. Considering that biomixtures contain an important amount of lignocellulosic substrates, their bioaugmentation with degrading ligninolytic fungi represents a promising way to improve BPS. The fungus Trametes versicolor was employed for the bioaugmentation of rice husk-compost-soil (GCS) biomixtures in order to optimize the removal of the highly toxic insecticide/nematicide carbofuran (CFN). Composition of biomixtures has not been optimized before, and usually, a volumetric composition of 50:25:25 (lignocellulosic substrate:humic component:soil) is employed. Optimization of the biomixture composition was performed with a central composite design, using the volumetric content of rice husk (pre-colonized by the fungus) and the volumetric ratio compost/soil as design variables. Performance of biomixtures was comprehensively assayed considering CFN removal, the production of toxic transformation products (3-hydroxycarbofuran/3-ketocarbofuran), the ability to mineralize [14C]carbofuran, and the residual toxicity in the matrix. According to the models, the optimal volumetric composition of the GCS biomixture is 30:43:27, which maximizes removal and mineralization rate, and minimizes the accumulation of transformation products. Results support the value of assessing new biomixture formulations according to the target pesticide in order to obtain their optimal performance, before their use in BPS.Universidad de Costa Rica/[802-B2-046]/UCR/Costa RicaUniversidad de Costa Rica/[802-B4-503]/UCR/Costa RicaUniversidad de Costa Rica/[802-B4-609]/UCR/Costa RicaMinisterio de Ciencia, Tecnología y Telecomunicaciones/[FI-093-13]/MICITT/Costa RicaMinisterio de Ciencia, Tecnología y Telecomunicaciones/[802-B4-503]/MICITT/Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro en Investigación en Contaminación Ambiental (CICA

Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo

International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100−105 M⊙, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass ∼150 M⊙ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200 M⊙ and effective aligned spin 0.8 at 0.056 Gpc−3 yr−1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpc−3 yr−1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]† Deceased, August 2020