The high energy limit of the trajectory representation of quantum mechanics

The trajectory representation in the high energy limit (Bohr correspondence principle) manifests a residual indeterminacy. This indeterminacy is compared to the indeterminacy found in the classical limit (Planck's constant to 0) [Int. J. Mod. Phys. A 15, 1363 (2000)] for particles in the classically allowed region, the classically forbiden region, and near the WKB turning point. The differences between Bohr's and Planck's principles for the trajectory representation are compared with the differences between these correspondence principles for the wave representation. The trajectory representation in the high energy limit is shown to go to neither classical nor statistical mechanics. The residual indeterminacy is contrasted to Heisenberg uncertainty. The relationship between indeterminacy and 't Hooft's information loss and equivalence classes is investigated.Comment: 12 pages of LaTeX. No figures. Incorporated into the "Proceedings of the Seventh International Wigner Symposium" (ed. M. E. Noz), 24-29 August 2001, U. of Maryland. Proceedings available at http://www.physics.umd.edu/robo

Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans.

BACKGROUND: Monogenic protein aggregation diseases, in addition to cell selectivity, exhibit clinical variation in the age of onset and progression, driven in part by inter-individual genetic variation. While natural genetic variants may pinpoint plastic networks amenable to intervention, the mechanisms by which they impact individual susceptibility to proteotoxicity are still largely unknown. RESULTS: We have previously shown that natural variation modifies polyglutamine (polyQ) aggregation phenotypes in C. elegans muscle cells. Here, we find that a genomic locus from C. elegans wild isolate DR1350 causes two genetically separable aggregation phenotypes, without changing the basal activity of muscle proteostasis pathways known to affect polyQ aggregation. We find that the increased aggregation phenotype was due to regulatory variants in the gene encoding a conserved autophagy protein ATG-5. The atg-5 gene itself conferred dosage-dependent enhancement of aggregation, with the DR1350-derived allele behaving as hypermorph. Surprisingly, increased aggregation in animals carrying the modifier locus was accompanied by enhanced autophagy activation in response to activating treatment. Because autophagy is expected to clear, not increase, protein aggregates, we activated autophagy in three different polyQ models and found a striking tissue-dependent effect: activation of autophagy decreased polyQ aggregation in neurons and intestine, but increased it in the muscle cells. CONCLUSIONS: Our data show that cryptic natural variants in genes encoding proteostasis components, although not causing detectable phenotypes in wild-type individuals, can have profound effects on aggregation-prone proteins. Clinical applications of autophagy activators for aggregation diseases may need to consider the unexpected divergent effects of autophagy in different cell types

Advanced tracking systems design and analysis

The results of an assessment of several types of high-accuracy tracking systems proposed to track the spacecraft in the National Aeronautics and Space Administration (NASA) Advanced Tracking and Data Relay Satellite System (ATDRSS) are summarized. Tracking systems based on the use of interferometry and ranging are investigated. For each system, the top-level system design and operations concept are provided. A comparative system assessment is presented in terms of orbit determination performance, ATDRSS impacts, life-cycle cost, and technological risk

Blocked All-Pairs Shortest Paths Algorithm on Intel Xeon Phi KNL Processor: A Case Study

Manycores are consolidating in HPC community as a way of improving performance while keeping power efficiency. Knights Landing is the recently released second generation of Intel Xeon Phi architecture. While optimizing applications on CPUs, GPUs and first Xeon Phi's has been largely studied in the last years, the new features in Knights Landing processors require the revision of programming and optimization techniques for these devices. In this work, we selected the Floyd-Warshall algorithm as a representative case study of graph and memory-bound applications. Starting from the default serial version, we show how data, thread and compiler level optimizations help the parallel implementation to reach 338 GFLOPS.Comment: Computer Science - CACIC 2017. Springer Communications in Computer and Information Science, vol 79

Aquatic Insects of Upper Three Runs Creek, Savannah River Plant, South Carolina. Part IV: Caddisflies (Trichoptera) of the Lower Reaches

Ninety-three species of caddisflies, representing 14 families, were identified from collections obtained from two localities on Upper Three Runs Creek, Savannah River Site, Aiken County, South Carolina. Collections of adult caddisflies were made biweekly over a 1-yr period with ultraviolet light traps. The similarity index, Jaccard\u27s Coefficient of Communities, showed that the two sites were over 78% similar with 73 species in common. Three species, Oxyethira setosa Denning, Triaenodes smithi Ross, and Nyctiophylax serratus Lago & Harris, are new distributional records for South Carolina. Two species of Triaenodes are new to science. Other species, which were considered to be endemic to the Upper Three Runs Creek drainage, rare outside of the drainage, or of limited distribution, included Cheumatopsyche richardsoni Gordon, Oxyethira dunbartonensis Kelley, Protoptila morettii Morse, Hydrophysche elissoma Ross, Triaenodes ochraceus (Betten and Mosely), Neotrichia falca Ross, Oecetis morsei Bueno-Soria, and Pycnopsyche virginica (Banks)

The Cost of Stability in Coalitional Games

A key question in cooperative game theory is that of coalitional stability, usually captured by the notion of the \emph{core}--the set of outcomes such that no subgroup of players has an incentive to deviate. However, some coalitional games have empty cores, and any outcome in such a game is unstable. In this paper, we investigate the possibility of stabilizing a coalitional game by using external payments. We consider a scenario where an external party, which is interested in having the players work together, offers a supplemental payment to the grand coalition (or, more generally, a particular coalition structure). This payment is conditional on players not deviating from their coalition(s). The sum of this payment plus the actual gains of the coalition(s) may then be divided among the agents so as to promote stability. We define the \emph{cost of stability (CoS)} as the minimal external payment that stabilizes the game. We provide general bounds on the cost of stability in several classes of games, and explore its algorithmic properties. To develop a better intuition for the concepts we introduce, we provide a detailed algorithmic study of the cost of stability in weighted voting games, a simple but expressive class of games which can model decision-making in political bodies, and cooperation in multiagent settings. Finally, we extend our model and results to games with coalition structures.Comment: 20 pages; will be presented at SAGT'0

Influence of regional tectonics and pre-existing structures on the formation of elliptical calderas in the Kenyan Rift

Calderas are formed by the collapse of large magma reservoirs and are commonly elliptical in map view. The orientation of elliptical calderas is often used as an indicator of the local stress regime; but, in some rift settings, pre-existing structural trends may also influence the orientation. We investigated whether either of these two mechanisms controls the orientation of calderas in the Kenyan Rift. Satellite-based mapping was used to identify the rift border faults, intra-rift faults and orientation of the calderas to measure the stress orientations and pre-existing structural trends and to determine the extensional regime at each volcano. We found that extension in northern Kenya is orthogonal, whereas that in southern Kenya is oblique. Elliptical calderas in northern Kenya are orientated NW–SE, aligned with pre-existing structures and perpendicular to recent rift faults. In southern Kenya, the calderas are aligned NE–SW and lie oblique to recent rift faults, but are aligned with pre-existing structures. We conclude that, in oblique continental rifts, pre-existing structures control the development of elongated magma reservoirs. Our results highlight the structural control of magmatism at different crustal levels, where pre-existing structures control the storage and orientation of deeper magma reservoirs and the local stress regime controls intra-rift faulting and shallow magmatism. Supplementary material: Details of the Standard Deviation Ellipse function and statistical methods are available at http://www.geolsoc.org.uk/SUP18849

Computational tools for the study of the genomes of filamentous fungi

During the past year, we have developed and deployed several new computational tools to provide new means of access to information used for research in the biology of filamentous fungi. These new tools complement and extend other resources available for access to both molecular and biological data

Report of the Secretary of War: Wagon Road Routes in Utah Territory

Report of the secretary of war, communicating, in compliance with a resolution of the Senate, Captain Simpson\u27s report and map of wagon road routes in Utah Territory