Table-top laser-based proton acceleration in nanostructured targets

The interaction of ultrashort, high intensity laser pulses with thin foil targets leads to ion acceleration on the target rear surface. To make this ion source useful for applications, it is important to optimize the transfer of energy from the laser into the accelerated ions. One of the most promising ways to achieve this consists in engineering the target front by introducing periodic nanostructures. In this paper, the effect of these structures on ion acceleration is studied analytically and with multidimensional particle-in-cell simulations.Weassessed the role of the structure shape, size, and the angle of laser incidence for obtaining the efficient energy transfer. Local control of electron trajectories is exploited to maximize the energy delivered into the target. Based on our numerical simulations, we propose a precise range of parameters for fabrication of nanostructured targets, which can increase the energy of the accelerated ions without requiring a higher laser intensity.This work has been partially supported by the Xunta de Galicia/FEDER under contract Agrup2015/11 (PC034) and by MINECO under contracts MAT2015-71119-R and FIS2015-71933-REDT. The authors would like to acknowledge the OSIRIS Consortium, consisting of UCLA and IST (Lisbon, Portugal) for the use of OSIRIS, for providing access to the OSIRIS framework. M Blanco also thanks the Ministry of Education of the Spanish government for the FPU fellowship. Camilo Ruiz also thanks MINECO project FIS2016-75652-P M Vranic acknowledges the support of ERC-2010-AdG Grant 267841 and LASERLAB-EUROPE IV—GA No. 654148. Simulations were performed at the Accelerates cluster (Lisbon, Portugal)S

Structural and optical characterisation of planar waveguides obtained via sol-gel

8 páginas, 6 figuras, 1 tabla.-- Trabajo presentado a la "International Conference on Applications of Optics and Photonics" celebrada en Braga (Portugal) en Mayo del 2011.Planar waveguides of SiO2:TiO2 (multilayer structure) and SiO2:CeO2 (thick layer) were prepared onto commercial glass substrates using a sol-gel technique combined with dip-coating. These glassy coatings were structural characterised by Transmission Electron Microscopy (TEM) Energy Dispersive X-ray analysis and by Confocal Microscopy. Thicknesses of 1230 nm and 4,15 μm and refractive indices of 1.59 and 1.48 for SiO2:TiO2 (70:30) and SiO2:CeO2 (95:5) waveguides were obtained, respectively, by Spectroscopic Ellypsometry. Losses of 0.8 dB/cm were measured by double prism method in the SiO2:CeO2 system.The authors acknowledge funding from MICINN (TEC2006-10469, CEN 2007-2014, SURFALUX SOL-00030930 and MAT2010-18519), from DGA (Group of Excellence in Laser Material Processing and Characterisation) and XUNTA DE GALICIA (INCITE08PXIB206013PR).Peer reviewe

Ultraintense Femtosecond Magnetic Nanoprobes Induced by Azimuthally Polarized Laser Beams

We report a novel scheme to generate laser-induced, ultrafast, intense (Tesla scale), spatially isolated, magnetic fields. Three-dimensional particle-in-cell simulations show that a femtosecond azimuthally polarized infrared vector beam, aimed at a conducting circular aperture, produces an intense axially polarized tip-shaped femtosecond magnetic field, extending over micrometer distances and being isolated from the electric field. Our results are backed up by an analytic model, demonstrating the underlying physics and guiding for optimal parameters. In particular, we find the conditions under which the magnetic nanoprobe is substantially enhanced, reaching 4 T when driven by a 1011 W/cm2 laser field, which reflects a selective enhancement by a factor of ∼6. Our scheme offers a promising tool to control, probe, and tailor magnetic nanodomains in femtosecond time scales through pure magnetic interaction by using structured laser beams.The authors thank Luis López, Eduardo Martı́nez, and Victor J. Raposo for fruitful discussions. The authors thank the support from Ministerio de Economı́a y Competitividad (FIS2015-71933- REDT), Xunta de Galicia/ FEDER (ED431B 2017/64 and ED431E 2018/08), and Ministerio de Ciencia, Innovación y Universidades (EQC2018-0041 17-P). C.H.-G. acknowledges support from a 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation. C.H.-G., E.C.J., and L.P. acknowledge support from Junta de Castilla y León (SA046U16, SA287P18) and Ministerio de Economı́a y Competitividad (FIS2016-75652-P). M.B. is funded by the FPU grant program of MECD. The authors acknowledge the OSIRIS Consortium, consisting of UCLA and IST (Lisbon, Portugal) for the use of OSIRIS, for providing access to the OSIRIS framework

Phase matching effects in high harmonic generation at the nanometer scale

Plasmon resonances are known to amplify the electromagnetic fields near metallic nanostructures, providing a promising scheme to generate extreme-ultraviolet harmonics using low power drivings. During high-order harmonic generation (HHG), the driving and harmonic fields accumulate a phase di erence as they propagate through the target. In a typical set-up –a laser focused into a gas jet– the propagation distances amount to several wavelengths, and the cumulative phase-mismatch a ects strongly the e ciency and properties of the harmonic emission. In contrast, HHG in metallic nanostructures is considered to overcome these limitations, as the common sources of phase mismatch –optical density and focusing geometry– are negligible for subwavelength propagation distances. We demonstrate that phase matching still plays a relevant role in HHG from nanostructures due to the non-perturbative character of HHG, that links the harmonic phase to the intensity distribution of the driving field. Our computations show that widely used applications of phase matching control, such as quantum path selection and the increase of contrast in attosecond pulse generation, are also feasible at the nanoscale.Junta de Castilla y León (SA046U16) and MINECO (FIS2013-44174-P, FIS2016-75652-P, FIS2015-71933-REDT, SEV-2015-0522, FIS2013-46768-P, FIS2016-79508-P). M. Blanco is funded by FPU grant program of MECD. C. H.-G. is funded by Marie Curie International Outgoing Fellowship within the EU Seventh Framework Programme for Research and Technological Development (2007-2013), grant Agreement No. 328334. A. Chacón and M. Lewenstein also acknowledge support from Adv. ERC grant OSYRIS, Generalitat de Catalunya (SGR 874, CERCA Program), and Fundació Privada CellexS

Soda-lime glass as biocompatible material to fabricate capillary-model devices by laser technologies

Microfluidic devices have been widely developed in the last decades because of the huge number of fields where they can be applied. Among all the different fabrication techniques available, laser direct writing stands out since it is a fast, accurate, versatile and non-contact method. It is particularly well-suited when working with glass, a robust and cost-efficient material. These laser advantages allow the direct fabrication of not only high quality single microchannel devices but also complex and bifurcated structures. This work establishes a roadmap for manufacturing capillary-model devices with good biocompability in soda-lime glass substrates with pulsed lasers operating in the nanosecond, picosecond and femtosecond temporal range. We determine the optimal laser parameters required for fabricating channels with a diameter:depth rate of 2:1, keeping a semi-circular section. The presence of tin doping (∼2%) in the soda-lime glass is shown to enable the fabrication with nanosecond pulses, and to improve the quality of the channels, reducing the cracking at the sides, when picosecond or femtosecond pulses were used. On the other hand, two regimes of surface roughness are found: a low roughness regime for channels fabricated with nanosecond lasers and a high roughness regime for those fabricated with pico and femtosecond lasers. Human umbilical vein endothelial cells (HUVEC) are employed for cell culturing for evaluating the biocompatibility of the channels. Structures manufactured with the nanosecond laser resulted more suitable in terms of cell adhesion than those fabricated with the picosecond and femtosecond lasers, due to the different surface roughness regimes obtained. In order to increase the biocompatibility of the channels fabricated with pico and femtosecond lasers and to improve the cell growth, a controlled post-thermal treatment is carried out for smoothing the surface

Phase matching effects in high harmonic generation at the nanometer scale

Plasmon resonances are known to amplify the electromagnetic fields near metallic nanostructures, providing a promising scheme to generate extreme-ultraviolet harmonics using low power drivings. During high-order harmonic generation (HHG), the driving and harmonic fields accumulate a phase difference as they propagate through the target. In a typical set-up –a laser focused into a gas jet– the propagation distances amount to several wavelengths, and the cumulative phase-mismatch affects strongly the efficiency and properties of the harmonic emission. In contrast, HHG in metallic nanostructures is considered to overcome these limitations, as the common sources of phase mismatch –optical density and focusing geometry– are negligible for subwavelength propagation distances. We demonstrate that phase matching still plays a relevant role in HHG from nanostructures due to the non-perturbative character of HHG, that links the harmonic phase to the intensity distribution of the driving field. Our computations show that widely used applications of phase matching control, such as quantum path selection and the increase of contrast in attosecond pulse generation, are also feasible at the nanoscale.Junta de Castilla y León (SA046U16) and MINECO (FIS2013-44174-P, FIS2016-75652-P, FIS2015-71933-REDT, SEV-2015-0522, FIS2013-46768-P, FIS2016-79508-P). M. Blanco is funded by FPU grant program of MECD. C. H.-G. is funded by Marie Curie International Outgoing Fellowship within the EU Seventh Framework Programme for Research and Technological Development (2007–2013), grant Agreement No. 328334. A. Chacón and M. Lewenstein also acknowledge support from Adv. ERC grant OSYRIS, Generalitat de Catalunya (SGR 874, CERCA Program), and Fundació Privada Cellex

Transformaciones de haz mediante microlentes selfoc activas

[EN]: In this paper light propagation in an active selfoc microlens with complex refractive index and gradient parameter are examined. The ray-transfer matrix of an active material regarded as a diffraction-free first order optical system is presented to describe the beam transformations in active selfoc microlenses. Results concerning Gaussian beam transformationsand on-axis irradiance through the active selfoc microlens are discussed and commented. © Sociedad Española de Óptica.[ES]: En este trabajo se estudia la propagación de la luz a través de una microlente selfoc activa con un índice de refracción y parámetro de gradiente complejos. La matriz de transferencia de rayos, vista como un sistema óptico de primer orden libre de efectos de difracción, es introducida para describir las transformaciones que puede sufrir un haz en microlentes selfoc activas. Por último se presentan y comentan los resultados correspondientes a las transformaciones de haces Gaussianos y a la irradiancia en eje a través de la microlente selfoc activa.This work has been sponsored by Xunta de Galicia/Feder (INCITE08PXIB206013PR), Ministerio de Ciencia e Innovación (MAT2010-18519) and CDTI (SURFALUX SOL-00030930), Spain. Besides, Ana I. Gomez-Varela wants to acknowledge the financial support from the FPU (Formación de Profesorado Universitario) grant 2009 (Ministerio de Educación, Spain).Peer Reviewe

Sub-micron magnetic patterns and local variations of adhesion force induced in non-ferromagnetic amorphous steel by femtosecond pulsed laser irradiation

Periodic ripple and nanoripple patterns are formed at the surface of amorphous steel after femtosecond pulsed laser irradiation (FSPLI). Formation of such ripples is accompanied with the emergence of a surface ferromagnetic behavior which is not initially present in the non-irradiated amorphous steel. The occurrence of ferromagnetic properties is associated with the laser-induced devitrification of the glassy structure to form ferromagnetic (α-Fe and Fe₃C) and ferrimagnetic [(Fe,Mn)₃O₄ and Fe₂CrO4] phases located in the ripples. The generation of magnetic structures by FSPLI turns out to be one of the fastest ways to induce magnetic patterning without the need of any shadow mask. Furthermore, local variations of the adhesion force, wettability and nanomechanical properties are also observed and compared to those of the as-cast amorphous alloy. These effects are of interest for applications (e.g., biological, magnetic recording, etc.) where both ferromagnetism and tribological/adhesion properties act synergistically to optimize material performance

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery