Metas y principios de la Liga de Consumidores

El objetivo de la Liga Nacional de Consumidores es organizar una demanda efectiva de bienes hechos en condiciones justa

Measurement of recall with and without text.

Thesis (Ed.M.)--Boston Universit

Alien Registration- Kelley, Florence J. (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/11836/thumbnail.jp

Fact Sheet on Women\u27s Studies Programs in 1977

1. There are now 276 women\u27s studies programs on college and university campuses in the United States. The growth rate of these programs in the last 18 months was 80 percent. 2. Women\u27s studies programs can be found in the District of Columbia and in all but nine of the 50 states. Those states without programs are Alaska, Idaho, Louisiana, Maine, Mississippi, North Dakota, Rhode Island, West Virginia, and Wyoming

Metas y principios de la Liga de Consumidores

Publicación original: Kelley, Florence (1899). Aims and Principles of the Consumers' League. The American Journal of Sociology, 5, 3: 289-304)

Textes sur la méthode et l'organisation de l'intervention sociale

Traduction de textes consacrés à la construction des connaissances dans l’intervention social

The Iowa Homemaker vol.3, no.12

Table of Contents A Greeting to Iowa Homemakers by Dr. Louise Stanley, page 3 A New Book on “Meal Planning and Table Service” by Florence E. Busse, page 4 A Bill of Rights for the Child by Lulu R. Lancaster, page 4 Shrubs as a Garden Background by Juanita Beard, page 5 ‘Tis Egg Time Again by Beth Bailey McLean, page 6 The New Domestic System by Claude L. Benner, page 7 A Time Budget for the Homemaker by Ruth M. Lindquist, page 8 Figures That Do Not Lie by Mae L. Kelley, page 9 The Cooking of Meats by P. Mabel Nelson, page 10 The Psychology of Clothing by Eveleth Pedersen, page 11 Iowa State Women in Rural Schools by W. H. Lancelot, page 12 A Yarn about Yarns by Irene Christian, page 13 Tea Room Accounting by George M. Fuller, page 14 Who’s There and Where by Dryden Quist, page 15 Editorial, page 16 Homemaker as Citizen, page 17 The Eternal Question, page 18 Mrs. Purchaser Chooses Upholstery by Lucile Barta, page 1

Gender Differences in Immune Reconstitution: A Multicentric Cohort Analysis in Sub-Saharan Africa

In sub-Saharan Africa, men living with HIV often start ART at more advanced stages of disease and have higher early mortality than women. We investigated gender difference in long-term immune reconstitution

Cytosolic 5'-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response.

International audienceBACKGROUND: Double stranded RNA (dsRNA) is widely accepted as an RNA motif recognized as a danger signal by the cellular sentries. However, the biology of non-segmented negative strand RNA viruses, or Mononegavirales, is hardly compatible with the production of such dsRNA. METHODOLOGY AND PRINCIPAL FINDINGS: During measles virus infection, the IFN-beta gene transcription was found to be paralleled by the virus transcription, but not by the virus replication. Since the expression of every individual viral mRNA failed to activate the IFN-beta gene, we postulated the involvement of the leader RNA, which is a small not capped and not polyadenylated RNA firstly transcribed by Mononegavirales. The measles virus leader RNA, synthesized both in vitro and in vivo, was efficient in inducing the IFN-beta expression, provided that it was delivered into the cytosol as a 5'-trisphosphate ended RNA. The use of a human cell line expressing a debilitated RIG-I molecule, together with overexpression studies of wild type RIG-I, showed that the IFN-beta induction by virus infection or by leader RNA required RIG-I to be functional. RIG-I binds to leader RNA independently from being 5-trisphosphate ended; while a point mutant, Q299A, predicted to establish contacts with the RNA, fails to bind to leader RNA. Since the 5'-triphosphate is required for optimal RIG-I activation but not for leader RNA binding, our data support that RIG-I is activated upon recognition of the 5'-triphosphate RNA end. CONCLUSIONS/SIGNIFICANCE: RIG-I is proposed to recognize Mononegavirales transcription, which occurs in the cytosol, while scanning cytosolic RNAs, and to trigger an IFN response when encountering a free 5'-triphosphate RNA resulting from a mislocated transcription activity, which is therefore considered as the hallmark of a foreign invader

Factors associated with paradoxical immune response to antiretroviral therapy in HIV infected patients: a case control study

<p>Abstract</p> <p>Background</p> <p>A paradoxical immunologic response (PIR) to Highly Active Antiretroviral Therapy (HAART), defined as viral suppression without CD4 cell-count improvement, has been reported in the literature as 8 to 42%, around 15% in most instances. The present study aims to determine, in a cohort of HIV infected patients in Brazil, what factors were independently associated with such a discordant response to HAART.</p> <p>Methods</p> <p>A case-control study (1:4) matched by gender was conducted among 934 HIV infected patients on HAART in Brazil. Cases: patients with PIR, defined as CD4 < 350 cells/mm³(hazard ratio for AIDS or death of at least 8.5) and undetectable HIV viral load on HAART for at least one year. Controls: similar to cases, but with CD4 counts ≥ 350 cells/mm³. Eligibility criteria were applied. Data were collected from medical records using a standardized form. Variables were introduced in a hierarchical logistic regression model if a p-value < 0.1 was determined in a bivariate analysis.</p> <p>Results</p> <p>Among 934 patients, 39 cases and 160 controls were consecutively selected. Factors associated with PIR in the logistic regression model were: total time in use of HAART (OR 0.981; CI 95%: 0.96-0.99), nadir CD4-count (OR 0.985; CI 95%: 0.97-0.99), and time of undetectable HIV viral load (OR 0.969; CI 95%: 0.94-0.99).</p> <p>Conclusions</p> <p>PIR seems to be related to a delay in the management of immunodeficient patients, as shown by its negative association with nadir CD4-count. Strategies should be implemented to avoid such a delay and improve the adherence to HAART as a way to implement concordant responses.</p