2,781 research outputs found
Evaluation of children’s centres in England (ECCE). Strand 1: First survey of children’s centre leaders in the most deprived areas
This is the final version of the report. Available from the Department for Education via the link in this record.The evaluation of children’s centres in England (ECCE) is a 6-year study commissioned by the Department for Education (DfE) and undertaken by NatCen Social Research, the University of Oxford and Frontier Economics.
The aim of this report is to profile children’s centres in the most disadvantaged areas, providing estimates on different aspects of provision and to explore different models of provision. The profile covers all main aspects of provision including management, staff, services, users and finance and involves nearly 500 children’s centres, representative of all phase 1 and 2 centres in the most disadvantaged area
Muon Simulations for Super-Kamiokande, KamLAND and CHOOZ
Muon backgrounds at Super-Kamiokande, KamLAND and CHOOZ are calculated using
MUSIC. A modified version of the Gaisser sea level muon distribution and a
well-tested Monte Carlo integration method are introduced. Average muon energy,
flux and rate are tabulated. Plots of average energy and angular distributions
are given. Implications on muon tracker design for future experiments are
discussed.Comment: Revtex4 33 pages, 16 figures and 4 table
Recommended from our members
Stratigraphic relations and hydrologic properties of the Paintbrush Tuff (PTn) hydrologic unit, Yucca Mountain, Nevada
Yucca Mountain is being investigated as a potential site for a high- level nuclear waste repository. The intent of this study was to clarify stratigraphic relations within the Paintbrush Tuff (PTn) unit at Yucca Mountain in order to better understand vertical and lateral variations in hydrologic properties as they relate to the lithologic character of these rocks. This report defines informal stratigraphic units within the PTn interval, demonstrates their lateral continuity in the Yucca Mountain region, describes later and vertical variations within them, and characterizes their hydrologic properties and importance to numerical flow and transport models. We present tables summarizing the depth to stratigraphic contacts in cored borehole studies, and unit descriptions and correlations in 10 measured sections
Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.
Recent work has highlighted the importance of transient low-frequency oscillatory (LFO; <4 Hz) activity in the healthy primary motor cortex during skilled upper-limb tasks. These brief bouts of oscillatory activity may establish the timing or sequencing of motor actions. Here, we show that LFOs track motor recovery post-stroke and can be a physiological target for neuromodulation. In rodents, we found that reach-related LFOs, as measured in both the local field potential and the related spiking activity, were diminished after stroke and that spontaneous recovery was closely correlated with their restoration in the perilesional cortex. Sensorimotor LFOs were also diminished in a human subject with chronic disability after stroke in contrast to two non-stroke subjects who demonstrated robust LFOs. Therapeutic delivery of electrical stimulation time-locked to the expected onset of LFOs was found to significantly improve skilled reaching in stroke animals. Together, our results suggest that restoration or modulation of cortical oscillatory dynamics is important for the recovery of upper-limb function and that they may serve as a novel target for clinical neuromodulation
Photometry and Spectroscopy of GRB 030329 and Its Associated Supernova 2003dh: The First Two Months
We present extensive optical and infrared photometry of the afterglow of
gamma-ray burst (GRB) 030329 and its associated supernova (SN) 2003dh over the
first two months after detection (2003 March 30-May 29 UT). Optical
spectroscopy from a variety of telescopes is shown and, when combined with the
photometry, allows an unambiguous separation between the afterglow and
supernova contributions. The optical afterglow of the GRB is initially a
power-law continuum but shows significant color variations during the first
week that are unrelated to the presence of a supernova. The early afterglow
light curve also shows deviations from the typical power-law decay. A supernova
spectrum is first detectable ~7 days after the burst and dominates the light
after ~11 days. The spectral evolution and the light curve are shown to closely
resemble those of SN 1998bw, a peculiar Type Ic SN associated with GRB 980425,
and the time of the supernova explosion is close to the observed time of the
GRB. It is now clear that at least some GRBs arise from core-collapse SNe.Comment: 57 pages, 13 figures, accepted by ApJ, revised per referee's
comments, includes full photometry table. Data available at
ftp://cfa-ftp.harvard.edu/pub/kstanek/GRB030329 or through WWW at
http://cfa-www.harvard.edu/cfa/oir/Research/GRB
Casimir Energy for a Spherical Cavity in a Dielectric: Applications to Sonoluminescence
In the final few years of his life, Julian Schwinger proposed that the
``dynamical Casimir effect'' might provide the driving force behind the
puzzling phenomenon of sonoluminescence. Motivated by that exciting suggestion,
we have computed the static Casimir energy of a spherical cavity in an
otherwise uniform material. As expected the result is divergent; yet a
plausible finite answer is extracted, in the leading uniform asymptotic
approximation. This result agrees with that found using zeta-function
regularization. Numerically, we find far too small an energy to account for the
large burst of photons seen in sonoluminescence. If the divergent result is
retained, it is of the wrong sign to drive the effect. Dispersion does not
resolve this contradiction. In the static approximation, the Fresnel drag term
is zero; on the mother hand, electrostriction could be comparable to the
Casimir term. It is argued that this adiabatic approximation to the dynamical
Casimir effect should be quite accurate.Comment: 23 pages, no figures, REVTe
Observability of the Bulk Casimir Effect: Can the Dynamical Casimir Effect be Relevant to Sonoluminescence?
The experimental observation of intense light emission by acoustically
driven, periodically collapsing bubbles of air in water (sonoluminescence) has
yet to receive an adequate explanation. One of the most intriguing ideas is
that the conversion of acoustic energy into photons occurs quantum
mechanically, through a dynamical version of the Casimir effect. We have argued
elsewhere that in the adiabatic approximation, which should be reliable here,
Casimir or zero-point energies cannot possibly be large enough to be relevant.
(About 10 MeV of energy is released per collapse.) However, there are
sufficient subtleties involved that others have come to opposite conclusions.
In particular, it has been suggested that bulk energy, that is, simply the
naive sum of , which is proportional to the volume, could
be relevant. We show that this cannot be the case, based on general principles
as well as specific calculations. In the process we further illuminate some of
the divergence difficulties that plague Casimir calculations, with an example
relevant to the bag model of hadrons.Comment: 13 pages, REVTe
Basins of attraction on random topography
We investigate the consequences of fluid flowing on a continuous surface upon
the geometric and statistical distribution of the flow. We find that the
ability of a surface to collect water by its mere geometrical shape is
proportional to the curvature of the contour line divided by the local slope.
Consequently, rivers tend to lie in locations of high curvature and flat
slopes. Gaussian surfaces are introduced as a model of random topography. For
Gaussian surfaces the relation between convergence and slope is obtained
analytically. The convergence of flow lines correlates positively with drainage
area, so that lower slopes are associated with larger basins. As a consequence,
we explain the observed relation between the local slope of a landscape and the
area of the drainage basin geometrically. To some extent, the slope-area
relation comes about not because of fluvial erosion of the landscape, but
because of the way rivers choose their path. Our results are supported by
numerically generated surfaces as well as by real landscapes
A mathematical model for fibro-proliferative wound healing disorders
The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current medical treatments are thus unreliable.
In this paper, the authors apply an existing deterministic mathematical model for fibroplasia and wound contraction in adult mammalian dermis (Olsenet al., J. theor. Biol. 177, 113–128, 1995) to investigate key clinical problems concerning these healing disorders. A caricature model is proposed which retains the fundamental cellular and chemical components of the full model, in order to analyse the spatiotemporal dynamics of the initiation, progression, cessation and regression of fibro-contractive diseases in relation to normal healing. This model accounts for fibroblastic cell migration, proliferation and death and growth-factor diffusion, production by cells and tissue removal/decay.
Explicit results are obtained in terms of the model processes and parameters. The rate of cellular production of the chemical is shown to be critical to the development of a stable pathological state. Further, cessation and/or regression of the disease depend on appropriate spatiotemporally varying forms for this production rate, which can be understood in terms of the bistability of the normal dermal and pathological steady states—a central property of the model, which is evident from stability and bifurcation analyses.
The work predicts novel, biologically realistic and testable pathogenic and control mechanisms, the understanding of which will lead toward more effective strategies for clinical therapy of fibro-proliferative disorders
- …