60 research outputs found
In advance of a broken attestant, or where is art’s critical subject?
Two concurrent understandings of criticality in art assign it as a potential property of artworks themselves, or bemoan it as lacking in art’s audiences. This division can be traced to its roots in the Romantic conception of criticality, in which the critical procedure completes an unfinished work. This act of completion, and an accompanying conception of transformatory potential, is generally held to occur in the presence of a primary audience: an idea that is undermined by recent attributions of critical force to non-present secondary audiences. This article traces these orientations of thought as they structure recent approaches to practice, then offers an example of a mode of practice that refuses to attribute any critical or transformatory capacity to either its original material effects or a primary audience. Any critical or transformatory force is played out as the work propagates and adjusts itself in its afterlife
A study of the interaction of end-binding proteins with microtubules
Dynamic microtubules control cell shape, cell locomotion and the proper segregation of chromosomes. End Binding (EB) proteins are the key components of the microtubule (MT) plus tip (+TIP) protein network. EBs bind to the MT plus end and regulate microtubule dynamics. EBs localise to the microtubule tip by recognising the nucleotide state of tubulin. Mammalian cells express three members of the EB family (EB1, EB2 and EB3) that localise to spatial distinct sites on the microtubule in cells. Perturbation experiments in cells and in vitro reconstitution experiments have shown that EB1 and EB3 accelerate MT assembly and increase catastrophe frequency. This is a paradoxical effect, as an increase in growth speed should increase the size of the GTP cap thus decreasing the probability of catastrophe. To study this paradoxical effect an image analysis routine was developed to gain insight into any structural re-arrangement at the microtubule tip. An algorithm was developed to extract fluorescence intensity data along the length of a microtubule from time-lapse images. Curve fitting to these data allowed determination of the MT end position with sub-pixel resolution, the measurement of taper (i.e. the length difference of protofilaments at the microtubule end) and the quantitative analysis of the comet-shaped distributions of EB proteins at microtubule ends. The method was verified using synthetic images of MTs and then applied to time lapse movies of dynamic MTs from in vitro experiments where either the tubulin concentration or the EB3 concentration was varied. It was discovered that EB3 may increase microtubule taper, thereby de-stabilising the microtubule tip structure.
Binding of the three EB proteins to spatial distinct sites at the MT tip was carefully re-investigated in-vitro by pair-wise comparison, and in relation to the MT tip. All three EB proteins were found to localise to distinct sites with EB3 found to bind closest to the MT tip and EB2 being the furthest from the MT tip. Based on structural data that became available during the course of the project, and additional evidence of different nucleotide preferences between EB1/EB3 and EB2, a dual nucleotide recognition model was conceived to explain these spatially distinct locations. The model assumes that an EB protein is sensitive to the nucleotide state at both E-sites close to its binding site at the interface of 4 tubulin dimers. All three EB proteins showed evidence of dual nucleotide recognition in mixed nucleotide lattice experiments designed to directly test the model.
EB proteins recognise spatial distinct sites by recognising the pairwise nucleotide state of tubulin. As EB3 binds closest to the MT tip, it is best placed to affect microtubule dynamics by increasing taper, promoting a quicker growth phase and destabilising the microtubule. Within cells this is a useful concept as it can be up regulated to increase the dynamicity of MTs ensuring more efficient re-organisation of the cytoskeleton during cell differentiation or neuronal elongation
Noble gases in the Cameroon line and the He, Ne, and Ar isotopic compositions of high mu (HIMU) mantle
Sr-Nd-Pb-Hf isotope results from ODP Leg 187: Evidence for mantle dynamics of the Australian-Antarctic Discordance and origin of the Indian MORB source
New high precision PIMMS Hf and Pb isotope data for 14–28 Ma basalts recovered during ODP Leg 187 are compared with zero-age dredge samples from the Australian-Antarctic Discordance (AAD). These new data show that combined Nd-Hf isotope systematics can be used as an effective discriminant between Indian and Pacific MORB source mantle domains. In particular, Indian mantle is displaced to lower εNd and higher εHf ratios compared to Pacific mantle. As with Pb isotope plots, there is almost no overlap between the two mantle types in Nd-Hf isotope space. On the basis of our new Nd-Hf isotope data, we demonstrate that Pacific MORB-source mantle was present near the eastern margin of the AAD from as early as 28 Ma, its boundary with Indian MORB-source mantle coinciding with the eastern edge of a basin-wide arcuate depth anomaly that is centered on the AAD. This observation rules out models requiring rapid migration of Pacific MORB mantle into the Indian Ocean basin since separation of Australia from Antarctica. Although temporal variations in isotopic composition can be discerned relative to the fracture zone boundary of the modern AAD at 127°E, the distribution of different compositional groups appears to have remained much the same relative to the position of the residual depth anomaly for the past 30 m.y. Thus significant lateral flow of mantle along the ridge axis toward the interface appears unlikely. Instead, the dynamics that maintain both the residual depth anomaly and the isotopic boundary between Indian and Pacific mantle are due to eastward migration of the Australian and Antarctic plates over a stagnated, but slowly upwelling, slab oriented roughly orthogonal to the ridge axis. Temporal and spatial variations in the compositions of Indian MORB basalts within the AAD can be explained by progressive displacement of shallower Indian MORB-source mantle by deeper mantle having a higher εHf composition ascending ahead of the upwelling slab. Models for the origin of the distinctive composition of the Indian MORB-source based on recycling of a heterogeneous enriched component that consist of ancient altered ocean crust plus<10% pelagic sediment are inconsistent with Nd-Hf isotope systematics. Instead, the data can be explained by a model in which Indian mantle includes a significant proportion of material that was processed in the mantle wedge above a subduction zone and was subsequently mixed back into unprocessed upper mantle
The Vehicle, Spring 2010
Table of Contents
ForgettingRashelle McNairpage 34
MuseMary Lieskepage 35
My CompulsionAshton Tembypage 38
MemoryKate Vandermeerpage 41
Killmercialize MeGreg Petersonpage 42
PenJake Smithpage 46
GrassKate Vandermeerpage 48
Character CreationMary Lieskepage 52
Ring Around TheKim Hunter-Perkinspage 54
The Great Cursive ScareJake Smithpage 55
OpiateDoug Urbanskipage 61
What Happens to Little Girls...Jennifer O\u27Neilpage 63
Poetry
Sunny DaysRyan Poolpage 2
AtlantisDoug Urbanskipage 4
Garbage CityKate Vandermeerpage 6
Fat Girl ThongsKim Hunter-Perkinspage 7
MercilessRosalia Pecorapage 19
ChemistryMary Lieskepage 20
He-Who-Stopped-TalkingJustin Sudkamppage 22
In Which Iris Contemplates a Barren EarthSean Slatterypage 24
At the Bottom of the WorldNick Canadaypage 27
Dogma: Mush!Scott Maypage 28
ThiefMary Lieskepage 29
Prose
Coming HomeDoug Urbanskipage 8
DodoDan Davispage 31
The Poet in the PedestrianScott Maypage 37
Toxic RainJacob Swansonpage 40
What\u27s Your Greatest Fear?Justine Fittonpage 43
Soul VoiceHolly Thomaspage 49
Conversations with a SniperKim Hunter-Perkinspage 56
LettersDaniel Paquinpage 65
Art
San Marcos, MexicoKate Vandermeercover
Contemplation of the World\u27s EndNicholas Giffordpage 18
Little Lady SitsSarah Hadwigerpage 26
MoodAlycia Rockeypage 30
Four Ducks in a RowMegan Mathypage 36
The Daily EasternBen Tillerypage 39
BirdsAlycia Rockeypage 45
March of the BugsMegan Mathypage 47
Mexico Work ExperienceKate Vandermeerpage 53
Feather and JewelsAlycia Rockeypage 60
The ForgottenMegan Mathypage 64
Special Features
Fall 2009-Spring 2010 Vehicle Award Winnerspage 1
James K. Johnson Creative Writing Awardpage 74
Kim Hunter-PerkinsWinning Entries (Poetry)page 75
Clint WalkerWinning Entry (Fiction)page 86
Faculty Spotlight: Professor Jason Brownpage 99
About the Contributorspage 106
About the Editorspage 110https://thekeep.eiu.edu/vehicle/1093/thumbnail.jp
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
SPARC 2022 book of abstracts
Welcome to the Book of Abstracts for the 2022 SPARC conference. Our conference is called “Moving Forwards” reflecting our re-emergence from the pandemic and our desire to reconnect our PGR community, in celebration of their research. PGRs have continued with their research endeavours despite many challenges, and their ongoing successes are underpinned by the support and guidance of dedicated supervisors and the Doctoral School Team. To recognise supervision excellence we will be awarding our annual Supervisor of the Year prizes, based on the wonderful nominations received from their PGR students.Once again, we have received a tremendous contribution from our postgraduate research community; with over 60 presenters, 12 Three-Minute Thesis finalists, and 20 poster presentations, the conference showcases our extraordinarily vibrant, inclusive, and resilient PGR community at Salford. This year there will be prizes to be won for ‘best in conference’ presentations, in addition to the winners from each parallel session. Audience members too could be in for a treat, with judges handing out spot prizes for the best questions asked, so don’t miss the opportunity to put your hand up. These abstracts provide a taster of the diverse and impactful research in progress and provide delegates with a reference point for networking and initiating critical debate. Take advantage of the hybrid format: in online sessions by posting a comment or by messaging an author to say “Hello”, or by initiating break time discussions about the amazing research you’ve seen if you are with us in person. Who knows what might result from your conversation? With such wide-ranging topics being showcased, we encourage you to take up this great opportunity to engage with researchers working in different subject areas from your own. As recent events have shown, researchers need to collaborate to meet global challenges. Interdisciplinary and international working is increasingly recognised and rewarded by all major research funders. We do hope, therefore, that you will take this opportunity to initiate interdisciplinary conversations with other researchers. A question or comment from a different perspective can shed new light on a project and could lead to exciting collaborations, and that is what SPARC is all about. SPARC is part of a programme of personal and professional development opportunities offered to all postgraduate researchers at Salford. More information about this programme is available on our website: Doctoral School | University of Salford. Registered Salford students can access full details on the Doctoral School hub: Doctoral School Hub - Home (sharepoint.com) You can follow us on Twitter @SalfordPGRs and please use the #SPARC2022 to share your conference experience.We particularly welcome taught students from our undergraduate and master’s programmes as audience members. We hope you enjoy the presentations on offer and that they inspire you to pursue your own research career. If you would like more information about studying for a PhD here at the University of Salford, your lecturers can advise, or you can contact the relevant PGR Support Officer; their details can be found at Doctoral School | University of Salford. We wish you a rich and rewarding conference experience
In Advance of a Broken Attestant
An investigation of the status of criticality in recent practice. The paper drew on a distinction between critical art objects and critical audiences made by Anton Vidokle in his account of Unitednationsplaza, and offered an overview of the complex relation between pedagodic curatorial practices such as Vidokle's, and their primary and secondary publics. This was then used to indicate a possible approach to an object-based public practice which rejects its primary audience in order to pay more attention to the critical potential of secondary ones.
Session: Art’s Convulsions: Revolution and the Long Avant-Gard
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