851 research outputs found
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Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes
Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited. This report describes the use of tert-alkyl oxalate salts, derived from tertiary alcohols, to introduce tertiary substituents into a variety of heterocyclic substrates. This reaction has reasonably broad scope, proceeds rapidly under mild conditions, and is initiated by either photochemical or thermal activation. Insights into the underlying mechanism of the higher yielding visible-light initiated process were obtained by flash photolysis studies, whereas computational studies provided insight into the reaction scope
New direction for gamma-rays
The origin of energetic gamma-ray bursts is still unknown. But the detection
of polarization of gamma-rays provides fresh insight into the mechanism driving
these powerful explosions.Comment: Nature "News & Views", RE Coburn & Boggs (astro-ph/0305377
Knowledge Graph Completion to Predict Polypharmacy Side Effects
The polypharmacy side effect prediction problem considers cases in which two
drugs taken individually do not result in a particular side effect; however,
when the two drugs are taken in combination, the side effect manifests. In this
work, we demonstrate that multi-relational knowledge graph completion achieves
state-of-the-art results on the polypharmacy side effect prediction problem.
Empirical results show that our approach is particularly effective when the
protein targets of the drugs are well-characterized. In contrast to prior work,
our approach provides more interpretable predictions and hypotheses for wet lab
validation.Comment: 13th International Conference on Data Integration in the Life
Sciences (DILS2018
Domain scaling and marginality breaking in the random field Ising model
A scaling description is obtained for the --dimensional random field Ising
model from domains in a bar geometry. Wall roughening removes the marginality
of the case, giving the correlation length in , and for power law behaviour with
, . Here, (lattice, continuum) is one of four rough wall exponents provided by the
theory. The analysis is substantiated by three different numerical techniques
(transfer matrix, Monte Carlo, ground state algorithm). These provide for
strips up to width basic ingredients of the theory, namely free energy,
domain size, and roughening data and exponents.Comment: ReVTeX v3.0, 19 pages plus 19 figures uuencoded in a separate file.
These are self-unpacking via a shell scrip
The clinical features of the piriformis syndrome: a systematic review
Piriformis syndrome, sciatica caused by compression of the sciatic nerve by the piriformis muscle, has been described for over 70 years; yet, it remains controversial. The literature consists mainly of case series and narrative reviews. The objectives of the study were: first, to make the best use of existing evidence to estimate the frequencies of clinical features in patients reported to have PS; second, to identify future research questions. A systematic review was conducted of any study type that reported extractable data relevant to diagnosis. The search included all studies up to 1 March 2008 in four databases: AMED, CINAHL, Embase and Medline. Screening, data extraction and analysis were all performed independently by two reviewers. A total of 55 studies were included: 51 individual and 3 aggregated data studies, and 1 combined study. The most common features found were: buttock pain, external tenderness over the greater sciatic notch, aggravation of the pain through sitting and augmentation of the pain with manoeuvres that increase piriformis muscle tension. Future research could start with comparing the frequencies of these features in sciatica patients with and without disc herniation or spinal stenosis
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Comparison of 5-year progression of retinitis pigmentosa involving the posterior pole among siblings by means of SD-OCT: a retrospective study
The blockchain technology promises to transform finance, money and evengovernments. However, analyses of blockchain applicability and robustness typicallyfocus on isolated systems whose actors contribute mainly by running the consensusalgorithm. Here, we highlight the importance of considering trustless platformswithin the broader ecosystem that includes social and communication networks. Asan example, we analyse the flash-crash observed on 21st June 2017 in the Ethereumplatform and show that a major phenomenon of social coordination led to acatastrophic cascade of events across several interconnected systems. We proposethe concept of “emergent centralisation” to describe situations where a single systembecomes critically important for the functioning of the whole ecosystem, and arguethat such situations are likely to become more and more frequent in interconnectedsocio-technical systems. We anticipate that the systemic approach we propose willhave implications for future assessments of trustless systems and call for the attentionof policy-makers on the fragility of our interconnected and rapidly changing world
Spontaneous Splenic Rupture: A Rare Complication of Acute Pancreatitis in a Patient with Crohn's Disease
Crohn's disease (CD) is an idiopathic inflammatory bowel disease which can involve any part of the gastrointestinal tract. It frequently involves the ileum, colon and the anorectum. Although rare, acute pancreatitis as a complication of CD involving the duodenum has been described in the literature. We describe a 37-year-old male with CD presenting with acute pancreatitis and spontaneous splenic rupture. The potential mechanisms associated with acute pancreatitis along with spontaneous rupture of the spleen in this patient population and its treatment will be discussed. Common complaints such as upper abdominal pain in a patient with CD should undergo workup to exclude less commonly involved sites such as the pancreas and spleen. Close monitoring in the critical care setting is recommended in carefully selected and hemodynamically stable patients with splenic rupture. Surgical treatment is considered as the standard of care in hemodynamically unstable patients
Scale-invariance of galaxy clustering
Some years ago we proposed a new approach to the analysis of galaxy and
cluster correlations based on the concepts and methods of modern statistical
Physics. This led to the surprising result that galaxy correlations are fractal
and not homogeneous up to the limits of the available catalogs. The usual
statistical methods, which are based on the assumption of homogeneity, are
therefore inconsistent for all the length scales probed so far, and a new, more
general, conceptual framework is necessary to identifythe real physical
properties of these structures. In the last few years the 3-d catalogs have
been significatively improved and we have extended our methods to the analysis
of number counts and angular catalogs. This has led to a complete analysis of
all the available data that we present in this review. The result is that
galaxy structures are highly irregular and self-similar: all the available data
are consistent with each other and show fractal correlations (with dimension ) up to the deepest scales probed so far (1000 \hmp) and even more
as indicated from the new interpretation of the number counts. The evidence for
scale-invariance of galaxy clustering is very strong up to 150 \hmp due to
the statistical robustness of the data but becomes progressively weaker
(statistically) at larger distances due to the limited data. In These facts
lead to fascinating conceptual implications about our knowledge of the universe
and to a new scenario for the theoretical challenge in this field.Comment: Latex file 165 pages, 106 postscript figures. This paper is also
available at http://www.phys.uniroma1.it/DOCS/PIL/pil.html To appear in
Physics Report (Dec. 1997
A primary care, multi-disciplinary disease management program for opioid-treated patients with chronic non-cancer pain and a high burden of psychiatric comorbidity
BACKGROUND: Chronic non-cancer pain is a common problem that is often accompanied by psychiatric comorbidity and disability. The effectiveness of a multi-disciplinary pain management program was tested in a 3 month before and after trial. METHODS: Providers in an academic general medicine clinic referred patients with chronic non-cancer pain for participation in a program that combined the skills of internists, clinical pharmacists, and a psychiatrist. Patients were either receiving opioids or being considered for opioid therapy. The intervention consisted of structured clinical assessments, monthly follow-up, pain contracts, medication titration, and psychiatric consultation. Pain, mood, and function were assessed at baseline and 3 months using the Brief Pain Inventory (BPI), the Center for Epidemiological Studies-Depression Scale scale (CESD) and the Pain Disability Index (PDI). Patients were monitored for substance misuse. RESULTS: Eighty-five patients were enrolled. Mean age was 51 years, 60% were male, 78% were Caucasian, and 93% were receiving opioids. Baseline average pain was 6.5 on an 11 point scale. The average CESD score was 24.0, and the mean PDI score was 47.0. Sixty-three patients (73%) completed 3 month follow-up. Fifteen withdrew from the program after identification of substance misuse. Among those completing 3 month follow-up, the average pain score improved to 5.5 (p = 0.003). The mean PDI score improved to 39.3 (p < 0.001). Mean CESD score was reduced to 18.0 (p < 0.001), and the proportion of depressed patients fell from 79% to 54% (p = 0.003). Substance misuse was identified in 27 patients (32%). CONCLUSIONS: A primary care disease management program improved pain, depression, and disability scores over three months in a cohort of opioid-treated patients with chronic non-cancer pain. Substance misuse and depression were common, and many patients who had substance misuse identified left the program when they were no longer prescribed opioids. Effective care of patients with chronic pain should include rigorous assessment and treatment of these comorbid disorders and intensive efforts to insure follow up
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