Software application for bill splitting

Individuals of a group may at times prefer to split the expense of a group activity, such as group lunch or dinner, among themselves. Techniques described enable splitting of a group bill by allocating items of the bill to corresponding users. Such bill splitting can be implemented using a variety of interfaces, including voice UI, conversational UI, and visual interfaces. Also, techniques described can be integrated with other platforms to enable online reviews and payments

Book Reviews

Book Review

Track Reconstruction Progress from the DMTPC Directional Dark Matter Experiment

he Dark Matter Time Projection Chamber (DMTPC) collaboration is developing prototype detectors to measure both the energies and directions of nuclear recoils. The intended application is to exploit the expected directional anisotropy of dark matter velocities at Earth to unambiguously observe dark matter induced recoils. The detector consist of low-pressure CF[subscript 4] TPC's with CCD cameras, PMT's, and charge amplifiers for readout. This talk gives an overview of the experiment and describes recent advances in hardware and analysis

Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling

Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells in aggressive breast cancers typically exhibit significant and stable heterogeneity in their Myc levels, which correlates with refractoriness to therapy and poor prognosis. This suggests that Myc heterogeneity confers some selective advantage on breast tumor growth and progression. To investigate this, we created a traceable MMTV-Wnt1-driven in vivo chimeric mammary tumor model comprising an admixture of low-Myc- and reversibly switchable high-Myc-expressing clones. We show that such tumors exhibit interclonal mutualism wherein cells with high-Myc expression facilitate tumor growth by promoting protumorigenic stroma yet concomitantly suppress Wnt expression, which renders them dependent for survival on paracrine Wnt provided by low-Myc-expressing clones. To identify any therapeutic vulnerabilities arising from such interdependency, we modeled Myc/Ras/p53/Wnt signaling cross talk as an executable network for low-Myc, for high-Myc clones, and for the 2 together. This executable mechanistic model replicated the observed interdependence of high-Myc and low-Myc clones and predicted a pharmacological vulnerability to coinhibition of COX2 and MEK. This was confirmed experimentally. Our study illustrates the power of executable models in elucidating mechanisms driving tumor heterogeneity and offers an innovative strategy for identifying combination therapies tailored to the oligoclonal landscape of heterogenous tumors

O restituciji u Srbiji, februar 2014

This World Jewish Restitution Organization (WJRO) position paper reviews the current state of restitution in Serbia. It covers private property, Jewish communal property, heirless formerly-Jewish owned property, and Jewish cultural property that was confiscated or sold under duress during the Holocaust and/or subsequently nationalized under the communist regime in the area of the former Yugoslavia that is now Serbia. There is now an international consensus on the restitution of Holocaust-era property. Serbia and 46 other countries endorsed the Terezin Declaration on Holocaust Era Assets and Related Issues, establishing principles for property restitution. In 2010, 43 countries endorsed guidelines and based practices for immovable property restitution. Serbia participated with 38 other countries in November 2012 in the immovable property review conference, reaffirming its commitment to the ‘Terezin Declaration' and the ‘Guidelines and Best Practices'. In this paper, WJRO urges the government of Serbia to take steps to make further progress toward meeting the international consensus on restitution. WJRO urges the Government of Serbia to address the following important issues Communal property, Private property, Heirless property, Art, Judaica, and other cultural property.Ovo istraživanje se odnosi na process restitucije u Srbiji: privatnu imovinu Jevreja koja je oduzeta u periodu nakon Drugog svetskog rata, jevrejsku imovinu bez naslednika koja je oduzeta, brojnu imovinu koja je pripada jevrejskim zajednicama, kao i nepokretna imovina koja je bila oduzeta u toku Holokausta ili konfiskovana/nacionalizovana nakon Drugog svetskog rata. I pored posebnosti evropskih države u procesima podržavljavanja jevrejske imovine napravljen je konsenzus među evropskim državama koji se odnosi na imovinu oduzetu kao posledica Holokausta i u godinama nakon Drugog svetskog rata. Terezinska deklaracija koju je potpisala Srbija sa još 46 drugih zemalja je osnova za povraćaj imovine oduzete za vreme Holokausta ali i druga pitanja koja su u vezi sa tim. Srbija je sa 38 drugih zemalja učestvovala na sastanku novembra 2012. Uvidom u sadašnje stanje Srbiji WJRO (Svetska Jevrejska Ogranizacija za Restituciju) se obraća Vladi Srbije i drugim važnim državnim institucijama da obezbede što skorije rešavanje ovih pitanja koja se odnose na komunalnu jevrejsku imovinu, privatnu imovinu, imovinu bez naslednika kao i drugu nepokretnu imovinu, umetnine, Judaiku i kulturno blago

Randomized Controlled Trial of Physical Exercise in Diabetic Veterans With Length-Dependent Distal Symmetric Polyneuropathy

Rationale: Physical exercise is an essential adjunct to the management of patients with type 2 diabetes mellitus. Therapeutic interventions that improve blood flow to peripheral nerves, such as exercise, may slow the progression of neuropathy in the diabetic patient.Aims: This randomized clinical trial was conducted to determine whether a structured program of aerobic, isokinetic strength, or the combination of aerobic–isokinetic strength exercise intervention alters peripheral nerve function in glycemic-controlled diabetic patients with advanced length-dependent distal symmetric polyneuropathy.Methods: Forty-five patients with type 2 diabetes mellitus exhibiting tight glycemic control (HbA1c intergroup range 7.2–8.0%) were randomized by block design across four experimental groups: sedentary controls (n = 12), aerobic exercise (n = 11), isokinetic strength (n = 11), or the combination of aerobic–isokinetic strength training (n = 11). Patients randomized to training groups exercised 3× per week for 12 weeks, whereas patients randomized to the sedentary control group received standard of care. To minimize attention and educational bias, all patients attended a 12-session health promotion educational series. At baseline, immediately following intervention, and again at 12-week post-intervention, detailed nerve conduction studies were conducted as a primary outcome measure. At these same intervals, all patients completed as secondary measures quantitative sensory testing, symptom-limited treadmill stress tests, and a Short-Form 36-Veterans Questionnaire (SF-36V).Results: Of the 45 patients randomized into this study, 37 (82%) had absent sural nerve responses, 19 (42%) had absent median sensory nerve responses, and 17 (38%) had absent ulnar sensory nerve responses. By comparison, responses from tibial nerves were absent in only three (7%) subjects while responses from peroneal nerves were absent in five (11%) subjects. Eleven (92%) of 12 patients that had volunteered to be biopsied exhibited abnormal levels of epidermal nerve fiber densities. Exercise, regardless of type, did not alter sensory or motor nerve electrodiagnostic findings among those patients exhibiting measurable responses (ANOVA). There was, however, a modest (p = 0.01) beneficial effect of exercise on sensory nerve function (Fisher’s Exact Test). Importantly, the beneficial effect of exercise on sensory nerve function was enhanced (p = 0.03) during the post-intervention interval. In addition, three of six patients that had undergone exercise intervention exhibited a marked 1.9 ± 0.3-fold improvement in epidermal nerve fiber density. By comparison, none of three sedentary patients whom agreed to be biopsied a second time showed improvement in epidermal nerve fiber density. Compared to baseline values within groups, and compared with sedentary values across groups, neither aerobic, isokinetic strength, or the combination of aerobic–isokinetic strength exercise intervention altered peak oxygen uptake. Patients that underwent aerobic or the combined aerobic–isokinetic strength exercise intervention, however, demonstrated an increase in treadmill test duration that was sustained over the 12-week post-intervention period.Conclusion: A 12-week course of physical exercise, regardless of type, does not alter sensory or motor nerve electrodiagnostic findings. In a subset of patients, a short-term structured program of aerobic exercise may selectively improve sensory nerve fiber function. Large-scale exercise lifestyle intervention trials are warranted to further evaluate the impact of aerobic exercise on sensory nerve fiber function in diabetic neuropathic patients.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT00955201

Amphibians in Zootaxa: 20 years documenting the global diversity of frogs, salamanders, and caecilians

Zootaxa is a mega-journal that since its inception, 20 years ago, has contributed to the documentation of the planet?s biodiversity. Its role concerning terrestrial vertebrates has been crucial especially for amphibians, which are the most threatened class of vertebrates. As current editors of the Amphibia section, we reviewed the state of knowledge of taxonomic publications on amphibians over the last two decades (from 2001 to 2020). Our review reveals that 2,533 frogs, 259 salamanders, and 55 caecilians have been named in these 20 years, mainly in the tropical regions of South America, Asia, and Africa. More than half (57%) of these species descriptions were published in only 10 journals. At least 827 species of the new amphibians (29% of the total) were described in Zootaxa. This mega-journal has served also as a place of publication for monographs and systematic reviews, in addition to short articles documenting the vocalizations of anurans and the morphology of embryos and larvae. Its efficient evaluation process, the freedom of manuscript length, including full-color figures, and free of cost for the authors, has made Zootaxa a favorite for amphibian researchers. In an era of accelerating rates of biodiversity loss, documenting, describing, naming, and proposing evolutionary scenarios for species is, more than ever, an urgent task.Fil: Rivera Correa, Mauricio. Universidad de Antioquia; ColombiaFil: Baldo, Juan Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Vera Candioti, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; ArgentinaFil: Goyannes Dill Orrico, Victor. Universidade Estadual de Santa Cruz; BrasilFil: Blackburn, David C.. University Of Florida. Florida Museum Of History; Estados UnidosFil: Castroviejo Fisher, Santiago. Pontificia Universidade Católica do Rio Grande do Sul; BrasilFil: Chan, Kin Onn. National University of Singapore; SingapurFil: Gambale, Priscilla. Universidade Federal de Goiás; BrasilFil: Gower, David J.. Natural History Museum; Reino UnidoFil: Quah, Evan S. H.. National University of Singapore; SingapurFil: Rowley, Jodi J. L.. University of New South Wales; AustraliaFil: Twomey, Evan. Goethe Universitat Frankfurt; AlemaniaFil: Vences, Miguel. Technische Universitat Carolo Wilhelmina Zu Braunschweig.; Alemani