Nachwort: Perspektiven für den Hamburger Professorinnen- und Professorenkatalog

Dieser Band dokumentiert die vier Reden der Zentralen Veranstaltung der Universität anlässlich der Freischaltung des Hamburger Professorinnen- und Professorenkatalogs, ergänzt um ein Nachwort von Ole Fischer, dem Leiter des Universitätsarchivs. In ihrem Grußwort bezeichnete die Vizepräsidentin der Universität Jetta Frost die Erstellung eines elektronischen Professorinnen- und Professorenkatalogs als „nicht nur zeitgemäß, sondern überfällig“ und zur „Selbstvergegenwärtigung unserer Identität als Universität“ notwendig. Als Leiter der Arbeitsstelle für Universitätsgeschichte und Projektverantwortlicher betont Rainer Nicolaysen die Bedeutung des Katalogs als wichtige Grundlage universitäts- und wissenschaftsgeschichtlicher Forschung. Matthias Glasow dokumentiert in einem „Werkstattbericht“ über die Konzeption, Genese und Anwendung des HPK. Der Historiker Ulf Morgenstern, der schon vor mehr als zehn Jahren an der Entwicklung des Leipziger Professorenkatalogs beteiligt gewesen ist, erweitert den Horizont über das Hamburger Beispiel hinaus. Ole Fischer betont in seinem Nachwort, Professorinnen- und Professorenkataloge seien „insbesondere ein Startpunkt für eine kritische Auseinandersetzung mit einzelnen Personen und den personellen Strukturen der Universität Hamburg“.This volume documents speeches of the University\u27s central event on the occasion of the release of the Hamburg catalogue of professors, supplemented by an epilogue. In her welcoming address, the Vice-President of the university Jetta Frost described the creation of an electronic catalogue of professors as "not only contemporary, but overdue" and necessary for the "self-presentation of our identity as a university". As head of the Centre for University History and responsible for the project, Rainer Nicolaysen stresses the importance of the catalogue as an important basis for research into the history of universities and science. Matthias Glasow documents the conception, genesis and application of the catalogue. The historian Ulf Morgenstern who was involved in the development of the Leipzig Professors\u27 Catalogue more than ten years ago, broadens the horizon beyond the Hamburg example. In his epilogue, Ole Fischer, Head of the Univerisy Archive, stresses that professorial catalogues are "particularly a starting point for a critical examination of individuals and the personal structures of the University of Hamburg"

Design Research Methods—Applied Theory and Studio

This paper was presented at the 2020 Schools of Thought Conference hosted by the Christopher C. Gibbs College of Architecture at the University of Oklahoma.Today, the curriculum at schools of architecture is generally subdivided into design studio (practice) and the adjacent scientific or scholarly subjects ranging from natural sciences to technology to humanities, often with their own separate faculty, degrees, and institutional structures. This separation is widely experienced as a fragmentation of a discipline that claims to be integrative and wholistic. This essay provides a sketch for an alternative pedagogical format of integrated design research methods and studio at the graduate level, which could help bridge these perceived institutional gaps, but also offer a research agenda of its own kind. Design Research Methods is framed here as an applied theory, since exemplary design approaches themselves are selected, analyzed, comparatively discussed, and serve as a primer in the studio environment, while in turn the studio tests various theoretical concepts, design approaches, tools, and methods, and provides feedback to theory. This applied theory is not meant to replace traditional forms of critical inquiry, reading, and writing but should serve as a complementary addition that empowers students to define their own research and design agenda for their thesis year and beyond.Ye

Simple Determination of Affinity Constants of Antibodies by Competitive Immunoassays

The affinity constant, also known as the equilibrium constant, binding constant, equilibrium association constant, or the reciprocal value, the equilibrium dissociation constant (Kd), can be considered as one of the most important characteristics for any antibody–antigen pair. Many methods based on different technologies have been proposed and used to determine this value. However, since a very large number of publications and commercial datasheets do not include this information, significant obstacles in performing such measurements seem to exist. In other cases where such data are reported, the results have often proved to be unreliable. This situation may indicate that most of the technologies available today require a high level of expertise and effort that does not seem to be available in many laboratories. In this paper, we present a simple approach based on standard immunoassay technology that is easy and quick to perform. It relies on the effect that the molar IC50 approaches the Kd value in the case of infinitely small concentrations of the reagent concentrations. A two-dimensional dilution of the reagents leads to an asymptotic convergence to Kd. The approach has some similarity to the well-known checkerboard titration used for the optimization of immunoassays. A well-known antibody against the FLAG peptide, clone M2, was used as a model system and the results were compared with other methods. This approach could be used in any case where a competitive assay is available or can be developed. The determination of an affinity constant should belong to the crucial parameters in any quality control of antibody-related products and assays and should be mandatory in papers using immunochemical protocols.This research received no external funding.Peer Reviewe

Atmospheric Interferences : On the production of physical presence in the age of digital representation

Wissenschaftliches Kolloquium vom 19. bis 22. April 2007 in Weimar an der Bauhaus-Universität zum Thema: ‚Die Realität des Imaginären. Architektur und das digitale Bild

Colorectal cancer mortality 10 years after a single round of guaiac faecal occult blood test (gFOBT) screening:experiences from a Danish screening cohort

BACKGROUND: In Denmark, colorectal cancer (CRC) is the third most frequent cancer. Randomised trials have shown that guaiac faecal occult blood test (gFOBT) screening can reduce CRC mortality, but a recent large randomised study from Finland did not find any effect. A feasibility study was carried out in Denmark in 2005–2006 where residents aged 50–74 years in 2 Danish counties were invited once to participate in gFOBT screening. We used the unique Danish registers to assess the impact of gFOBT screening in this group on CRC incidence and mortality. METHODS: In this cohort study, we followed a group comprising 166 277 individuals invited to screening and a reference group comprising the remaining 1 240 348 Danes of the same age. We linked the Danish population and health service registers to obtain information about colonoscopies, polypectomies, incident CRC and cause of death. RESULTS: After a median follow-up time of 8.9 years, the CRC mortality was significantly lower in the screening group than in the reference group with an adjusted HR (aHR) of 0.92 (95% CI 0.86 to 0.99), while the aHR for all-cause mortality was 0.95 (95% CI 0.94 to 0.96). For screening participants, the aHR for CRC mortality and all-cause mortality was 0.72 (0.64 to 0.80) and 0.59 (0.57 to 0.60), respectively. CONCLUSIONS: About 10 years after a single round of gFOBT screening, we found a significant 8% deficit in CRC mortality in the screening group compared with other Danes. We found almost the same deficit in all-cause mortality, and on this basis, it is not possible to conclude that one screening round had an effect on CRC mortality. Our study indicated that close monitoring of the outcome of CRC screening is warranted

Gesamtverzeichnis der Hamburger Universitätsreden, Neue Folge

Dieser Band dokumentiert die vier Reden der Zentralen Veranstaltung der Universität anlässlich der Freischaltung des Hamburger Professorinnen- und Professorenkatalogs, ergänzt um ein Nachwort von Ole Fischer, dem Leiter des Universitätsarchivs. In ihrem Grußwort bezeichnete die Vizepräsidentin der Universität Jetta Frost die Erstellung eines elektronischen Professorinnen- und Professorenkatalogs als „nicht nur zeitgemäß, sondern überfällig“ und zur „Selbstvergegenwärtigung unserer Identität als Universität“ notwendig. Als Leiter der Arbeitsstelle für Universitätsgeschichte und Projektverantwortlicher betont Rainer Nicolaysen die Bedeutung des Katalogs als wichtige Grundlage universitäts- und wissenschaftsgeschichtlicher Forschung. Matthias Glasow dokumentiert in einem „Werkstattbericht“ über die Konzeption, Genese und Anwendung des HPK. Der Historiker Ulf Morgenstern, der schon vor mehr als zehn Jahren an der Entwicklung des Leipziger Professorenkatalogs beteiligt gewesen ist, erweitert den Horizont über das Hamburger Beispiel hinaus. Ole Fischer betont in seinem Nachwort, Professorinnen- und Professorenkataloge seien „insbesondere ein Startpunkt für eine kritische Auseinandersetzung mit einzelnen Personen und den personellen Strukturen der Universität Hamburg“.This volume documents speeches of the University\u27s central event on the occasion of the release of the Hamburg catalogue of professors, supplemented by an epilogue. In her welcoming address, the Vice-President of the university Jetta Frost described the creation of an electronic catalogue of professors as "not only contemporary, but overdue" and necessary for the "self-presentation of our identity as a university". As head of the Centre for University History and responsible for the project, Rainer Nicolaysen stresses the importance of the catalogue as an important basis for research into the history of universities and science. Matthias Glasow documents the conception, genesis and application of the catalogue. The historian Ulf Morgenstern who was involved in the development of the Leipzig Professors\u27 Catalogue more than ten years ago, broadens the horizon beyond the Hamburg example. In his epilogue, Ole Fischer, Head of the Univerisy Archive, stresses that professorial catalogues are "particularly a starting point for a critical examination of individuals and the personal structures of the University of Hamburg"

Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways

An integrated analysis of Maglemose bone points reframes the Early Mesolithic of Southern Scandinavia

The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, with one of the most iconic artefacts being the bone point. Although great in number they remain understudied. Here we present a combined investigation of the typology, protein-based species composition, and absolute chronology of Maglemosian bone points. The majority of the bone points are made from cervids and bovines. However, changes both in species composition and barb morphology can be directly linked to a paucity of finds lasting nearly 600 years in Southern Scandinavia around 10,300 cal BP. We hypothesize that this hiatus was climate-driven and forced hunter-gatherers to abandon the lakes. Furthermore, the marked change in bone points coincides with a change in lithic technology. We, therefore, propose that the Maglemose culture in Southern Scandinavia is fundamentally divided into an Early Complex and a Late Complex