152 research outputs found
In situ solid-state NMR and XRD studies of the ADOR process and the unusual structure of zeolite IPC-6
R.E.M. and M.N. thank the Royal Society and the E.P.S.R.C. (Grants EP/L014475/1, EP/K025112/1 and EP/K005499/1) for funding work in this area. R.E.M. and J.Č. acknowledge the Czech Science Foundation for the project P106/12/G015 and OP VVV "Excellent Research Teams", project No. CZ.02.1.01/0.0/0.0/15_003/0000417 - CUCAM. S.E.A. would like to thank the ERC (EU FP7 Consolidator Grant 614290 “EXONMR”) and the Royal Society and Wolfson Foundation for a merit award. The UK 850 MHz solid-state NMR Facility used in this research was funded by EPSRC and BBSRC (contract reference PR140003), as well as the University of Warwick including via part funding through Birmingham Science City Advanced Materials Projects 1 and 2 supported by Advantage West Midlands (AWM) and the European Regional Development Fund (ERDF). W.A.S. and D.S.W. acknowledge the Research Council of Norway and NOTUR are acknowledged for providing the computer time at the Norwegian supercomputer facilities (under the project number NN2875k).The assembly–disassembly–organization–reassembly (ADOR) mechanism is a recent method for preparing inorganic framework materials and, in particular, zeolites. This flexible approach has enabled the synthesis of isoreticular families of zeolites with unprecedented continuous control over porosity, and the design and preparation of materials that would have been difficult—or even impossible—to obtain using traditional hydrothermal techniques. Applying the ADOR process to a parent zeolite with the UTL framework topology, for example, has led to six previously unknown zeolites (named IPC-n, where n = 2, 4, 6, 7, 9 and 10). To realize the full potential of the ADOR method, however, a further understanding of the complex mechanism at play is needed. Here, we probe the disassembly, organization and reassembly steps of the ADOR process through a combination of in situ solid-state NMR spectroscopy and powder X-ray diffraction experiments. We further use the insight gained to explain the formation of the unusual structure of zeolite IPC-6.PostprintPeer reviewe
Ecosystem Services and Disservices of Mangrove Forests and Salt Marshes
Coastal wetlands such as mangrove forests and salt marshes provide a range of important benefits to people, broadly defined as ecosystem services. These include provisioning services such as fuelwood and food, regulating services such as carbon sequestration and wave attenuation, and various tangible and intangible cultural services. However, strong negative perceptions of coastal wetlands also exist, often driven by the perceived or actual ecosystem disservices that they also produce. These can include odour, a sense of danger, and their real or perceived role in vector and disease transmission (e.g. malaria). This review provides an introduction to the ecosystem services and disservices concepts and highlights the broad range of services and disservices provided by mangrove forests and salt marshes. Importantly, we discuss the key implications of ecosystem services and disservices for the management of these coastal ecosystems. Ultimately, a clear binary does not exist between ecosystem services and disservices; an ecosystem service to one stakeholder can be viewed as a disservice to another, or a service can change seasonally into a disservice, and vice versa. It is not enough to only consider the beneficial ecosystem services that coastal wetlands provide: instead, we need to provide a balanced view of coastal wetlands that incorporates the complexities that exist in how humans relate to and interact with them
VEGF regulates local inhibitory complement proteins in the eye and kidney
10.1172/JCI86418Journal of Clinical Investigation1271199-21
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
Mediators of lifestyle behaviour changes in obese pregnant women. Secondary analyses from the DALI lifestyle randomised controlled trial
A better understanding of what drives behaviour change in obese pregnant overweight women is needed to improve the effectiveness of lifestyle interventions in this group at risk for gestational diabetes (GDM). Therefore, we assessed which factors mediated behaviour change in the Vitamin D and Lifestyle Intervention for GDM Prevention (DALI) Lifestyle Study. A total of 436 women, with pre-pregnancy body mass index ≥29 kg/m 2 , ≤19 + 6 weeks of gestation and without GDM, were randomised for counselling based on motivational interviewing (MI) on healthy eating and physical activity, healthy eating alone, physical activity alone, or to a usual care group. Lifestyle was measured at baseline, and at 24–28 and 35–37 weeks of gestation. Outcome expectancy, risk perception, task self-efficacy and social support were measured at those same time points and considered as possible mediators of intervention effects on lifestyle. All three interventions resulted in increased positive outcome expectancy for GDM reduction, perceived risk to the baby and increased task self-efficacy. The latter mediated intervention effects on physical activity and reduced sugared drink consumption. In conclusion, our MI intervention was successful in increasing task self-efficacy, which was related to improved health behaviours
Proglašen Zakonik kanona istočnih crkava
The hydrothermal
synthesis of a zeolite with properties suitable
for use in the assembly–disassembly–organization–reassembly
(ADOR) process was designed, and a zeolite called SAZ-1 was successfully
prepared. This zeolite was then used as a parent in the ADOR process,
and two new daughter zeolites, IPC-15 and IPC-16, were prepared. The
X-ray powder diffraction patterns of the new zeolites match well with
those predicted using computational methods. The three materials form
an isoreticular series with decreasing pores size from 14-ring to
12-ring to 10-ring
Zombie journals: designing a technological infrastructure for a precarious graduate student journal
Open access article. Creative Commons Attribution Non-commercial License (CC-BY-NC) applies.Background: The Meeting of the Minds graduate student journal is edited primarily by students from our Masters programme. This means that our editorial board is subject to high annual turnover and that our technological infrastructure and workflow needed to be easy to train for, accommodate differing levels of technological skill and editorial interest, and provide archiving that did not require a continuing interest in the journal by future generations of students. Analysis: This article provides a detailed and comparative account of the "off-the-shelf" systems and software used in developing the journal with an explanation of the rationale behind our choices. Conclusion and implications: The choices we made can be adopted by other journals interested in a low-cost, "future-proof" approach to developing a publishing infrastructure.Ye
"Let's start a journal!": the multidisciplinary graduate student journal as educational opportunity
Sherpa Romeo green journal. Open access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) applies.The University of Lethbridge is a medium-sized, primarily undergraduate, comprehensive research university on the Canadian Prairies in Alberta. It has a small but growing graduate school, within which most students are studying at the masters level. For many years, the graduate student elected representative body, the Graduate Students Association (GSA), has sponsored an annual refereed conference, Meeting of the Minds. In 2015 the GSA decided to supplement this conference with an accompanying journal, also called Meeting of the Minds. This article discusses the lessons learned in establishing this journal and overseeing its first two years of operations (and first year of publication). The article concentrates on two sets of problems: 1) philosophical, economic, and sociological issues that arose at the conceptual level while establishing a multidisciplinary, institution-focused graduate journal; and 2) technical, bibliographic, organizational, and economic issues encountered in attempting to address these conceptual concerns and ensure the long-term viability of the research accepted and published. Although the journal was not able to solve all the problems that arose during the first two years of operation, several solutions on the organizational, technological, economic, and bibliographic levels were developed that might be used by others establishing similar scholar- or student-led journals.Ye
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Randomised control trial of the effectiveness of an integrated psychosocial health promotion intervention aimed at improving health and reducing substance use in established psychosis (IMPaCT)
© 2017 The Author(s). Background: People with psychosis have a reduced life expectancy of 10-20years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Therapy) in improving health and reducing cardiovascular risk in psychosis. Methods: A multicentre, two arm, parallel cluster RCT was conducted across five UK mental health NHS trusts. Community care coordinators (CC) were randomly assigned to training and supervision in delivering IMPaCT Therapy or treatment as usual (TAU) to current patients with psychosis (cluster). The primary outcome was the physical and mental health subscales of the Short form-36 (SF-36) questionnaire. Results: Of 104 care coordinators recruited, 52 (with 213 patients) were randomised to deliver IMPaCT therapy and 52 (with 193 patients) randomised to TAU. Of 406 patients, 318 (78%) and 301 (74%) attended 12- and 15-month follow-up respectively. IMPaCT therapy showed no significant effect on the physical or mental health component SF-36 scores versus TAU at 12 or 15months. No effect was observed for cardiovascular risk indicators, except for HDL cholesterol, which improved more with IMPACT therapy than TAU (Treatment effect (95% CI); 0.085 (0.007 to 0.16); p= 0.034). The 22% of patients who received > 180min of IMPACT Therapy in addition to usual care achieved a greater reduction in waist circumference than did controls, which was clinically significant. Conclusion: Training and supervising community care coordinators to use IMPaCT therapy in patients with psychosis is insufficient to significantly improve physical or mental health quality of life. The search for effective, pragmatic interventions deliverable in health care services continues. Trial registration: The trial was retrospectively registered with ISRCTN registry on 23/4/2010 at ISRCTN58667926 ; recruitment started on 01/03/2010 with first randomization on 09.08.2010 ISRCTN58667926
Epistemic Consequentialism: Haters Gonna Hate
Epistemic consequentialism has been charged with ignoring the epistemic separateness of propositions and with (thereby) allowing trade-offs between propositions. Here, I do two things. First, I investigate the metaphor of the epistemic separateness of propositions. I argue that either (i) the metaphor is meaningfully unpacked in a way that is modeled on the moral separateness of persons, in which case it doesn’t support a ban on trade-offs or (ii) it isn’t meaningfully unpacked, in which case it really doesn’t support a ban on trade-offs. Second, I consider the strategy of arguing against the trade-off permitting conception of epistemic rationality that is central to epistemic consequentialism on the basis of our intuitive verdicts about the permissibility of trade-offs in cases. I argue the execution of this strategy suffers a methodological mistake that, once corrected, vitiates the probative value of those intuitive verdicts. Hence the conclusion: the separateness of propositions provides no support for a ban on trade-offs, and an influential independent argument for such a ban is flawed
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