Interaction pattern for the complex of B-DNAFullerene compounds with a set of known replication proteins using docking study

Fullerenes have attracted considerable attention due to their unique chemical structure and potential applications which has opened wide venues for possible human exposure to various fullerene types. Therefore, in depth knowledge of how fullerene may interfere with various cellular processes becomes quite imperative. The present study was designed to investigate how the presence of fullerene affect the binding of DNA with different enzymes involved in replication process. Different fullerenes were first docked with DNA and then binding scores of different enzymes was analyzed with fullerene docked DNA. C30, C40 & C50 once docked with DNA, reduced the binding score of primase, whereas no significant change in the binding score was observed with the helicase, ssb protein, dna pol δ, dna pol ɛ, ligase, DNA clamp, and topoisomerases. On the contrast, the binding score of RPA14 decreases in fluctuating manner while interacting with increasing molecular weight of fullerene bound single-stranded DNA complex. The study revealed the affect of fullerene family interacting with DNA on the binding pattern of enzymes involved in replication process. Study suggests that the presence of most of fullerenes may not affect the activity of these enzymes necessary for replication process whereas C30, C40 & C50 may disrupt the activity of primase, (strating point for DNA polymerase) its docking score decreases from 13820 to 10702

Unlocking Academic Success: Exploring the Impact of Teacher-Student Relationships on ESL Learners' Performance

The current study, examined the fundamental role of positive teacher-student relationships in shaping students' English language acquisition journey. Drawing insights from the Social-Cognitive Theory of Self-Efficcy and Well-Being in Education, the research highlights the multifaceted impact of these interactions on learners' holistic development. Through a comprehensive synthesis of previous studies, the study reveals that effective teacher-student interactions foster intrinsic motivation and active engagement in language learning. Such interactions also enhance students' self-efficacy, resilience, and overall well-being. By addressing individual learning needs and preferences, teachers create inclusive and productive learning environments. Additionally, nurturing relatedness and autonomy within these relationships fosters students' sense of connection and ownership over their learning process. This research emphasizes the enduring influence of teacher-student relationships beyond academic outcomes, encompassing emotional well-being and personal growth. As education evolves, understanding and nurturing these relationships remain critical for cultivating comprehensive and enriching learning experiences

The State is the King: A Marxist Approach to Sophocles’ Antigone

Marxist approach enunciates that economic and sociopolitical realities are the actual factors that outline the human experience and the economy has a pivotal role to play in all aspects of life. Marxism also concentrates upon the conception that individual experiences are based upon the socioeconomic systems which also shape the behavior of the groups. It questions the perception that gaining and retaining political and economic power is the motivating drive behind all political and social activities. In other words, economics lays the foundation of social, political, and ideological realities. It also affects human perception and develops a perspective. Antigone is a major tragedy by Sophocles. Sophocles has discussed the perception of human nature throughout his plays and he has dealt with various aspects of human life. Likewise, many critics have analyzed his plays from a myriad of lenses and perspectives. Eagleton (1976) also emphasizes the convoluted interrelationships between the socio-economic base and the social institutions and values (including literature) which make the superstructure. Winnington Ingram (1980) also acknowledges the obscurity in deriving meaning in Antigone. Several critics have focused their attention on its sociopolitical aspects, which include the desirable degree of respect to established law, and the relationship based on gender, and preference of the duties toward the family on the duty to social laws. The present study aims at exploring the considerations (mainly economic, and political) behind the perpetuation of authority and exhibiting the role of gender and class in the hegemony of the domineering over the meek in the play, Antigone, and also tries to uncover the role of ideology in fashioning the attitude of the subjugated to be tyrannized and how the oppressor subdues the mindfulness of the outranked. The study also intended to corroborate that Sophocles antedated the Marxist principles

Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications

Considering the rising global health challenges and public expectations in terms of safety and cost effectiveness, it is necessary to promote effective, safer and cheaper alternative treatment options, particularly to benefit low- and middle-income countries (LMICs). Therapeutic regimens implying natural sources i.e., plants and their secondary metabolites have been trusted by a large proportion of sufferers and extensively searched for their pharmacological actions. Berberis aristata, commonly known as Zarishk, Daruharidra and Indian barberry, is being used in traditional medicine systems across the globe, particularly Asian countries i.e., India and China, and has also gained much attention in the current era of modern medicine. The protective effects of B. aristata against a number of diseases are attributed to its bioactive metabolites, mostly alkaloids, including berberine, berbamine, aromoline, jatrorrhizine, oxyberberine, palmatine, tetrahydropalmatine, and lupeol. However, a comprehensive report describing the ethnopharmacological relevance, important secondary metabolites, cytotoxicity, and recent advances in its therapeutic efficacy against various ailments is either outdated or still lacking. Therefore, the current review summarizes the recent updates regarding the implications of B. aristata and its potential bioactive secondary metabolites in targeting various acute and chronic diseases including diabetes, cardiovascular complications, cancer, hepatic dysfunction, infectious diseases, oxidative stress, inflammation, neurodegeneration, and ageing-associated symptoms with special emphasis on the biochemical and molecular mechanisms/pathways

New OLEDs Based on Zirconium Metal-Organic Framework

The search for new smart-materials in solid-state light-emitting applications, like hybrid organic–inorganic light-emitting devices (OLEDs), has seen an intense growth in the recent years. Among all the possibilities, metal-organic frameworks (MOFs) have emerged as promising smart materials due to their chemical and structural properties. Herein, for the first time, the use of a Zr-based MOF (Zr-NDC, NDC = dimethyl 2,6-naphthalenedicarboxylate) as electroluminescent active material in OLED devices is reported. The results indicate that, independently of the properties of the polymer used to form the emissive layer, the OLED emission is due to radiative electron and hole recombination in the MOF. A tuning of the optoelectronic properties of the device by incorporating Coumarin 153, (C153) and 4-(Dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran, into the MOF pores is demonstrated. Using different MOFLED architectures, and MOF composition, it is possible to elucidate the photoluminescence and electroluminescence mechanisms, providing the clues for further improvements. It is observed that the current density as well as the electroluminescent behavior depends on the dopant fluorophores. It is also shown that defects within the Zr-MOF play a role in the OLED optoelectronic properties. The results clearly demonstrate the potential of MOFs as new tunable electroluminescent materials for OLED applications.This work was supported by the JCCM and MINECO through projects MAT2011-25472, MAT2014-52085-C2-2-P, MAT2014-57646-P, and PEII- 2014-003-P. M. Gutiérrez thanks the MINECO for the PhD Fellowship. C. Martín thanks the Research Foundation-Flanders for her postdoctoral fellowship. The authors are also indebted to Belspo program through IAP VI/27 and VII/05 and to the KULeuven Research Fund through GOA 2011/3 and C14/15/053. The authors gratefully acknowledge financial support from the European Union’s Seventh Framework Programme (FP7/2007-2013 under grant agreement no. 310651 SACSPeer Reviewe

Stress neuropeptide levels in adults with chest pain due to coronary artery disease: potential implications for clinical assessment

: Substance P (SP) and neuropeptide Y (NPY) are neuropeptides involved in nociception. The study of biochemical markers of pain in communicating critically ill coronary patients may provide insight for pain assessment and management in critical care. Purpose of the study was to to explore potential associations between plasma neuropeptide levels and reported pain intensity in coronary critical care adults, in order to test the reliability of SP measurements for objective pain assessment in critical care