1,555 research outputs found
A note on boundedness of operators in Grand Grand Morrey spaces
In this note we introduce grand grand Morrey spaces, in the spirit of the
grand Lebesgue spaces. We prove a kind of \textit{reduction lemma} which is
applicable to a variety of operators to reduce their boundedness in grand grand
Morrey spaces to the corresponding boundedness in Morrey spaces. As a result of
this application, we obtain the boundedness of the Hardy-Littlewood maximal
operator and Calder\'on-Zygmund operators in the framework of grand grand
Morrey spaces.Comment: 8 page
Kaluza-Klein Dark Matter and Galactic Antiprotons
Extra dimensions offer new ways to address long-standing problems in beyond
the standard model particle physics. In some classes of extra-dimensional
models, the lightest Kaluza-Klein particle is a viable dark matter candidate.
In this work, we study indirect detection of Kaluza-Klein dark matter via its
annihilation into antiprotons. We use a sophisticated galactic cosmic ray
diffusion model whose parameters are fully constrained by an extensive set of
experimental data. We discuss how fluxes of cosmic antiprotons can be used to
exclude low Kaluza-Klein masses.Comment: 14 pages, 7 figures, 3 table
The Effect of Two Speed Endurance Training Regimes on Performance of Soccer Players.
In order to better understand the specificity of training adaptations, we compared the effects of two different anaerobic training regimes on various types of soccer-related exercise performances. During the last 3 weeks of the competitive season, thirteen young male professional soccer players (age 18.5±1 yr, height 179.5±6.5 cm, body mass 74.3±6.5 kg) reduced the training volume by ~20% and replaced their habitual fitness conditioning work with either speed endurance production (SEP; n = 6) or speed endurance maintenance (SEM; n = 7) training, three times per wk. SEP training consisted of 6-8 reps of 20-s all-out running bouts followed by 2 min of passive recovery, whereas SEM training was characterized by 6-8 x 20-s all-out efforts interspersed with 40 s of passive recovery. SEP training reduced (p<0.01) the total time in a repeated sprint ability test (RSAt) by 2.5%. SEM training improved the 200-m sprint performance (from 26.59±0.70 to 26.02±0.62 s, p<0.01) and had a likely beneficial impact on the percentage decrement score of the RSA test (from 4.07±1.28 to 3.55±1.01%) but induced a very likely impairment in RSAt (from 83.81±2.37 to 84.65±2.27 s). The distance covered in the Yo-Yo Intermittent Recovery test level 2 was 10.1% (p<0.001) and 3.8% (p<0.05) higher after SEP and SEM training, respectively, with possibly greater improvements following SEP compared to SEM. No differences were observed in the 20- and 40-m sprint performances. In conclusion, these two training strategies target different determinants of soccer-related physical performance. SEP improved repeated sprint and high-intensity intermittent exercise performance, whereas SEM increased muscles' ability to maximize fatigue tolerance and maintain speed development during both repeated all-out and continuous short-duration maximal exercises. These results provide new insight into the precise nature of a stimulus necessary to improve specific types of athletic performance in trained young soccer players
Towards a unified theory of Sobolev inequalities
We discuss our work on pointwise inequalities for the gradient which are
connected with the isoperimetric profile associated to a given geometry. We
show how they can be used to unify certain aspects of the theory of Sobolev
inequalities. In particular, we discuss our recent papers on fractional order
inequalities, Coulhon type inequalities, transference and dimensionless
inequalities and our forthcoming work on sharp higher order Sobolev
inequalities that can be obtained by iteration.Comment: 39 pages, made some changes to section 1
Comparing spatial patterns of marine vessels between vessel-tracking data and satellite imagery
Monitoring marine use is essential to effective management but is extremely challenging, particularly where capacity and resources are limited. To overcome these limitations, satellite imagery has emerged as a promising tool for monitoring marine vessel activities that are difficult to observe through publicly available vessel-tracking data. However, the broader use of satellite imagery is hindered by the lack of a clear understanding of where and when it would bring novel information to existing vessel-tracking data. Here, we outline an analytical framework to (1) automatically detect marine vessels in optical satellite imagery using deep learning and (2) statistically contrast geospatial distributions of vessels with the vessel-tracking data. As a proof of concept, we applied our framework to the coastal regions of Peru, where vessels without the Automatic Information System (AIS) are prevalent. Quantifying differences in spatial information between disparate datasets—satellite imagery and vessel-tracking data—offers insight into the biases of each dataset and the potential for additional knowledge through data integration. Our study lays the foundation for understanding how satellite imagery can complement existing vessel-tracking data to improve marine oversight and due diligence
Telomere lengths in human oocytes, cleavage stage embryos and blastocysts
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase. When telomere length becomes critically short, cell senescence occurs. Telomere length therefore reflects both cellular ageing and capacity for division. We have measured telomere length in human germinal vesicle (GV) oocytes and pre-implantation embryos, by quantitative fluorescence in-situ hybridisation (Q-FISH), providing baseline data towards our hypothesis that telomere length is a marker of embryo quality. The numbers of fluorescent foci suggest that extensive clustering of telomeres occurs in mature GV stage oocytes, and in pre-implantation embryos. When calculating average telomere length by assuming that each signal presents one telomere, the calculated telomere length decreased from the oocyte to the cleavage stages, and increased between the cleavage stages and the blastocyst (11.12 vs 8.43 vs 12.22kb respectively, p<0.001). Other methods of calculation, based upon expected maximum and minimum numbers of telomeres, confirm that telomere length in blastocysts is significantly longer than cleavage stages. Individual blastomeres within an embryo showed substantial variation in calculated average telomere length. This study implies that telomere length changes according to the stage of pre-implantation embryo development
Metabolic Signatures of Lung Cancer in Biofluids: NMR-Based Metabonomics of Blood Plasma
In this work, the variations in the metabolic profile of blood plasma from lung cancer patients and healthy controls were investigated through NMR-based metabonomics, to assess the potential of this approach for lung cancer screening and diagnosis. PLS-DA modeling of CPMG spectra from plasma, subjected to Monte Carlo Cross Validation, allowed cancer patients to be discriminated from controls with sensitivity and specificity levels of about 90%. Relatively lower HDL and higher VLDL + LDL in the patients' plasma, together with increased lactate and pyruvate and decreased levels of glucose, citrate, formate, acetate, several amino acids (alanine, glutamine, histidine, tyrosine, valine), and methanol, could be detected. These changes were found to be present at initial disease stages and could be related to known cancer biochemical hallmarks, such as enhanced glycolysis, glutaminolysis, and gluconeogenesis, together with suppressed Krebs cycle and reduced lipid catabolism, thus supporting the hypothesis of a systemic metabolic signature for lung cancer. Despite the possible confounding influence of age, smoking habits, and other uncontrolled factors, these results indicate that NMR-based metabonomics of blood plasma can be useful as a screening tool to identify suspicious cases for subsequent, more specific radiological tests, thus contributing to improved disease management.ERDF - Competitive Factors Thematic Operational ProgrammeFCT/PTDC/ QUI/68017/2006FCOMP-01-0124-FEDER-007439SFRH/BD/ 63430/2009National UNESCO Committee - L'Oréal Medals of Honor for Women in Science 200Portuguese National NMR Network - RNRM
Antideuterons as a Signature of Supersymmetric Dark Matter
Once the energy spectrum of the secondary component is well understood,
measurements of the antiproton cosmic-ray flux at the Earth will be a powerful
way to indirectly probe for the existence of supersymmetric relics in the
galactic halo. Unfortunately, it is still spoilt by considerable theoretical
uncertainties. As shown in this work, searches for low-energy antideuterons
appear in the mean time as a plausible alternative, worth being explored. Above
a few GeV/n, a dozen spallation antideuterons should be collected by the future
AMS experiment on board ISSA. For energies less than about 3 GeV/n, the
antideuteron spallation component becomes negligible and may be supplanted by a
potential supersymmetric signal. If a few low-energy antideuterons are
discovered, this should be seriously taken as a clue for the existence of
massive neutralinos in the Milky Way.Comment: 16 pages, 9 figure
Earliest evidence of dental caries manipulation in the Late Upper Palaeolithic
Prehistoric dental treatments were extremely rare, and the few documented cases are known from
the Neolithic, when the adoption of early farming culture caused an increase of carious lesions. Here
we report the earliest evidence of dental caries intervention on a Late Upper Palaeolithic modern
human specimen (Villabruna) from a burial in Northern Italy. Using Scanning Electron Microscopy
we show the presence of striations deriving from the manipulation of a large occlusal carious cavity
of the lower right third molar. The striations have a “V”-shaped transverse section and several
parallel micro-scratches at their base, as typically displayed by cutmarks on teeth. Based on in
vitro experimental replication and a complete functional reconstruction of the Villabruna dental
arches, we confirm that the identified striations and the associated extensive enamel chipping on
the mesial wall of the cavity were produced ante-mortem by pointed flint tools during scratching
and levering activities. The Villabruna specimen is therefore the oldest known evidence of dental
caries intervention, suggesting at least some knowledge of disease treatment well before the
Neolithic. This study suggests that primitive forms of carious treatment in human evolution entail an
adaptation of the well-known toothpicking for levering and scratching rather than drilling practices
An algebraic proof of Bogomolov-Tian-Todorov theorem
We give a completely algebraic proof of the Bogomolov-Tian-Todorov theorem.
More precisely, we shall prove that if X is a smooth projective variety with
trivial canonical bundle defined over an algebraically closed field of
characteristic 0, then the L-infinity algebra governing infinitesimal
deformations of X is quasi-isomorphic to an abelian differential graded Lie
algebra.Comment: 20 pages, amspro
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