A note on boundedness of operators in Grand Grand Morrey spaces

In this note we introduce grand grand Morrey spaces, in the spirit of the grand Lebesgue spaces. We prove a kind of \textit{reduction lemma} which is applicable to a variety of operators to reduce their boundedness in grand grand Morrey spaces to the corresponding boundedness in Morrey spaces. As a result of this application, we obtain the boundedness of the Hardy-Littlewood maximal operator and Calder\'on-Zygmund operators in the framework of grand grand Morrey spaces.Comment: 8 page

Molar macrowear reveals Neanderthal eco-geographic dietary variation

Neanderthal diets are reported to be based mainly on the consumption of large and medium sized herbivores, while the exploitation of other food types including plants has also been demonstrated. Though some studies conclude that early Homo sapiens were active hunters, the analyses of faunal assemblages, stone tool technologies and stable isotopic studies indicate that they exploited broader dietary resources than Neanderthals. Whereas previous studies assume taxon-specific dietary specializations, we suggest here that the diet of both Neanderthals and early Homo sapiens is determined by ecological conditions. We analyzed molar wear patterns using occlusal fingerprint analysis derived from optical 3D topometry. Molar macrowear accumulates during the lifespan of an individual and thus reflects diet over long periods. Neanderthal and early Homo sapiens maxillary molar macrowear indicates strong eco-geographic dietary variation independent of taxonomic affinities. Based on comparisons with modern hunter-gatherer populations with known diets, Neanderthals as well as early Homo sapiens show high dietary variability in Mediterranean evergreen habitats but a more restricted diet in upper latitude steppe/coniferous forest environments, suggesting a significant consumption of high protein meat resources

Scanning Probe Microscopy on heterogeneous CaCu3Ti4O12 thin films

The conductive atomic force microscopy provided a local characterization of the dielectric heterogeneities in CaCu3Ti4O12 (CCTO) thin films deposited by MOCVD on IrO2 bottom electrode. In particular, both techniques have been employed to clarify the role of the inter- and sub-granular features in terms of conductive and insulating regions. The microstructure and the dielectric properties of CCTO thin films have been studied and the evidence of internal barriers in CCTO thin films has been provided. The role of internal barriers and the possible explanation for the extrinsic origin of the giant dielectric response in CCTO has been evaluated

Unusual median pores of Alona head shields recovered from recent and pre-industrial sediments of alpine lakes

We report the finding of Alona (affinis-quadrangularis) - type headshields with atypical median pores, recovered from the sediments of high-mountain lakes. Subfossil Cladocera remains were analyzed in the framework of the European Project EMERGE (2000-2002, European Mountain lakes Ecosystem: Regionalisation, diaGnostic & socioeconomic Evaluation), to evaluate changes in their assemblages consequent to industrial pollution. Observed response includes an increase in A. affinis with respect to A. quadrangularis after industrialization. According to the literature, the atypical head shields are most probably attributable to A. affinis. However, being detected in high mountain lakes, these remains may be interpreted as a result of mutations, as the intensity of UV radiation is high in these environments. In this sense, they might be interpreted as the abnormal Daphnia?s and Chydorus? ephippia, which were also detected in the sediments of these lakes

Zooplankton abundance and diversity in Lake Bracciano, Latium, Italy

The zooplankton community structure in Lake Bracciano (Latium, Central Italy) was studied in monthly surveys throughout an annual cycle (November 1998 – October 1999). The seasonal cycles and population dynamics of the dominant species are described and discussed. Copepods numerically dominated the community throughout the study period with calanoid Eudiaptomus padanus etruscosexsetosus making up the largest share of zooplankton density; moreover it accounted for the largest portion of total biovolume. Cladocerans represented a significant component of the zooplankton in the summer and autumn months. No substantial differences in regard to results of previous investigations (1971, 1972, 1984) were observed. The only differences for which there is evidence consist of the appearance of Filinia terminalis, never previously found in the lake, and the replacement of Keratella cochlearis instead of Kellicottia longispina as dominant species. However, the results of the comparison of the different investigations confirm that the trophic state of the pelagial region may be classified as oligo-mesotrophic

T Cell Leukemia/Lymphoma 1A is essential for mouse epidermal keratinocytes proliferation promoted by insulin-like growth factor 1

T Cell Leukemia/Lymphoma 1A is expressed during B-cell differentiation and, when overexpressed, acts as an oncogene in mouse (Tcl1a) and human (TCL1A) B-cell chronic lymphocytic leukemia (B-CLL) and T-cell prolymphocytic leukemia (T-PLL). Furthermore, in the murine system Tcl1a is expressed in the ovary, testis and in pre-implantation embryos, where it plays an important role in blastomere proliferation and in embryonic stem cell (ESC) proliferation and self-renewal. We have also observed that Tcl1-/-adult mice exhibit alopecia and deep ulcerations. This finding has led us to investigate the role of TCL1 in mouse skin and hair follicles. We have found that TCL1 is expressed in the proliferative structure (i.e.The secondary hair germ) and in the stem cell niche (i.e.The bulge) of the hair follicle during regeneration phase and it is constitutively expressed in the basal layer of epidermis where it is required for the correct proliferative-differentiation program of the keratinocytes (KCs). Taking advantage of the murine models we have generated, including the Tcl1-/-and the K14-TCL1 transgenic mouse, we have analysed the function of TCL1 in mouse KCs and the molecular pathways involved. We provide evidence that in the epidermal compartment TCL1 has a role in the regulation of KC proliferation, differentiation, and apoptosis. In particular, the colony-forming efficiency (CFE) and the insulin-like growth factor 1 (IGF1)-induced proliferation are dramatically impaired, while apoptosis is increased, in KCs from Tcl1-/-mice when compared to WT. Moreover, the expression of differentiation markers such as cytokeratin 6 (KRT6), filaggrin (FLG) and involucrin (IVL) are profoundly altered in mutant mice (Tcl1-/-). Importantly, by over-expressing TCL1A in basal KCs of the K14-TCL1 transgenic mouse model, we observed a significant rescue of cell proliferation, differentiation and apoptosis of the mutant phenotype. Finally, we found TCL1 to act, at least in part, via increasing phospho-ERK1/2 and decreasing phospho-P38 MAPK. Hence, our data demonstrate that regulated levels of Tcl1a are necessary for the correct proliferation and differentiation of the interfollicular KC

Predatory impact of the mosquitofish (Gambusia holbrooki Girard) on zooplanktonic populations in a pond at Tenuta di Castelporziano (Rome, Central Italy)

A study of a permanent pond located in a nature reserve in Central Italy was carried out over two periods (1985-87; 1995-98) to determine the structure and dynamics of planktonic biocoenosis. The composition of the zooplankton community was quite different in the two periods of study: in the first period, rotifers, small-bodied cladocerans and larval copepods were the dominant groups; in the second there was a shift from rotifers and microcrustaceans to dominance by large-bodied Daphnidae and adult copepods. The possibility is stressed that Gambusia holbrooki, present in 1985 and absent in 1995, may be responsible for the changes in the planktonic community

In vitro evaluation of bacteriocinlike inhibitory substances produced by lactic acid bacteria isolated during traditional sicilian cheese making

Bacteriocins are antimicrobial proteins produced by bacteria that inhibit the growth of other bacteria with a bactericidal or bacteriostatic mode of action. Many lactic acid bacteria (LAB) produce a high diversity of different bacteriocins. Bacteriocinogenic LAB are generally recognised as safe (GRAS) and useful to control the frequent development of pathogens and spoilage microorganisms. For this reason they are commonly used as starter cultures in food fermentations. In this study, the authors describe the results of a screening on 699 LAB isolated from wooden vat surfaces, raw milk and traditional Sicilian cheeses, for the production of bacteriocin-like inhibitory substances, by comparing two alternative methods. The antagonistic activity of LAB and its proteinaceous nature were evaluated using the spot-on-thelawn and the well-diffusion assay (WDA) and the sensitivity to proteolytic (proteinase K, protease B and trypsin), amylolytic (a-amylase) and lipolytic (lipase) enzymes. The indicator strains used were: Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Salmonella enteritidis. A total of 223 strains (belonging to the species Enterococcus spp., Lactobacillus spp., Pediococcus spp., Streptococcus spp., Leuconostoc spp. and Lactococcus lactis) were found to inhibit the growth of Listeria monocytogenes by using the spot-on-the-lawn method; only 37 of these were confirmed by using the WDA. The direct addition of bacteriocin-producing cultures into dairy products can be a more practical and economic option for the improvement of the safety and quality of the final product

The Hybrid Integrated Circuit of the ALICE Inner Tracking System upgrade

The upgrade of the Inner Tracking System scheduled during the second long shutdown is an important milestone of the ALICE upgrade and it will provide a high improvement of its performances. In this contribution the smallest operator unit of the detector, the Hybrid Integrated Circuits, is presented

Kaluza-Klein Dark Matter and Galactic Antiprotons

Extra dimensions offer new ways to address long-standing problems in beyond the standard model particle physics. In some classes of extra-dimensional models, the lightest Kaluza-Klein particle is a viable dark matter candidate. In this work, we study indirect detection of Kaluza-Klein dark matter via its annihilation into antiprotons. We use a sophisticated galactic cosmic ray diffusion model whose parameters are fully constrained by an extensive set of experimental data. We discuss how fluxes of cosmic antiprotons can be used to exclude low Kaluza-Klein masses.Comment: 14 pages, 7 figures, 3 table