The Study of the Contract Award in Selected Company

Bakalářská práce se zaobírá studiem průběhu zakázky ve společnosti GRD servis, s.r.o., která se zabývá výrobou převážně P.O.S. a P.O.P. produktů neboli produktů pro podporu prodeje. Teoretická část obsahuje vysvětlení pojmů, jež s danou problematikou souvisí. V analytické části se zaměřuji na stávající průběh zakázky společnosti vysvětlený na konkrétním případě a následně uvádím nové návrhy pro zlepšení, které by měly vést ke zlepšení průběhu zakázky ve společnosti.Bachelor thesis deals with the study during the engagement at GRD Service, which manufactures mainly P.O.S. and P.O.P. product or products to promote sales. The theoretical part contains an explanation of terms that relate to this topic. In the analytical part I focus on the current course of the contract explained on the case and then I mention the new proposals for improvement, which should lead to an improvement during the engagement in company.

Proposal Marketing Mix for Selected Company

Bakalárska práca sa zameriava na zmapovanie aktuálneho stavu spoločnosti, ktorá pôsobí na trhu ako predajňa s prírodným kamenným obkladom, dlažbami a rôznymi doplnkami do záhrady. Obsah práce je rozdelený do troch častí. Prvá časť práce obsahuje teóriu zameranú na základné pojmy marketingu. Druhou časťou je analýza v ktorej je podnik predstavený, a taktiež jednotlivé prvky marketingového mixu. Posledná časť práce obsahuje na základe zistení z predchádzajúcej časti nové návrhy na zlepšenie súčasného marketingového mixu spoločnosti.The bachelor's thesis focuses on mapping the current state of the company, which operates in the market as a store with natural stone tiles, paving and various garden accessories. The content of the work is divided into three parts. The first part of the thesis contains a theory focused on the basic concepts of marketing. The second part is the analysis in which the company is presented, as well as the individual elements of the marketing mix. The last part of the work contains, based on the findings from the previous part, new proposals to improve the current marketing mix of the company.

Use of Retomo software for computational modeling in biomechanics

Tato bakalářská práce se zabývá problematikou svalově kosterní biomechaniky. Přesněji tvorbou modelu geometrie vycházejícího z CT dat pomocí programu RETOMO a následně výpočtového modelu. Úvodní část je věnována stručnému vysvětlení pojmů výpočetní tomografie a metody konečných prvků. V následující kapitole je vypracovaná rešerše programů sloužících pro tvorbu modelů geometrie z CT dat v biomechanice. Dále se práce zabývá popisem vybraných funkcionalit a uživatelského prostředí programu RETOMO, přičemž je kladen největší důraz na tvorbu modelu geometrie z CT dat. Při realizaci bakalářské práce byly v analyzovaném programu vytvořeny dva modely geometrie, a to pomocí odlišných funkcí segmentace, které byly následně navzájem porovnány a poté porovnány i s modelem geometrie vytvořené v jiném programu. K porovnání odchylek geometrie jednotlivých modelů byl využit program GOM Inspect. Nakonec byly vytvořeny výpočtové modely za pomoci programu CATIA a následně provedena deformační a napěťová analýza pomocí programu ANSYS. Výsledky jednotlivých řešení byly navzájem analyzovány, porovnány a vyhodnoceny.This bachelor thesis deals with the issue of musculoskeletal biomechanics. More precisely, of creating a geometry model based on CT data using the RETOMO program and then a computational model. The introductory part is devoted to a brief explanation of the concepts of computed tomography and finite element methods. The following chapter provides a search of programs used to create models of geometry from CT data in biomechanics. Furthermore, the work deals with the description of selected functionalities and user environment of the RETOMO program, with the greatest emphasis on the creation of a geometry model from CT data. During the implementation of the bachelor's thesis, two models of geometry were created in the analysed program, using different segmentation functions, which were then compared with each other and then compared with a model of geometry created in another program. The GOM Inspect program was used to compare the geometry deviations of individual models. Finally, computational models were created using the CATIA program and then deformation and stress analysis was performed using the ANSYS program. The results of individual solutions were analysed, compared and evaluated.

Porovnanie českého a nemeckého národohospodárskeho pohľadu na predvojnové zbrojenie

Názory ekonomických teoretikov na dopady zbrojenia na celkový vývoj v spoločnosti a stav ekonomiky sú rôzne. Táto práca porovnávala teoretický postoj k otázkam zbrojenia v tridsiatych rokov dvadsiateho storočia v Československu a v Nemecku. Ako zdroje informácií pre popis prevládajúceho národohospodárskeho prístupu práca využíva dobovú tlač, archívne materiály a súčasné materiály zaoberajúce sa touto tematikou. Hlavný prúd ekonomického myslenia v Československu nesúhlasí s vysokými štátnymi výdavkami do zbrojenia, pretože pôsobia degeneratívne a smerujú k militarizácii ekonomiky. Príprava obrany štátu si vyžaduje zvýšenie daní, klesanie životnej úrovne, obmedzenie exportu, či zníženie produktívnych investícií, atď. Preto nie je žiadúce tieto princípy používať v rámci mierovej ekonomiky a sú platné iba v prípade ohrozenia existencie štátu, avšak aj vtedy sa musí jednať o čo najmenšie zásahy do tržného princípu. Dôraz bol kladený na neinflačné získavanie finančných prostriedkov - v prvom rade dane a potom úver. Predstaviteľmi boli Karel Engliš, Alois Rašín, pohľady ktorých sa odzrkadlili v oficiálnom Hospodársko-finančnom pláne, či Ladislav Chmela. V opozícii proti ich názorom stáli Josef Macek a Rudolf Brož, reprezentujúci ,,keynesiánsky" pohľad. V Nemecku naopak bola miera štátnych zásahov...There are a variety of views from economic theorists on effects of armament on the overall development of certain societies and the state of its economy. The aim of this paper is to compare the theoretical approach to the issue of pre-war armament in 1930s in Czechoslovakia and Germany. As a source of information for the description of the prevailing theoretical economic approach, this paper uses contemporary newspaper articles, archived materials and present-day materials concerning this topic. The main stream of economic thinking in Czechoslovakia does not agree with high governmental expenditure on armament, because it may have a degenerative effect which would lead to militarisation of economy. War preparation results in higher taxes, a fall in standard of living, limited export, and decrease in productive investment, etc. Therefore it is not eligible to implement these principles under the conditions of peace economy and they are relevant only in case of a direct threat to the existence of a state. However, even then it has to be a derogation of the principle of free trade to the slightest possible extent. Emphasis was placed on non-inflationary obtaining of financial means - first via taxes and then a credit. Representatives were Karel Englis and Alois Rasin, whose ideas were reflected in the...Institute of Economic StudiesInstitut ekonomických studiíFaculty of Social SciencesFakulta sociálních vě

Age-Associated Decline in Dendritic Cell Function and the Impact of Mediterranean Diet Intervention in Elderly Subjects

Introduction: Aging is accompanied by increased susceptibility to infection and age-associated chronic diseases. It is also associated with reduced vaccine responses, which is often attributed to immunosenescence and the functional decline of the immune system. Immunosenescence is characterized by a chronic, low-grade, inflammatory state termed inflammaging. Habitants of Mediterranean (MED) regions maintain good health into old age; often attributed to MED diets. Hypothesis: Adoption of a MED-diet by elderly subjects, in Norfolk (UK), may improve immune responses of these individuals and in particular, dendritic cell (DC) function. Experimental approach: A total of 120 elderly subjects (65–79 years old) recruited onto the Nu-AGE study, a multicenter European dietary study specifically addressing the needs of the elderly, across five countries, and were randomized to the control or MED-diet groups, for one year. Blood samples were taken pre- and post-intervention for DC analysis and were compared with each other, and to samples obtained from 45 young (18–40 years old) subjects. MED-diet compliance was assessed using high performance liquid chromatography-with tandem mass spectrometry analysis of urine samples. Immune cell and DC subset numbers and concentrations of secreted proteins were determined by flow cytometric analysis. Results: As expected, reduced myeloid DC numbers were observed in blood samples from elderly subjects compared with young. The elevated secretion of the adipokine, resistin, after ex vivo stimulation of peripheral blood mononuclear cells from elderly subjects, was significantly reduced after MED-diet intervention. Conclusion: This study provides further evidence of numerical and functional effects of aging on DCs. The MED-diet showed potential to impact on the aging immune cells investigated and could provide an economical approach to address problems associated with our aging population

Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs

Circulating nucleic acids (CNAs), for example, circulating tumor DNA (ctDNA) and circulating microRNA (miRNA), represent promising biomarkers in several diseases including cancer. They can be isolated from many body fluids, such as blood, saliva, and urine. Also ascites, cerebrospinal fluids, and pleural effusion may be considered as a source of CNAs, but with several and intrinsic limitations. Therefore, blood withdrawal represents one of the best sources for CNAs due to the very simple and minimally invasive way of sampling. Moreover, it can be repeated at different time points, giving the opportunity for a real-time monitoring of the disease

Baseline JAK phosphorylation profile of peripheral blood leukocytes, studied by whole blood phosphospecific flow cytometry, is associated with 1-year treatment response in early rheumatoid arthritis

Background: We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4(+) T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the baseline phosphorylation profiles of Janus kinases (JAKs) in blood leukocytes with respect to treatment response in early RA. Methods: Thirty-five DMARD-naive patients with early RA provided blood samples for whole blood flow cytometric determination of phosphorylation of JAKs in CD4(+) and CD8(+) T cells, CD19(+) B cells, and CD14(+) monocytes. Treatment response was determined after 1 year of treatment with synthetic DMARDs, with remission defined as absence of tender and swollen joints and normal erythrocyte sedimentation rate. Exact logistic regression was used to investigate the association of baseline variables with treatment response. Ninety-five percent CIs of means were estimated by bias-corrected bootstrapping. Results: High JAK3 phosphorylation in CD4(+) and CD8(+) T cells, CD19(+) B cells, and CD14(+) monocytes and low JAK2 phosphorylation in CD14(+) monocytes were significantly associated with remission following treatment with synthetic DMARDs. Conclusions: Baseline JAK phosphorylation profile in peripheral blood leukocytes may provide a means to predict treatment response achieved by synthetic DMARDs among patients with early RA.Peer reviewe