Semantic reasoning for intelligent emergency response applications

Emergency response applications require the processing of large amounts of data, generated by a diverse set of sensors and devices, in order to provide for an accurate and concise view of the situation at hand. The adoption of semantic technologies allows for the definition of a formal domain model and intelligent data processing and reasoning on this model based on generated device and sensor measurements. This paper presents a novel approach to emergency response applications, such as fire fighting, integrating a formal semantic domain model into an event-based decision support system, which supports reasoning on this model. The developed model consists of several generic ontologies describing concepts and properties which can be applied to diverse context-aware applications. These are extended with emergency response specific ontologies. Additionally, inference on the model performed by a reasoning engine is dynamically synchronized with the rest of the architectural components. This allows to automatically trigger events based on predefined conditions. The proposed ontology and developed reasoning methodology is validated on two scenarios, i.e. (i) the construction of an emergency response incident and corresponding scenario and (ii) monitoring of the state of a fire fighter during an emergency response

Anticonvulsant valproic acid and other short-chain fatty acids as novel anticancer therapeutics: Possibilities and challenges

Results from numerous pre-clinical studies suggest that a well known anticonvulsant drug valproic acid (VPA) and other short-chain fatty acids (SCFAs) cause significant inhibition of cancer cell proliferation by modulating multiple signaling pathways. First of all, they act as histone deacetylase (HDAC) inhibitors (HDIs), being involved in the epigenetic regulation of gene expression. Afterward, VPA is shown to induce apoptosis and cell differentiation, as well as regulate Notch signaling. Moreover, it up-regulates the expression of certain G protein-coupled receptors (GPCRs), which are involved in various signaling pathways associated with cancer. As a consequence, some pre-clinical and clinical trials were carried out to estimate anticancer effectiveness of VPA, in monotherapy and in new drug combinations, while other SCFAs were tested in pre-clinical studies. The present manuscript summarizes the most important information from the literature about their potent anticancer activities to show some future perspectives related to epigenetic therapy

Re-writing histories of colonization in video games: the case of Elizabeth LaPensée

The article is aimed at presentation of the case study in video games creation by Indigenous auteur and designer, Elizabeth LaPensée, which at the same time demonstrates how video games can both mediatize the process of re-writing history and decolonize popular imagination. The analysis of LaPensée’s three games: Invaders, Thunderbird Strikes, and When the Rivers Were Trails to some extent follows her own strategies of self-identification as Anishinabee (Ojibwe). Drawing upon reconfiguration of the auteur theory and the framework of ludostylistics by Astrid Ensslin, we also strive to demonstrate how the notion of a singular author is in fact grounded in collective and collaborative qualities of indigenous digital culture, including digital game design.The article is aimed at presentation of the case study in video games creation by Indigenous auteur and designer, Elizabeth LaPensée, which at the same time demonstrates how video games can both mediatize the process of re-writing history and decolonize popular imagination. The analysis of LaPensée’s three games: Invaders, Thunderbird Strikes, and When the Rivers Were Trails to some extent follows her own strategies of self-identification as Anishinabee (Ojibwe). Drawing upon reconfiguration of the auteur theory and the framework of ludostylistics by Astrid Ensslin, we also strive to demonstrate how the notion of a singular author is in fact grounded in collective and collaborative qualities of indigenous digital culture, including digital game design

Cognitive disorders in children's hydrocephalus

Background and objective Hydrocephalus is defined as an increase of volume of cerebrospinal fluid in the ventricular system of the brain. It develops as a result of cerebrospinal fluid flow disorder due to dysfunctions of absorption or, less frequently, as a result of the increase of its production. Hydrocephalus may lead to various cognitive dysfunctions in children. Materials and methods In order to determine cognitive functioning in children with hydrocephalus, the authors reviewed available literature while investigating this subject. Results The profile of cognitive disorders in children with hydrocephalus may include a wide spectrum of dysfunctions and the process of neuropsychological assessment may be very demanding. The most frequently described cognitive disorders within children's hydrocephalus include attention, executive, memory, visual, spatial or linguistic dysfunctions, as well as behavioral problems

Modelling groundwater flow and nitrate transport: a case study of an area used for precision agriculture in the middle part of the Vistula River valley, Poland

The present paper discusses studies related to the preparation of a hydrogeological model of groundwater flow and nitrate transport in an area where a precision farming system is applied. Components of water balance were determined using the UnSat Suite Plus software (HELP model), while the average infiltration rate calculated for the study area equalled 20 per cent. The Visual MODFLOW software was used for the purpose of modelling in the saturated zone. Hy- drogeological parameters of the model layers, inclusive of hydraulic conductivity, were defined on the basis of results of column tests that were carried out under laboratory conditions (column experiment). Related to the dose of mineral nitrogen used in precision fertilisation (80 kg N/ha), scenarios of the spread of nitrates in the soil-water environment were worked out. The absolute residual mean error calculated for nitrate concentrations obtained from laboratory and modelling studies equalled 0.188 mg/L, the standard error of the estimate equalling 0.116 mg/L. Results obtained were shown graphically in the form of hydroisohypse maps and nitrate isolines. Conclusions were drawn regarding the possibility of using numerical modelling techniques in predicting transport and fate of nitrates from fertilisers applied in precision agriculture systems