TB183: Investment, Ownership and Operating Costs of Supplemental Irrigation Systems for Maine Wild Blueberries

This study investigates the investment and annual cost of supplemental irrigation equipment used on lowbush blueberries and calculates breakeven yields required to pay for annual costs and the earliest possible payoff period to recover investment costs. Using an economic-engineering approach to simulating investment and operating costs, this project assesses breakeven requirements on irrigation investment. The report reviews several of the technical factors contributing to the irrigation decision, calculate economic costs and are breakeven measures, but only introduce some of the financial factors for a grower to consider.https://digitalcommons.library.umaine.edu/aes_techbulletin/1025/thumbnail.jp

DNA Barcoding of the First Recorded American Burying Beetle, Nicrophorus americanus, in Clark County, Arkansas

The American Burying Beetle (ABB), Nicrophorus americanus, is a red-listed endangered species under the Endangered Species Act (16 U.S.C. 1531 et seq.). We serendipitously recorded 3 individuals of this species during a forensic study in the summer of 2013. These specimens represent the first known records for Clark County, AR and the southeastern-most record in the State since the extirpation of the species from the region in the late 1800’s. Two males and one female were collected, photographed, sexed and measured. One male specimen was deceased upon discovery. The remaining two individuals were released. The U.S. Fish and Wildlife Service (USFWS) was notified of the accidental catch and death of an endangered species as required and the specimen was awarded to Ouachita Baptist University for further study. The deceased specimen was used for DNA barcode sequence analysis. A 400bp section of the cytochrome c oxidase I (COI) gene was amplified using gene specific primers and then sequenced using Sanger sequencing methods. Sequence analysis revealed the collected beetle to be 98.5% identical to the ABB voucher sequence and was 86% similar to other Nicrophorus species. Taken together the DNA sequence analysis results and taxonomic identification both support the identification of our specimen

Avaliação do potencial produtivo da videira Niágara Rosada na Região de Pelotas.

O Objetivo do trabalho é avaliar a produção de videira ?Niágara Rosada? na região de Pelotas, com e sem a utilização da cobertura da parreiral com plástico transparente

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism

Older patients are more likely to acquire and die from acute respiratory distress syndrome (ARDS) and muscle weakness may be more clinically significant in older persons. Recent data implicate muscle ring finger protein 1 (MuRF1) in lung injury-induced skeletal muscle atrophy in young mice and identify an alternative role for MuRF1 in cardiac metabolism regulation through inhibition of fatty acid oxidation

A Metabolomic Endotype of Bioenergetic Dysfunction Predicts Mortality in Critically Ill Patients with Acute Respiratory Failure

Acute respiratory failure (ARF) requiring mechanical ventilation, a complicating factor in sepsis and other disorders, is associated with high morbidity and mortality. Despite its severity and prevalence, treatment options are limited. In light of accumulating evidence that mitochondrial abnormalities are common in ARF, here we applied broad spectrum quantitative and semiquantitative metabolomic analyses of serum from ARF patients to detect bioenergetic dysfunction and determine its association with survival. Plasma samples from surviving and non-surviving patients (N = 15/group) were taken at day 1 and day 3 after admission to the medical intensive care unit and, in survivors, at hospital discharge. Significant differences between survivors and non-survivors (ANOVA, 5% FDR) include bioenergetically relevant intermediates of redox cofactors nicotinamide adenine dinucleotide (NAD) and NAD phosphate (NADP), increased acyl-carnitines, bile acids, and decreased acyl-glycerophosphocholines. Many metabolites associated with poor outcomes are substrates of NAD(P)-dependent enzymatic processes, while alterations in NAD cofactors rely on bioavailability of dietary B-vitamins thiamine, riboflavin and pyridoxine. Changes in the efficiency of the nicotinamide-derived cofactors\u27 biosynthetic pathways also associate with alterations in glutathione-dependent drug metabolism characterized by substantial differences observed in the acetaminophen metabolome. Based on these findings, a four-feature model developed with semi-quantitative and quantitative metabolomic results predicted patient outcomes with high accuracy (AUROC = 0.91). Collectively, this metabolomic endotype points to a close association between mitochondrial and bioenergetic dysfunction and mortality in human ARF, thus pointing to new pharmacologic targets to reduce mortality in this condition

The positive impact of a facilitated peer mentoring program on academic skills of women faculty

<p>Abstract</p> <p>Background</p> <p>In academic medicine, women physicians lag behind their male counterparts in advancement and promotion to leadership positions. Lack of mentoring, among other factors, has been reported to contribute to this disparity. Peer mentoring has been reported as a successful alternative to the dyadic mentoring model for women interested in improving their academic productivity. We describe a facilitated peer mentoring program in our institution's department of medicine.</p> <p>Methods</p> <p>Nineteen women enrolled in the program were divided into 5 groups. Each group had an assigned facilitator. Members of the respective groups met together with their facilitators at regular intervals during the 12 months of the project. A pre- and post-program evaluation consisting of a 25-item self-assessment of academic skills, self-efficacy, and academic career satisfaction was administered to each participant.</p> <p>Results</p> <p>At the end of 12 months, a total of 9 manuscripts were submitted to peer-reviewed journals, 6 of which are in press or have been published, and another 2 of which have been invited to be revised and resubmitted. At the end of the program, participants reported an increase in their satisfaction with academic achievement (mean score increase, 2.32 to 3.63; <it>P </it>= 0.0001), improvement in skills necessary to effectively search the medical literature (mean score increase, 3.32 to 4.05; <it>P </it>= 0.0009), an improvement in their ability to write a comprehensive review article (mean score increase, 2.89 to 3.63; <it>P </it>= 0.0017), and an improvement in their ability to critically evaluate the medical literature (mean score increased from 3.11 to 3.89; <it>P </it>= 0.0008).</p> <p>Conclusions</p> <p>This facilitated peer mentoring program demonstrated a positive impact on the academic skills and manuscript writing for junior women faculty. This 1-year program required minimal institutional resources, and suggests a need for further study of this and other mentoring programs for women faculty.</p

A broken silence? Mass Observation, Armistice Day and ‘everyday life’ in Britain 1937–1941

Between 1937 and 1941 the social survey organization Mass Observation collected material on the ways that the British people experienced and thought about the commemorative practices that marked the anniversary of the Armistice of 1918. What they found was that while people were largely united in their observation of the rituals of remembrance, their thoughts and feelings about these practices were diverse. For some, the acts of commemoration were a fitting way to pay tribute to both the dead and the bereaved. For others, these acts were hypocritical in a nation preparing for war. This article draws on the Mass Observation material to trace some of the diverse ways that remembrance was embodied in everyday life, practised, experienced and understood by the British people as the nation moved once again from peace to war, arguing that studies of the practices of remembrance alone tell us little about how they have been understood by participants

Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO)

The protection provided by natural versus hybrid immunity from COVID-19 is unclear. We reflect on the challenges from trying to conduct a randomized post-SARS-CoV-2 infection vaccination trial study with rapidly evolving scientific data, vaccination guidelines, varying international policies, difficulties with vaccine availability, vaccine hesitancy, and a constantly evolving virus

Design and Rationale of the Fontan Udenafil Exercise Longitudinal (FUEL) Trial

The Fontan operation creates a circulation characterized by elevated central venous pressure and low cardiac output. Over time, these characteristics result in a predictable and persistent decline in exercise performance that is associated with an increase in morbidity and mortality. A medical therapy that targets the abnormalities of the Fontan circulation might, therefore, be associated with improved outcomes. Udenafil, a phosphodiesterase type 5 inhibitor, has undergone phase I/II testing in adolescents who have had the Fontan operation and has been shown to be safe and well tolerated in the short-term. However, there are no data regarding the long-term efficacy of udenafil in this population. The Fontan Udenafil Exercise Longitudinal (FUEL) Trial is a randomized, double blind, placebo controlled phase III clinical trial being conducted by the Pediatric Heart Network in collaboration with Mezzion Pharma Co., Ltd. This trial is designed to test the hypothesis that treatment with udenafil will lead to an improvement in exercise capacity in adolescents who have undergone the Fontan operation. A safety extension trial, the FUEL Open-Label Extension Trial (FUEL OLE), offers the opportunity for all FUEL subjects to obtain open-label udenafil for an additional 12 months following completion of FUEL, and evaluates the long-term safety and tolerability of this medication. This manuscript describes the rationale and study design for FUEL and FUEL OLE. Together, these trials provide an opportunity to better understand the role of medical management in the care of those who have undergone the Fontan operation