Superluminous supernovae: No threat from Eta Carinae

Recently Supernova 2006gy was noted as the most luminous ever recorded, with a total radiated energy of ~10^44 Joules. It was proposed that the progenitor may have been a massive evolved star similar to eta Carinae, which resides in our own galaxy at a distance of about 2.3 kpc. eta Carinae appears ready to detonate. Although it is too distant to pose a serious threat as a normal supernova, and given its rotation axis is unlikely to produce a Gamma-Ray Burst oriented toward the Earth, eta Carinae is about 30,000 times nearer than 2006gy, and we re-evaluate it as a potential superluminous supernova. We find that given the large ratio of emission in the optical to the X-ray, atmospheric effects are negligible. Ionization of the atmosphere and concomitant ozone depletion are unlikely to be important. Any cosmic ray effects should be spread out over ~10^4 y, and similarly unlikely to produce any serious perturbation to the biosphere. We also discuss a new possible effect of supernovae, endocrine disruption induced by blue light near the peak of the optical spectrum. This is a possibility for nearby supernovae at distances too large to be considered "dangerous" for other reasons. However, due to reddening and extinction by the interstellar medium, eta Carinae is unlikely to trigger such effects to any significant degree.Comment: 19 pages, 2 figures; Revised version as accepted for publication in Astrobiolog

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Lack of Effective Anti-Apoptotic Activities Restricts Growth of Parachlamydiaceae in Insect Cells

The fundamental role of programmed cell death in host defense is highlighted by the multitude of anti-apoptotic strategies evolved by various microbes, including the well-known obligate intracellular bacterial pathogens Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae. As inhibition of apoptosis is assumed to be essential for a successful infection of humans by these chlamydiae, we analyzed the anti-apoptotic capacity of close relatives that occur as symbionts of amoebae and might represent emerging pathogens. While Simkania negevensis was able to efficiently replicate within insect cells, which served as model for metazoan-derived host cells, the Parachlamydiaceae (Parachlamydia acanthamoebae and Protochlamydia amoebophila) displayed limited intracellular growth, yet these bacteria induced typical features of apoptotic cell death, including formation of apoptotic bodies, nuclear condensation, internucleosomal DNA fragmentation, and effector caspase activity. Induction of apoptosis was dependent on bacterial activity, but not bacterial de novo protein synthesis, and was detectable already at very early stages of infection. Experimental inhibition of host cell death greatly enhanced parachlamydial replication, suggesting that lack of potent anti-apoptotic activities in Parachlamydiaceae may represent an important factor compromising their ability to successfully infect non-protozoan hosts. These findings highlight the importance of the evolution of anti-apoptotic traits for the success of chlamydiae as pathogens of humans and animals

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Effects of a balanced translocation between chromosomes 1 and 11 disrupting the DISC1 locus on white matter integrity

Objective Individuals carrying rare, but biologically informative genetic variants provide a unique opportunity to model major mental illness and inform understanding of disease mechanisms. The rarity of such variations means that their study involves small group numbers, however they are amongst the strongest known genetic risk factors for major mental illness and are likely to have large neural effects. DISC1 (Disrupted in Schizophrenia 1) is a gene containing one such risk variant, identified in a single Scottish family through its disruption by a balanced translocation of chromosomes 1 and 11; t(1;11) (q42.1;q14.3). Method Within the original pedigree, we examined the effects of the t(1;11) translocation on white matter integrity, measured by fractional anisotropy (FA). This included family members with (n = 7) and without (n = 13) the translocation, along with a clinical control sample of patients with psychosis (n = 34), and a group of healthy controls (n = 33). Results We report decreased white matter integrity in five clusters in the genu of the corpus callosum, the right inferior fronto-occipital fasciculus, acoustic radiation and fornix. Analysis of the mixed psychosis group also demonstrated decreased white matter integrity in the above regions. FA values within the corpus callosum correlated significantly with positive psychotic symptom severity. Conclusions We demonstrate that the t(1;11) translocation is associated with reduced white matter integrity in frontal commissural and association fibre tracts. These findings overlap with those shown in affected patients with psychosis and in DISC1 animal models and highlight the value of rare but biologically informative mutations in modeling psychosis

Racecraft and Southern History

“Racecraft and the History of the South” will be the subject of a talk by Columbia University historian Barbara Fields, as she gives the inaugural Gilder-Jordan lecture March 8. The lecture, scheduled for 7:00 p.m. in the auditorium of the Overby Center, brings Fields back to the University of Mississippi, where she was Ford Foundation Visiting Scholar in 1988. Fields is the author of Slavery and Freedom on the Middle Ground: Maryland during the 19th Century. She received her PhD in history at Yale University, where she wrote a dissertation under the direction of C. Vann Woodward. In 1982 she contributed an essay, “Ideology and Race in American History,” to a volume honoring Woodward on his retirement. In that often-assigned and influential essay, along with other work, Fields has analyzed the meanings of race as “a purely ideological notion.” The article continued, “To treat race as an ideology, and to insist upon treating it in connection with surrounding ideologies, is to open up a vast realm of further complications.” Those complications have been the subject of a great deal of scholarship in the past generation. Coauthor or coeditor of Slaves No More, Free at Last, and Freedom: The Documentary History of Emancipation, Fields has also written about the history of emancipation in the U.S. and Brazil.https://egrove.olemiss.edu/gilder-jordan/1012/thumbnail.jp