How can Data Analytics Results be Exploited in the Early Phase of Product Development? 13 Design Principles for Data-Driven Product Planning

The megatrend digitalization turns mechatronic products into continuous collectors and generators of use phase data. By analyzing this data, manufacturers can uncover valuable insights about the products and the users. Especially in product planning, these insights could be used to plan promising future product generations. The systematic exploitation of data analytics results, however, represents a serious challenge, as research on the topic is still scarce. In this paper, we present 13 design principles for exploiting data analytics results in product planning. The results are based on a systematic literature review and a workshop with a research consortium. The evaluation of the design principles is demonstrated with a real case of a manufacturing company. The identified design principles represent a first contribution to a still scarcely explored research field

A DNA Segregation Module for Synthetic Cells

The bottom-up construction of an artificial cell requires the realization of synthetic cell division. Significant progress has been made toward reliable compartment division, yet mechanisms to segregate the DNA-encoded informational content are still in their infancy. Herein, droplets of DNA Y-motifs are formed by liquid–liquid phase separation. DNA droplet segregation is obtained by cleaving the linking component between two populations of DNA Y-motifs. In addition to enzymatic cleavage, photolabile sites are introduced for spatio-temporally controlled DNA segregation in bulk as well as in cell-sized water-in-oil droplets and giant unilamellar lipid vesicles (GUVs). Notably, the segregation process is slower in confinement than in bulk. The ionic strength of the solution and the nucleobase sequences are employed to regulate the segregation dynamics. The experimental results are corroborated in a lattice-based theoretical model which mimics the interactions between the DNA Y-motif populations. Altogether, engineered DNA droplets, reconstituted in GUVs, can represent a strategy toward a DNA segregation module within bottom-up assembled synthetic cells

Telegrams from B. D. Connerly et al. to Senator Langer Opposing Sale of Indian Land, September 1, 1955

These seven telegrams, dated September 1, 1955 except as noted below, from the senders listed below to United States (US) Senator William Langer express the senders\u27 opposition to a sale of Indian land to take place at New Town, North Dakota on the Forth Berthold Reservation. While the wording of the telegrams varies, all ask for this sale to be halted until further study is made. The senders include: The Reverend B. D. Connerly of Carrington, North Dakota, Marvin Kirk of Ramsey Country, North Dakota, Walter F. Jarvis of Fargo, North Dakota, The Reverend Helmuth Fitchler of Glen Ullin, North Dakota, Mrs. George Lincoln of Hunter, North Dakota, The Social Action Committee of the Congregation Christian Conference of North Dakota (dated August 31, 1955) And Mr. and Mrs. Charles Pierce of Scranton, North Dakota (dated Sepember 2, 1955). See also: Telegram from Senator Langer to B. D. Connerly Et Al. Regarding Sale of Indian Lands, September 2, 1955https://commons.und.edu/langer-papers/1795/thumbnail.jp

Comparative AMS radiocarbon dating of pretreated versus non-pretreated tropical wood samples

Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 268 (2010): 910-913, doi:10.1016/j.nimb.2009.10.062.Several wood samples collected from Dorslandboom, a large African baobab (Adansonia digitata L.) from Namibia, were investigated by AMS radiocarbon dating subsequent to pretreatment and, alternatively, without pretreatment. The comparative statistical evaluation of results showed that there were no significant differences between fraction modern values and radiocarbon dates of the samples analyzed after pretreatment and without pretreatment, respectively. The radiocarbon date of the oldest sample was 993 ± 20 BP. Dating results also revealed that Dorslandboom is a multi-generation tree, with several stems showing different ages.This material is based on work supported by U.S. National Science Foundation under Cooperative Agreement OCE-022828996. Part of the research was supported by grants from the Romanian Academy and the Romanian National University Research Council (PN II – ID 2354) and also by Nova Research Inc

Climatic signals in growth and its relation to ENSO events of two Prosopis species following a latitudinal gradient in South America

Semiarid environments throughout the world have lost a major part of their woody vegetation and biodiversity due to the effects of wood cutting, cattle grazing and subsistence agriculture. The resulting state is typically used for cattle production, but the productivity of these systems is often very low, and erosion of the unprotected soil is a common problem. Such dry-land degradation is of great international concern, not only because the resulting state is hardly productive but also because it paves the way to desertification. The natural distribution of the genus Prosopis includes arid and semiarid zones of the Americas, Africa and Asia, but the majority of the Prosopis species are, however, native to the Americas. In order to assess a likely gradient in the response of tree species to precipitation, temperature and their connection to El Niño southern oscillation (ENSO) events, two Prosopis species were chosen along a latitudinal gradient in Latin America, from northern Peru to central Chile: Prosopis pallida from a semi-arid land in northern and southern Peru and P. chilensis from a semiarid land in central Chile. Growth rings of each species were crossdated at each sampling site using classical dendrochronological techniques. Chronologies were related with instrumental climatic records in each site, as well as with SOI and N34 series. Cross-correlation, spectral and wavelet analysis techniques were used to assess the relation of growth with precipitation and temperature. Despite the long distance among sites, the two Prosopis species presented similar responses. Thus, the two species' growth is positively correlated to precipitation, while with temperature it is not. In northern Peru, precipitation and growth of P. pallida present a similar cyclic pattern, with a period of around 3 years. On the other hand, P. pallida in southern Peru, and P. chilensis also present this cyclic pattern, but also another one with lower frequency, coinciding with the pattern of precipitation. Both cycles are within the range of the ENSO band

Modeling the potential distribution of the threatened Grey-necked Picathartes Picathartes oreas across its entire range

Understanding the distribution and extent of suitable habitats is critical for the conservation of endangered and endemic taxa. Such knowledge is limited for many Central African species, including the rare and globally threatened Grey-necked Picathartes Picathartes oreas, one of only two species in the family Picathartidae endemic to the forests of Central Africa. Despite growing concerns about land-use change resulting in fragmentation and loss of forest cover in the region, neither the extent of suitable habitat nor the potential species’ distribution is well known. We combine 339 (new and historical) occurrence records of Grey-necked Picathartes with environmental variables to model the potential global distribution. We used a Maximum Entropy modelling approach that accounted for sampling bias. Our model suggests that Grey-necked Picathartes distribution is strongly associated with steeper slopes and high levels of forest cover, while bioclimatic, vegetation health, and habitat condition variables were all excluded from the final model. We predicted 17,327 km2 of suitable habitat for the species, of which only 2,490 km2 (14.4%) are within protected areas where conservation designations are strictly enforced. These findings show a smaller global distribution of predicted suitable habitat forthe Grey-necked Picathartes than previously thought. This work provides evidence to inform a revision of the International Union for Conservation of Nature (IUCN) Red List status, and may warrant upgrading the status of the species from “Near Threatened” to “Vulnerable”