10 research outputs found
Highly Differentiated, Resting Gn-Specific Memory CD8+ T Cells Persist Years after Infection by Andes Hantavirus
- Author
- AC Boon
- AF Ochsenbein
- Andrés Mori
- B Bengsch
- B Hjelle
- Brian Hjelle
- C de Carvalho Nicacio
- C de Carvalho Nicacio
- C Schmaljohn
- C KT Rossi
- Constanza Castillo
- CP Ferrer
- D Safronetz
- DD Pinschewer
- DJ McClain
- DM Custer
- E Hammarlund
- ED Kilpatrick
- Elena Llop
- EM van Leeuwen
- F Koster
- FA Ennis
- Francisca Valdivieso
- GJ Woo
- GM Dong
- H Asada
- H Feldmann
- H Galeno
- HL Van Epps
- HL Van Epps
- J Koch
- J Toro
- JD Meissner
- JM Park
- JR Dantas Jr
- JW Hooper
- JW Hooper
- K Araki
- KH Ely
- KY Lee
- M Bharadwaj
- M Ferres
- M Liang
- M Paiardini
- M Wang
- Marcela Ferrés
- MC Weissenbacher
- Michael Gale
- MR Klein
- MV da Silva
- N Sen
- O Bannard
- PA Goepfert
- PA Vial
- Pablo Vial
- PJ Alff
- PJ Alff
- PJ Padula
- PJ Padula
- R Thimme
- Rebecca Graumann
- S Marsh
- S Mattar
- SM Kaech
- SR Burrows
- T Manigold
- T Nakamura
- T Nakamura
- T Tuuminen
- Tobias Manigold
- V Appay
- V Bayard
- Valeska Simon
- VP Martinez
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
In man, infection with South American Andes virus (ANDV) causes hantavirus cardiopulmonary syndrome (HCPS). HCPS due to ANDV is endemic in Southern Chile and much of Argentina and increasing numbers of cases are reported all over South America. A case-fatality rate of about 36% together with the absence of successful antiviral therapies urge the development of a vaccine. Although T-cell responses were shown to be critically involved in immunity to hantaviruses in mouse models, no data are available on the magnitude, specificity and longevity of ANDV-specific memory T-cell responses in patients. Using sets of overlapping peptides in IFN-Îł ELISPOT assays, we herein show in 78 Chilean convalescent patients that Gn-derived epitopes were immunodominant as compared to those from the N- and Gc-proteins. Furthermore, while the relative contribution of the N-specific response significantly declined over time, Gn-specific responses remained readily detectable ex vivo up to 13 years after the acute infection. Tetramer analysis further showed that up to 16.8% of all circulating CD3+CD8+ T cells were specific for the single HLA-B*3501-restricted epitope Gn465â473 years after the acute infection. Remarkably, Gn465â473âspecific cells readily secreted IFN-Îł, granzyme B and TNF-α but not IL-2 upon stimulation and showed a ârevertantâ CD45RA+CD27âCD28âCCR7âCD127â effector memory phenotype, thereby resembling a phenotype seen in other latent virus infections. Most intriguingly, titers of neutralizing antibodies increased over time in 10/17 individuals months to years after the acute infection and independently of whether they were residents of endemic areas or not. Thus, our data suggest intrinsic, latent antigenic stimulation of Gn-specific T-cells. However, it remains a major task for future studies to proof this hypothesis by determination of viral antigen in convalescent patients. Furthermore, it remains to be seen whether Gn-specific T cells are critical for viral control and protective immunity. If so, Gn-derived immunodominant epitopes could be of high value for future ANDV vaccines
Silver and Cyanine Staining of Oligonucleotides in Polyacrylamide Gel
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins
- Author
- Adolfo GarcĂa-Sastre
- Aldo Barrera
- Angela Choi
- Ariana Hirsh
- BJ Laidlaw
- C Dreyfus
- CJ Henry Dunand
- DC Ekiert
- DC Ekiert
- DJ DiLillo
- DJ DiLillo
- F Krammer
- F Krammer
- F Krammer
- F Krammer
- F Krammer
- Florian Krammer
- GJ Smith
- GM Li
- H Chen
- I Margine
- I Margine
- Irina Margine
- J Stevens
- J Sui
- J Wrammert
- JC Krause
- JD Easterbrook
- JM Fonville
- JW Yewdell
- K Ito
- K Jayasundara
- Kimihito Ito
- M Terajima
- Marcela Ferres
- MS Miller
- N Pica
- Nicole M Bouvier
- NS Heaton
- Peter Palese
- R Gao
- R Nachbagauer
- Rafael A Medina
- Raffael Nachbagauer
- Randy A Albrecht
- RJ Garten
- S Jegaskanda
- S Jegaskanda
- Sayaka Iida
- SE Ohmit
- T Horimoto
- TJ Wohlbold
- TJ Wohlbold
- X Xu
- X Yang
- X Yu
- Y Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Using Drosophila models and tools to understand the mechanisms of novel human cancer driver gene function
- Author
- A Banreti
- A Fire
- A Garcia-Bellido
- A Garelli
- A Jenett
- A Prahallad
- A Schlesinger
- A Tian
- AA Teleman
- AC Spradling
- AC Spradling
- AG Stephen
- AH Brand
- AK Dingwall
- AL Parks
- AM Brumby
- AM Huang
- B Akten
- B Vogelstein
- BE Housden
- C Alexandre
- C Bokel
- C Gonzalez
- C Kadoch
- C Kandoth
- C Nusslein-Volhard
- C Vaure
- C Wang
- CJ Potter
- CK Qu
- D Ferres-Marco
- D Hadjieconomou
- D Hanahan
- DA Wassarman
- DM Roberts
- E Bangi
- E Bier
- E Eroglu
- E Gateff
- E Kunttas-Tatli
- E Schmukler
- EF Wagner
- EZ Kvon
- F Bonnay
- F Chen
- F Port
- F Rossi
- FD Karim
- G Deblois
- G Dietzl
- G Toba
- GM Rubin
- GM Rubin
- H Kajiho
- H Tan
- HJ Bellen
- I Eerola
- J Bischof
- J Colombani
- J Cordero
- J Pae
- JA Bosch
- JA Botella
- JA Williams
- JB Cordero
- JC Pastor-Pareja
- JL Imler
- JM Murillo-Maldonado
- JM Tennessen
- JR Miller
- JR Thackeray
- JS Wu
- JW Bigenzahn
- K Harvey
- KG Golic
- KG Golic
- KJ Venken
- L Ho
- L Hu
- LM Boon
- LT Reiter
- LW Ellisen
- M Cully
- M Dominguez
- M Enomoto
- M Gladstone
- M Kim
- M Steklov
- M Stern
- M Tipping
- M Yaniv
- MA Lemmon
- MA Simon
- MB Stark
- MH Bailey
- MM Tangredi
- MS Cohen
- MV Liberti
- N Mashtalir
- N Perrimon
- P Deak
- P Fischer
- P Muller
- P Rorth
- PJ Stogios
- R Yagi
- RA Pagliarini
- RM Freeman Jr
- RN Salomon
- RW Justice
- S Artavanis-Tsakonas
- S Basu
- S Kitajima
- S Levinson
- S Mittag
- S Ohsawa
- S Oldham
- SA Richards
- SB Breitkopf
- SJ Bray
- SJ Gratz
- SL Schmid
- SN Villegas
- ST Thibault
- T Igaki
- T Lee
- T Palomero
- T Xu
- T Xu
- T Zoranovic
- TH Morgan
- UB Pandey
- V Hietakangas
- V Janssens
- V Thorsson
- VA Rudrapatna
- W Cai
- W Cai
- W Song
- WC Lee
- WL Wooderchak-Donahue
- YM Yamashita
- YY Cho
- ZQ Shi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
The formation, overgrowth and metastasis of tumors comprise a complex series of cellular and molecular events resulting from the combined effects of a variety of aberrant signaling pathways, mutations, and epigenetic alterations. Modeling this complexity in vivo requires multiple genes to be manipulated simultaneously, which is technically challenging. Here, we analyze how Drosophila research can further contribute to identifying pathways and elucidating mechanisms underlying novel cancer driver (risk) genes associated with tumor growth and metastasis in humans.Work in the authors laboratory is supported by the Spanish Ministry of Economy and Competitiveness and co-financed by FEDER funds (BFU2015-64239-R, the Spanish State Research Agency, through the âSevero Ochoaâ Program for Centers of Excellence in R&D (SEV-2013-0317), the Scientific Foundation of the Spanish Association Against Cancer (AECC) (CICPF16001DOMĂ), and the Valencian Regional Governmentâs Prometeo Programme for research groups of excellence (PROMETEO/2017/146) to M.D.Peer reviewe
Cell proliferation control by Notch signalling during imaginal discs development in <em>Drosophila</em>
- Author
- Andersson ER Sandberg R, Lendahl U
- Andrade-Zapata I Baonza A
- ArtavanisTsakonas S Rand MD, Lake RJ
- Bach EA Ekas LA, Ayala-Camargo A, et al.
- Baena-Lopez LA Garcia-Bellido A
- Baena-Lopez LA Nojima H, Vincent JP
- Baker NE Yu SY
- Baker WK
- Baonza A Freeman M
- Baonza A Garcia-Bellido A
- Baonza A Roch F, Martin-Blanco E
- Baron M
- Blair SS
- Blaumueller CM Qi H, Zagouras P, et al.
- Bossuyt W De Geest N, Aerts S, et al.
- Bray S Bernard F
- Bray SJ
- Bruckner K Perez L, Clausen H, et al.
- Brumby AM Richardson HE
- Brumby AM Richardson HE
- Camp D Currie K, Labbe A, et al.
- Chao JL Tsai YC, Chiu SJ, et al.
- Cho KO Choi KW
- Christiansen AE Ding T, Bergmann A
- Cohen B Shimizu M, Izrailit J, et al.
- Couso JP Knust E, MartĂnez Arias A
- de Celis JF Garcia-Bellido A
- De Nooij JC Hariharan IK
- Diaz-Benjumea F Cohen SM
- Djiane A Zaessinger S, Babaoglan AB, et al.
- Dohda T Maljukova A, Liu L, et al.
- Doherty D Feger G, Younger-Shepherd S, et al.
- Dominguez M
- Dominguez M Brunner M, Hafen E, et al.
- Dominguez M de Celis JF
- Dominguez M Ferres-Marco D, Gutierrez-Avino FJ,
- DomĂnguez M Hafen E
- Duman-Scheel M Weng L, Xin S, et al.
- Edgar BA
- Elsum I Yates L, Humbert PO, et al.
- Estella C Voutev R, Mann RS
- Ferres-Marco D Gutierrez-Garcia I, Vallejo DM, e
- Firth LC Baker NE
- Fortini ME
- Fortini ME Bilder D
- Furriols M Bray S
- Giraldez AJ Cohen SM
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- Grzeschik NA Amin N, Secombe J, et al.
- Gutierrez-Avino FJ Ferres-Marco D, Dominguez M
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- Herz HM Bergmann A
- Herz HM Chen Z, Scherr H, et al.
- Hori K Sen A, Artavanis-Tsakonas S
- Irvine KD Rauskolb C
- Irvine KD Wieschaus E
- Ishikawa HO Takeuchi H, Haltiwanger RS, et al.
- Jarman AP Grell EH, Ackerman L, et al.
- Johnston LA Edgar BA
- Johnston LA Sanders AL
- Jones S Zhang X, Parsons DW, et al.
- Kandachar V Roegiers F
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- Klein T Martinez-Arias A
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- Kopan R Ilagan MX
- Kumar JP Moses K
- Lane ME Sauer K, Wallace K, et al.
- Lawrence PA Morata G
- Leong GR Goulding KR, Amin N, et al.
- Ling H Sylvestre JR, Jolicoeur P
- Louvi A Artavanis-Tsakonas S
- Lu H Bilder D
- Massari ME Murre C
- Masucci JD Miltenberger RJ, Hoffmann FM
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- Milan M Cohen SM
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- Pagliarini RA Xu T
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- Parsons LM Portela M, Grzeschik NA, et al.
- Paul L Wang SH, Manivannan SN, et al.
- Penton A Selleck SB, Hoffmann FM
- Radtke F Raj K
- Rafel N Milan M
- Ranganathan P Weaver KL, Capobianco AJ
- Rauskolb C Irvine KD
- Reis T Edgar BA
- Reynolds-Kenneally J Mlodzik M
- Robinson BS Huang J, Hong Y, et al.
- Roignant JY Treisman JE
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- Singh A Choi KW
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- Sukhanova MJ Du W
- Thomas BJ Gunning DA, Cho J, et al.
- Thompson BJ Mathieu J, Sung HH, et al.
- Treisman JE Heberlein U
- Tsai YC Sun YH
- Vaccari T Bilder D
- Vaccari T Bilder D
- Vaccari T Lu H, Kanwar R, et al.
- Vaccari T Rusten TE, Menut L, et al.
- Wang SH Simcox A, Campbell G
- Weng AP Millholland JM, Yashiro-Ohtani Y, et al.
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- Zhao B Tumaneng K, Guan KL
- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Human bartonellosis: seroepidemiological and clinical features with an emphasis on data from Brazil - A review
- Author
- A Curi
- Abbott RC
- Adams WC
- Adelson ME
- Al-Majali AM
- Amano Y
- Amaro MH
- Amaro MH
- Anderson B
- Antoniou M
- Apalsch AM
- Arisoy EM
- Avidor B
- Avidor B
- Azevedo ZM
- Baddour LM
- Baker J
- Baneth G
- Bass JW
- Battierman HJ
- Baylor P
- Benslimani A
- Benson LA
- Bergmans AMC
- Bermond D
- Bernini PM
- Billeter SA
- Birtles JB
- Blanco JR
- Blanco Ramos J
- Boulouis HJ
- Bown KJ
- Breathnach AS
- Breitschwerdt EB
- Breitschwerdt EB
- Breitschwerdt EB
- Breitschwerdt EB
- Brenner DJ
- Brouqui P
- Brouqui P
- Brouqui P
- Brouqui P
- Bruneel F
- C Lamas
- Carithers HA
- Carithers HA
- Castle KT
- Chamberlin J
- Chang CC
- Chang CC
- Chang CC
- Chang CC
- Chomel BB
- Chomel BB
- Chomel BB
- Chomel BB
- Chomel BB
- Chrousous GA
- Comer JA
- Comer JA
- Costa PS
- Curi ALL
- Curi ALL
- Dalton MJ
- Daly JS
- Daniels WB
- Diederen BM
- Diniz PP
- Drancourt M
- Ehrenborg C
- Ellis BA
- Eremeeva ME
- ERS Lemos
- Fabbi M
- Ferres GM
- Filoni C
- Fournier PE
- Garcia FU
- Garcia-Garcia JA
- Gass JDM
- Gazineo JL
- Golden SF
- Greenbaum B
- Groves MG
- Guibal F
- Gurfield AN
- Hadfield TL
- Hadley S
- Hamilton DH
- Harrison TG
- Heller R
- Henn JB
- Henn JB
- Henn JB
- Hjelm E
- Hmaimess G
- Hoen B
- Holmberg M
- Holmes AH
- Honadel TE
- Hong PH
- Houpikian P
- Huarcaya E
- Hulzebos CV
- Jackson LA
- Jacobs RF
- Jacomo V
- Jalava J
- Jardine C
- Johnson JF
- Katner HP
- Kelly K
- Kerkhoff FT
- Kikuchi E
- Kodama T
- Koehler JE
- Koehler JE
- Kordick DL
- Kordick DL
- Kordick DL
- Kosek M
- Kosoy M
- Kosoy M
- Krause R
- Kumasaka K
- La Scola B
- La Scola B
- La VD
- Lamas C
- Lamas C
- Lamas C
- Lawson PA
- Lerdluedeeporn P
- Lewis DW
- Li DM
- Lucey D
- Lyon LW
- MagalhĂŁes RF
- Maggiore G
- Maguiña C
- Maillard R
- Mainardi J
- Margileth AM
- Margileth AM
- Maruyama S
- Massei F
- Maurin M
- Maurin M
- Maurin M
- McGill S
- Mediannikov O
- Miller P
- MN BĂłia
- Mohle-Boetani JC
- Murakami K
- Noah DL
- Noah DL
- O'Reilly KL
- O'Rourke LG
- Oliveira AHP
- Ormerod LD
- Pinto Jr VL
- Podsiadly E
- Pollock SC
- Ramos AJ
- Raoult D
- Raoult D
- Raoult D
- Raoult D
- Rath PM
- Reed JB
- Regnery RL
- Regnery RL
- Regnery RL
- Regnery RL
- Regnery RL
- Resto-Ruiz S
- Ricketts WE
- Ridder GJ
- Riviello JJ Jr
- Robson JMB
- Rocha JL
- Rolain JM
- Rolain JM
- Rolain JM
- Rotily M
- Roux V
- Sanchez E
- Sander A
- Schattner A
- Schutze GE
- Schwartzman WA
- Seki N
- Selby G
- Siciliano RF
- Skerget M
- Slhessarenko N
- Smith HM
- Soheilian M
- Solano-Gallego L
- Solley WA
- Spach DH
- Spach DH
- Spach DH
- Spaulding WB
- Stein A
- Stevens H
- Stockmeyer B
- Suhler EB
- Sweeney VP
- Tappero JW
- Tea A
- Tolan RW Jr
- Tsukahara M
- Velho PE
- Velho PENF
- Ventura A
- Wade NK
- Waldwogel K
- Walter RS
- Wear DJ
- Wear DJ
- Whitman BW
- Wikswo ME
- Wong MT
- Yamashita CA
- Zangwill KM
- Zanutto MS
- Zarkovic A
- Zeaiter Z
- Znazen A
- Publication venue
- Instituto Oswaldo Cruz, MinistĂ©rio da SaĂșde
- Publication date
- 01/01/2008
- Field of study
Bartonellae are fastidious Gram-negative bacteria that are widespread in nature with several animal reservoirs (mainly cats, dogs, and rodents) and insect vectors (mainly fleas, sandflies, and human lice). Thirteen species or subspecies of Bartonella have been recognized as agents causing human disease, including B. bacilliformis, B. quintana, B. vinsonii berkhoffii, B. henselae, B. elizabethae, B. grahamii, B. washoensis, B. koehlerae, B. rocha-limaea, and B. tamiae. The clinical spectrum of infection includes lymphadenopathy, fever of unknown origin, endocarditis, neurological and ophthalmological syndromes, Carrion's disease, and others. This review provides updated information on clinical manifestations and seroepidemiological studies with an emphasis on data available from Brazil
Bunyaviruses: Hantavirus and Others
- Author
- A Al-Hazmi
- A Antoniadis
- A Batieha
- A Braito
- A Carhan
- A Ehrnst
- A Estrada-Pena
- A Estrada-Pena
- A Gargili
- A Gligic
- A Izri
- A Macneil
- A Markotic
- A Papa
- A Zaki
- AA Alrajhi
- AA Sall
- AA Sall
- AB Sabin
- AC Terzian
- AD Haddow
- AD Haddow
- AD Labeaud
- AF Deutman
- AJ Battisti
- AJ Georges
- AK Overby
- AK Overby
- AK Patel
- AL Hoch
- AL Siam
- AL Siam
- AL Siam
- AN Freiberg
- AP Rosa
- AR Filipe
- B Botros
- B Deng
- B Hjella
- B Mundel
- B Niklasson
- B Niklasson
- B Niklasson
- B Niklasson
- B Settergren
- B Settergren
- BH Bird
- BJ Beaty
- BJ Beaty
- BJ Beaty
- C Chastel
- C Drosten
- C Schmaljohn
- C Terrosi
- CA Roux Le
- CA Whitehouse
- CB Gundersen
- CB Jonsson
- CDC
- CDC
- Centers for Disease Control and Prevention and National Institutes of Health
- CH Calisher
- CJ Bao
- CJ Peters
- CN Peyrefitte
- CN Peyrefitte
- CR Anderson
- CR Pringle
- CS Schmaljohn
- CW Woods
- D Cohen
- D Dionisio
- D Fontenille
- D Fontenille
- D Li
- DA Bente
- DJ Velden Van
- DL Moore
- DM Watts
- DR Roberts
- E Zhioua
- EF Dunn
- EO Nuzum
- F Baldelli
- F Weber
- FA Martinez-Garcia
- FF Schwentker
- FP Pinheiro
- FP Pinheiro
- FP Pinheiro
- FP Pinheiro
- G Dobler
- G Groen Van Der
- G Myhrman
- GB Kirya
- GE Glass
- GE Glass
- GJ Mertz
- GJ Mertz
- GM Dong
- GM Findlay
- GN Konstantinou
- GR Defoliart
- GW Anderson Jr
- H Hoogstraal
- H Hoogstraal
- HB Vasconcelos
- HB Vasconcelos
- HH Balfour Jr
- HJ Kang
- HW Lee
- HW Lee
- I Freed
- J Casals
- J Ettinger
- J Gear
- J He
- J Meegan
- JA Coetzer
- JA Sheedy
- JC Morrill
- JC Morrill
- JC Young
- JD Joubert
- JE Childs
- JE Childs
- JE Childs
- JF Obijeski
- JL Brown
- JM Bales
- JM Meegan
- JT Huiskonen
- JT Huiskonen
- JT Paweska
- JT Paweska
- JT Paweska
- JT Paweska
- JT Paweska
- JW Huggins
- JW Leduc
- JW Leduc
- JW LeDuc
- JW LeDuc
- JW LeDuc
- K Ahmad
- K Park
- K Soares-Weiser
- K Terasaki
- KC Smithburn
- KE Dixon
- KJ Baisley
- KJ Linthicum
- KJ Linthicum
- KS Abdel-Wahab
- KT McKee Jr
- L Epelboin
- L Nicoletti
- L Santos
- L Schrire
- L Zhang
- L Zhao
- LJ Strausbaugh
- LK Mcmullan
- LL Cheng
- LL Rodriguez
- LW Laughlin
- M Al-Hazmi
- M Ayoub
- M Ferres
- M Hemmersbach-Miller
- M Hukic
- M Imam El
- M Mardani
- M Portolani
- M Rusu
- M Salib
- M Valassina
- M Weidmann
- MA Darwish
- MB Sherman
- MC Livonesi
- MD Bowen
- ME Piper
- MF Saeed
- MF Saeed
- MF Saeed
- MG Ciufolini
- MG Ciufolini
- MG Cusi
- MJ Hewlett
- MK Borucki
- ML Moreli
- MM Olive
- MP Mouraao
- MR Nunes
- MS Bastos
- MS Ibrahim
- N May Le
- O Ergonul
- O Ergonul
- OR Causey
- P Hunter
- P Jansen Van Vuren
- P Padula
- P Verani
- P Verani
- P Verani
- P Verani
- PF Vasconcelos
- PG Chambers
- PR Pittman
- R Abu-Elyazeed
- R Daubney
- R Eitrem
- R Eitrem
- R Flick
- R Swanepoel
- R Swanepoel
- R Swanepoel
- R Swanepoel
- R Swanepoel
- R Swanepoel
- RB Tesh
- RB Tesh
- RG Endris
- RM Elliott
- RM Wells
- RN Charrel
- RN Charrel
- RS Azevedo
- RS Rust
- RW Chun
- S Garcia
- S Saidi
- S Sanbonmatsu-Gamez
- S Sanbonmatsu-Gamez
- S Won
- SA Kamal
- SA Maar
- SR Gerrard
- SS Kahlon
- SS Karti
- ST Nichol
- T Briese
- T Francis
- T Kitamura
- T Shoemaker
- TA Madani
- TF Tsai
- TG Popova
- TJ Hart
- TM Yuill
- VR Nerurkar
- W Yassin
- WH Thompson
- WK Reisen
- WM Hammon
- WW Henderson
- X Collao
- X Lamballerie De
- X Shi
- XJ Yu
- Y Liu
- Y Sun
- YA Myasnikov
- YZ Zhang
- YZ Zhang
- Z Gai
- Z Kocak Tufan
- ZT Gai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott TEF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdelaal SA
- Abdeldayem H
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- Abellan M
- Abosamak NE
- Abou Chaar MK
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Za'nouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf S
- Acebes Garcia F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina M
- Adamoli L
- Addae-Boateng E
- Ademuyiwa AO
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal A
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmed NR
- Ahmeidat A
- Ahn JH
- Aiken T
- Aime A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akilli H
- Akin E
- Akkour K
- Akkulak M
- Akmenkalne L
- Al Abdallah M
- Al Abdel S
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
- Al-Habib A
- Al-Habsi R
- Al-Ishaq Z
- Al-Khayal K
- Al-Masri M
- Al-Mohammad A
- Al-mukhtar A
- Al-Najjar H
- Al-omishy H
- Al-Sarireh B
- Al-Tamimi Y
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko F
- Alam F
- Alam N
- Alam R
- Alameer E
- Alamri A
- Alamri A
- Alanbuki A
- Alatar A
- Alawneh F
- Alazawi D
- Albertsmeier M
- Albertsmeiers M
- Albi Martin B
- Alburakan A
- Alcaide Matas F
- Alconchel F
- Aldayri Z
- Aldecoa Ansorregui I
- Alderson D
- Aldokali N
- Aleksic L
- Alemanno G
- Alexoudi V
- Alfaro-Goldaracena A
- Alfieri S
- Alga A
- Alghamdi M
- Alhalal H
- Alhamed A
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- Alobeed O
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- Alzamanan M
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- Zafar SN
- Zakai D
- Zakaria AD
- Zakaria R
- Zakaria Z
- Zambelli MF
- Zambon M
- Zamora L
- Zamvar V
- Zani S
- Zanotti S
- Zanus G
- Zapardiel I
- Zarabini AG
- Zatecky J
- Zegarac M
- Zelic M
- Zeller N
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zivanovic M
- Zivkovic M
- Zizzo M
- Zografos C
- Zonta S
- Zorrilla Ortuzar J
- Zourntou S
- Zouzoulas D
- Zubaidi A
- Zullo A
- Publication venue
- Br J Surg
- Publication date
- 11/11/2020
- Field of study
BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; Pâ=â0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
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- Aambakk MB
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- Abdel-Latief A
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- Aboufakher R
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- Wiviott Stephen D.
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- Zimmerman T
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- Zughaib M
- Zuidgeest JA
- Zuppiroli A
- Zwart PA
- Zweiker R
- Ă ngman K
- Ădes I
- Ăstberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit
A review on the occurrence of companion vector-borne diseases in pet animals in Latin America
- Author
- A Barbabosa-Pliego
- A Barrantes-GonzĂĄlez
- A Belli
- A Canese
- A Chikweto
- A Chikweto
- A Criado-Fornelio
- A Donnio
- A Drut
- A Falqueto
- A Herrer
- A Herrer
- A Herrer
- A Herrer
- A Humar
- A Kent
- A Lai
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- A LĂłpez-CĂ©spedes
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- A Moreira-Soto
- A Pinter
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- A Rassi
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- C Fernandez
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- C Genchi
- C Hermosilla
- C Kalogeropoulos
- C Lamas
- C Medici Olaso
- C Nieto-Sanchez
- C Pesquera
- C Ponce
- C PĂ©rez
- C PĂ©rez Vera
- C Reis
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- C Vieira
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- K Abarca
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- World Health Organization (WHO). The global burden of disease
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