Vulvitis química cáustica

La patología vulvar representa y refleja un significativo número de procesos gnósicos de variada etiología.Si bien los más prevalentes están vinculados a la infectología del tracto genital inferior no son menos significativos los referidos a procesos químicos y tumorales.La edad representa expresiones según las crisis vitales de la mujer dado que desde la infancia a la senectud debe considerarse la incidencia de patologías acordes a las mismas.Facultad de Ciencias Médica

Vulvitis química cáustica

La patología vulvar representa y refleja un significativo número de procesos gnósicos de variada etiología.Si bien los más prevalentes están vinculados a la infectología del tracto genital inferior no son menos significativos los referidos a procesos químicos y tumorales.La edad representa expresiones según las crisis vitales de la mujer dado que desde la infancia a la senectud debe considerarse la incidencia de patologías acordes a las mismas.Facultad de Ciencias Médica

Cáncer de cuello uterino en edad avanzada

La presencia del carcinoma de cuello uterino en mujeres en edad avanzada representa progresivamente un problema de salud pública que requiere la atención y reflexión de los profesionales del equipo de salud,habida cuenta que su prevalencia se incrementa y la respuesta en materia de políticas de salud debe expresarse más enfáticamente a efectos de ofrecer programas de inclusión epidemiológica.Facultad de Ciencias Médica

Cáncer de cuello uterino en edad avanzada

La presencia del carcinoma de cuello uterino en mujeres en edad avanzada representa progresivamente un problema de salud pública que requiere la atención y reflexión de los profesionales del equipo de salud,habida cuenta que su prevalencia se incrementa y la respuesta en materia de políticas de salud debe expresarse más enfáticamente a efectos de ofrecer programas de inclusión epidemiológica.Facultad de Ciencias Médica

Depósito y caracterización de recubrimientos cerámicos de Al2o3 sobre acero 1020 por termorrociado

RESUMEN: Se determinaron los parámetros necesarios para la elaboración de recubrimientos de , sobre aceros AISI 1020, utilizando como mecanismo de anclaje entre el sustrato y el cerámico una aleación a base de Ni, los polvos utilizados fueron comerciales y el método de deposición por aspersión con llama oxiacetilénica. Los revestimientos se analizaron por EDS (espectroscopía de dispersión de energías, SEM (microscopía electrónica de barrido), OM (microscopía óptica), la adherencia se cuantificó bajo la norma ASTM C633-08. Los parámetros obtenidos para la proyección de Ni son apropiados ya que producen recubrimientos uniformes con baja porosidad cerrada. Los parámetros para la proyección de la alúmina deben revisarse ya que el recubrimiento obtenido es poco uniforme, poroso y de espesor irregular, esto se debe al alto punto de fusión de la alúmina y a la amplia distribución en la granulometría del polvo. Las pruebas de adhesión dejan ver una buena adhesión entre el sustrato y la aleación de Ni, pero se observa una falla adhesiva entre la alúmina y la capa de Ni.ABSTRACT: This paper discuses about the required parameters to fabricate coatings Al2O3, on AISI 1020 steels by thermal spray, using as anchoring mechanism between the substrate and the ceramic an alloy based , powders were commercial, and spraying with oxyacetylene flame were the deposition method used. The coatings were analyzed by EDS (energy dispersive spectroscopy, SEM (scanning electron microscopy), OM (optical microscopy), and the adhesion was measured under the ASTM C633-08 standard. The obtained parameters for the Ni projection are suitable because they produce uniform coatings with low closed porosity. The parameters for the projection of the alumina should be reviewed since the obtained coating is not uniform, it has porous and irregular thickness, this is due to the high melting point of alumina and to the wide distribution in the powder granulometry. The results show a good adhesion between the substrate and the Ni alloy, but an adhesive failure between the alumina and the Ni layer

Antigen production after latency reversal and expression of inhibitory receptors in CD8+ T cells limit the killing of HIV-1 reactivated cells

The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently, fundamental questions concerning the limitations of the recognition and killing of LRA-reactivated cells by effector cells such as CD8+ T cells remain to be answered. Here, we developed a novel experimental framework where we combine the use of cytotoxic CD8+ T-cell lines and ex vivo CD8+ T cells from HIV-1-infected individuals with functional assays of LRA-inducible reactivation to delineate immune barriers to clear the reservoir. Our results demonstrate the potential for early recognition and killing of reactivated cells by CD8+ T cells. However, the potency of LRAs when crossing the barrier for antigen presentation in target cells, together with the lack of expression of inhibitory receptors in CD8+ T cells, are critical events to maximize the speed of recognition and the magnitude of the killing of LRA-inducible provirus. Taken together, our findings highlight direct limitations in LRA potency and CD8+ T cell functional status to succeed in the cure of HIV-1 infection

Comparative study of the use of Doxycycline and Oxytetracycline to treat Anaplasmosis in fattening lambss

Lamb icteric carcasses condemnation due to Anaplasma ovis is causing relevant economic losses. A comparative study was developed on the effects of different antibiotics to treat ovine anaplasmosis in fattening lambs. A total of 100 A. ovis naturally infected lambs were selected and randomly divided into four groups of 25 lambs: Group ID, treated with injectable doxycycline; Group OD, oral doxycycline; Group O, injectable oxytetracycline; and Group C, untreated animals for the control group. Clinical, haematological, and molecular analyses were performed before the treatment and 12 and 45 days after the beginning of the treatments, and carcass condemnation was followed after slaughter. The A. ovis bacterial load was high before the treatments in the four groups and decreased significantly 45 days after treatment in the ID and O Groups (p < 0.001). The parameters that were related to haemolysis showed similar results. At the abattoir, 15 out of the 47 examined carcasses were condemned; 7 of C Group, 6 of OD Group, 2 of O Group, and 0 of ID Group. It can be concluded that injectable doxycycline and oxytetracycline significantly reduce A. ovis bacterial load in blood and carcass condemnation at the abattoir. Further studies are needed in order to confirm these encouraging findings

Mental impact of Covid-19 among Spanish healthcare workers. A large longitudinal survey

Aims: Longitudinal data on the mental health impact of the coronavirus disease 2019 (Covid-19) pandemic in healthcare workers is limited. We estimated prevalence, incidence and persistence of probable mental disorders in a cohort of Spanish healthcare workers (Covid-19 waves 1 and 2) -and identified associated risk factors. Methods: 8996 healthcare workers evaluated on 5 May-7 September 2020 (baseline) were invited to a second web-based survey (October-December 2020). Major depressive disorder (PHQ-8 ≥ 10), generalised anxiety disorder (GAD-7 ≥ 10), panic attacks, post-traumatic stress disorder (PCL-5 ≥ 7), and alcohol use disorder (CAGE-AID ≥ 2) were assessed. Distal (pre-pandemic) and proximal (pandemic) risk factors were included. We estimated the incidence of probable mental disorders (among those without disorders at baseline) and persistence (among those with disorders at baseline). Logistic regression of individual-level [odds ratios (OR)] and population-level (population attributable risk proportions) associations were estimated, adjusting by all distal risk factors, health care centre and time of baseline interview. Results: 4809 healthcare workers participated at four months follow-up (cooperation rate = 65.7%; mean = 120 days s.d. = 22 days from baseline assessment). Follow-up prevalence of any disorder was 41.5%, (v. 45.4% at baseline, p < 0.001); incidence, 19.7% (s.e. = 1.6) and persistence, 67.7% (s.e. = 2.3). Proximal factors showing significant bivariate-adjusted associations with incidence included: work-related factors [prioritising Covid-19 patients (OR = 1.62)], stress factors [personal health-related stress (OR = 1.61)], interpersonal stress (OR = 1.53) and financial factors [significant income loss (OR = 1.37)]. Risk factors associated with persistence were largely similar. Conclusions: Our study indicates that the prevalence of probable mental disorders among Spanish healthcare workers during the second wave of the Covid-19 pandemic was similarly high to that after the first wave. This was in good part due to the persistence of mental disorders detected at the baseline, but with a relevant incidence of about 1 in 5 of HCWs without mental disorders during the first wave of the Covid-19 pandemic. Health-related factors, work-related factors and interpersonal stress are important risks of persistence of mental disorders and of incidence of mental disorders. Adequately addressing these factors might have prevented a considerable amount of mental health impact of the pandemic among this vulnerable population. Addressing health-related stress, work-related factors and interpersonal stress might reduce the prevalence of these disorders substantially. Study registration number: NCT04556565.Instituto de Salud Carlos III/ Ministerio de Ciencia e Innovación/ FEDER (J. A., grant number COV20/00711); Project “PI17/00521”, funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, PERIS, Health Dpt, Generaliat de Catalunya (I. A., grant number SLT017/20/000009); ISCIII-FSE+, Miguel Servet (P. M., grant number CP21/00078); ISCIII-FSE, Sara Borrell (P. M., grant number CD18/00049), Generalitat de Catalunya (2017SGR452). Additional partial funding was received from the Gerencia Regional de Salud de Castilla y León (SACYL) (J. M. P. T., grant number GRS COVID 32/A/20).S

Four-month incidence of suicidal thoughts and behaviors among healthcare workers after the first wave of the Spain COVID-19 pandemic

Healthcare workers (HCW) are at high risk for suicide, yet little is known about the onset of suicidal thoughts and behaviors (STB) in this important segment of the population in conjunction with the COVID-19 pandemic. We conducted a multicenter, prospective cohort study of Spanish HCW active during the COVID-9 pandemic. A total of n = 4809 HCW participated at baseline (May-September 2020; i.e., just after the first wave of the pandemic) and at a four-month follow-up assessment (October-December 2020) using web-based surveys. Logistic regression assessed the individual- and population-level associations of separate proximal (pandemic) risk factors with four-month STB incidence (i.e., 30-day STB among HCW negative for 30-day STB at baseline), each time adjusting for distal (pre-pandemic) factors. STB incidence was estimated at 4.2% (SE = 0.5; n = 1 suicide attempt). Adjusted for distal factors, proximal risk factors most strongly associated with STB incidence were various sources of interpersonal stress (scaled 0-4; odds ratio [OR] range = 1.23-1.57) followed by personal health-related stress and stress related to the health of loved ones (scaled 0-4; OR range 1.30-1.32), and the perceived lack of healthcare center preparedness (scaled 0-4; OR = 1.34). Population-attributable risk proportions for these proximal risk factors were in the range 45.3-57.6%. Other significant risk factors were financial stressors (OR range 1.26-1.81), isolation/quarantine due to COVID-19 (OR = 1.53) and having changed to a specific COVID-19 related work location (OR = 1.72). Among other interventions, our findings call for healthcare systems to implement adequate conflict communication and resolution strategies and to improve family-work balance embedded in organizational justice strategies.This work was supported by grants from the Instituto de Salud Carlos III (ISCIII)/Ministerio de Ciencia e Innovación/FEDER, Spain (Jordi Alonso, grant number COV20/00711); ISCIII-FEDER, Spain (Jordi Alonso, grant number PI17/00521); ISCIII-FSE, Spain: Sara Borrell and Miguel Servet grants (Philippe Mortier, grant number CD18/00049 and CP21/00078); Generalitat de Catalunya, Spain (2017SGR452); and PERIS, Departament de Salut, Spain (Itxaso Alayo; SLT017/20/000009). Additional partial funding was received from the Gerencia Regional de Salud de Castilla y León (SACYL), Spain (José María Pelayo Terán, grant number GRS COVID 32/A/20).S