Transformações no mundo laboral e novos desafios do sindicalismo português

O problema da transformação das relações laborais tem necessariamente de ser discutido à luz do actual contexto de globalização económica para que se compreendam as consequências deste processo para o movimento sindical e os novos desafios que este tem hoje pela frente. Como se sabe, a economia mundial assentou desde sempre em múltiplos desequilíbrios entre centros e periferias. Mas, hoje, os contrastes entre pólos de desenvolvimento e zonas de exclusão e de miséria não só assumem contornos ..

Sindicalismo e relações laborais

Ao organizarmos um número temático da Revista Crítica de Ciências Sociais em torno das questões do sindicalismo e das relações laborais, partimos de dois pressupostos: primeiro, que o mundo do trabalho é hoje atravessado por uma profunda metamorfose; segundo, que, apesar da profundidade dessa mudança, o mundo global deste início de milénio está a assistir a um ressurgimento dos problemas laborais. A intensidade das transformações sociais na esfera produtiva é de tal ordem que muitos dos conce..

Sindicalismo e relações laborais

Ao organizarmos um número temático da Revista Crítica de Ciências Sociais em torno das questões do sindicalismo e das relações laborais, partimos de dois pressupostos: primeiro, que o mundo do trabalho é hoje atravessado por uma profunda metamorfose; segundo, que, apesar da profundidade dessa mudança, o mundo global deste início de milénio está a assistir a um ressurgimento dos problemas laborais. A intensidade das transformações sociais na esfera produtiva é de tal ordem que muitos dos conce..

Elderly Centered Design for Interaction – The Case of the S4S Medication Assistant

AbstractSeveral aspects of older adults’ life can benefit from recent technological developments, but success in harnessing this potential depends on careful design and accessible, easy to use products. Design and development must be centered on the elderly and adequately consider interaction. In this paper we follow this design approach and put it to the test in developing a concrete application, aimed to contribute to lower the high levels of non-adherence to medication in the elderly population. The “Medication Assistant” application was developed following an iterative method centered, from the start, on the elderly and interaction design. The method repeats short-time development cycles integrating definition of scenarios and goals, requirements engineering, design, prototyping and evaluation. Evaluation, by end-users, of the increasingly refined prototypes, is a key characteristic of the method. The evaluation results provide information related to strengths and weaknesses of the application and yield suggestions regarding changes and improvements, valuable support further development. Results regarding evaluation of the second prototype of “Medication Assistant” are presented

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

© The Author(s) 2022 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demonstrate that CRC diversity is forged by asynchronous forms of molecular alterations, where mutational and chromosomal instability collectively boost CRC genetic and microenvironment intra-tumor heterogeneity. We were able to depict predictor signatures of cancer-related genes that can foresee heterogeneity levels across the different tumor consensus molecular subtypes (CMS) and primary tumor location. Finally, we show that high genetic and microenvironment heterogeneity are associated with lower metastatic potential, whereas late-emerging copy number variations favor metastasis development and polyclonal seeding. This study provides an exhaustive portrait of the interplay between genetic and microenvironment intra-tumor heterogeneity across CMS subtypes, depicting molecular events with predictive value of CRC progression and metastasis development.This work was financed by national funds from FCT - Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences - UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy - i4HB. This research was also funded by: PTDC/MED-ONC/28660/2017 from Fundação para a Ciência e Tecnologia (FCT) to A.R.G. A.R.G is recipient of Researcher Grant CEECIND/02699/2017 from FCT. The biobanking of CRC samples from Hospital Santa Maria, Lisbon, Portugal was supported by FCT research grant PIC/IC/82821/2007. This work was produced with the support of INCD funded by FCT and FEDER under the project 22153-01/SAICT/2016.info:eu-repo/semantics/publishedVersio

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Trabalho procura justiça : a resolução dos conflitos laborais na sociedade portuguesa

Tese de doutoramento em Sociologia (Sociologia do Estado do Direito e da Administração) apresentada à Faculdade de Economia da Universidade de Coimbr

O Estado e a resolução dos conflitos de trabalho

O presente artigo debruça-se sobre o papel central desempenhado pelo Estado na resolução dos conflitos colectivos de trabalho emergentes da negociação colectiva. Partindo-se dos instrumentos de resolução dos conflitos - conciliação, mediação, arbitragem e portarias de regulamentação de trabalho - procura-se caracterizar a lógica de actuação do Estado e dos parceiros sociais face a esses mesmos mecanismos. Concluí-se pelo contraste entre os modelos que regulam a macro-concertação e a negociação colectiva