Circularity and life cycle environmental impact assessment of batteries for electric vehicles: Industrial challenges, best practices and research guidelines

Circular economy (CE) strategies, aimed at reducing resource consumption and waste generation, can help mitigate the environmental impacts of battery electric vehicles (BEV), thereby providing a more efficient alternative to petrol-fuelled vehicles. Lithium-ion batteries (LIB) are commonly used in BEV because of their higher performance than that of the benchmarks. However, how to analyse the CE innovations through life-cycle assessment (LCA) and how environmental savings relate to different CE strategies remain unclear. Therefore, the purpose of this study was to i) identify and characterise the CE strategies most studied thus far in LCA studies on electric vehicle batteries, ii) evaluate the reasons behind the variability in the environmental impacts and savings between LIB with different chemistries, and iii) provide guidelines for the development of robust LCA studies for LIB by integrating CE management scenarios. The results showed that LCA-supported CE strategies have not been sufficiently explored in the literature, causing variability in methodological choices and research outcomes. While battery recycling was a dominant topic contemplated in 80% of the analysed LCA studies, other CE strategies, such as battery upgrading or remanufacturing, received little attention. The normalised impacts for LIB varied from 4400 kg CO2 eq. to 55,000 kg CO2 eq. based on several factors subject to the practitioners’ choices, such as the battery chemistry considered, impact assessment method applied, available inventories used, and the CE scenario analysed. LCA methodological guidelines for determining the environmental sustainability of the CE strategies for electric vehicle batteries were provided based on the findings

Exploring the applicability of circular design criteria for electric vehicle batteries

Battery electric vehicles (BEVs) represent a promising solution to mitigate carbon emissions by road transportation. However, life cycle assessment (LCA) studies on BEVs have demonstrated that batteries are responsible for around 30% of the vehicle’s environmental impacts. Therefore, the integration of circular economy (CE) criteria in battery design and life cycle management is key to improve resource efficiency and environmental sustainability. Nevertheless, literature analysing the implementation of CE design criteria in BEVs´ battery development is scarce. Focusing on Li-ion batteries (LIB) for BEVs, this paper examines the potential for implementation of life cycle-based CE design criteria. Accordingly, a CE design assessment tool, including a list of 53 relevant design criteria gathered from the literature, industrial practice and EU legislation, with application to BEVs´ batteries, was shared with industrial stakeholders from the H2020 LIBERTY project (LC-BAT-10-2020 No. 963522) to receive feedback. The industrial stakeholders were asked to evaluate the potential implementation of each CE design criteria based on the relationship between importance and viability by providing scores from 0% to 94%.The results indicate that the most important CE design criteria are related to the manufacturing stage of LIBs, including innovations oriented to increase the performance and quality of the final product by anticipating to new legislation requirements, including resource and environmental aspects, for BEVs. On the other hand, design criteria related to the end of life (EOL) management of LIBs show low implementation potential due to low viability scores. The benefits of considering CE design criteria in LIB development are discussed as well as the potential trade-offs in order to support well-informed decision-making. This includes an analysis of the causes for the low score for some CE design criteria and the opportunities to improve their implementation potential to increase the resource efficiency and environmental performance of BEVs´ LIBs

Twitter e información política en la prensa digital: la red social como fuente de declaraciones en la era Trump

[ES] A través del análisis de contenido de una muestra de artículos de The New York Times publicados durante el primer año de legislatura del presidente de EUA, Donald Trump, la presente investigación cuantifica el número de veces que declaraciones realizadas a través de Twitter son utilizadas como fuente por los periodistas. Los resultados apuntan a que la red social se ha legitimado ya como fuente periodística en la prensa digital de referencia y de la información política, más allá de contextos electorales. El estudio contribuye a profundizar en los cambios que la red social ha introducido en el uso de fuentes periodísticas en el ámbito de las hard news.[EN] Based on a sample of articles published by The New York Times in 2017 covering three important political issues, this research quantifies the number of tweets that end being used as journalistic sources. With the president of the United States, Donald Trump, as the main protagonist, the results point to the fact that Twitter statements are consolidated as a content used on a recurring basis also in the most reliable media. In this way, the study contributes to deepen into the changes that the social network has introduced in the use of journalistic sources in the field of hard news.Justel-Vázquez, S.; Fernandez-Planells, A.; Victoria-Mas, M.; Lacasa-Mas, I. (2018). Twitter and political information in the main digital media: The social network as a source of statements in the Trump era. El profesional de la información. 27(5):984-992. https://doi.org/10.3145/epi.2018.sep.03S98499227

Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase.

IMP dehydrogenase(IMPDH) is an essential enzyme that catalyzes the rate-limiting step in the guanine nucleotide pathway. In eukaryotic cells, GTP binding to the regulatory domain allosterically controls the activity of IMPDH by a mechanism that is fine-tuned by post-translational modifications and enzyme polymerization. Nonetheless, the mechanisms of regulation of IMPDH in bacterial cells remain unclear. Using biochemical, structural, and evolutionary analyses, we demonstrate that, in most bacterial phyla, (p)ppGpp compete with ATP to allosterically modulate IMPDH activity by binding to a, previously unrecognized, conserved high affinity pocket within the regulatory domain. This pocket was lost during the evolution of Proteobacteria, making their IMPDHs insensitive to these alarmones. Instead, most proteobacterial IMPDHs evolved to be directly modulated by the balance between ATP and GTP that compete for the same allosteric binding site. Altogether, we demonstrate that the activity of bacterial IMPDHs is allosterically modulated by a universally conserved nucleotide-controlled conformational switch that has divergently evolved to adapt to the specific particularities of each organism. These results reconcile the reported data on the crosstalk between (p)ppGpp signaling and the guanine nucleotide biosynthetic pathway and reinforce the essential role of IMPDH allosteric regulation on bacterial GTP homeostasis.post-print540 K

Aquatic ecosystems in Byers Peninsula, Livingston Island. An Antarctic Noah’s Ark in a changing world

第6回極域科学シンポジウム[OB] 極域生物圏11月17日（火）　統計数理研究所 セミナー室1（D305

Vertical Transmission of Bacterial Eye Infections, Angola, 2011–2012

To determine transmission rates for neonatal conjunctivitis causative microorganisms in Angola, we analyzed 312 endocervical and 255 conjunctival samples from mothers and newborns, respectively, during 2011–2012. Transmission rates were 50% for Chlamydia trachomatis and Neisseria gonorrhoeae and 10.5% for Mycoplasma genitalium. Possible pathogenic effects of M. genitalium in children’s eyes are unknown

Eosinophil as a Protective Cell in S. aureus Ventilator-Associated Pneumonia

Cell counts of leukocytes subpopulations are demonstrating to have an important value in predicting outcome in severe infections. We evaluated here the render of leukogram counts to predict outcome in patients with ventilator-associated pneumonia (VAP) caused by Staphylococcus aureus. Data from patients admitted to the ICU of Hospital Clínico Universitario de Valladolid from 2006 to 2011 with diagnosis of VAP caused by S. aureus were retrospectively collected for the study (n=44). Leukocyte counts were collected at ICU admission and also at VAP diagnosis. Our results showed that nonsurvivors had significant lower eosinophil counts at VAP diagnosis. Multivariate Cox regression analysis performed by the Wald test for forward selection showed that eosinophil increments from ICU admission to VAP diagnosis and total eosinophil counts at VAP diagnosis were protective factors against mortality in the first 28 days following diagnosis: (HR [CI 95%], P): (0.996 [0.993–0.999], 0.010); (0.370 [0.180–0.750], 0.006). Patients with eosinophil counts <30 cells/mm3 at diagnosis died earlier. Eosinophil counts identified survivors: (AUROC [CI 95%], P): (0.701 [0.519–0.882], 0.042). Eosinophil behaves as a protective cell in patients with VAP caused by S. aureus

The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors

ABSTRACT Besides the well-characterized protein network involved in the replication stress response, several regulatory RNAs have been shown to play a role in this critical process. However, it has remained elusive whether they act locally at the stressed forks. Here, by investigating the RNAs localizing on chromatin upon replication stress induced by hydroxyurea, we identified a set of lncRNAs upregulated in S-phase and controlled by stress transcription factors. Among them, we demonstrate that the previously uncharacterized lncRNA lncREST (long non-coding RNA REplication STress) is transcriptionally controlled by p53 and localizes at stressed replication forks. LncREST-depleted cells experience sustained replication fork progression and accumulate un-signaled DNA damage. Under replication stress, lncREST interacts with the protein NCL and assists in engaging its interaction with RPA. The loss of lncREST is associated with a reduced NCL-RPA interaction and decreased RPA on chromatin, leading to defective replication stress signaling and accumulation of mitotic defects, resulting in apoptosis and a reduction in tumorigenic potential of cancer cells. These findings uncover the function of a lncRNA in favoring the recruitment of replication proteins to sites of DNA replication

Biomarkers-based personalized follow-up in chronic heart failure improves patient's outcomes and reduces care associate cost.

Heart failure (HF) is a major and growing medical and economic problem, with high prevalence and incidence rates worldwide. Cardiac Biomarker is emerging as a novel tool for improving management of patients with HF with a reduced left ventricular ejection fraction (HFrEF). This is a before and after interventional study, that assesses the impact of a personalized follow-up procedure for HF on patient's outcomes and care associated cost, based on a clinical model of risk stratification and personalized management according to that risk. A total of 192 patients were enrolled and studied before the intervention and again after the intervention. The primary objective was the rate of readmissions, due to a HF. Secondary outcome compared the rate of ED visits and quality of life improvement assessed by the number of patients who had reduced NYHA score. A cost-analysis was also performed on these data. Admission rates significantly decreased by 19.8% after the intervention (from 30.2 to 10.4), the total hospital admissions were reduced by 32 (from 78 to 46) and the total length of stay was reduced by 7 days (from 15 to 9 days). The rate of ED visits was reduced by 44% (from 64 to 20). Thirty-one percent of patients had an improved functional class score after the intervention, whereas only 7.8% got worse. The overall cost saving associated with the intervention was € 72,769 per patient (from € 201,189 to € 128,420) and €139,717.65 for the whole group over 1 year. A personalized follow-up of HF patients led to important outcome benefits and resulted in cost savings, mainly due to the reduction of patient hospitalization readmissions and a significant reduction of care-associated costs, suggesting that greater attention should be given to this high-risk cohort to minimize the risk of hospitalization readmissions