DOES DESIGN-BUILD (DB) OUTPERFORM CONSTRUCTION MANAGEMENT AT RISK (CMAR)? A COST AND SCHEDULE COMPARATIVE STUDY OF DB PROJECTS AND CMAR PROJECTS

Design-Build (DB) and Construction Management at Risk (CMAR) are two widely used alternative project delivery systems in the construction industry. Previous studies have found inconclusive results on which of the two has better cost and schedule performances when applied in construction projects. This study chose unit cost, change order factor, cost growth, schedule growth, and construction intensity as the metrics to measure the cost and schedule performance of both DB projects and CMAR projects. Two statistical analysis tools, Analysis of Variance and Wilcoxon Signed Rank Test, were applied to see if there is any difference between the two project delivery systems’ means of the five measurements. The test results were used to determine which project delivery system has better performance in the real world. The results showed that Design-Build is superior to Construction Management at Risk in construction intensity, while Construction Management at Risk has better performance on the change order, cost growth, and schedule growth. And there is no difference in unit cost

Evidence and modeling of turbulence bifurcation in L-mode confinement transitions on Alcator C-Mod

© 2020 Author(s). Analysis and modeling of rotation reversal hysteresis experiments show that a single turbulent bifurcation is responsible for the Linear to Saturated Ohmic Confinement (LOC/SOC) transition and concomitant intrinsic rotation reversal on Alcator C-Mod. Plasmas on either side of the reversal exhibit different toroidal rotation profiles and therefore different turbulence characteristics despite the profiles of density and temperature, which are indistinguishable within measurement uncertainty. Elements of this bifurcation are also shown to persist for auxiliary heated L-modes. The deactivation of subdominant (in the linear growth rate and contribution to heat transport) ion temperature gradient and trapped electron mode instabilities is identified as the only possible change in turbulence within a reduced quasilinear transport model across the reversal, which is consistent with the measured profiles and inferred heat and particle fluxes. Experimental constraints on a possible change from strong to weak turbulence, outside the description of the quasilinear model, are also discussed. These results indicate an explanation for the LOC/SOC transition that provides a mechanism for the hysteresis through the dynamics of subdominant modes and changes in their relative populations and does not involve a change in the most linearly unstable ion-scale drift-wave instability

Wolbachia and DNA barcoding insects: patterns, potential and problems

Wolbachia is a genus of bacterial endosymbionts that impacts the breeding systems of their hosts. Wolbachia can confuse the patterns of mitochondrial variation, including DNA barcodes, because it influences the pathways through which mitochondria are inherited. We examined the extent to which these endosymbionts are detected in routine DNA barcoding, assessed their impact upon the insect sequence divergence and identification accuracy, and considered the variation present in Wolbachia COI. Using both standard PCR assays (Wolbachia surface coding protein – wsp), and bacterial COI fragments we found evidence of Wolbachia in insect total genomic extracts created for DNA barcoding library construction. When >2 million insect COI trace files were examined on the Barcode of Life Datasystem (BOLD) Wolbachia COI was present in 0.16% of the cases. It is possible to generate Wolbachia COI using standard insect primers; however, that amplicon was never confused with the COI of the host. Wolbachia alleles recovered were predominantly Supergroup A and were broadly distributed geographically and phylogenetically. We conclude that the presence of the Wolbachia DNA in total genomic extracts made from insects is unlikely to compromise the accuracy of the DNA barcode library; in fact, the ability to query this DNA library (the database and the extracts) for endosymbionts is one of the ancillary benefits of such a large scale endeavor – for which we provide several examples. It is our conclusion that regular assays for Wolbachia presence and type can, and should, be adopted by large scale insect barcoding initiatives. While COI is one of the five multi-locus sequence typing (MLST) genes used for categorizing Wolbachia, there is limited overlap with the eukaryotic DNA barcode region

Poor sleep quality, antepartum depression and suicidal ideation among pregnant women.

To evaluate the independent and combined associations of maternal self-reported poor sleep quality and antepartum depression with suicidal ideation during the third trimester METHODS: A cross-sectional study was conducted among 1298 pregnant women (between 24 and 28 gestational weeks) attending prenatal clinics in Lima, Peru. Antepartum depression and suicidal ideation were assessed using the Patient Health Questionnaire-9 (PHQ-9). The Pittsburgh Sleep Quality Index (PSQI) questionnaire was used to assess sleep quality. Multivariate logistical regression procedures were used to estimate odds ratios (OR) and 95% confidence intervals (95% CI) after adjusting for putative confounders. Approximately, 17% of women were classified as having poor sleep quality (defined using the recommended criteria of PSQI global score of >5 vs. ≤5). Further, the prevalence of antepartum depression and suicidal ideation were 10.3% and 8.5%, respectively in this cohort. After adjusting for confounders including depression, poor sleep quality was associated with a 2.81-fold increased odds of suicidal ideation (OR=2.81; 95% CI 1.78-4.45). When assessed as a continuous variable, each 1-unit increase in the global PSQI score resulted in a 28% increase in odds for suicidal ideation, even after adjusting for depression (OR=1.28; 95% CI 1.15-1.41). The odds of suicidal ideation was particularly high among depressed women with poor sleep quality (OR=13.56 95% CI 7.53-24.41) as compared with women without either risk factor. This cross-sectional study utilized self-reported data. Causality cannot be inferred, and results may not be fully generalizable. Poor sleep quality, even after adjusting for depression, is associated with antepartum suicidal ideation. Our findings support the need to explore sleep-focused interventions for pregnant women

Elementos para el debate e interpretación del Buen vivir/Sumak kawsay

Resumen: Elementos para el debate e interpretación del Buen vivir/Sumak kawsay es un trabajo que reflexiona sobre el origen, historia, elementos constitutivos e interpretaciones del Buen vivir (Sumak kawsaySuma qamaña). Esta formulación de pensamiento que logró desarrollarse en los países andinos, particularmente en Ecuador y Bolivia; plasmarse en sus respectivas constituciones (Ecuador 2008 y Bolivia 2009) y convertirse en una propuesta que desde América Latina cada día adquiere mayor trascendencia, y poco a poco se convierte en un tema de reflexión universal. Estudiamos sus elementos esenciales y las diversas interpretaciones que hasta el momento se han formulado, incorporando elementos que desde pueblos originarios de diversas latitudes enriquecen el concepto. Por tratarse de no solo de una propuesta filosófico-política, sino de una cosmovisión general que articula las constituciones referidas, con sus implicaciones, estudiamos el Buen vivir en la Constitución Ecuatoriana de 2008 y hacemos un esfuerzo por descender hasta niveles más concretos como las políticas migratorias del gobierno ecuatoriano en el marco del concepto antedicho. Finalmente, incorporamos a vista de pájaro, algunos elementos coincidentes, como la visión del pueblo Jñatjo, del Municipio de San Felipe del Progreso en el Estado de México. Este trabajo tiene como finalidad contribuir al debate y difusión de un tema de trascendencia y actualidad, que por diversos motivos se desconoce grandemente en México y otros países de la región, aunque poco a poco se va convirtiendo en un tópico de su interés

Strong and radiative decays of X(3872) as a hadronic molecule with a negative parity

Properties of X(3872) are studied by regarding it as a $DD^{\ast}$ hadronic molecule with $J^{PC} = 2^{-+}$ in the phenomenological Lagrangian approach. We find that our model with about 97.6% isospin zero component explains the existing data nicely, for example, the ratio $\mathcal{B}(X(3872) \to J/\psi\pi^+\pi^-\pi^0)/\mathcal{B}(X(3872) \to J/\psi\pi^+\pi^-)$. We predict the partial widths of the radiative decays of $X(3872) \to \gamma J/\psi$, $\gamma \psi(2S)$ and the strong decays of $X(3872) \to J/\psi \pi^+ \pi^-$, $J/\psi \pi^+\pi^-\pi^0$ as well as $X(3872) \to \chi_{cJ}\pi^0$. Our analysis shows that the measurement of the ratio $\mathcal{B}(X(3872) \to \chi_{c0}\pi^0)/\mathcal{B}(X(3872) \to \chi_{c1}\pi^0)$ may signal the nature of X(3872)

DNA repair: Disorders

No description supplie

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinicopathologic-based nosology is the assumption that pathologic protein aggregation at autopsy reflects pathogenesis at disease onset. While these aggregates may in exceptional cases be on a causal pathway in humans (e.g., aggregated α-synuclein in SNCA gene multiplication or aggregated β-amyloid in APP mutations), their near universality at postmortem in sporadic PD and AD suggests they may alternatively represent common outcomes from upstream mechanisms or compensatory responses to cellular stress in order to delay cell death. These 3 conceptual frameworks of protein aggregation (pathogenic, epiphenomenon, protective) are difficult to resolve because of the inability to probe brain tissue in real time. Whereas animal models, in which neither PD nor AD occur in natural states, consistently support a pathogenic role of protein aggregation, indirect evidence from human studies does not. We hypothesize that (1) current biomarkers of protein aggregates may be relevant to common pathology but not to subgroup pathogenesis and (2) disease-modifying treatments targeting oligomers or fibrils might be futile or deleterious because these proteins are epiphenomena or protective in the human brain under molecular stress. Future precision medicine efforts for molecular targeting of neurodegenerative diseases may require analyses not anchored on current clinicopathologic criteria but instead on biological signals generated from large deeply phenotyped aging populations or from smaller but well-defined genetic-molecular cohorts

Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009

BACKGROUND: In highly populated African urban areas where access to clean water is a challenge, water source contamination is one of the most cited risk factors in a cholera epidemic. During the rainy season, where there is either no sewage disposal or working sewer system, runoff of rains follows the slopes and gets into the lower parts of towns where shallow wells could easily become contaminated by excretes. In cholera endemic areas, spatial information about topographical elevation could help to guide preventive interventions. This study aims to analyze the association between topographic elevation and the distribution of cholera cases in Harare during the cholera epidemic in 2008 and 2009. METHODS: We developed an ecological study using secondary data. First, we described attack rates by suburb and then calculated rate ratios using whole Harare as reference. We illustrated the average elevation and cholera cases by suburbs using geographical information. Finally, we estimated a generalized linear mixed model (under the assumption of a Poisson distribution) with an Empirical Bayesian approach to model the relation between the risk of cholera and the elevation in meters in Harare. We used a random intercept to allow for spatial correlation of neighboring suburbs. RESULTS: This study identifies a spatial pattern of the distribution of cholera cases in the Harare epidemic, characterized by a lower cholera risk in the highest elevation suburbs of Harare. The generalized linear mixed model showed that for each 100 meters of increase in the topographical elevation, the cholera risk was 30% lower with a rate ratio of 0.70 (95% confidence interval=0.66-0.76). Sensitivity analysis confirmed the risk reduction with an overall estimate of the rate ratio between 20% and 40%. CONCLUSION: This study highlights the importance of considering topographical elevation as a geographical and environmental risk factor in order to plan cholera preventive activities linked with water and sanitation in endemic areas. Furthermore, elevation information, among other risk factors, could help to spatially orientate cholera control interventions during an epidemic