Shedding light on the taxonomic diversity of the south american miocene caimans: the status of Melanosuchus fisheri (Crocodylia, Alligatoroidea)

Melanosuchus niger Spix is distributed throughout the Amazon River basin today. The extinct Melanosuchus fisheri Medina from the late Miocene of Venezuela was erected based on two almost complete, but heavily deformed skulls (the holotype MCNC 243 and the referred specimen MCZ 4336), which show morphological differences from each other. The comparison indicates that only the holotype can be referred to Melanosuchus Gray. We propose MCZ 4336 is a representative of the caimanine Globidentosuchus brachyrostris Scheyer, Aguilera, Delfino, Fortier, Carlini, Sánchez, Carrillo-Briceño, Quiroz and Sãnchez-Villagra. Although the taxonomy of M. fisheri is taken into question herein, the classification of the holotype still sustains the hypothesis that the genus is registered in South America since the late Miocene

Propofol induce higher amnesic effect than sevoflurane and isoflurane anaesthesia in the rat

Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Las representaciones de las amenazas a la biodiversidad en el cine de animación: implicaciones para su enseñanza en la Educación Primaria

La crisis de biodiversidad por la que atraviesa el planeta forma parte de la crisis global social, económica y ambiental en la que estamos inmersos. La pérdida de biodiversidad tiene efectos no solo sobre las especies, también sobre los ecosistemas y los servicios ecosistémicos de los que dependemos. Por ello es necesario adoptar medidas para detener esta grave pérdida. La educación puede ser una vía complementaria a la gestión y la conservación, pero se requieren estrategias innovadoras para incorporar ciertos contenidos socioambientales al aula. El cine animado puede llevar contenidos y valores proambientales a la escuela. Para determinar si este tipo de cine puede mostrar las graves amenazas que pesan sobre la biodiversidad se plantea la presente investigación. Por ello se realiza una selección de películas de animación y mediante un análisis de contenido se obtienen resultados que indican que, en la muestra analizada se encuentran representados, aunque con distintas frecuencias, todos los grandes problemas que tiene la biodiversidad. Esto nos invita a pensar que el uso de este tipo de cine, previa selección adecuada, puede introducir estos importantes conceptos en el aula y contribuir a la adquisición de contenidos y valores proambientales.The biodiversity crisis that the planet is going through is part of the global social, economic and envi-ronmental crisis in which we are immersed. Biodiversity loss has effects not only on species, but also on the ecosystems and ecosystem services on which we depend. It is necessary to take measures to stop this serious loss. Education can be a complementary way to those of management and conservation, but in-novative strategies are required to incorporate certain socio-environmental content into the classroom. Animated cinema can bring pro-environmental content and values to school. The present research is proposed to determine if this type of cinema can show the serious threats of biodiversity. For this reason, a number of animated films is selected. A content analysis is carried out and the results indicate that, in the analyzed sample, all the great problems that biodiversity has are represented, although in different frequencies. This invites us to think that the use of this type of cinema, after appropriate selection, can introduce these important concepts in the classroom and contribute to the acquisition of pro-environmental content and values

Cognitive Performance and Morning Levels of Salivary Cortisol and α-Amylase in Children Reporting High vs. Low Daily Stress Perception

The aim of the present study was to assess the effects of daily stress perception on cognitive performance and morning basal salivary cortisol and alpha-amylase levels in healthy children aged 9-12. Participants were classified by whether they had low daily perceived stress (LPS, n = 27) or a high daily perceived stress (HPS, n = 26) using the Children Daily Stress Inventory (CDSI). Salivary cortisol and alpha-amylase were measured at awakening and 30 minutes later. Cognitive performance was assessed using the Cognitive Drug Research assessment system. The HPS group exhibited significantly poorer scores on speed of memory (p < .05) and continuity of attention (p < .05) relative to the LPS group. The HPS group also showed significantly lower morning cortisol levels at awakening and at +30 minutes measures in comparison with the LPS group (p < .05), and mean morning cortisol levels were negatively correlated with speed of memory (p < .05) in the 53 participants. No significant differences were observed between both groups in alpha-amylase levels. These findings suggest that daily perceived stress in children may impoverish cognitive performance via its modulating effects on the HPA axis activit

Language Barriers, Physician-Patient Language Concordance, and Glycemic Control Among Insured Latinos with Diabetes: The Diabetes Study of Northern California (DISTANCE)

BackgroundA significant proportion of US Latinos with diabetes have limited English proficiency (LEP). Whether language barriers in health care contribute to poor glycemic control is unknown.ObjectiveTo assess the association between limited English proficiency (LEP) and glycemic control and whether this association is modified by having a language-concordant physician.DesignCross-sectional, observational study using data from the 2005-2006 Diabetes Study of Northern California (DISTANCE). Patients received care in a managed care setting with interpreter services and self-reported their English language ability and the Spanish language ability of their physician. Outcome was poor glycemic control (glycosylated hemoglobin A1c &gt; 9%).Key resultsThe unadjusted percentage of patients with poor glycemic control was similar among Latino patients with LEP (n = 510) and Latino English-speakers (n = 2,683), and higher in both groups than in whites (n = 3,545) (21% vs 18% vs. 10%, p &lt; 0.005). This relationship differed significantly by patient-provider language concordance (p &lt; 0.01 for interaction). LEP patients with language-discordant physicians (n = 115) were more likely than LEP patients with language-concordant physicians (n = 137) to have poor glycemic control (27.8% vs 16.1% p = 0.02). After controlling for potential demographic and clinical confounders, LEP Latinos with language-concordant physicians had similar odds of poor glycemic control as Latino English speakers (OR 0.89; CI 0.53-1.49), whereas LEP Latinos with language-discordant physicians had greater odds of poor control than Latino English speakers (OR 1.76; CI 1.04-2.97). Among LEP Latinos, having a language discordant physician was associated with significantly poorer glycemic control (OR 1.98; CI 1.03-3.80).ConclusionsLanguage barriers contribute to health disparities among Latinos with diabetes. Limited English proficiency is an independent predictor for poor glycemic control among insured US Latinos with diabetes, an association not observed when care is provided by language-concordant physicians. Future research should determine if strategies to increase language-concordant care improve glycemic control among US Latinos with LEP

Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-beta-Induced Neuronal Death

Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an astrocyte-specific intracellular signaling pathway involving an interaction of the phosphatase calcineurin with the transcription factor FOXO3 is a major driver in AD-associated pathological inflammation, suggesting a potential new druggable target for this devastating disease. We have now developed decoy molecules to interfere with calcineurin/FOXO3 interactions, and tested them in astrocytes and neuronal co-cultures exposed to amyloid-beta (A beta) toxicity. We observed that interference of calcineurin/FOXO3 interactions exerts a protective action against A beta-induced neuronal death and favors the production of a set of growth factors that we hypothesize form part of a cytoprotective pathway to resolve inflammation. Furthermore, interference of the A beta-induced interaction of calcineurin with FOXO3 by decoy compounds significantly decreased amyloid-beta protein precursor (A beta PP) synthesis, reduced the A beta PP amyloidogenic pathway, resulting in lower A beta levels, and blocked the expression of pro-inflammatory cytokines TNF alpha and IL-6 in astrocytes. Collectively, these data indicate that interrupting pro-inflammatory calcineurin/FOXO3 interactions in astrocytes triggered by A beta accumulation in brain may constitute an effective new therapeutic approach in AD. Future studies with intranasal delivery, or brain barrier permeable decoy compounds, are warranted.Peer ReviewedPostprint (author's final draft

Metallofluorescent Nanoparticles for Multimodal Applications

Herein, we describe the synthesis and application of cross-linked polystyrene-based dual-function nano- and microparticles containing both fluorescent tags and metals. Despite containing a single dye, these particles exhibit a characteristic dual-band fluorescence emission. Moreover, these particles can be combined with different metal ions to obtain hybrid metallofluorescent particles. We demonstrate that these particles are easily nanofected into living cells, allowing them to be used for effective fingerprinting in multimodal fluorescence-based and mass spectrometry-based flow cytometry experiments. Likewise, the in situ reductions of the metal ions enable other potential uses of the particles as heterogeneous catalysts