Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Bellido, M Victoria

Bellido-Estevez, Inmaculada

Fernandez-Baena, M.

Garcia-Pérez, A.

Gómez-Luque, A.

English

Bellido-Estévez, Inmaculada

Bellido Estévez, María Victoria

Fernández Baena, Mariano

Repositorio Institucional Universidad de Málaga

          Propofol induce higher amnesic effect than sevoflurane and isoflurane anaesthesia in the rat.  Bellido I, Bellido MV, Fernandez-Baena M, Garcia-Perez A and Gomez-Luque A.  D. Pharmacology and Clinical Therapeutic. Medicine School. S. Anaesthesia, Carlos Haya University Hospital and Virgen de la Victoria University Hospital, Malaga, Spain.   Post-operative amnesia is frequently referred by the patients, thus determine which anaesthetics may induce more amnesic effect will provide us to select the most appropriate compound for each patient. Aim: To quantify the postoperative amnesic effects of Propofol vs. Sevoflurane vs. Isoflurane anaesthesia. Male Sprague-Dawley rats (N=42, 6 months old, weight 231±41 g, Charles River-Spain) were randomized into 7 groups (6 rats/group) which received: sham volatile (none), sham iv (saline), Propofol (PRO, induction dose 15 mg/kg-1 followed by 0,8 mg. kg-1. min-1), Sevoflurane (SEVO) and Isoflurane (ISO) groups (received 1 minimum alveolar concentration (MAC) (2% inspired concentration SEVO or ISO in oxygen/1 h, respectively), PRO-SEVO and PRO-ISO groups (received the same referred doses in association). Anaesthesia was done during 1 h. The 8 arms radial labyrinth test was done 24 h post-anaesthesia to quantify the memory function. The open-field test was used to quantify the locomotor activity.  Labyrinth test data showed a reduction of the retrograde memory in the treated groups (percentage of change vs. Sham): Increased reaction time in first accurate choice PRO+ISO +85.1% >PRO+SEVO +66.3% >PRO +60.5% =ISO +54.6% >SEVO +43.2% (p<0.05). None of the treatments affects the locomotor function (open-field test).   Conclusion: Propofol induce higher memory deficit than Sevoflurane and Isoflurane. Subvencionado: Plan Propio de la Universidad de Málaga “Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech”. 

Propofol induce higher amnesic effect than sevoflurane and isoflurane anaesthesia in the rat

https://riuma.uma.es/xmlui/bitstream/10630/5601/1/Amnesia-PRO-SEVO-ISO-murcia-2013-RIUMAx.pdf

Propofol induce higher amnesic effect than sevoflurane and isoflurane anaesthesia in the rat

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Repositorio Institucional Universidad de Málaga