Microstructures and mineral chemistry of lherzolites in mantle xenoliths from Catalonia (NE Spain)

Los xenolitos de lherzolitas con espinela en la Zona Volcánica de Cataluña muestran tres tipos principales de microestructuras: protogranulares, porfidoclásticas y equigranulares. La química de elementos mayores de los minerales indica que no hay relación composicional entre los tres tipos. Sin embargo, las tendencias del componente jadeítico en el clinopiroxeno y de la composición de la espinela sí estarían influenciadas por la deformación. Estas tendencias, junto con los datos termobarométricos, indican que las lherzolitas más deformadas se reequilibraron a menor temperatura y presión que las menos deformadas. Las microestructuras porfidoclásticas y equigranulares se originaron probablemente en relación con zonas de cizalla durante el desarrollo inicial del rift neógenoSpinel lherzolite xenoliths from the Catalan Volcanic Zone show three main types of microstructures: protogranular, porphyroclastic and equigranular. Major element chemistry of minerals suggests that there is no compositional relationship between the three types. However, the evolution of the jadeitic component of clinopyroxene on the one hand, and the spinel composition on the other hand would be related to deformation. These compositional trends along with thermobarometric data indicate that more deformed lherzolites were reequilibrated at lower temperature and pressure than the least deformed ones. Porphyroclastic and equigranular microstructures were most likely originated by shearing during the early stages of the Neogene riftin

Predicting cardiovascular disease morbidity and mortality in chronic kidney disease in Spain. The rationale and design of NEFRONA: a prospective, multicenter, observational cohort study

Background: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of traditional risk factors to fully account for the elevated CVD risk (reverse epidemiology effect) and the presence of emerging risk factors specifically related to kidney failure. Therefore, diagnostic tools capable of improving cardiovascular risk assessment beyond traditional risk factors are currently warranted. We present the protocol of a 4-year prospective study aimed to assess the predictive value of non-invasive imaging techniques and biomarkers for CVD events and mortality in patients with CKD. Methods: From November 2009 to October 2010, 4137 asymptomatic adult patients with stages 2 to 5 CKD will be recruited from nephrology services and dialysis units throughout Spain. During the same period, 843 participants without CKD (control group) will be recruited from lists of primary care physicians, only at baseline. During the follow-up, CVD events and mortality will be recorded from all CKD patients. Clinical and laboratory characteristics will be collected in a medical documentation sheet. Three trained itinerant teams will carry out a carotid ultrasound to assess intima-media thickness and presence of plaques. A composite atherosclerosis score will be constructed based on carotid ultrasound data and measurement of ankle-brachial index. In CKD patients, presence and type of calcifications will be assessed in the wall of carotid, femoral and brachial arteries, and in cardiac valves, by ultrasound. From all participants, blood samples will be collected and stored in a biobank to study novel biomarkers. Conclusions: The NEFRONA study is the first large, prospective study to examine the predictive value of several non-invasive imaging techniques and novel biomarkers in CKD patients throughout Spain. Hereby, we present the protocol of this study aimed to explore the most effective way in which these tests can be integrated with traditional risk factors to maximize CVD detection in this population

The Effect of a Physical Activity Program on the Total Number of Primary Care Visits in Inactive Patients: A 15-Month Randomized Controlled Trial

Abstract Background: Effective promotion of exercise could result in substantial savings in healthcare cost expenses in terms of direct medical costs, such as the number of medical appointments. However, this is hampered by our limited knowledge of how to achieve sustained increases in physical activity. Objectives: To assess the effectiveness of a Primary Health Care (PHC) based physical activity program in reducing the total number of visits to the healthcare center among inactive patients, over a 15-month period. Research Design: Randomized controlled trial. Subjects: Three hundred and sixty-two (n = 362) inactive patients suffering from at least one chronic condition were included. One hundred and eighty-three patients (n = 183; mean (SD); 68.3 (8.8) years; 118 women) were randomly allocated to the physical activity program (IG). One hundred and seventy-nine patients (n = 179; 67.2 (9.1) years; 106 women) were allocated to the control group (CG). The IG went through a three-month standardized physical activity program led by physical activity specialists and linked to community resources. Measures: The total number of medical appointments to the PHC, during twelve months before and after the program, was registered. Self-reported health status (SF-12 version 2) was assessed at baseline (month 0), at the end of the intervention (month 3), and at 12 months follow-up after the end of the intervention (month 15). Results: The IG had a significantly reduced number of visits during the 12 months after the intervention: 14.8 (8.5). The CG remained about the same: 18.2 (11.1) (P = .002). Conclusions: Our findings indicate that a 3-month physical activity program linked to community resources is a shortduration, effective and sustainable intervention in inactive patients to decrease rates of PHC visits. Trial Registration: ClinicalTrials.gov NCT0071483

Jornada "Experiències d'Aprenentatge Servei a la Universitat de Barcelona". Desenvolupament i experiències presentades.

La Jornada, titulada “Experiències d’Aprenentatge Servei a la Universitat de Barcelona”, te la finalitat de facilitar una reflexió conjunta sobre l’aplicació de l’ApS a la tasca docent i compartir les experiències desenvolupades a la nostra universitat. L'infome presenta el desenvolupament de la jornada i el recull dels pòsters presentats pels participants.ICE-IDP, Grup ApS (UB

Jardins per a la salut

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes botàniques de 128 espècies presents en el Jardí Ferran Soldevila de l’Edifici Històric de la UB. Els treballs han estat realitzats manera individual per part dels estudiants dels grups M-3 i T-1 de l’assignatura Botànica Farmacèutica durant els mesos de febrer a maig del curs 2014-15 com a resultat final del Projecte d’Innovació Docent «Jardins per a la salut: aprenentatge servei a Botànica farmacèutica» (codi 2014PID-UB/054). Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pels professors de l’assignatura. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica. També s’ha pretès motivar els estudiants a través del retorn de part del seu esforç a la societat a través d’una experiència d’Aprenentatge-Servei, deixant disponible finalment el treball dels estudiants per a poder ser consultable a través d’una Web pública amb la possibilitat de poder-ho fer in-situ en el propi jardí mitjançant codis QR amb un smartphone

Compartir ideas. La Universidad va al Instituto: un proyecto de aprendizaje- servicio transversal de la Universidad de Barcelona

Compartir ideas. La universidad va al instituto es un proyecto de aprendizaje servicio transversal de la Universidad de Barcelona. Este representa una propuesta de aprendizaje servicio que bajo una estructura común permite la participación de estudiantes y profesorado de distintas disciplinas en un mismo proyecto. El aprendizaje servicio (ApS) es una propuesta formativa que permite el desarrollo de diferentes tipos de aprendizajes a partir de la implicación en necesidades sociales reales con la intención de transformarlas (Tapia, 2001; Martínez, 2008; Puig, 2009). En este tipo de proyectos están presentes simultáneamente la intencionalidad pedagógica y la intencionalidad solidaria. Se pueden definir como experiencias educativas solidarias protagonizadas por estudiantes, que tienen como objetivo atender a una necesidad de los destinatarios a la vez que planificar y mejorar la calidad de los aprendizajes (Tapia, 2006)

Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure

Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups. LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted

The Bordelle metabasites and the Lousada gneisses (Lugo): a likely bimodal Pre-Hercynian association in the West- Asturian-Leonese Zone

Las metabasitas y los gneises que afloran en metasedimentos del Cámbrico Inferior, dentro de la Zona Asturoccidental-Leonesa, podrían constituir una serie ígnea bimodal pre-hercínica. Se distinguen cuatro tipos de metabasitas: metaperidotitas, esquistos anfibólico-cloríticos, anfibolitas con megacristales, y anfibolitas comunes. Los tipos más melanocráticos serían cumulados formados a partir de una toleita continental. Los ortogneises son intrusivos, leucocráticos, equivalentes a microgranitos feldespático alcalinos porfídicos, o a riolitas, metalumínicos, potásicos y de naturaleza calcoalcalina. Tanto las metabasitas como los ortogneises podrían relacionarse con un episodio magmático de distensión continental, que precedió a la apertura del Océano Rheico, durante el Paleozoico Inferior. El emplazamiento de los magmas toleíticos en la corteza inferior habría favorecido la fusión de sedimentos inmaduros, dando lugar a magmas graníticos, que se habrían intruido simultáneamente con los basaltos, en la potente serie terrígena de la zonaMetabasites and orthogneisses, which could form a pre-Hercynian bimodal igneous association, crop out within the Lower Cambrian metasediments of the West Asturian-Leonese Zone. Four types of metabasites are distinguished: metaperidotites, chlorite-amphibole schists, amphibolites with megacrystals, and common amphibolites. The most melanocratic types are interpreted as cumulates from a continental tholeiite. The orthogneisses are intrusive, leucocratic, equivalent to peraluminous and potassic porphyritic alkali feldspar microgranites or rhyolites of calc-alkaline nature. Both metabasites and orthogneisses could be related to the continental rift magmatic episode preceding the formation of the Rheic Ocean during the Lower Paleozoic. The emplacement of tholeiitic magmas at the lower crust would favoured the melting of immature sediments forming granitic magmas, which were intruded with the basalts, into a thick pile of terrigenous sediment

Predicting cardiovascular disease morbidity and mortality in chronic kidney disease in Spain. The rationale and design of NEFRONA: a prospective, multicenter, observational cohort study

Abstract Background Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of traditional risk factors to fully account for the elevated CVD risk (reverse epidemiology effect) and the presence of emerging risk factors specifically related to kidney failure. Therefore, diagnostic tools capable of improving cardiovascular risk assessment beyond traditional risk factors are currently warranted. We present the protocol of a 4-year prospective study aimed to assess the predictive value of non-invasive imaging techniques and biomarkers for CVD events and mortality in patients with CKD. Methods From November 2009 to October 2010, 4137 asymptomatic adult patients with stages 2 to 5 CKD will be recruited from nephrology services and dialysis units throughout Spain. During the same period, 843 participants without CKD (control group) will be recruited from lists of primary care physicians, only at baseline. During the follow-up, CVD events and mortality will be recorded from all CKD patients. Clinical and laboratory characteristics will be collected in a medical documentation sheet. Three trained itinerant teams will carry out a carotid ultrasound to assess intima-media thickness and presence of plaques. A composite atherosclerosis score will be constructed based on carotid ultrasound data and measurement of ankle-brachial index. In CKD patients, presence and type of calcifications will be assessed in the wall of carotid, femoral and brachial arteries, and in cardiac valves, by ultrasound. From all participants, blood samples will be collected and stored in a biobank to study novel biomarkers. Conclusions The NEFRONA study is the first large, prospective study to examine the predictive value of several non-invasive imaging techniques and novel biomarkers in CKD patients throughout Spain. Hereby, we present the protocol of this study aimed to explore the most effective way in which these tests can be integrated with traditional risk factors to maximize CVD detection in this population.</p