229 research outputs found
Lasso Estimation of an Interval-Valued Multiple Regression Model
A multiple interval-valued linear regression model considering all the
cross-relationships between the mids and spreads of the intervals has been
introduced recently. A least-squares estimation of the regression parameters
has been carried out by transforming a quadratic optimization problem with
inequality constraints into a linear complementary problem and using Lemke's
algorithm to solve it. Due to the irrelevance of certain cross-relationships,
an alternative estimation process, the LASSO (Least Absolut Shrinkage and
Selection Operator), is developed. A comparative study showing the differences
between the proposed estimators is provided
Antiferromagnetism in four dimensions: search for non-triviality
We present antiferromagnetism as a mechanism capable of modifying
substantially the phase diagram and the critical behaviour of statistical
mechanical models. This is particularly relevant in four dimensions, due to the
connection between second order transition points and the continuum limit as a
quantum field theory. We study three models with an antiferromagnetic
interaction: the Ising and the O(4) Models with a second neighbour negative
coupling, and the \RP{2} Model. Different conclusions are obtained depending
on the model.Comment: 4 pages LateX. Contribution to Lat9
Phase diagram of d=4 Ising Model with two couplings
We study the phase diagram of the four dimensional Ising model with first and
second neighbour couplings, specially in the antiferromagnetic region, by using
Mean Field and Monte Carlo methods. From the later, all the transition lines
seem to be first order except that between ferromagnetic and disordered phases
in a region including the first-neighbour Ising transition point.Comment: Latex file and 4 figures (epsfig required). It replaces the preprint
entitled "Non-classical exponents in the d=4 Ising Model with two couplings".
New analysis with more statistical data is performed. Final version to appear
in Phys. Lett.
Functional Integral Bosonization for Impurity in Luttinger Liquid
We use a functional integral formalism developed earlier for the pure
Luttinger liquid (LL) to find an exact representation for the electron Green
function of the LL in the presence of a single backscattering impurity. This
allows us to reproduce results (well known from the bosonization techniques)
for the suppression of the electron local density of states (LDoS) at the
position of the impurity and for the Friedel oscillations at finite
temperature. In addition, we have extracted from the exact representation an
analytic dependence of LDoS on the distance from the impurity and shown how it
crosses over to that for the pure LL.Comment: 7 pages, 1 LaTeX produced figur
Male breast cancer: correlation between immunohistochemical subtyping and PAM50 intrinsic subtypes, and the subsequent clinical outcomes.
Male breast cancer is a rare disease that is still poorly understood. It is mainly classified by immunohistochemistry as a luminal disease. In this study, we assess for the first time the correlation between molecular subtypes based on a validated six-marker immunohistochemical panel and PAM50 signature in male breast cancer, and the subsequent clinical outcome of these different subtypes. We collected 67 surgical specimens of invasive male breast cancer from four different Spanish pathology laboratories. Immunohistochemical staining for the six-marker panel was performed on tissue microarrays. PAM50 subtypes were determined in a research-use-only nCounter Analysis System. We explored the association of immunohistochemical and PAM50 subtypes. Overall survival and disease-free survival were analyzed in the different subtypes of each classification. The distribution of tumor molecular subtypes according PAM50 was: 60% luminal B, 30% luminal A and 10% human epidermal growth factor receptor 2 (Her2) enriched. Only one Her2-enriched tumor was also positive by immunohistochemistry and was treated with trastuzumab. None of the tumors were basal-like. Using immunohistochemical surrogates, 51% of the tumors were luminal B, 44% luminal A, 4% triple-negative and 1% Her2-positive. The clinicopathological characteristics did not differ significantly between immunohistochemical and PAM50 subtypes. We found a significant worse overall survival in Her2-enriched compared with luminal tumors. Male breast cancer seems to be mainly a genomic luminal disease with a predominance of the luminal B subtype. In addition, we found a proportion of patients with Her2-negative by immunohistochemistry but Her2-enriched profile by PAM50 tumors with a worse outcome compared with luminal subtypes that may benefit from anti-Her2 therapies.We gratefully acknowledge Nanostring Technologies team for providing the reagents for PAM50 subtypes determination as well as technical support, Maria José Lozano for her support with samples immunostaining and Jose M Roldan for the edition of the artwork. Angela Santonja has a predoctoral grant PFIS-ISCIII (FI12/00489)
Assessing sea grass meadows condition at “El Río” Special Area of Conservation off “La Graciosa e Islotes del Norte de Lanzarote” Marine Reserve
Cymodosea nodosa meadows, known as ‘sebadales’ or ‘manchones’ at Canary Islands, represent EUNIS
habitat type code A5.5311, called Macaronesian Cymodocea beds. As it’s described at European
Union Habitats Directive (92/43/CEE) Annex 1, sea grass meadows belong to 1110 Sandbanks which
are slightly covered by seawater all the time, within Natura 2000 Network.
Several ‘sebadales’ throughout the archipelago are included in this Network as Special Areas of Conservation.
Cymodosea nodosa is regionally included within the Canary Islands Protected Species List
(Ley 4/2010), as a species ‘of interest to ecosystems of Canary Islands”, is usually found at a narrow
depth range (10 to 20 m of depth) and, on the whole, best structured meadows are settled at sheltered
bays, away from wave and current beating, flimsier at exposed areas. Deeper meadows are also sparser,
being C. nodosa replaced by green algae Caulerpa prolifera and Caulerpa racemosa, although mixed
algae-sea grass meadows are often found at different depths.
The project Assessment of marine flora (‘sebadal’, ma¨erl, ‘mujo’) of ‘La Graciosa e Islotes del Norte
de Lanzarote’ Marine Reserve, funded by ‘Viceconsejer´ıa de Pesca y Aguas de la Consejer´ıa de Agricultura,
Ganader´ıa, Pesca y Aguas’, Canary Islands Government, has had the aim of assessing sea grass
meadows condition and distribution at ‘El R´ıo’ Natura 2000 Network Special Area of Conservation, the
channel between La Graciosa and Lanzarote. ‘LA GRACIOSA 1311’ cruise was performed within the
framework of the project.
First of all previous information on sea grass shallow distribution (up to a depth of 20 m) in the study
area was reviewed. Afterwards, a tugged underwater video camera was used onboard of the Marine
Reserve Surveillance Vessel to update cartographic info performing a grid of sampling stations, covering
previously known distribution limits and verifying current presence/absence data and density.
Furthermore, population parameters were obtained in order to assess ‘sebadal’ condition. Fixed stations
were selected in regards to this process, and methodology applied on them was as follows: five radial
arranged transects were performed, identifying fragmentation (it estimates meadow continuity regarding
observed cover), density (mean value of several shoots number counts with 20 x 20 cm grids placed every
2 m), height (mean value in cm of 10 independent samples by transect) and fish and macroinvertebrate
species richness for each transect.
Graphic picture of sea grass density was made depending on two levels: low density level transects (
10 shoots/grid ( 50 shoots/m2) and medium density level transects ( 10 shoots/grid ( 50 shoots/m2).
Main study result is an estimate for the study region (‘El R´ıo’) and time of year of Cymodocea nodosa
population total distribution cover which comes to 1.640.076 m2, including a higher density ‘sebadal’ of
178.256 m2
Effects of the anthropogenics pressures (marine litter) on the coastal ecosystems of the Marine Reserve “Isla de La Graciosa e islotes del norte de Lanzarote”
The European Marine Strategy Framework Directive (2008/56/EC) considers marine litter as one of its
environmental descriptors, requiring the development and standardization of criteria and methodologies
for its use to test the good environmental status of marine conditions. The assessment of the impact
caused by litter accumulation in the shoreline lacked specific monitoring planning and had not been
systematically performed to date in Canary Islands.
During the project ”Evaluation of the effect of the anthropogenic pressures (marine litter in beaches and
alteration of shallow seabed by boats anchoring) on the coastal ecosystems of the “Marine Reserve of Isla
de La Graciosa e islotes del norte de Lanzarote (MRLG)” developed with the financial help of the Canary
Islands Government (Council of Agriculture, Ranching, Fishing and Waters), two surveys were carried
out, ”LA GRACIOSA 1310” and “LA GRACIOSA 1311”, both developed at MRLG and its vicinities.
The aim has been to depict MRLG shoreline and to locate marine litter accumulation points the most,
contributing with some tools to assess and manage the coastal ecosystems of the marine reserve.
Total shoreline sampled at both surveys together was 38326 m, 1834 m at Alegranza, 1366 m at Monta˜na
Clara, 24656 m at La Graciosa Island, and the rest, 10470 m, at the Lanzarote’s shoreline portion bathed
by MRLG waters. Shoreline sampling was made qualitatively sorting the sampling stations, according
to litter presence and distribution, by means of a upward numerical coding related to the type of waste
or garbage found. Moreover, each station was additionally depicted according to the type of substrate as
well as to the prevailing type of waste, defining what we named “transects”.
To validate methodology to European standards, a more exhaustive experimental sampling was made
in four transects identified as high density or high concentration of marine litter, following guidelines
of a method developed for OSPAR maritime area during the first half of 2000 decade (OSPAR, 2007).
It involves evaluating the possibilities and needs of adjustment of this methodology to the particular
conditions of our region (Gonz´alez, et al., 2013 a and b).
As preliminary results, the spatial distribution of garbage coastal accumulation will be shown in a cartographic
base, expressed as relative abundance by island, according to a 4 degrees scale (no litter, low,
medium and high litter presence) and according to the dominant kind of garbage in each transect. An
example with one of the most densely occupied with trash transects is shown to illustrate a sampling
method without the requirement of trash collection. This method uses a sampling unit of 1x1 m grid,
divided in 10x10 cm subgrids. This grid is set parallel to sampling direction repeatedly. Distance between
grids is determined by a randomizing software. Sampling direction zigzags from sea border to
beach back shore, making 45° degrees angles. Subgrids occupied by trash are counted once the grid is
set. Waste is depict and identified following a guide developed for this purpose by OSPAR in 2010
Energy and Flux Measurements of Ultra-High Energy Cosmic Rays Observed During the First ANITA Flight
The first flight of the Antarctic Impulsive Transient Antenna (ANITA)
experiment recorded 16 radio signals that were emitted by cosmic-ray induced
air showers. For 14 of these events, this radiation was reflected from the ice.
The dominant contribution to the radiation from the deflection of positrons and
electrons in the geomagnetic field, which is beamed in the direction of motion
of the air shower. This radiation is reflected from the ice and subsequently
detected by the ANITA experiment at a flight altitude of 36km. In this paper,
we estimate the energy of the 14 individual events and find that the mean
energy of the cosmic-ray sample is 2.9 EeV. By simulating the ANITA flight, we
calculate its exposure for ultra-high energy cosmic rays. We estimate for the
first time the cosmic-ray flux derived only from radio observations. In
addition, we find that the Monte Carlo simulation of the ANITA data set is in
agreement with the total number of observed events and with the properties of
those events.Comment: Added more explanation of the experimental setup and textual
improvement
Menus for Feeding Black Holes
Black holes are the ultimate prisons of the Universe, regions of spacetime
where the enormous gravity prohibits matter or even light to escape to
infinity. Yet, matter falling toward the black holes may shine spectacularly,
generating the strongest source of radiation. These sources provide us with
astrophysical laboratories of extreme physical conditions that cannot be
realized on Earth. This chapter offers a review of the basic menus for feeding
matter onto black holes and discusses their observational implications.Comment: 27 pages. Accepted for publication in Space Science Reviews. Also to
appear in hard cover in the Space Sciences Series of ISSI "The Physics of
Accretion onto Black Holes" (Springer Publisher
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