Quantifying the radiation belt seed population in the 17 March 2013 electron acceleration event

Abstract We present phase space density (PSD) observations using data from the Magnetic Electron Ion Spectrometer instrument on the Van Allen Probes for the 17 March 2013 electron acceleration event. We confirm previous results and quantify how PSD gradients depend on the first adiabatic invariant. We find a systematic difference between the lower-energy electrons (1-MeV with a source region within the radiation belts. Our observations show that the source process begins with enhancements to the 10s-100s-keV energy seed population, followed by enhancements to the \u3e1-MeV population and eventually leading to enhancements in the multi-MeV electron population these observations provide the clearest evidence to date of the timing and nature of the radial transport of a 100s keV electron seed population into the heart of the outer belt and subsequent local acceleration of those electrons to higher radiation belt energies. Key Points Quantification of phase space density gradients inside geostationary orbit Clear differences between the source of low energy and relativistic electrons Clear observations of how the acceleration process evolves in energy

Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species

Resistance to apoptosis is a major obstacle preventing effective therapy for malignancy. Mitochondria localized anti-death proteins of the Bcl-2 family play a central role in inhibiting apoptosis and therefore present valid targets for novel therapy. The peripheral benzodiazepine receptor (PBR) shares a close physical association with the permeability transition pore complex (PTPC), a pivotal regulator of cell death located at mitochondrial contact sites. In this study we investigated the cytotoxicity of the PBR ligand, PK11195, in the micromolar concentration range. PK11195 induced antioxidant inhibitable collapse of the inner mitochondrial membrane potential (ΔΨm) and mitochondrial swelling in HL60 human leukaemia cells, but not in SUDHL4 lymphoma cells (which exhibited a higher level of reduced glutathione and relative tolerance to chemotherapy or pro-oxidant induced ΔΨm dissipation). PK11195 induced the production of hydrogen peroxide that was not inhibited by Bcl-2 transfection, nor depletion of mitochondrial DNA. ROS production was however blocked by protonophore, implicating a requirement for ΔΨm. Our findings suggest that PK11195-induced cytotoxicity relies upon Bcl-2 resistant generation of oxidative stress; a process only observed at concentrations several orders of magnitude higher that required to saturate its receptor. © 2001 Cancer Research Campaign www.bjcancer.co

Experimental Proof of a Magnetic Coulomb Phase

Spin ice materials are magnetic substances in which the spin directions map onto hydrogen positions in water ice. Recently this analogy has been elevated to an electromagnetic equivalence, indicating that the spin ice state is a Coulomb phase, with magnetic monopole excitations analogous to ice's mobile ionic defects. No Coulomb phase has yet been proved in a real magnetic material, as the key experimental signature is difficult to resolve in most systems. Here we measure the scattering of polarised neutrons from the prototypical spin ice Ho2Ti2O7. This enables us to separate different contributions to the magnetic correlations to clearly demonstrate the existence of an almost perfect Coulomb phase in this material. The temperature dependence of the scattering is consistent with the existence of deconfined magnetic monopoles connected by Dirac strings of divergent length.Comment: 18 pages, 4 fig

A study of omega bands and Ps6 pulsations on the ground, at low altitude and at geostationary orbit

We investigate the electrodynamic coupling between auroral omega bands and the inner magnetosphere. The goal of this study is to determine the features to which omega bands map in the magnetosphere. To establish the auroral-magnetosphere connection, we appeal to the case study analysis of the data rich event of September 26, 1989. At 6 magnetic local time (MLT), two trains of Ps6 pulsations (ground magnetic signatures of omega bands) were observed to drift over the Canadian Auroral Network For the OPEN Program Unified Study (CANOPUS) chain. At the same time periodic ionospheric flow patterns moved through the collocated Bistatic Auroral Radar System (BARS) field of view. Similar coincident magnetic variations were observed by GOES 6, GOES 7 and SCATHA, all of which had magnetic foot points near the CANOPUS/BARS stations. SCATHA, which was located at 6 MLT, 0.5 RE earthward of GOES 7 observed the 10 min period pulsations, whereas GOES 7 did not. In addition, DMSP F6 and F8 were over-flying the region and observed characteristic precipitation and flow signatures. From this fortunate constellation of ground and space observations, we conclude that auroral omega bands are the electrodynamic signature of a corrugated current sheet (or some similar spatially localized magnetic structure) in the near-Earth geostationary magnetosphere

First energetic neutral atom images from Polar

Energetic neutral atoms are created when energetic magnetospheric ions undergo charge exchange with cold neutral atoms in the Earth\u27s tenuous extended atmosphere (the geocorona). Since they are unaffected by the Earth\u27s magnetic field, these energetic neutrals travel away in straight line trajectories from the points of charge exchange. The remote detection of these particles provides a powerful means through which the global distribution and properties of the geocorona and ring current can be inferred. Due to its 2 × 9 RE polar orbit, the Polar spacecraft provides an excellent platform from which to observe ENAs because it spends much of its time in the polar caps which are usually free from the contaminating energetic charged particles that make observations of ENAs more difficult. In this brief report, we present the first ENA imaging results from Polar. Storm-time ENA images are presented for a northern polar cap apogee pass on August 29, 1996 and for a southern polar cap perigee pass on October 23, 1996. As well, we show with a third event (July 31, 1996) that ENA emissions can also be detected in association with individual substorm

Status of the Whipple Observatory Cerenkov air shower imaging telescope array

Recently the power of the Cerenkov imaging technique in Very High Energy gamma-ray astronomy was demonstrated by the detection of the Crab nebula at high statistical significance. In order to further develop this technique to allow the detection of weaker or more distant sources a second 10 m class reflector was constructed about 120 m from the original instrument. The addition of the second reflector will allow both a reduction in the energy threshold and an improvement in the rejection of the hadronic background. The design and construction of the second reflector, Gamma Ray Astrophysics New Imaging TElescope (GRANITE) is described

A detailed study of the diastereoselective catalytic hydrogenation of 6-hydroxytetrahydroisoquinoline-(3R)-carboxylic ester intermediates

A key step towards a highly-selective antagonist of ionotropic glutamate receptors entails the diastereoselective arene hydrogenation of an enantiopure tetrahydroisoquinoline. An extensive screen using parallel reactors was conducted and led to the discovery of several Pd/C catalysts giving high yield and improved diastereoselectivity from 75 : 25 to 95 : 5. A detailed kinetic study of the best system was performed and supports the reduction occuring in two-steps.