Cochrane and non-Cochrane systematic reviews in leading orthodontic journals: a quality paradigm?

The aims of this study were to assess and compare the methodological quality of Cochrane and non-Cochrane systematic reviews (SRs) published in leading orthodontic journals and the Cochrane Database of Systematic Reviews (CDSR) using AMSTAR and to compare the prevalence of meta-analysis in both review types. A literature search was undertaken to identify SRs that consisted of hand-searching five major orthodontic journals [American Journal of Orthodontics and Dentofacial Orthopedics, Angle Orthodontist, European Journal of Orthodontics, Journal of Orthodontics and Orthodontics and Craniofacial Research (February 2002 to July 2011)] and the Cochrane Database of Systematic Reviews from January 2000 to July 2011. Methodological quality of the included reviews was gauged using the AMSTAR tool involving 11 key methodological criteria with a score of 0 or 1 given for each criterion. A cumulative grade was given for the paper overall (0-11); an overall score of 4 or less represented poor methodological quality, 5-8 was considered fair and 9 or greater was deemed to be good. In total, 109 SRs were identified in the five major journals and on the CDSR. Of these, 26 (23.9%) were in the CDSR. The mean overall AMSTAR score was 6.2 with 21.1% of reviews satisfying 9 or more of the 11 criteria; a similar prevalence of poor reviews (22%) was also noted. Multiple linear regression indicated that reviews published in the CDSR (P < 0.01); and involving meta-analysis (β = 0.50, 95% confidence interval 0.72, 2.07, P < 0.001) showed greater concordance with AMSTA

Is there Initial Upper Palaeolithic in Western Tian Shan? Example of an open-air site Katta Sai 2 (Uzbekistan)

The paper presents the results of multidisciplinary studies on the open-air loess site Katta Sai 2 located in thewestern piedmonts of Tian Shan in Uzbekistan. Two archaeological horizons contain features associated with theInitial Upper Palaeolithic (IUP) - both Levallois and blade/bladelet volumetric technology, together with anUpper Palaeolithic toolkit. The cultural traits observed in Katta Sai 2 might have local roots dating back to MIS 5aand can be found in so-called Obirakhmatian technocomplex determined in several archaeological sites in theregion. Thus, the obtained results question the hypothesis of non-local origins of IUP complexes associated withthe early modern human migration from the Near East to Mongolia along the piedmonts of Pamir and Tian Shan.Until reliable anthropological and genetic data are obtained, it seems to be too early to conclude about therelationship between modern human migration and the appearance of IUP assemblages, at least across thewestern parts of Central Asia

Rosacea: new concepts in classification and treatment

Rosacea is a chronic inflammatory dermatosis mainly affecting the cheeks, nose, chin, and forehead. Rosacea is characterized by recurrent episodes of flushing or transient erythema, persistent erythema, phymatous changes, papules, pustules, and telangiectasia. The eyes may also be involved. Due to rosacea affecting the face, it has a profound negative impact on quality of life, self-esteem, and well-being. In addition to general skin care, there are several approved treatment options available for addressing these features, both topical and systemic. For some features, intense pulse light, laser, and surgery are of value. Recent advances in fundamental scientific research have underscored the roles of the innate and adaptive immune systems as well as neurovascular dysregulation underlying the spectrum of clinical features of rosacea. Endogenous and exogenous stimuli may initiate and aggravate several pathways in patients with rosacea. This review covers the new phenotype-based diagnosis and classification system reflecting pathophysiology, and new and emerging treatment options and approaches. We address new topical and systemic formulations, as well as recent evidence on treatment combinations. In addition, ongoing studies investigating novel therapeutic interventions will be summarized.Dermatology-oncolog

ICT-enabled Refugee Integration: A Research Agenda

The recent phenomenon that has become known as the European refugee crisis is, in reality, a global problem. Accordingly, issues regarding refugee integration have become a central debate topic worldwide. In this paper, we examine how refugees use information and communication technology (ICT) in different regions across the world to understand how ICT supports their desperate journey to safety, their stay in temporary settlement camps, and their post-settlement inclusion in host countries. We conducted a series of interviews with Syrian refugees in Berlin, Germany, to collect preliminary insights. Then, we organized panel discussions at two key information systems conferences (ICIS 2016 and ECIS 2017) that involved participants from various countries. The panel discussions revealed seven key research themes: accessibility to information, availability of education and linguistic resources, admissibility to labor markets and entrepreneurship opportunities, communicability with home country, connectedness with local population, interactivity with host government, and volunteer coordination. We discuss how ICT might help to address issues related to each theme, present research questions relevant to each theme, and supply an illustration of how ICT has been employed to address an aspect of each theme. Insights gathered lead to theoretical implications and future opportunities for research in the information systems field, practical implications for different stakeholders interested in refugee integration to consider, and social implications related to refugee crisis that we cannot ignore

Irreversible pulpitis - A source of antibiotic over-prescription?

Antibiotic resistance is a growing public health concern. Antibiotics continue to be prescribed by some clinicians to resolve dental pain even though research indicates that antibiotics are not effective for treating conditions such as irreversible pulpitis. The objective of this study was to determine the extent to which current research and evidence around irreversible pulpitis has been translated into dental practice and the gaps in dentists’ knowledge. An on-line clinical vignette format survey questionnaire about treatment of irreversible pulpitis was distributed to the members of the Academy of Operative Dentistry and Academy of General Dentistry (US based international dental bodies). Their responses were recorded and evaluated. A total of 403 dentists participated in the survey. Over a third (39.3%) indicated they would prescribe antibiotics for symptomatic irreversible pulpitis in a permanent tooth occurring without any signs of systemic infection. The rest indicated they would not prescribe antibiotics; most of them would prescribe an analgesic combined with pulpectomy. Those who had undertaken advanced education training achieved a significantly higher mean knowledge score compared to those with just a primary dental degree (p=0.011). Similarly, full or part time academicians had a higher mean knowledge score than the clinicians who work only in private practice (p=0.014). Some dentists continue to prescribe antibiotics inappropriately for alleviating pain due to irreversible pulpitis. Antibiotic prescribing practices of dentists with advanced education or academic engagement were better as compared to the other participants. There is clear evidence of antibiotic over-prescribing for irreversible pulpitis which needs to be addressed urgently