112 research outputs found
"Introduction" de l'ouvrage "De l'usage de l'art en politique"
Introduction de l'ouvrage "De l'usage de l'art en politique". L'usage de la pratique artistique dans une histoire culturelle du politique constitue un champ de recherche fĂ©cond que cet ouvrage se propose d'aborder. Les contributions envisagent la question dans l'Europe occidentale, du siĂšcle des LumiĂšres Ă la veille de la premiĂšre guerre mondiale, c'est-Ă -dire pendant une longue pĂ©riode de bouleversements des systĂšmes et des reprĂ©sentations politiques. Acquisitions et dons d'Ćuvres d'art, construction d'une identitĂ© rĂ©gionale ou nationale autour d'Ćuvres patrimoniales, reprĂ©sentation du pouvoir politique illustrent la variĂ©tĂ© des relations entre art et politique aux Ă©poques moderne et contemporaine. L'ouvrage ouvre une rĂ©flexion sur l'usage de l'art par le politique aujourd'hui
Time-resolved monitoring of polycyclic aromatic hydrocarbons adsorbed on atmospheric particles
Real-time monitoring of individual particles from atmospheric aerosols was
performed by means of a specifically developed single-particle fluorescence
spectrometer (SPFS). The observed fluorescence was assigned to particles
bearing polycyclic aromatic hydrocarbons (PAH). This assignment was supported
by an intercomparison with classical speciation on filters followed by gas
chromatography-mass spectrometry (GC-MS) analysis. As compared with
daily-averaged data, our time resolved approach provided information about the
physicochemical dynamics of the particles. In particular, distinctions were
made between background emissions related to heating, and traffic peaks during
rush hours. Also, the evolution of the peak fluorescence wavelength provided an
indication of the aging of the particles during the day.Comment: 8 pages, 6 figure
Genetic and ecological correlates of intraspecific variation in pitviper venom composition detected using matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF-MS) and isoelectric
Abstract. The ability to detect biochemical diversity in animal venoms has wide-ranging implications for a diverse array of scientific disciplines. Matrix-assisted laser desorption time-of-flight mass spectrometry (and, for comparative purposes, isoelectric focusing) were used to characterize venoms from a geographically diverse sample of Trimeresurus stejnegeri (n<229) from Taiwan. Previously unrealised levels of heterogeneity were detected in venom phospholipase A 2 isoforms (PLA 2 ) and in whole venom profiles. Geographic variation in venom was primarily between Taiwan and two Pacific islets. Despite the common assumption that venom variation is a product of neutral molecular evolution, statistical testing failed to link venom variation with phylogenetic descent convincingly. Instead, pronounced differences in venom composition may be the product of natural selection for regional diets or of independent founder effects. More data are required on the functional differences between the isoforms to distinguish between these alternatives
Recruitment of Glycosyl Hydrolase Proteins in a Cone Snail Venomous Arsenal: Further Insights into Biomolecular Features of Conus Venoms
Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities. We report here for the first time, the presence of high molecular weight compounds that participate in the envenomation cocktail used by these marine snails. Using a combination of proteomic and transcriptomic approaches, we identified glycosyl hydrolase proteins, of the hyaluronidase type (Hyal), from the dissected and injectable venoms (âinjectable venomâ stands for the venom variety obtained by milking of the snails. This is in contrast to the âdissected venomâ, which was obtained from dissected snails by extraction of the venom glands) of a fish-hunting cone snail, Conus consors (Pionoconus clade). The major Hyal isoform, Conohyal-Cn1, is expressed as a mixture of numerous glycosylated proteins in the 50 kDa molecular mass range, as observed in 2D gel and mass spectrometry analyses. Further proteomic analysis and venom duct mRNA sequencing allowed full sequence determination. Additionally, unambiguous segment location of at least three glycosylation sites could be determined, with glycans corresponding to multiple hexose (Hex) and N-acetylhexosamine (HexNAc) moieties. With respect to other known Hyals, Conohyal-Cn1 clearly belongs to the hydrolase-type of Hyals, with strictly conserved consensus catalytic donor and positioning residues. Potent biological activity of the native Conohyals could be confirmed in degrading hyaluronic acid. A similar Hyal sequence was also found in the venom duct transcriptome of C. adamsonii (Textilia clade), implying a possible widespread recruitment of this enzyme family in fish-hunting cone snail venoms. These results provide the first detailed Hyal sequence characterized from a cone snail venom, and to a larger extent in the Mollusca phylum, thus extending our knowledge on this protein family and its evolutionary selection in marine snail venoms
Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa
Groundwater in sub-Saharan Africa supports livelihoods and poverty alleviation1,2, maintains vital ecosystems, and strongly influences terrestrial water and energy budgets. Yet the hydrological processes that govern groundwater recharge and sustainabilityâand their sensitivity to climatic variabilityâare poorly constrained4. Given the absence of firm observational constraints, it remains to be seen whether model-based projections of decreased water resources in dry parts of the region4 are justified. Here we show, through analysis of multidecadal groundwater hydrographs across sub-Saharan Africa, that levels of aridity dictate the predominant recharge processes, whereas local hydrogeology influences the type and sensitivity of precipitationârecharge relationships. Recharge in some humid locations varies by as little as five per cent (by coefficient of variation) across a wide range of annual precipitation values. Other regions, by contrast, show roughly linear precipitationârecharge relationships, with precipitation thresholds (of roughly ten millimetres or less per day) governing the initiation of recharge. These thresholds tend to rise as aridity increases, and recharge in drylands is more episodic and increasingly dominated by focused recharge through losses from ephemeral overland flows. Extreme annual recharge is commonly associated with intense rainfall and flooding events, themselves often driven by large-scale climate controls. Intense precipitation, even during years of lower overall precipitation, produces some of the largest years of recharge in some dry subtropical locations. Our results therefore challenge the âhigh certaintyâ consensus regarding decreasing water resources in such regions of sub-Saharan Africa. The potential resilience of groundwater to climate variability in many areas that is revealed by these precipitationârecharge relationships is essential for informing reliable predictions of climate-change impacts and adaptation strategies
Mise en oeuvre et tests de protocoles ecrits en Estelle
SIGLECNRS T 59189 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
L'apport de la kinésithérapie dans le traitement des dysfoncfions temporo-mandibulaires
BORDEAUX2-BU Sci.Homme/Odontol. (330632102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Brevet : la prescription de l'action en nullitĂ© de brevet. Approche comparĂ©e Ătats-Unis et France: En droit français
International audienc
Brevet: la prescription de l'action en nullitĂ© de brevet. Approche comparĂ©e Ătats-Unis et France
International audienc
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