Cognitive Efficacy of Quetiapine in Early-Onset First-Episode Psychosis: A 12-Week Open Label Trial

Twenty-three adolescents with psychotic disorders, aged from 13 to 18years, participated in a 12-week open label trial (17 adolescents completed the study) in order to examine the impact of quetiapine on clinical status and cognitive functions (encompassing processing speed, attention, short-term memory, long-term memory and executive function). An improvement in Clinical Global Impression and Positive and Negative Symptom Scale (P's≤0.001) was observed. In addition, after controlling for amelioration of symptoms, a significant improvement was observed on one executive function (P=0.044; Trail Making Part B). The remaining cognitive abilities showed stability. In addition, we observed an interaction between quetiapine doses (>300mg/day or <300mg/day) and time, where lower doses showed more improvement in verbal short-term memory (P=0.048), inhibition abilities (P=0.038) and positive symptoms (P=0.020). The neuropsychological functioning of adolescents with psychotic disorders remained mainly stable after 12weeks of treatment with quetiapine. However, lower doses seemed to have a better impact on two components of cognition (inhibition abilities and verbal short-term memory) and on positive symptom

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Rundfunkereignisse. Mediale Festveranstaltungen im Dritten Reich

Mehrere Studien haben seit 1945 den konstitutiven Charakter zeremonieller Akte für den Staat Hitlers herausgearbeitet. Wenig beachtet wurde allerdings die Tatsache, dass die wichtigsten von ihnen live im Rundfunk übertragen wurden. Ziel der vorliegenden Arbeit ist es, diesem Versäumnis abzuhelfen und die nationalsozialistischen Feiern im Hinblick auf ihr Verhältnis zum Rundfunk zu analysieren. Die Übertragungen wurden von allen Sendern übernommen und im Rahmen von obligatorischen Gemeinschaftsempfängen rezipiert. Daraus darf man schließen, dass die Feiern nicht nur von den Zuschauern vor Ort, sondern von der ganzen Bevölkerung erlebt werden sollten. Sie wurden von Anfang an als mediale Festveranstaltungen konzipiert. Daniel Dayan und Elihu Katz haben für wichtige, national oder weltweit live im Fernsehen übertragene Ereignisse den Begriff "Medienereignisse" ins Leben gerufen. In Anlehnung daran werden in der vorliegenden Arbeit die NS-Feiern als Rundfunkereignisse bezeichnet. Ian Kershaw hat gezeigt, inwiefern Hitlers Herrschaft eine charismatische gewesen ist. Eine solche Herrschaft setzt voraus, dass zwischen dem Führer und den Geführten persönliche Beziehungen existieren. Wenn dies im Dritten Reich an sich nicht möglich war, so haben doch bei Rundfunkereignissen die Sende- und Empfangsbedingungen dafür gesorgt, dass die Deutschen das Gefühl haben konnten, der "Führer" spreche direkt zu ihnen. Ferner erlaubten es Rundfunkereignisse den Machthabern, die Einheit zwischen Volk und "Führer" zur Schau zu stellen und dadurch Hitlers Legitimität zu beweisen. Aus beiden Gründen lässt sich behaupten, dass Rundfunkereignisse ein wichtiges Instrument zur Machtsicherung gewesen sind. Rundfunkereignisse boten schließlich einen Anlass, die "Volksgemeinschaft" erfahrbar zu machen. Dadurch trugen sie dazu bei, dass diese von vielen Deutschen nicht als leere Propagandaformel, sondern als ein Projekt empfunden wurde, für das es sich lohnte sich einzusetzen.Several studies since 1945 have elaborated the constitutive character of ceremonial acts for Hitler’s state. However the fact that the most important of these were live radio broadcasts has so far received little consideration. The aim of the present work is to remedy this omission and to analyze National Socialist celebrations regarding their relation to radio. The broadcasts were accepted by all stations and heard during community listening sessions. Thus one may conclude that the celebrations were not only to be experienced by the spectators present but by the population as a whole. From the beginning they were conceived as media celebrations. Daniel Dayan and Elihu Katz have coined the term "media events" for important, national or even worldwide events broadcasted live. Following this usage the National Socialist celebrations are called radio events in this work. Ian Kershaw has shown to which extent Hitler’s role has been charismatic. This kind of domination presumes a personal relationship between the leader and the led. Although this was not actually practical during the Third Reich, the radio arrangement made it possible for the Germans to feel the "Führer" was speaking to them directly. Further radio events allowed those in power to display the unity of the people and the "Führer" and thereby to prove Hitler’s legitimacy. For both reasons one can claim that radio events were an important instrument to secure power. Radio events offered more than just an occasion to make the Volksgemeinschaft tangible. They contributed to the fact that the Volksgemeinschaft was experienced and understood not as an empty propaganda term, but rather as a political project worth supporting

Enquête sur une émission légendaire de la télévision française : les cinq dernières minutes (1958-1973)

Enquiry on a French Legendary Television Program: Les Cinq Dernières Minutes (The hast Five Minutes) (1958-1973), Muriel Favre. In the 1960s, television viewers were wild about the investigations carried out by Inspector Bourrel and his assistant Dupuy in Les Cinq Dernières Minutes. A minute examination of this program shows how television functioned at the beginning and provides additional proof that the interest of police series is as an indicator of the cultural and mental state of a society.Favre Muriel. Enquête sur une émission légendaire de la télévision française : les cinq dernières minutes (1958-1973). In: Vingtième Siècle, revue d'histoire, n°55, juillet-septembre 1997. pp. 101-111

Recalage basé plans de nuages de points pour la navigation dans des environnements structurés

National audienceLes algorithmes traditionnels de recalage de nuages de points 3D, basés sur l’algorithme d’Iterative Closest Point (ICP), reposent sur la mise en correspondance de points. Dans les environnements bien structurés, tels que les bâtiments, les plans peuvent être segmentés et utilisés pour le recalage, de manière similaire à l’approche classique d’ICP basée sur les points. L’utilisation de plans réduit considérablement le nombre d’entrées de l’ICP. Cet article présente un algorithme de recalage précis et robuste basé sur les plans. La transformation optimale est estimée par une approche de minimisation en deux étapes, en effectuant successivement une minimisation robuste plan à plan et un recalage robuste non linéaire point à plan. Les expériences sur le jeu de données de référence Autonomous Systems Lab (ASL) montrent que la méthode proposée permet de recaler avec succès 100% des scans des trois séquences d’intérieur. Les expériences montrent également que la méthode proposée est robuste dans les scénarios de mouvements importants et plus précise que les autres algorithmes de l’état de l’art évalués. En outre, un nouveau jeu de données, LOOP’IN, est fourni. Il est composé de deux boucles dans des scènes d’intérieur d’environnements réels, avec un grand nombre de scans capturés avec un LiDAR 3D. Les tests menés sur le jeu de données LOOP’IN montrent que l’algorithme est capable de recaler de longues séquences, de fermer des boucles et de construire une carte incrémentale de l’environnement exploré

A Plane-based Approach for Indoor Point Clouds Registration

International audienceIterative Closest Point (ICP) is one of the mostly used algorithms for 3D point clouds registration. This classical approach can be impacted by the large number of points contained in a point cloud. Planar structures, which are less numerous than points, can be used in well-structured man-made environment. In this paper we propose a registration method inspired by the ICP algorithm in a plane-based registration approach for indoor environments. This method is based solely on data acquired with a LiDAR sensor. A new metric based on plane characteristics is introduced to find the best plane correspondences. The optimal transformation is estimated through a two-step minimization approach, successively performing robust plane-to-plane minimization and non-linear robust point-to-plane registration. Experiments on the Autonomous Systems Lab (ASL) dataset show that the proposed method enables to successfully register 100% of the scans from the three indoor sequences. Experiments also show that the proposed method is more robust in large motion scenarios than other state-of-the-art algorithms

Recalage basé plans de nuages de points pour la navigation dans des environnements structurés

National audienceLes algorithmes traditionnels de recalage de nuages de points 3D, basés sur l’algorithme d’Iterative Closest Point (ICP), reposent sur la mise en correspondance de points. Dans les environnements bien structurés, tels que les bâtiments, les plans peuvent être segmentés et utilisés pour le recalage, de manière similaire à l’approche classique d’ICP basée sur les points. L’utilisation de plans réduit considérablement le nombre d’entrées de l’ICP. Cet article présente un algorithme de recalage précis et robuste basé sur les plans. La transformation optimale est estimée par une approche de minimisation en deux étapes, en effectuant successivement une minimisation robuste plan à plan et un recalage robuste non linéaire point à plan. Les expériences sur le jeu de données de référence Autonomous Systems Lab (ASL) montrent que la méthode proposée permet de recaler avec succès 100% des scans des trois séquences d’intérieur. Les expériences montrent également que la méthode proposée est robuste dans les scénarios de mouvements importants et plus précise que les autres algorithmes de l’état de l’art évalués. En outre, un nouveau jeu de données, LOOP’IN, est fourni. Il est composé de deux boucles dans des scènes d’intérieur d’environnements réels, avec un grand nombre de scans capturés avec un LiDAR 3D. Les tests menés sur le jeu de données LOOP’IN montrent que l’algorithme est capable de recaler de longues séquences, de fermer des boucles et de construire une carte incrémentale de l’environnement exploré

Fall Detector Adapted to Nursing Home Needs through an Optical-Flow based CNN

International audienceFall detection in specialized homes for the elderly is challenging. Vision-based fall detection solutions have a significant advantage over sensor-based ones as they do not instrument the resident who can suffer from mental diseases. This work is part of a project intended to deploy fall detection solutions in nursing homes. The proposed solution, based on Deep Learning, is built on a Convolutional Neural Network (CNN) trained to maximize a sensitivity-based metric. This work presents the requirements from the medical side and how it impacts the tuning of a CNN. Results highlight the importance of the temporal aspect of a fall. Therefore, a custom metric adapted to this use case and an implementation of a decision-making process are proposed in order to best meet the medical teams requirements. Clinical relevance This work presents a fall detection solution enabled to detect 86.2% of falls while producing only 11.6% of false alarms in average on the considered databases