Optimalisasi Kinerja Karyawan Sarung Tenun dengan Peningkatan Faktor-faktor yang Mempengaruhinya

This research aims to analyze the employee\u27s performance of woven sarong industries in Pekalongan. The population is 10 woven sarong industries in Pekalongan with a total respondents size of 105 weaving employees obtained using Purposive Sampling technique. SEM analysis was used to examine the effect of job training andwork motivation as the exogenous variable, competence as the intervening variable, and job performance as the endogenous variable. The results show that job trainning has a positive effect on the competence, competence has a positive effect on the job performance, the competence mediates the relationship between job training and job performance, and work motivation has a positive effect on the job performance

ALTERNATIVE RESOLUTION OF INTELLECTUAL PROPERTY DISPUTES AS PART OF INVESTMENT IN THE CREATIVE INDUSTRY SECTOR UNDER INDONESIAN LAW

Purpose: The amount of investment in Indonesia both foreign and domestic increases in number each year. One of the growing investment in Indonesia is the creative industry. Creativity from this creative industry produces a variety of works protected by intellectual property. The development of intellectual property law advanced rapidly. One form of intellectual property is copyright. The many interests in the implementation of this copyright cause some problems and disputes. Indonesia itself recognizes some non-court settlement disputes namely arbitration and mediation so that intellectual property may remain protected. Methodology: This research study gathered secondary data from literature review, online article, dialogues and different document available on the internet regarding the copyright law. In addition, this research study has analysed different Indonesian law regarding copyright. Main Findings: There are rights in copyright protected by law. In-Law No. 28 of 2014 it is possible to settle disputes outside the court through several methods. Article 95 of Law No. 28 of 2014 on Copyright stipulates that Settlement of Copyright disputes may be made through alternative dispute resolution, arbitration, or courts. Implications/Applications: The findings of the study are helpful in gaining knowledge regarding law available regarding copyright and settlement of Copyright disputes through alternative dispute resolution, arbitration, or courts, etc

Peneguhan Karakter Islam Peserta Didik Melalui Rukun Iman Dengan Metode 3p (Pemahaman Pengamalan Pembiasaan)

Pada masa dimana pendidikan sudah menyebar luas ke seluruh pelosok negeri, ternyata masih banyak peserta didik yang memiliki karakter kurang baik sehingga mencerminkan bahwa  tujuan dari pendidikan belum sepenuhnya berhasil tercapai terutama dalam menanamkan karakter mulia pada peserta didik. Dari kejadian tersebut maka tujuan dari penelitian ini adalah untuk mengetahui peneguhan karakter Islami peserta didik melalui rukun iman dengan menggunakan 3P (Pemahaman Pengamalan Pembiasaan) di SMP Muhammadiyah Cilawu. Penelitian ini menggunakan pendekatan kualitatif. Pengumpulan data dilakukan dengan teknik wawancara. Hasil dari penelitian ini bahwa penggunaan dan penerapan metode 3P (Pemahaman Pengamalan Pembiasaan) dalam rukun iman, untuk meneguhkan karakter peserta didik efektif diterapkan karena segala sesuatu hal harus melalui pemahaman terlebih dahulu, sehingga dengan adanya paham maka akan timbul sebuah pemikiran dan keyakinan yang menjadikan  karakter seorang peserta didik itu baik layaknya sebagai orang yang beriman pada Allah SWT. Setelah dipahami, rukun iman tersebut diamalkan serta dibiasakan dalam kehidupan sehari-hari

Assessment parameters for coal-fired generation plant site selection

In order to meet future demand for electricity, Tenaga Nasional Berhad (TNB) is committedto the long-term strategic planning in locating suitable sites for future development of power stations.Site selection is an important process in the early planning stage of any power plant development asit will have significant implications on the capital investment, operational as well as the environmentand socio-economic costs of the power plant.The aim of this presentation is to briefly describe the ten (10) main assessment parametershaving the most profound effects on the selection of potential coal-fired generation plant sites.These assessment parameters were derived based on a survey of approximately 40 experts, comprisingfrom various specialists such as engineers from TNB, senior officers from Department Of EnvironmentMalaysia (DOE), scientist from University Malaya (UM) and a number of other independentconsultants

The LARGE Principle of Cellular Reprogramming: Lost, Acquired and Retained Gene Expression in Foreskin and Amniotic Fluid-Derived Human iPS Cells

Human amniotic fluid cells (AFCs) are routinely obtained for prenatal diagnostics procedures. Recently, it has been illustrated that these cells may also serve as a valuable model system to study developmental processes and for application in regenerative therapies. Cellular reprogramming is a means of assigning greater value to primary AFCs by inducing self-renewal and pluripotency and, thus, bypassing senescence. Here, we report the generation and characterization of human amniotic fluid-derived induced pluripotent stem cells (AFiPSCs) and demonstrate their ability to differentiate into the trophoblast lineage after stimulation with BMP2/BMP4. We further carried out comparative transcriptome analyses of primary human AFCs, AFiPSCs, fibroblast-derived iPSCs (FiPSCs) and embryonic stem cells (ESCs). This revealed that the expression of key senescence-associated genes are down-regulated upon the induction of pluripotency in primary AFCs (AFiPSCs). By defining distinct and overlapping gene expression patterns and deriving the LARGE (Lost, Acquired and Retained Gene Expression) Principle of Cellular Reprogramming, we could further highlight that AFiPSCs, FiPSCs and ESCs share a core self-renewal gene regulatory network driven by OCT4, SOX2 and NANOG. Nevertheless, these cell types are marked by distinct gene expression signatures. For example, expression of the transcription factors, SIX6, EGR2, PKNOX2, HOXD4, HOXD10, DLX5 and RAXL1, known to regulate developmental processes, are retained in AFiPSCs and FiPSCs. Surprisingly, expression of the self-renewal-associated gene PRDM14 or the developmental processes-regulating genes WNT3A and GSC are restricted to ESCs. Implications of this, with respect to the stability of the undifferentiated state and long-term differentiation potential of iPSCs, warrant further studies

Proliferation and survival of human amniotic epithelial cells during their hepatic differentiation

Stem cells derived from placental tissues are an attractive source of cells for regenerative medicine. Amniotic epithelial cells isolated from human amnion (hAECs) have desirable and competitive characteristics that make them stand out between other stem cells. They have the ability to differentiate toward all three germ layers, they are not tumorigenic and they have immunosuppressive properties. Although liver transplantation is the best way to treat acute and chronic hepatic failure patients, there are several obstacles. Recently, stem cells have been spotlighted as alternative source of hepatocytes because of their potential for hepatogenic differentiation. In this work, we aimed to study the proliferation and survival of the hAECs during their hepatic differentiation. We have also analyzed the changes in pluripotency and hepatic markers. We differentiated amniotic cells applying a specific hepatic differentiation (HD) protocol. We determined by qRT-PCR that hAECs express significant levels of SOX-2, OCT-4 and NANOG during at least 15 days in culture and these pluripotent markers diminish during HD. SSEA-4 expression was reduced during HD, measured by immunofluorescence. Morphological characteristics became more similar to hepatic ones in differentiated cells and representative hepatic markers significantly augmented their expression, measured by qRT-PCR and Western blot. Cells achieved a differentiation efficiency of 75%. We observed that HD induced proliferation and promoted survival of hAECs, during 30 days in culture, evaluated by 3H-thymidine incorporation and MTT assay. HD also promoted changes in hAECs cell cycle. Cyclin D1 expression increased, while p21 and p53 levels were reduced. Immunofluorescence analysis showed that Ki-67 expression was upregulated during HD. Finally, ERK 1/2 phosphorylation, which is intimately linked to proliferation and cell survival, augmented during all HD process and the inhibition of this signaling pathway affected not only proliferation but also differentiation. Our results suggest that HD promotes proliferation and survival of hAECs, providing important evidence about the mechanisms governing their hepatic differentiation. We bring new knowledge concerning some of the optimal transplantation conditions for these hepatic like cells.Fil: Maymo, Julieta Lorena. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Riedel, Rodrigo Nicolas. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Pérez Alcázar, Germán Antonio. Hospital Universitario Virgen Macarena;Fil: Magatti, Marta. Istituto Ospedaliero;Fil: Maskin, Bernardo. Hospital Nacional Professor Dr. Alejandro Posadas; ArgentinaFil: Dueñas, José Luis. Hospital Universitario Virgen Macarena;Fil: Parolini, Ornella. Istituto Ospedaliero;Fil: Sánchez-Margalet, Víctor. Hospital Universitario Virgen Macarena;Fil: Varone, Cecilia Laura. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentin

Perkawinan paksa dan Akibat hukumnya di desa Bogak Kecamatan Tanjung Tiram Kabupaten Batu Bara Sumatra Utara

Penelitian ini bertujuan untuk mengetahui tentang perkawinan paksa dan akibat hukumnya. Penelitian ini dilakukan di Desa Bogak Kecamatan Tanjung Tiram Kabupaten Batu Bara Sumatera Utara. Penelitian ini menggunakan metode kualitatif dengan jenis penelitian yuridis sosiologis. Sumber data yang digunakan terdiri dari data primer dan data sekunder. Hasil penelitian menyimpulkan bahwa faktor keluarga merupakan faktor yang paling dominan sebagai penyebab terjadinya perkawinan paksa, kemudian faktor ekonomi, faktor pendidikan, dan faktor lingkungan termasuk penyebab terjadinya perkawinan paksa di Desa Bogak Kecamatan Tanjung Tiram. Sedangkan faktor adat bukan penyebab terjadinya perkawinan paksa di Desa Bogak Kecamatan Tanjung Tiram. Sementara itu, perkawinan paksa yang dilakukan di Desa Bogak Kecamatan Tanjung Tiram dalam Islam hukumnya sah dikarenakan peran orang tua kandung perempuan memiliki hak ijbar atau hak untuk mengawinkan anak perempuannya meskipun tanpa persetujuan dari anak perempuannya tersebut

Kontribusi antara Daya Ledak Tungkai Kaki terhadap Hasil Belajar Praktek Tolak Peluru Mahasiswa Jurusan Pendidikan Kepelatihan Olahraga Fakultas Ilmu Keolahragaan Universitas Negeri Padang

Penelitian ini bertujuan untuk mengetahui tentang kontribusi antara “daya ledak tungkai kaki sebagai variabel bebas dan hasil belajar praktek tolak peluru sebagai varibel terikat, penelitian ini dilaksanakan di Fakultas Ilmu Keolahragaan UNP. Teknik  pengambilan sampel dengan teknik Random Sampling dan didapat sampel sebanyak 60 orang mahasiswa. Pengambilan data daya ledak tungkai kaki dengan cara melakukan vertical jump. Untuk hasil belajar praktek tolak peluru dengan melakukan perlakuan / tolak peluru.        Analisis data dan pengujian hipotesis penelitian menggunakan teknik analisis korelasi product moment dengan taraf signifikan α = 0,05, Dari analisis data dapat diperoleh hasil : 1) Terdapat kontribusi yang berarti antara daya ledak tungkai kaki terhadap hasil belajar  praktek tolak peluru dengan perolehan  rhitung 0,550 > rtabel  0,250. 2) terdapat kontribusi yang berarti antara daya ledak tungkai kaki terhadap hasil belajar praktek tolak peluru dalam hal ini tingkat hubungan daya ledak tungkai kaki dengan  hasil belajar praktek tolak peluru sebesar 30,2%, maksudnya semakin bagus daya ledak tungkai kaki seseorang maka semakin baik pula  hasil belajar praktek tolak peluru