619 research outputs found
Biodistribuição do 18FDG em ratos nude balb-c nu/nu normaiS
Resumo do poster apresentado ao XII Congresso Nacional de Medicina Nuclear, 12-14 Novembro 2009, Mealhad
The COVID-19 pandemic: yet another catalyst for governmental mass surveillance?
This commentary addresses the use of surveillance technologies in the context of the Covid-19 pandemic, using examples from the current geopolitical frame, and questioning the possible consequences of data collection for the individual and for society. In this regard, some questions emerge: in the fight against the pandemic, what measures and tools of surveillance are being adopted by the different states? Will the extraordinary measures, that are now being implemented, become permanent? And if so, what will the consequences be for privacy and democracy?info:eu-repo/semantics/publishedVersio
Photodynamic inactivation of Lasiodiplodia theobromae: lighting the way towards an environmentally friendly phytosanitary treatment
The fungus Lasiodiplodia theobromae is one of the main causal agents of trunk canker and dieback of grapevine. The objective of this work was to evaluate the efficiency of photodynamic inactivation (PDI) of L. theobromae with synthetic and natural photosensitizers and irradiation with either sunlight or artificial photosynthetically active radiation. Although the growth of the mycelium could not be completely prevented with natural sunlight irradiation, phenothiazine dyes (methylene blue, MB; toluidine blue O, TBO), riboflavin and a cationic porphyrin (Tetra-Py+-Me) caused complete inhibition under continuous irradiation with artificial light. Free radicals were the main cytotoxic agents in the PDI with MB, indicating the predominance of the type I mechanism. PDI with MB or Tetra-Py+-Me may represent a promising approach for the sanitation of vine material in greenhouse nurseries, in order to reduce the risk of infection upon grafting.publishe
Whole exome sequencing of patients with diffuse idiopathic skeletal hyperostosis and calcium pyrophosphate crystal chondrocalcinosis
Objectives: DISH/CC is a poorly understood phenotype
characterised by peripheral and axial enthesopathic
calcifications, frequently fulfilling the radiological
criteria for Diffuse Idiopathic Skeletal Hyperostosis
(DISH, MIM 106400), and in some cases associated
with Calcium Pyrophosphate Dihydrate (CPPD) Chondrocalcinosis
(CC). The concurrence of DISH and CC
suggests a shared pathogenic mechanism. In order to
identify genetic variants for susceptibility we performed
whole exome sequencing in four patients showing this
phenotype.
Materials and methods: Exome data were filtered in
order to find a variant or a group of variants that could
be associated with the DISH/CC phenotype. Variants
of interest were subsequently confirmed by Sanger sequencing.
Selected variants were screened in a cohort
of 65 DISH/CC patients vs 118 controls from Azores.
The statistical analysis was performed using PLINK
V1.07.
Results:We identified 21 genetic variants in 17 genes
that were directly or indirectly related to mineralization,
several are predicted to have a strong effect at a
protein level. Phylogenetic analysis of altered amino
acids indicates that these are either highly conserved
in vertebrates or conserved in mammals. In case-control
analyses, variant rs34473884 in PPP2R2D was significantly
associated with the DISH/CC phenotype
(p=0.028; OR=1.789, 95% CI= 1.060 - 3.021)).
Conclusion: The results of the present and preceding
studies with the DISH/CC families suggests that the
phenotype has a polygenic basis. The PPP2R2D gene could be involved in this phenotype in an as yet unknown way.FRCT: M3.1.2/F/023/2011info:eu-repo/semantics/publishedVersio
- …