First record of the Thuridilla indopacifica Gosliner, 1995 (Sacoglossa, Plakobranchidae) from the Gulf of Oman, Iran

Thuridilla indopacifica Gosliner, 1995 (Sacoglossa, Plakobranchidae) is a rare species in the Sacoglossan nudibranch that only reported from the South Africa and Western Australia. This study records T. indopacifica from the Gulf of Oman for the first time showing its expansion to the northwest of Indian Ocean

Nasser Khosrow and Sanai Poets of Bipolar or Multipolar? (Poetic awakening from dream to reality)

Different views have long been expressed about poetry, its essence and purpose. Poetry and the environment, together, are constantly changing and being influenced by each other. Poetry as a social necessity has always been a tool to promote worldly and spiritual purposes. Nasser Khosrow and Sanai, bipolar poets whose dark thoughts and ideas could not be found in the dark pole of their poetry and thought, and as a result of their inner intellectual and revolutionary awakening, marked a turning point in the history of culture and literature of this rich border. They figured out and made the poem, which they had previously employed in their worldly needs and lowly interests, as a means of spreading morality and religion, and they were epoch-making. Regardless of some of the intellectual contradictions that result from going through different mental states, their poetry has been a mirror of their society's pain and aspirations. This study, while explaining the characteristics of good and committed poetry and its mission, deals with the subject of intellectual awakening, its causes and contexts in the poetry and thought of these two poets, and examines the effect of this awakening on their intellectual orientation, whether it is possible between dark and light poles. Their thought was absolutely different, or this demarcation - in terms of their intellectual contradictions - is merely the result of views based on prejudice, absolutism and sanctification

Why are Men more susceptible to COVID-19: A narrative review of current global knowledge

Since its inception on December 2019, COVID-19 epidemic now has been titled a global emergency. Rich literature on the global descriptive epidemiology of the cases has shown that the burden of COVID-19 epidemic in terms of both morbidity and mortality is more pronounced among men. Physiological and genetic traits along with numerous differences in social and cultural profile of men are attributed to this discrepancy. This review attempted to delineate various proposed explanations for the observed gender-differences in COVID-19 morbidity and mortality

Recognition of the factors affecting survival in colon and rectal cancer patients referred to RCGLD center of Shahid Beheshti University of Medical Sciences: accelerated failure time parametric survival analysis with frailty

زمینه و هدف: عوامل تشخیصی سرطان کولورکتال بر بقای بیماران و تجویز درمان مناسب موثر است. با توجه به افزایش نرخ‌ این سرطان در ایران مخصوصاً در سنین جوانی و اینکه عوامل تشخیصی سرطان کولورکتال به عنوان یک سرطان واحد درک دقیقی از دو سرطان کولون و رکتوم و عوامل موثر بر آن فراهم نمی‌کند، بنابراین مطالعه حاضر به منظور تعیین عوامل خطر اختصاصی سرطان‌های کولون و رکتوم انجام گردید. روش بررسی: در این مطالعه توصیفی-تحلیلی تعداد 1219 بیمار مبتلا به سرطان‌های کولون و رکتوم طی دی ‌ماه 1383 تا مهرماه 1387 مورد بررسی قرار گرفتند. متغیر‌های دموگرافیک و بالینی در قالب تحلیل‌های یک متغیره و چند متغیره با رویکرد الگوی زمان شکست شتابنده تحلیل بقا و با انجام تصحیح توسط پارامتر شکنندگی توسط نرم‌افزار STATA 10 تجزیه و تحلیل شدند. یافته‌ها: بر اساس نتایج حاصل از این مطالعه برای سرطان کولون در زنان، بیماران بدون سابقه‌ی بیماری التهاب روده، بیماران با درجه‌ی تومور ضعیف متمایز شده و بیماران با مرحله‌ی پاتولوژیک I تومور احتمال بقای بالاتری به دست آمد و برای دو عامل سابقه‌ی مصرف الکل و اندازه‌ی تومور رابطه آماری معنی‌داری مشاهده نشد. همچنین برای سرطان رکتوم، بیماران با نوع اولین درمان عمل جراحی احتمال بقای بالاتری داشتند و برای دو عامل سابقه‌ی شخصی ابتلا به سرطان و مرحله‌ی پاتولوژیک تومور رابطه آماری معنی‌داری مشاهده نشد. همچنین برای هر دو نوع سرطان، رده‌‌های با شاخص توده بدنی 9/29–25 و بیشتر از 30 شاخص توده‌ی بدنی به ترتیب احتمال بقای بالاتر و رده‌ی کمتر از 5/18 احتمال بقای پایین‌تری را نشان دادند. در مجموع احتمال بقای بیماران مبتلا به سرطان رکتوم در مقایسه با بیماران مبتلا به سرطان کولون بالاتر بود. نتیجه‌گیری: ارزیابی جداگانه ی کولون و رکتوم، به درک بیشتری از عوامل موثر بر این سرطان‌ها می‌انجامد و می‌تواند در طراحی کارآزمایی‌های بالینی، تشخیص بهتر بیماری و یا تجویز درمان بهینه و اختصاصی کمک نماید

Distribution and pollution level of nickel and vanadium in sediments from south part of the Caspian Sea, Iran

765-771Distribution and pollution level of nickel and vanadium in sediment from south part of the Caspian Sea, north of Iran, were studied. Sediment samples obtained by Van Veen Grab from four stations, including, Turkaman, Amirabad, Fereydunkenar and Noushahr along the south part of the Caspian Sea, during fall of 2015 and april, summer and winter of 2016. The concentrations of metal were ranged from 21.63 µg/g to 55.45 µg/g for nickel and from 58.23 µg/g to 146.27 µg/g for vanadium in sediments samples collected from all stations. There was significant difference in metals concentration between different stations along the Caspian Sea (P < 0.05), and the highest mean concentration of metals was absorbed in Fereydunkenar estuary, followed by Amirabad, Turkaman and Noushahr, respectively. The results showed that there were significant differences between metals pollution during four seasons (P < 0.05), and the highest concentration of metals were absorbed in dry season (summer) and the lowest concentration in wet season (winter). There was a positive correlation between nickel and vanadium concentration in sediment samples, and the Pearson correlation was (r = 0.67) between nickel and vanadium in sediment samples. The positive correlation between heavy metals can be related to same source of both metals in the environment. Based on our results, anthropogenic activities such as oil industry and agriculture activities are the main sources of pollution in the coasts along south part of Caspian Sea

Complementary investigation and taxonomic identification of starfishes, (Echinodermata: Asteroidea) from the Northern Persian Gulf, Iran

Sea Stars are one of the most incredible creatures in the coastal and open waters. In this study, 11 species of starfishes have been identified which belonging to six genera and five families in northern islands of Persian Gulf during May 2017 to September 2018. Among the species, Astropecten hemprichi (Müller & Troschel, 1842), Astropecten indicus (Döderlein, 1888), Astropecten polyacanthus polyacanthus (Muller and Troschel, 1842), Astropecten polyacanthus phragmorous (Muller and Troschel, 1842), Luidia hardwicki (Gray, 1840), Aquilonastra iranica (Mortensen, 1940), Linckia multifora (Lamarck, 1816), Culcita novaeguineae (Muller & Troschel, 1842) and Pentaceraster mammillatus (Audouin, 1826) have been reported in the past. The species of Aquilonastra watersi (O'Loughlin and Rowe, 2006) and Linckia laevigata (Linnaeus, 1758) are new recordsin the Persian Gulf

Zataria multiflora Essential oil Prevent Iron Oxide Nanoparticles-induced Liver Toxicity in Rat Model

Over loading of iron oxide nanoparticles can causes the liver injury through overproduction of free radicals. Zataria multiflora Boiss. (Lamiaceae) has been used for many years in folk medicine due to its antioxidant and antibacterial activities. This study evaluates -for the first time- the effect of Z. multiflora essential oil (EO) against iron oxide nanoparticles hepatotoxicity in rat model. Male Wistar rats were divided randomly into 4 groups; control group (C), non-treated control group (NT), treatment groups, nanoparticles plus Z. multiflora EO at 100 and 200 mg/kg b.w. In following, the liver and blood tissue were collected for estimating antioxidant / oxidative stress parameters including lipid peroxidation (LP), glutathione (GSH), glutathione-S-transferase (GST), and liver enzyme asparate transaminase (AST) and also histopathological examinations. Iron oxide nanoparticles toxicity produced a significant increase in the levels of LP, ferric reducing ability of plasma (FRAP), and AST activity concomitant with decrease in the levels of GSH and GST activity compared to the control group. However, in the treatment groups received Z. multiflora EO, the levels of LP and AST activity reduced together with increasing in GSH content and GST activity were significantly reported. Histopathological studies also supported the biochemical assessments indicating hepatic improvements induced by nanoparticles. Z. multiflora EO protected the liver from injuries induced by iron oxide nanoparticles which can be correlated with its antioxidant activities. This can be a valuable candidate in modulating the oxidative hepatic injuries

Evaluation of the Antibacterial and Wound Healing Properties of a Burn Ointment Containing Curcumin, Honey, and Potassium Aluminium

Burn wounds can severely trouble the health system and life quality of patients. The present study aimed to analyze the synergistic healing properties of curcumin, honey, and potassium alum substances merged in a newly-devised burn ointment on second-degree burn wounds in rats. The MIC and MBC tests on 200 clinical isolates of Pseudomonas aeruginous are compared to imipenem in vitro. Their killing time and cytotoxicity are also studied using a standard isolate of P. aeruginous, fibroblast stem cells (FSC) and mouse embryonic fibroblasts (MEF). Furthermore, histopathological and histomorphological assessments are conducted on 150 male Wistar rats whitin four experimental groups to evaluate the efficiency of the prepared burn ointment. We found a significant wound healing in both macroscopical observations and microscopical evaluations. Both curcumin and honey show strong antimicrobial effects with no cytotoxicity. Also, the histopathological results present a considerable and comparable wound re-epithelization in the a group of rats treated with both honey and curcumin after 7 days. The burn ointment containing curcumin, honey, and potassium alum show considerable efficacy in accelerating the healing of experimentally-induced burn wounds in animals. Th novel onement product is propose as a powerful alternative for the topical treatment of burn injuries

Potential Protective Effect of Pretreatment with Caraway Essential Oil in vivo Model of Iron Nanoparticle-induced Liver Injury

Recently, there has been a great deal of interest in the use of the medicinal plants with high antioxidant compounds for curing liver injuries induced by hepatoxcitic agents. This study was to assess the protective effect of Carum carvi L. essential oil (E.O) on the hepatoxitic rats induced by overdose of iron oxide nanoparticles (NPs). The rats were distributed to 4 groups. In negative control group (NC), the rats received normal saline and DMSO daily for 3 days. In control group (C), iron oxide nanoparticles (Fe2O3) (200 mg/kg b.w) was injected daily for 3 days. In the treatment groups, iron oxide nanoparticles plus E.O at 100 & 200 mg/kg b.w were injected daily for 3 days. In following, cytochrome P450 (CYP450), glutathione S-transferase (GST), glutathione (GSH), aspartate transaminase (AST), alkaline phosphatase (ALP) and alanine transaminase (ALT) were estimated at 72 h after NP-treatment. The administration of the E.O could return considerably the decrease of the GST and GSH levels as well as the increase of the level of AST induced by iron oxide NPs. These results are in agreement with histopathological results. The data indicated that E.O provided an efficient prevention against iron oxide NPs-induced hepatotoxicity in rats