Elos de polissemia da construção pronominal a gente no português brasileiro contemporâneo

Este trabalho toma como objeto de análise a construção pronominal a gente do português brasileiro (PB) sob perspectiva da Gramática de Construções (GOLDBERG, 1995; 2006). O objetivo do artigo é analisar e descrever os elos de polissemia que essa construção estabelece no uso efetivo da língua, com base em aspectos sintáticos e semântico-pragmáticos. Metodologicamente, nossa análise é essencialmente qualitativa e se ampara em dados empíricos provenientes de uma fonte principal, o Banco de dados Iboruna, que reúne amostras da variedade do PB falado no interior do estado de São Paulo (GONÇALVES, 2007). Os resultados empíricos permitem mostrar quatro padrões de usos referenciais de a gente: (i) dêitico; (ii) inclusivo; (iii) exclusivo; (iv) indeterminado. Em função dos resultados, defendemos que, na rede de construções pronominais do PB, um mesmo esquema construcional de a gente instancia padrões construcionais com significados referenciais distintos, porém ligados por elos polissemia

Two protocols of aerobic exercise modulate the counter-regulatory axis of the renin-angiotensin system.

Aims: The renin-angiotensin system (RAS) is a dual system with two opposite arms: i) the classical one formed by the angiotensin converting enzyme (ACE), angiotensin (Ang) II and angiotensin type 1 (AT1) receptors; ii) the counter-regulatory arm consisting of ACE2, Ang-(1?7) and Mas receptor. Physical exercise can modulate this system, however, only animal studies have compared the effects of different intensity protocols on the RAS. No data with humans were provided. Therefore, we investigated the acute effect of two protocols of isowork aerobic exercise [High-Intensity Interval Exercise (HIIE) and Moderate-Intensity Continuous Exercise (MICE)] in plasma and urinary levels of RAS components in physically active men. Main methods: The HIIE protocol included a 5-minute warm-up cycling at 60?70% of heart rate peak (HRp) intensity followed by 10 sets of 30 s above 90% with 1 min of recovery and 3 min of cool down. The MICE protocol was performed at a constant power corresponding to 60?70% of HRp and finalized at the same total work of HIIE. Blood and urine samples were collected before and after the protocols. Plasma and urinary levels of ACE, ACE2, Ang-(1?7) and Ang II were analyzed by enzyme-linked immunoassay. Key findings: While the HIIE protocol significantly increased urinary levels of ACE and plasma levels of ACE2, the MICE protocol elevated urinary concentrations of ACE2 and of Ang-(1?7). A greater increase of urine concentrations of Ang-(1?7) occurred in the MICE if compared with the HIIE protocol. Significance: Aerobic physical exercise acutely increases the activity of the counter-regulatory RAS axis, mostly the MICE protocol

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Updated cardiovascular prevention guideline of the Brazilian Society of Cardiology: 2019

Sem informação113478788

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Performance and carcass quality of feedlot- or pasture-finished Nellore heifers according to feeding managements in the postweaning phase

The objective of this study was to evaluate the postweaning history of heifers kept on marandu grass pastures with three canopy heights, in a continuous-grazing system, during the rainy period, on feedlot-or pasture finishing. The effects of three canopy heights (15, 25 and 35 cm) associated with two supplements (mineral salt and protein-energy supplement) and two finishing systems in the dry period (feedlot and open pasture) were studied in the postweaning period during the rainy season. The adopted design was completely randomized, with seven replications (animals) in a 2 x 2 factorial arrangement. The animals which received protein-energy supplement reached the finishing period with greater body weight in relation to those fed mineral salt. In both feedlot and pasture finishing systems, compensatory gain effect was observed in the animals that remained on the low pastures during postweaning compared with the high pastures. This compensatory gain was not verified in the animals that received protein-energy supplement in relation to the mineral salt, and thus the animals were slaughtered beforehand. The heifers on pastures with 25 or 35 cm in height were slaughtered in the same period, and those kept on the low pastures were slaughtered afterwards. The studied factors in the postweaning phase did not affect the carcass characteristics. Animals finished in feedlot slaughtered with the same body weight as those finished on pasture show greater carcass yield, subcutaneous fat deposition and renal pelvic and inguinal fat and greater losses with trimmings for cleaning the main hindquarter meat cuts; however, they provide cuts with the same weight but greater fat cover

Medicamentos antidiabéticos utilizados com a finalidade de perda de peso

O presente estudo objetivou realizar um levantamento bibliográfico de medicamentos antidiabéticos utilizados para emagrecimento e suas consequências para a saúde humana. Os medicamentos mais comumente relatados na literatura foram Metformina, Liraglutida e Semaglutida. Os três medicamentos demonstraram ser efetivos no emagrecimento, tendo a Liraglutida efeito mais pronunciado, inclusive em estudos clínicos. Metformina e Semaglutida demonstraram reduzir peso principalmente quando associados à prática de exercício físico e mudança de hábito alimentar. Entretanto, esses medicamentos ainda não foram aprovados com a finalidade de emagrecimento, e uma série de efeitos colaterais foram relatados, principalmente associados ao sistema gastrointestinal como náusea, vômito e diarréia. Com base nos dados avaliados, a melhor forma de reduzir o peso corporal continua sendo a prática de atividade física e mudança do estilo de vida, e uma vez que tais práticas não são suficientes pode-se optar pelo uso de anorexígeno com a devida prescrição e orientação de um profissional de saúde. Destacamos ainda a maior necessidade do farmacêutico, responsável pela interface entre o medicamento e o paciente, no processo de educação para evitar o uso irracional de medicamentos antidiabéticos no intuito de emagrecer