Research on Conceptual Metaphors of Sense of national Community in China Daily English Reports

This paper takes the English reports on the sense of national community in China Daily, the mainstream media of China, from 2018 to 2022 as the research object. Based on conceptual metaphor, this article analyses the types, distribution characteristics and role of metaphors in the reports of “sense of national community”. Study finds out that eight different types of metaphors were used in English news reports, and that the frequency of different metaphor types was very unevenly distributed. There is an inappropriate use of religious metaphor in the report. This study has implications for Chinese mainstream media in delivering a sense of national community, spreading Chinese culture and enhancing national cultural confidence

Survey on the Acquisition of Chinese Vocabulary by International Students—A Case Study of Southwest Petroleum University

Vocabulary is the basic unit that constitutes a language, and is an important carrier for conveying information and constructing meaning. The study of Chinese vocabulary acquisition in China is mostly on the analysis of bias. The study adopts questionnaire survey method which take foreign students from Southwest Petroleum University as an example to study the vocabulary acquisition of the Chinese everyday language. The phenomenon of investigation was analyzed from Atkinson’s social cognitive perspective. The results of the study indicate that vocabulary of everyday terms has not been fully learned by international students even they got certificates. And everyday language vocabulary should receive attention from teachers to international students. In teaching process, it’s vital to give full play to the alignment between the social environment, social activities and learners, which could help international students improve their language competence

A novel dynamical filter based on multi-epochs least-squares to integrate the carrier phase and pseudorange observation for GNSS measurement

© 2020 by the authors. The high noise of pseudorange and the ambiguity of carrier phase observation restrain the GNSS (Global Navigation Satellite System) application in military, industrial, and agricultural, to name a few. Thus, it is crucial for GNSS technology to integrate the pseudorange and carrier phase observations. However, the traditional method proposed by Hatch has obtained only a low convergence speed and precision. For higher convergence speed and precision of the smoothed pseudorange, aiming to improve positioning accuracy and expand the application of GNSS, we introduced a new method named MELS (Multi-Epochs Least-Squares) that considered the cross-correlation of the estimating parameters inspired by DELS (Double-Epochs Least-Square). In this study, the ionospheric delay was compensated, and so its impact was limited to the performance of the filters, and then exploited the various filters to integrate carrier phase observation and pseudorange. We compared the various types of Hatch's filter and LS (Least-Square) methods using simulation datasets, which confirmed that the types of LS method provided a smaller residual error and a faster convergence speed than Hatch's method under various precisions of raw pseudorange. The experimental results from the measured GNSS data showed that LS methods provided better performance than Hatch's methods at E and U directions and a lower accuracy at N direction. Nevertheless, the types of LS method and Hatch's methods improved about 12% and 9-10% at the 3D direction, respectively, which illustrated the accumulating improvement at the enhanced directions was more than the decreased direction, proving that the types of LS method resulted to better performance than the Hatch's filters. Additionally, the curve of residual and precision based on various LS methods illustrated that the MELS only provided a millimeter accuracy difference compared with DELS, which was proved by the simulated and measured GNSS datasets

SEKOLAH SEPAKBOLA USIA MUDA DI BANDA ACEH

Sepakbola merupakan olahraga yang sangat populer dan digemari di dunia, begitu juga di Indonesia. Tak heran jika hampir semua negara di dunia berlomba-lomba menggalang prestasi membanggakan di cabang olahraga ini. Indonesia belum mampu meraih prestasi yang membanggakan di cabang olahraga sepakbola, bahkan Indonesia sulit bersaing di kancah Internasional. Klub-klub sepakbola Aceh juga tidak dapat berbuat banyak di kompetisi internal, sedangkan Aceh merupakan salah satu provinsi yang banyak memunculkan pemain muda berbakat.Kualitas persepakbolaan di Indonesia yang rendah dan minim prestasi ini dikarenakan kurang pembinaan dan pelatihan pemain mulai dari usia dini untuk didik menjadi pemain profesional. Sarana pelatihan yang ada di Indonesia belum serius ke arah profesional seperti akademi sepakbola di Eropa. Di negara-negara maju dalam sepakbola, prestasi tim nasional pada umumnya dilatarbelakangi oleh sistem dan proses pembinaan klub yang sudah mapan.Sekolah sepakbola usia muda di Banda Aceh merupakan sebuah sarana pelatihan dan pembinaan sepakbola pemain usia dini di Banda Aceh. Pemain tersebut akan dididik, dilatih dan dibina sejak dini sebagai usaha pembibitan pemain sepakbola Aceh yang potensial. Sekolah sepakbola ini berlokasi di Lhong Raya, sesuai dengan rencana pengembangan kawasan pusat olahraga di Banda Aceh. Dengan mengusung tema arsitektur metafora, diharapkan bangunan sekolah sepakbola ini dapat menjadi objek arsitektur yang melekat di masyarakat.Tahap awal dalam proses perancangan Sekolah Sepakbola Usia Muda di Banda Aceh ini adalah studi literatur data dan studi banding. Selanjutnya permasalahan yang ada diidentifikasi dan dianalisis sesuai dengan batasan perancangan. Dalam lingkup batasan tema arsitektur metafora dan kondisi iklim setempat selanjutnya melahirkan konsep perancangan sesuai dengan hasil analisis.Kata kunci: olahraga, sekolah, sepakbolaBanda Ace

Case Report: Ensartinib for gastric epithelioid inflammatory myofibrosarcoma with STRN-ALK fusion

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a highly aggressive malignant subtype of inflammatory myofibroblastoma (IMT) associated with poor prognosis. IMT can occur in various parts of the body, most frequently in the lungs, followed by the mesentery, omentum, retroperitoneum, and pelvis, among other areas; however, it is exceptionally rare in the stomach. Anaplastic lymphoma kinase (ALK) is a critical driver of lung cancer development and is currently the “gold standard” target for non-small cell lung cancer treatment. However, there are few reports on the use of ALK inhibitors for EIMS, necessitating further investigation. A male patient with postoperative inflammatory myofibroblastic sarcoma of the stomach received postoperative chemotherapy and had a stable outcome. However, a repeat CT scan performed 11 months later revealed disease progression. The patient later underwent immunohistochemistry testing that indicated ALK positivity, and next-generation sequencing revealed STRN-ALK fusion. Ensartinib 225 mg qd was administered as recommended, and the patient experienced only mild pruritus and no adverse effects such as rash. Eight months after CT follow-up, the patient’s subseptal soft tissue nodules had decreased, and the outcome was assessed as a partial response. The findings of this case report introduce a novel strategy for treating ALK-positive EIMS that utilizes ensartinib, a drug with previously demonstrated success in the treatment of ALK-positive cancer

Assessment Accuracy of Standard Point Positioning Enhanced by Observation and Position Domain Filtering Utilizing a Multi-Epoch Least-Squares Integration Method

To enhance the positioning accuracy of standalone GNSS receivers in environments unable to provide precise ephemeris and clock offset, such as undeveloped forest areas that lack network communication and power supply, this study employed the Time Difference Carrier Phase (TDCP) technology to improve the positioning accuracy of Standard Point Positioning (SPP), where the Least-Squares (LS) and the extended Multi-Epoch Least Squares (MELS) method were applied in the position domain filtering for a single GNSS receiver and compare its performance with the existing observation domain filtering method. Firstly, the simulated data sets with various positioning accuracies were used to verify the effectiveness and convergence of the LS filtering methods. The results indicate that the LS filtering method produces a lower root mean square (RMS) error than the original strategy. Secondly, this study uses two kinematic GNSS data sets to evaluate the performance of the observation and position domain filtering, with an emphasis on the MELS method. The numerical experiment results show that the position domain LS filtering method outperforms the other two methods. The open environment experiments result shows that the positioning domain filtering method achieved positioning accuracies of 0.202 m, 0.843 m, and 2.036 m in the E, N, and U directions, respectively, with improvements of 68.0%, 21.6%, and 24.0%, compared to the original algorithm which achieved positioning accuracies of 0.631 m, 1.076 m, and 2.680 m. It also achieved improvements of 24.0%, 4.0%, and 18.3%, respectively, compared to the observation domain filtering method with positioning accuracies of 0.353 m, 0.886 m, and 2.526 m. The forest scenes experiments result shows that the positioning domain filtering method achieved positioning accuracies of 1.308 m, 1.375 m, and 2.133 m in the E, N, and U directions, respectively, with improvements of 42.4%, 36.2%, and 27.6%, compared to original algorithm which achieved positioning accuracies of 1.863 m, 1.873 m, and 2.722 m, and also achieved improvements of 27.0%, 19.4% and 10.6%, respectively, comparing to observation domain filtering method with positioning accuracies of 1.661 m, 1.642 m and 2.359 m. Moreover, the examination of the LS method results based on different epochs reveals that the filtering accuracy increases as more epochs are incorporated into the position domain integration and the enhancement value reaches a few millimeters

A study of risk factors for tuberculous meningitis among patients with tuberculosis in China: An analysis of data between 2012 and 2019

PurposeThe present study aimed to explore the risk factors for tuberculous meningitis (TBM) among patients with tuberculosis (TB).MethodsThis retrospective study was conducted on patients with TB who were hospitalized in Beijing Chest Hospital between January 2012 and December 2019. Demographic and clinical data of patients with TB were extracted from electronic medical records using a standardized data collection system. Logistic regression was used to analyze the risk factors associated with TBM.ResultsOf the total number of 22,988 cases enrolled, 3.1% were cases of TBM, which included 127 definite and 581 probable TBM, respectively. Multivariate analysis showed that definite TBM was significantly associated with patients aged < 30 years [adjusted odds ratio (aOR) = 3.015, 95% confidence interval (CI): (1.451–6.266)], who were farmers [aOR = 1.490, 95%CI: (1.020–2.177)], with miliary pulmonary TB [aOR = 105.842, 95%CI: (71.704–156.235)], and with malnutrition [aOR = 2.466, 95%CI: (1.110–5.479)]. Additionally, probable TBM was significantly associated with patients aged < 30 years [aOR = 2.174, 95% CI: (1.450–3.261)], aged 30–59 years [aOR = 1.670, 95% CI: (1.222–2.282)], who were farmers [aOR = 1.482, 95%CI: (1.203–1.825)], with miliary pulmonary TB [aOR = 108.696, 95%CI: (87.122–135.613)], and with a digestive system TB [aOR = 2.906, 95%CI: (1.762–4.793)].ConclusionAn age of < 30 years, being a farmer, and having miliary pulmonary TB were risk factors for TBM among patients with TB. Further screening of patients with TB with aforementioned characteristics could facilitate clinicians to identify patients with TBM at an early stage

Ferromagnetic interlayer coupling in CrSBr crystals irradiated by ions

Layered magnetic materials are becoming a major platform for future spin-based applications. Particularly the air-stable van der Waals compound CrSBr is attracting considerable interest due to its prominent magneto-transport and magneto-optical properties. In this work, we observe a transition from antiferromagnetic to ferromagnetic behavior in CrSBr crystals exposed to high-energy, non-magnetic ions. Already at moderate fluences, ion irradiation induces a remanent magnetization with hysteresis adapting to the easy-axis anisotropy of the pristine magnetic order up to a critical temperature of 110 K. Structure analysis of the irradiated crystals in conjunction with density functional theory calculations suggest that the displacement of constituent atoms due to collisions with ions and the formation of interstitials favors ferromagnetic order between the layers

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk