Synthèse directe de monothioéthers, d'aminoacides polyhydroxylés et de lactames N-alkylés à partir de D-pentono-1,4-lactones

AMIENS-BU Sciences (800212103) / SudocSudocFranceF

Thiol-Poly(Sodium Styrene Sulfonate) (PolyNaSS-SH) Gold Complexes: From a Chemical Design to a One-Step Synthesis of Hybrid Gold Nanoparticles and Their Interaction with Human Proteins

International audienceThis study highlights recent advances in the synthesis of nanoconjugates based on gold (Au(III)) complex with a bioactive polymer bearing sulfonate groups called thiol-poly(sodium styrene sulfonate) (PolyNaSS-SH) with various molecular weights (5, 10, and 35 kDa). The three nanomaterials differ substantially in shape and structure. In particular, for PolyNaSS-SH of 35 kDa, we obtained a characteristic core−shell flower shape after chelation of the Au(III) ions and successively reduction with sodium borohydride (NaBH 4). The mechanism of formation of the hybrid nanoparticles (PolyNaSS-SH@AuNPs (35 kDa) and their interactions between plasmatic proteins (human serum albumin (HSA), collagen I (Col 1), and fibronectin (Fn)) were deeply studied from a chemical and physical point of view by using several analytical techniques such as Raman spectroscopy, UV−visible, transmission electron microscopy (TEM), 1 H NMR, and X-ray photoelectron spectroscopy (XPS)

Double functionalization for the design of innovative craniofacial prostheses

International audienceTitanium (Ti) is the most commonly used material for cranial prostheses. However, this material does not exhibit the same mechanical properties as the bone. Incorporating polymers onto Ti by combining both their properties is a solution to overcome this issue. Thus, sandwich materials made of two Ti skin sheets and a poly(methyl methacrylate) (PMMA) core are promising structures to design biomedical prostheses. The "grafting to" and "grafting from" procedures to functionalize the Ti/PMMA interface are described in this paper as two strategies for chemically connecting PMMA chains on Ti surfaces. The advantage of the first approach is the capacity to control the architecture of the grafted PMMA on Ti. Moreover, a method for selectively grafting a bioactive polymer such as poly(sodium styrene sulfonate) (PNaSS) on one side of the Ti and PMMA on the other side is developed. This contribution presents efficient ways of functionalizing Ti for biomedical applications

Trends in Metal-Based Composite Biomaterials for Hard Tissue Applications

International audienceAbstract The world of biomaterials has been continuously evolving. Where in the past only mono-material implants were used, the growth in technology and collaboration between researchers from different sectors has led to a tremendous improvement in implant industry. Nowadays, composite materials are one of the leading research areas for biomedical applications. When we look toward hard tissue applications, metal-based composites seem to be desirable candidates. Metals provide the mechanical and physical properties needed for load-bearing applications, which when merged with beneficial properties of bioceramics/polymers can help in the creation of remarkable bioactive as well biodegradable implants. Keeping this in mind, this review will focus on various production routes of metal-based composite materials for hard tissue applications. Where possible, the pros and cons of the techniques have been provided

Neutron microtomography to investigate the bone-implant interface – comparison with histological analysis

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