Rumah Indonesia Bernuansa “Indonesia Negara 1000 Budaya” Sebagai Sarana Informasi Sekaligus Untuk Memperkenalkan Budaya Indonesia Pada Masyarakat Di Perbatasan

Indonesia is a country that has an abundance of different cultures. With the abundance of culture possessed, Indonesia should be able to preserve it. However, in reality some Indonesian culture has been claimed by neighboring countries such as Reog Ponorogo is claimed by Malaysia, and others. So must to do an action that can minimize the threat. One solution is by the Rumah Indonesia. Rumah Indonesia is a public facility that concept "Indonesia is a Country of 1000 Culture". The goal is to make the establishment of information centers as well as introducing Indonesian culture to the people at the border. Which in turn can be everlasting to Indonesian culture and not claimed by neighboring countries

Comparison the Formation of Spark Corona Discharge between Tap and distilled Waters at Liquid Electrode System

In this paper, we studied the spark corona discharge in tap and distillited waters. The results show the shape of cone that generated on the tip of capillary tube is different with conductivity of liquids. The blue glow appears at the end of capillary tube and the drop extends into a cone. In addition, the conducitivity is affected on the relationship between the appearance of the blue glow discharge with the applied voltage. The size of the cone decreases with an increase in applied voltage. The cone diameter at the base of capillary tube oscillates with period approximately 1 Sec. this oscillates in the cone diameters is due to the change distance between the liquid electrode and the surface of liquid. The intensity of spark corona discharge that formed in tap water higher than that formed in distillited water. In addiation, when the applied voltage is 5 KV on distillted water, the drope extends into two cones while in tap water the drop extends into one cone. These contrast between two water types which under test (i.e. tap and distillited waters) is due to the differance in condictivity of water

SIMULASI TUBRUKAN PADA PENYEDERHANAAN STRUKTUR RANGKA MOBIL JENIS MONOCOQUE

Salah satu aspek yang perlu di perhatikan dalam merancang kendaraan ialah rangka, rangka merupakan bagian dari kendaraan yang memiliki fungsi sebagai fondasi yang menopang atau menyangga komponen kendaraan mulai dari mesin, drive train, suspensi, sistem kemudi, serta kelistrikan. Selain untuk menopang komponen kendaraan, rangka juga berfungsi sebagai salah satu faktor keselamatan pengemudi saat terjadi benturan. Tujuan dari penelitian ini adalah untuk mengetahui deformasi dan stress pada model sederhana dari rangka monocoque yang mengalami beberapa kondisi tubrukan. Metode penelitian yang digunakan ialah simulasi explicit dynamics analysis untuk menguji beban impact pada peyederhanaan struktur model rangka kendaraan jenis monocoque, dan melakukan simulasi Frontal crash 90 degree barrier, Frontal crash with offset, Pole offset crash, dan 90 degree side crash. Hasil dari penelitian di dapat bahwa pengujian car crash Totaldeformation dan Stress pada peyederhanaan struktur model rangka kendaraan jenis monocoque, Frontal crash berdampak lebih besar dari pada Side crash, dilihat dari hasil nilai total deformation dan stress yang lebih besar dari pada Side crash yaitu pada frontal crash memiliki Total deformation maksimal sebesar 129,92 mm dengan stress maksimal 642,92 Mpa sedangkan side crash memiliki Total deformation sebesar 44,2 mm dengan stress maksimal 473,5 Mpa

Determination of the Adequate Thickness of Granular Subbase Beneath Foundations

Where the native soils have poor structural qualities or are expansive, the soil investigation report may recommend importation of soils better suited to providing a subbase for structures. This requires considering two soil layers in bearing capacity calculations. Calculation of the ultimate bearing capacity of shallow footing on a two layered system of soil depends on the pattern of the failure surface that develops below the footing. For a weak clay layer overlaid by a top dense sand layer, previous studies assumed that the failure surface is a punching shear failure through the upper sand layer and Prandtl's failure mode in the bottom weak clay layer. In this paper, the bearing capacity of subbase layer underneath by a soft clay layer is investigated. The properties of the subbase material are measured in the laboratory. Design charts were obtained which can be used to select the suitable thickness of the subbase layer for a design allowable bearing capacity

How Transmembrane Inner Ear (TMIE) plays role in the auditory system: A mystery to us

Different cellular mechanisms contribute to the hearing sense, so it is obvious that any disruption in such processes leads to hearing impairment that greatly influences the global economy and quality of life of the patients and their relatives. In the past two decades, transmembrane inner ear (TMIE) protein has received a great deal of research interest because its impairments cause hereditary deafness in humans. This evolutionarily conserved membrane protein contributes to a fundamental complex that plays role in the maintenance and function of the sensory hair cells. Although the critical roles of the TMIE in mechanoelectrical transduction or hearing procedures have been discussed, there are little to no review papers summarizing the roles of the TMIE in the auditory system. In order to fill this gap, herein, we discuss the important roles of this protein in the auditory system including its role in mechanotransduction, olivocochlear synapse, morphology and different signalling pathways; we also review the genotype-phenotype correlation that can per se show the possible roles of this protein in the auditory system. © 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd

Adherence to antidiabetic medication during the month of Ramadan among diabetes mellitus patients in the kingdom of Saudi Arabia

Background: Ramadan may lead to reduced adherence to antidiabetic medications among Saudi diabetes patients due to fasting, changes in daily routine, social and cultural influences, health risks, and inadequate awareness. This study aimed to assess the Saudi population adherence to the diabetes management medication in Ramadan. Methodology: A convenience sampling method was used to recruit participants for the study. Participants were sourced from social media platforms, diabetes mellitus patient groups, and healthcare providers groups. The Medication Adherence Rating Scale (MARS), a tool, was used to assess medication compliance. Results: A total of 384 individuals were included in this study, 20.3% were from Riyadh, 52.3% were males, 35% aged 31-50 years, and 64.1% had type 2 diabetes mellitus of participants. Age between 31-50 years was negatively associated with compliance (β = -1.06, p = 0.002), while age between 51-65 years is positively associated ((β= 1.00, p = 0.003). Being male was negatively associated with compliance (β= -0.72, p = 0.001). Different fasting behaviors like non-fasting one day or more (β = -2.92, p < 0.001) and fasting all month (β = -2.90, p < 0.001), significantly affect compliance scores with negative associations indicating lower compliance during fasting periods. Various HbA1c levels were significant predictors of compliance. Higher HbA1c levels were associated with increased compliance. Conclusions: The study reveals that age, gender, fasting behaviors and HbA1c levels significantly impact medication compliance among patients with diabetes mellitus during Ramadan

J. Med. Genet.

Background: Primary microcephaly (MCPH) is a genetically heterogeneous disorder showing an autosomal recessive mode of inheritance. Affected individuals present with head circumferences more than three SDs below the age- and sex-matched population mean, associated with mild to severe mental retardation. Five genes (MCPH1, CDK5RAP2, ASPM, CENPJ, STIL) and two genomic loci, MCPH2 and MCPH4, have been identified so far. Methods and results: In this study, we investigated all seven MCPH loci in patients with primary microcephaly from 112 Consanguineous Iranian families. In addition to a thorough clinical characterisation, karyotype analyses were performed for all patients. For Homozygosity mapping, microsatellite markers were selected for each locus and used for genotyping. Our investigation enabled us to detect homozygosity at MCPH1 (Microcephalin) in eight families, at MCPH5 (ASPM) in thirtheen families. Three families showed homozygosity at MCPH2 and five at MCPH6 (CENPJ), and two families were linked to MCPH7 (STIL). The remaining 81 families were not linked to any of the seven known loci. Subsequent sequencing revealed eight, 10 and one novel mutations in Microcephalin, ASPM and CENPJ, respectively. In some families, additional features such as short stature, seizures or congenital hearing loss were observed in the microcephalic patient, which widens the spectrum of clinical manifestations of mutations in known microcephaly genes. Conclusion: Our results show that the molecular basis of microcephaly is heterogeneous; thus, the Iranian population may provide a unique source for the identification of further genes underlying this disorder

The Importance of Preventive Medicine in Family Practice: A Review of Current Guidelines and Recommendations

Prevention is seen as a critical topic in family practice. Primordial prevention, primary prevention, secondary prevention, tertiary prevention, and quaternary prevention are all part of this strategy to disease prevention. To avoid the formation and development of risk factors, primary prevention focuses on addressing the fundamental causes and social determinants of disease. Primary prevention is the practice of preventing illnesses before they arise via the use of treatments such as immunizations and health education. Secondary prevention focuses on illness identification and intervention as early as possible to avoid disease development. Tertiary prevention addresses illness outcomes by restoring health and offering rehabilitation. Finally, quaternary prevention seeks to safeguard patients against needless medical treatments and the harm caused by over-medicating. Risks frequently rise in tandem with frailty and comorbidities. In contrast, advantages frequently drop as life expectancy increases. Preventive management strategies should consider the patient's viewpoint and be mutually agreed upon. Healthcare providers must prioritize the deployment of preventive care services, even when clinical treatments are required, in order to overcome preventive care hurdles. Healthcare practitioners may play a critical role in illness prevention and contribute to family well-being by investing in preventive care and executing these measures

CD271-selected mesenchymal stem cells from adipose tissue enhance cartilage repair and are less angiogenic than plastic adherent mesenchymal stem cells

CD271 is a marker of bone marrow MSCs with enhanced differentiation capacity for bone or cartilage repair. However, the nature of CD271+ MSCs from adipose tissue (AT) is less well understood. Here, we investigated the differentiation, wound healing and angiogenic capacity of plastic adherent MSCs (PA MSCs) versus CD271+ MSCs from AT. There was no difference in the extent to which PA MSCs and CD271+ MSCs formed osteoblasts, adipocytes or chondrocytes in vitro. In contrast, CD271+ MSCs transplanted into athymic rats significantly enhanced osteochondral wound healing with reduced vascularisation in the repair tissue compared to PA MSCs and control animals; there was little histological evidence of mature articular cartilage formation in all animals. Conditioned medium from CD271+ MSC cultures was less angiogenic than PA MSC conditioned medium, and had little effect on endothelial cell migration or endothelial tubule formation in vitro. The low angiogenic activity of CD271+ MSCs and improved early stage tissue repair of osteochondral lesions when transplanted, along with a comparable differentiation capacity along mesenchymal lineages when induced, suggests that these selected cells are a better candidate than PA MSCs for the repair of cartilaginous tissue